CHEMICAL ENGINEERING RESEARCH & DESIGN
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2025
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IF 3.9
Da Wang,Miao Zhang,Qingjie Xie,Song Han,Sisi Xiao,Huijuan Wang
In this study the indigenous materials in plateau areas were used to cope with the challenge of increasing antibiotics pollution in Qinghai-Xizang Plateau. The barely straw was chosen as the raw material to prepare the manganese modified biochar (XBSMBC) and then combined with peroxymonosulfate (PMS) to set up the PMS/XBSMBC system to treat the enrofloxacin (ENR) in water. The study showed that there was a higher PMS activation and thus ENR degradation of the manganese modified biochar prepared from the barley straw than those from Xizang wheat straw and Henan wheat straw. The preparation parameters of the XBSMBC, including the mass ratio of barley straw to manganese and the pyrolysis temperature, for the PMS activation as well as the ENR degradation were reviewed and found that the 1:1 and 900°C were the optimal preparing conditions (XBSMBC-900 (1:1)). The influence of the XBSMBC-900 (1:1) additive amount, PMS dosage and solution initial pH on the ENR degradation was also ascertained. Results of quenching experimental studies and electron paramagnetic resonance demonstrated that ENR degradation in the PMS/XBSMBC system was achieved by a combined effect of SO 4 ·- , ·OH, ·O 2 - and 1 O 2 . Four possible pathways of ENR degradation were provided, and the toxicity analysis predictions were applied to infer the validity of the PMS/XBSMBC process for the ENR solution treatment.
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ACS Applied Materials & Interfaces
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2025
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IF 8.2
Man Zhang,Jingxi Yang,Junyuan Zhang,Keqi Wo,Xiangyang Dong,Hongbing Deng,Man Wang,Cheng Yang
The reconstruction of critical-sized bone defects remains a significant clinical challenge. Natural polymers used for bone defects exhibit excellent biocompatibility and degradability; however, their inadequate mechanical properties, absence of biomimetic topological structures, and limited osteogenic potential hinder their suitability for clinical applications. In this study, we developed an all-natural wood hydrogel by integrating natural lignocellulosic nanofibers into chitosan hydrogels through delignification and vacuum impregnation. The all-natural wood hydrogel effectively mimics the structure of natural bone. Strontium ions mimicked bone’s phosphate fibers, chitosan hydrogels emulated collagen fibers, and WW was used to recreate the layered, anisotropic bone tissue structures. Furthermore, the tensile strength of the all-natural wood hydrogel reached approximately 12 MPa, demonstrating a significant improvement in the mechanical strength. In vitro experiments confirmed that the all-natural wood hydrogel showed excellent biocompatibility, promoting cell proliferation and migration. Additionally, the release of strontium ions from the all-natural wood hydrogel supports angiogenesis and osteogenesis. Transcriptomic analysis initially revealed that the all-natural wood hydrogel modulates BMSCs activity by upregulating angiogenic and osteogenic genes while activating PI3K-AKT and calcium signaling pathways. Moreover, in in vivo experiments, this all-natural wood hydrogel is adaptable to various cranial defects and accelerates the repair of critical-sized bone defects. These findings offer insights into the development of all-natural wood hydrogels for enhancing bone regeneration.
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高影响因子
FOOD CHEMISTRY
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2025
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IF 9.8
Shan Huang,Danyu Lv,Yuhuan Geng,Fuhao Yue,Xinan Zeng,Mengwai Woo,Zhong Han,Ji Ma
Malachite green (MG) is a toxic contaminant commonly found in aquaculture, making its effective removal and detection crucially important. In this study, MIL-100(Fe) was synthesized via a microwave-assisted hydrothermal method under optimized conditions (150 °C, 200 W, 30 min; FeCl₃·6H 2 O:H₃BTC = 2:3). The resulting material exhibited excellent structural stability, a high specific surface area (1169.9 m 2 /g), and a remarkable MG adsorption capacity of 714.29 mg/g. To enable practical application and reusability, MIL-100(Fe) was immobilized onto a melamine sponge (MeS) using polyvinylidene fluoride (PVDF) as binding agent, forming a recyclable MeS/PVDF/MOF composite. When applied for solid-phase extraction of MG in conjunction with UV detection, the composite demonstrated high recovery rates (92.1–99.4 %), a low detection limit (2.29 μg/L), and consistent performance with over 80 % recovery after six reuse cycles in both real fish and wastewater samples. This study presents a simple, efficient and sustainable strategy for the adsorption and detection of MG in aquatic food matrices.
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JOURNAL OF ETHNOPHARMACOLOGY
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2024
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IF 4.8
Jingying Shi,Yawen Liu,Zijia Zhang,Xianchun Zhong,Yuhan Cao,Hui Ni,Qingqing He,Zhaojun Wang,Yameng Liu,Qinhua Chen,Jianming Wei,Haibo Wang,Likun Gong,Cen Xie,Jinjun Hou,Wanying Wu
Ethnopharmacological relevance Zexie-Baizhu Decoction (AA), a Chinese Classical Formula composed of Alisma orientalis (Sam.) Juzep . and Aractylodes Macrocephala Koidz in the specific ratio of 5:2, has a long history of use in treating metabolic disorders. Recent studies have demonstrated AA’s ameliorative effects on non-alcoholic fatty liver disease (NAFLD); however, the mechanism underlying its action on the gut and adipose tissue, key regulators of metabolism, have not been fully explored. Aim of the study This study aimed to investigate the mechanisms by which AA regulates the homeostasis of gut and adipose tissue in NAFLD. Materials and Methods AA (1500 mg/kg/day) or vehicle was administrated to the high-fat diet-induced and normal chow-fed mice (C57BL/6J). Plasma, the liver, gut microbiota, bile acids, and short-chain fatty acids in the gut, were systematically investigated. RNA sequencing analysis, reverse transcription quantitative real-time PCR, and Western Blotting were performed on the epididymal white adipose tissues (eWAT) to explore AA’s influence on NAFLD. Lipidomics of the liver and eWAT were analyzed by liquid chromatography-mass spectrometry and desorption electrospray ionization mass spectrometry imaging. Results Our study demonstrated that AA administration effectively alleviated liver injury induced by NAFLD, as evidenced by reduced hepatic fat accumulation and inflammation. Mechanistically, AA modulated the composition of the gut microbiota, promoting the growth of beneficial bacteria such as Akkermansia muciniphila and restoring the balance between Firmicutes and Bacteroidetes. Furthermore, AA regulated the levels of bile acids and short-chain fatty acids in the intestine, plasma, and liver. Correspondingly in the eWAT, AA administration activated bile acid receptor ( Gpbar1 ) and short-chain fatty acid receptor ( Ffar2 ), facilitating lipid breakdown and attenuating triglyceride accumulation. Transcriptome analysis revealed that AA influenced gene expression related to fatty acid metabolism, thermogenesis, insulin resistance, AMPK signaling, and the tricarboxylic acid (TCA) cycle, thereby improving NAFLD at the transcriptional level. Additionally, AA treatment significantly altered the lipid composition in the liver, reducing levels of diacylglycerols, triacylglycerols, phosphatidylserines, and cholesterol esters, while increasing levels of phosphatidic acids, phosphatidylethanolamines, and sphingomyelins. Conclusion Our study builds a connection between the gut and adipose tissue to understand the mechanism of AA on alleviating NAFLD, providing new insights into the development of targeted therapies for this condition.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Xingying Xue,Zhiwen Qi,Zhihong Wang,Ran Tao,Hao Zhou,Hongxia Chen,Jiandu Lei,Chengzhang Wang
In this study, magnetic nanocarriers (DU@Fe, D avg = 281.6 nm, zeta potential −28.0 mV) were fabricated using dextran, urushiol as the shell and superparamagnetic iron oxide nanoparticles (SPIONs) as the core. Subsequently, the specific ligand Lys-D-Ala-D-Ala of vancomycin (Van) was grafted onto the surface of DU@Fe, which generated nanoparticles (Lys-D-Ala-D-Ala@DU@Fe) with an average particle size of 385.5 nm and a zeta potential of −16.8 mV via specific and robust interaction. Ultimately, the immobilization capacity of Van reached up to 294.1 mg·g −1 for efficient antibacterial properties. Moreover, the assembly process adhered to the pseudo-second-order kinetics model ( R 2 = 0.998–0.999) and the Langmuir adsorption isotherm model ( R 2 = 0.999, 30 °C). Notably, V@DU@Fe effectively adhered to the cell envelopes of both Gram-negative and Gram-positive bacteria, achieving rapid bactericidal effects within 1 h. Furthermore, it maintained over 85.0 % of its initial antibacterial efficiency against S. aureus and S. epidermidis even after six recycles. Therefore, this study provides strategies and methods for the development of urushiol-dextran intelligent SPIONs nanomedicines.
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ACS Catalysis
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2024
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IF 11.3
Chong Qi,Yifu Bi,Yaolin Wang,Hong Yu,Yuanyu Tian,Peijie Zong,Qinhua Zhang,Haonan Zhang,Mingqing Wang,Tao Xing,Mingbo Wu,Xin Tu,Wenting Wu
Nonthermal plasma (NTP) offers the potential for converting CH4 with CO2 into liquid products under mild conditions, but controlling liquid selectivity and manipulating intermediate species remain significant challenges. Here, we demonstrate the effectiveness of the Cu/UiO-66-NH2 catalyst in promising the conversion of CH4 and CO2 into oxygenates within a dielectric barrier discharge NTP reactor under ambient conditions. The 10% Cu/UiO-66-NH2 catalyst achieved an impressive 53.4% overall liquid selectivity, with C2+ oxygenates accounting for ∼60.8% of the total liquid products. In situ plasma-coupled Fourier-transform infrared spectroscopy (FTIR) suggests that Cu facilitates the cleavage of surface adsorbed COOH species (*COOH), generating *CO and enabling its migration to the surface of Cu particles. This surface-bound *CO then undergoes C–C coupling and hydrogenation, leading to ethanol production. Further analysis using CO diffuse reflection FTIR and 1H nuclear magnetic resonance spectroscopy indicates that in situ generated surface *CO is more effective than gas-phase CO (g) in promoting C–C coupling and C2+ liquid formation. This work provides valuable mechanistic insights into C–C coupling and C2+ liquid production during plasma-catalytic CO2 oxidation of CH4 under ambient conditions. These findings hold broader implications for the rational design of more efficient catalysts for this reaction, paving the way for advancements in sustainable fuel and chemical production.
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Journal of Future Foods
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2025
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IF 7.2
Chao Yu,Zongshuo Li,Ying Wang,Yanxia Shu,Zhenghui Liu,Weidong Li
Cyclophosphamide (CTX) is a common anticancer drug that can cause immunosuppression and disrupt the intestinal microbiota when taken long-term or at high doses. Lonicerae Japonicae Flos polysaccharides (LJFP), identified as the principal bioactive constituents of L. Japonicae Flos, have emerged as promising immunomodulatory agents. Herein, we explored the molecular mechanisms through which LJFP alleviate CTX-induced immunosuppression in mice. As determined via gas chromatography (GC), LJFP contain arabinose, rhamnose, ribose, xylose, mannose, fructose, galactose, and glucose. LJFP mitigated the decline in body weight and immune organ indexes in CTX-induced mice, while promoting cytokine production. Moreover, LJFP stimulated immunity by reshaping the gut microbiota of mice, where Muribaculaceae and Alistipes played key roles. LJFP also increased short-chain fatty acid (SCFA) levels in the mouse colon and feces. Network pharmacology analyses identified 31 core targets and relevant signaling pathways implicated in the treatment of immunosuppression. Molecular docking indicated strong binding of the eight monosaccharide components to key targets EGFR, HSP90AA1, and IL2. Notably, fifteen of these targets specific to the gut further suggested that the mechanism through which LJFP ameliorates immunosuppression is intricately linked to the gut microbiota. The current findings highlight the potential of LJFP as a functional food or alternative therapeutic against immunosuppression.
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NEW JOURNAL OF CHEMISTRY
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2026
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IF 2.6
Peijie Hou,Wenling Dai,Zhen Zhang,Geng Chen,Xin Hu,Likun Guo,Lifang Zhang
Surface modification strategies play a vital role in preventing calculus formation and bacterial adhesion, which are crucial for improving the performance of degradable implantable medical devices such as ureteral stents. In this study, poly(glycolide-co-caprolactone) (PGACL), a representative biodegradable polyester with excellent elasticity and degradability, was selected as the substrate. Chitosan–amino acid graft copolymers were synthesized via EDC/HOBt mediated acylation and immobilized onto aminated PGACL sheets through a Schiff-base coupling reaction, followed by silver–ion coordination to introduce antibacterial properties. FTIR and 1H NMR analyses confirmed that different types of amino acids were successfully grafted onto the chitosan backbone. The modified PGACL sheets exhibited significantly improved hydrophilicity, enhanced antibacterial activity, and strong resistance to calculus formation, while maintaining favorable cytocompatibility. Among all coatings, the one containing thiol groups showed the best comprehensive performance, attributed to the formation of stable Ag–S coordination structures between thiol (–SH) groups and Ag+ ions. These results demonstrate that chitosan–amino acid–silver coatings provide a biocompatible and efficient surface-engineering strategy with both antibacterial and anti-calculus functions, offering a promising approach for the development of next-generation degradable polymeric materials for urological applications.
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高影响因子
FOOD RESEARCH INTERNATIONAL
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2026
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IF 8.8
Yuting Ye,Junlin Ge,Peiyi Yang,Xinran Liu,Danna Wang,Jingyu Hao,Sufang Duan,Lijun Sun,Guoqiang Zhang,Jian He,Xuebo Liu
Safe and effective strategies for managing adolescent anxiety disorders are urgently needed. This study demonstrates that goat milk-derived extracellular vesicles (gEVs), a natural nanostructure from dairy origin, effectively alleviate chronic restraint stress (CRS)-induced anxiety-like behaviors in adolescent mice through modulation of the gut–brain axis. The purified gEVs were characterized by transmission electron microscopy, nanoparticle tracking analysis, and western blotting, confirming their nanoscale morphology and vesicular protein markers. Behavioral tests revealed that oral gEVs significantly reversed CRS-induced anxiety-like behaviors. Mechanistically, gEVs suppressed neuroinflammation in the hippocampus and prefrontal cortex, restored brain-derived neurotrophic factor expression, and alleviated neuronal injury. Concurrently, gEVs enhanced intestinal tight junction protein expression, improved colonic barrier function, and modulated the gut microbiota composition by reducing the Firmicutes/Bacteroidetes ratio and increasing beneficial bacteria. These changes elevated short-chain fatty acid (SCFAs) levels, particularly acetate and propionate, which were negatively correlated with neuroinflammation and anxiety-like behaviors. Fecal microbiota transplantation confirmed the essential role of gut microbiota in mediating gEVs' anxiolytic effects. Moreover, early-life gEVs intervention significantly reduced anxiety susceptibility in adulthood. Collectively, these findings identify gEVs as a safe and effective dietary-derived nanomaterial capable of modulating the gut microbiota–SCFA–brain axis, offering promising potential for functional food development targeting adolescent anxiety management.
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JOURNAL OF CHROMATOGRAPHY A
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2026
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IF 4
Nan Wang,Hao Qi,Shi-Lei Ji,Lu-Liang Wang
Selective detection of metformin (Glucophage) as an undeclared adulterant in health products is hampered by the complexity of sample matrices and the limitations of conventional adsorbents. While molecularly imprinted polymers (MIPs) offer specificity, they often suffer from low capacity and slow mass transfer. To overcome these challenges, a hierarchical adsorbent by grafting MIPs onto magnetic covalent organic frameworks (MCOFs) was engineered. MIPs@MCOFs substrate provided extensive surface area for high-density imprinting, while the magnetic core facilitates easy separation. MIPs@MCOFs exhibited high adsorption capacity (55.49 mg/g) and adsorption rate (40 min ) for Met. Based on this material, a reliable MSPE-HPLC method was established. It exhibited a wide linear range (5–10 , 000 μg/L), a low detection limit (1.1 μg/L), and satisfactory precision with intra- and inter-day RSDs below 2.2% and 6.5%, respectively. The method was validated for analyzing real samples, offering a powerful solution for combating illegal pharmaceutical adulteration in the health product industry.
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Food Packaging and Shelf Life
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2026
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IF 10.8
Haiyu Yang,Xinghai Huang,Bingyou Luo,Kunying Yu,Chaosong Lu,Jingmin Mo,Peiyuan Li,Jianhua Wei,Haiyi Zhong
To achieve formulation simplification and green fabrication, this study proposes an integrated “extraction–film formation” strategy based on Natural Deep Eutectic Solvents (NADES). Choline chloride and urea were used as the NADES system combined with ultrasound to extract flavonoids from Dalbergia pinnata (Lour.) Prain (DPF), which are directly incorporated into a Gelatin/Chitosan (Gel/CS) matrix to prepare deep eutectic composite films (GCD1–4) by solution casting. This extract simultaneously serves as a homologous plasticizer and functional agent. It avoids the repeated addition of plasticizers, antibacterial, and antioxidant agents, which are commonly required in conventional film preparation. The results show that with increasing DPF content, the films transformed from “rigid and brittle” to “flexible”, the surface wettability shifted from hydrophilic to hydrophobic, water solubility significantly decreased, and UV shielding ability was enhanced. The GCD-2 film show antibacterial efficiencies of 73.37 ± 4.94 % and 96.78 ± 0.2 % against Staphylococcus aureus and Escherichia coli , respectively. Its DPPH and ABTS radical scavenging rates were 69.74 ± 0.67 % and 99.08 ± 0.9 %, respectively, demonstrated good antibacterial and antioxidant activities. Cell viability was close to 100 %, and the hemolysis rate was below 5 %, indicates good biocompatibility of the films. Furthermore, the GCD series of films demonstrated good biodegradability, indicates their strong environmental friendliness. In application tests, the GCD-2 film significantly reduced weight loss, browning, and decay in strawberries and apple slices, effectively inhibiting decay, and shows the best preservation effect. In conclusion, the Gel/CS/DPF composite films achieved synergistic “plasticization-antibacterial-antioxidation” effects through the green extract, demonstrating great potential as biodegradable active packaging materials for fruit preservation.
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PHYSICAL CHEMISTRY CHEMICAL PHYSICS
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2026
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IF 3
Xuemin Jing,Qianqian Liu,Xingyu Shi,Ziyi Sun,Zhenghui Liu,Zhenyang Li,Na Ni,Yu Chen
Polyvinylidene fluoride (PVDF) based polymer solid electrolytes are crucial plastic components in all-solid-state lithium-ion batteries (ASLIBs). However, the large-scale application of PVDF-based solid electrolytes without proper treatment will cause persistent environmental contamination and resource waste, thus highlighting an urgent need for effective recovery strategies. Herein, we firstly propose a hydrogen bond-driven strategy with ultrasonic assistance for ultrafast and eco-friendly recovery of PVDF nanoplastic from polymer solid electrolytes of ASLIBs. Utilizing the proposed hydrogen bond-driven strategy, a maximum F leaching efficiency of 98.2% from PVDF nanoplastic can be attained within a short timeframe and under mild conditions using eco-friendly solvents. Compared with traditional methods, ultrasonic treatment exhibits a significantly improved leaching efficiency of approximately 88%. This ultrafast recovery and notable enhancement can be attributed to the breakdown of C–F bonds in PVDF, which is realized by regulating hydrogen bond networks in green solvents combined with ultrasonic treatment. This study presents a novel strategy for the green, rapid and significantly enhanced recovery of PVDF nanoplastic from spent polymer solid electrolytes of ASLIBs.
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危险品化学品经营许可证（带存储）