JOURNAL OF SEPARATION SCIENCE
·
2017
·Vol. 40
·期 7
·1621-1628
·
IF 2.557
Chunying Li,Xiaoguo Ma,Xiaojun Zhang,Rui Wang,Xin Li,Qianjun Liu
Magnetic molecularly imprinted polymer nanoparticles for di-(2-ethylhexyl) phthalate were synthesized by surface imprinting technology with a sol–gel process and used for the selective and rapid adsorption and removal of di-(2-ethylhexyl) phthalate from aqueous solution. The prepared magnetic molecularly imprinted polymer nanoparticles were characterized using Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis, and vibrating sample magnetometry. The adsorption of di-(2-ethylhexyl) phthalate onto the magnetic molecularly imprinted polymer was spontaneous and endothermic. The adsorption equilibrium was achieved within 1 h, the maximum adsorption capacity was 30.7 mg/g, and the adsorption process could be well described by Langmuir isotherm model and pseudo-second-order kinetic model. The magnetic molecularly imprinted polymer displayed a good adsorption selectivity for di-(2-ethylhexyl) phthalate with respect to dibutyl phthalate and di- n -octyl phthalate. The reusability of magnetic molecularly imprinted polymer was demonstrated for at least eight repeated cycles without significant loss in adsorption capacity. The adsorption efficiencies of the magnetic molecularly imprinted polymer toward di-(2-ethylhexyl) phthalate in real water samples were in the range of 98–100%. These results indicated that the prepared adsorbent could be used as an efficient and cost-effective material for the removal of di-(2-ethylhexyl) phthalate from environmental water samples.
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
ORGANIC ELECTRONICS
·
2019
·
IF 3.495
Tongchao Chu,Xiuping Ju,Xiao Han,Hongmei Du,Yan Zhang,Jinsheng Zhao,Junhong Zhang
Three novel electrochromic copolymers PTPE-1, PTPE-2, and PTPE-3 were synthesized by changing the ratio of donor to acceptor using the Stille coupling polymerization . 5,8,14,17-tetrabromoquinoxaline[2′,3':9,10]phenanthro[4,5-abc] phenazine (monomer b) was first introduced and employed as multi-functionalized unit with bisquinoxaline structure and high planarity, which was used as the acceptor unit. Two electron-rich monomers ProDOT-decyl 2 (monomer a) and thiophene (monomer c) are selected as the co-monomers and donor units. The three polymers were tested by X-ray photoelectron spectroscopy (XPS), cyclic voltammetry (CV), spectro-electrochemistry, kinetics, thermogravimetric analysis (TG), etc. All three polymers have narrow band gaps of lower than 1.85 eV and satisfactory thermal stability. As to electrochromic switching properties, the polymers showed high optical contrast and fast response time both in the visible and near-infrared regions. The optical contrasts are 53.35% at 540 nm and 66.49% at 1325 nm for PTPE-3, and its coloration efficiencies are 163 cm 2 C −1 at 540 nm, 205 cm 2 C −1 at 1325 nm, with fast switch time of less than 1 s. The color changes of three polymers were diversified and distinct, PTPE-1 changes from chestnut color to blue-gray color, PTPE-2 changes from dull red color to wathet color and PTPE-3 changes from deep red color to light blue-gray color. The excellent properties of the polymers might result from their cross-linked structure and consequent formation of the compatible ion transport channel.
研究领域:
材料科学
·
电化学
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DOI
高影响因子
RESEARCH ON CHEMICAL INTERMEDIATES
·
2013
·Vol. 41
·期 6
·3349-3357
·
IF 0.88
Zhang Peizhi,Wan Fuxian,Li Ying,Li Chengkun,Jiang Lin
In the search for new benzimidazole derivatives with high antibacterial activity and for which bacterial resistance is low, novel ethyl 2-(alkoxyimino)-2-[1-(4-morpholinocarbonylmethyl)-1 H -benzimidazol-2-yl]acetates have been synthesized by multi-step reactions and characterized by 1 H NMR, IR, and ESI–MS analysis. The compounds were evaluated for in-vitro antibacterial activity against Escherichia coli and Staphylococcus aureus . The results revealed that four of the compounds had excellent bioactivity against S. aureus , with IC 50 values of 12.72–26.58 μg/mL, even better than that of the control agent (levofloxacin hydrochloride).
研究领域:
药物化学
·
微生物学
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
XiaoJing Zhang,ZhaoYi Miao,Yue Hu,XiaoTong Yang,YingYing Tang,Dong Zhu
Sensitive detection, especially in situ monitoring of intracellular MMP-2, is extremely desirable for cancer early diagnosis, evaluation of therapy, and discovery of the new anti-cancer drug. Herein, a programmed microcapsule-type MMP-2 responsive nanosensor based on mesoporous silica nanoparticles (MSN) is developed to realize in situ imaging monitoring of intracellular MMP-2. In the wrapping anti-MMP-2 antibody sealed microcapsule-type nanosensor, a black hole fluorescence quencher (BHQ-3) is covalently combined onto the inner walls of the MSN mesopores, and the fluorescein Cy5 is loaded in the cavity of MSN, resulting in fluorescence “OFF” state. With the existence of MMP-2, the anti-MMP-2 antibody which acts as a “bio-lid” could detach from the surface of the nanosensor owing to the binding MMP-2 with the antibody, leading to the release of the fluorescein Cy5 to produce fluorescence “ON” state. The prepared programmed microcapsule-type MMP-2 responsive nanosensor is capable of sensitive in situ imaging monitoring of intracellular MMP-2 and is further verified by tracking the change of intracellular MMP-2 level in response to MMP-2-repressive drugs. Thus, the nanosensor give a platform for in vivo detection of biomarkers for diagnosis, evaluation of therapy, and discovery of the new anti-cancer drug.
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高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2023
·
IF 3.8
Junjie Wang,Hui Zhou,Yang Li,Yeshu Mu,Jinghua Li,Chen Hong,Wen Luo
A novel series of benzo[ cd ]indol-2(1 H )-one-donepezil (BIO-DPZ) hybrids (5a-m, 6a-k) was designed, synthesized and evaluated as cholinesterase inhibitors and living cell imaging agents. These compounds were potent inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Compound 6a exhibited the strongest inhibitory activity against AChE with an IC 50 value of 0.16 μM. Compound 6i had the strongest inhibition of BuChE with an IC 50 value of 5.37 μM. Kinetic and molecular modeling studies showed that 6a bound both catalytic active site and peripheral anionic site of AChE. Compounds 6a and 6i both showed lower SH-SY5Y, HepG2 and HL-7702 cytotoxicity than the mitoxantrone. Promisingly, the most active compound, 6a, was successfully used in living SH-SY5Y cell imaging and had predictable lipophilicity and blood-brain-barrier permeation properties. These hybrids should undergo further systematic study in the treatment of Alzheimer's disease.
研究领域:
药理学
·
神经科学
·
药物化学
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DOI
高影响因子
Food Science & Nutrition
·
2024
·
IF 3.5
Jialing Lin,Chuanhui Zeng,Xueli Li,Qin Tang,Jing Liao,Yan Jiang,Xianchun Zeng
Heterocyclic amines (HAs) are a group of mutagenic and carcinogenic compounds produced from the processing of high-protein foods, which include 2-amino-3-methylimidazo[4, 5-f]quinoline (IQ) showing the strongest carcinogenic effect. Camels are able to digest HAs in foods, which provide rich microbial resources for the study. Thus, camel rumen and intestinal microbiota were used to degrade IQ, and the dominant microorganisms and their degradation characteristics were investigated. After three generations of culture with IQ as the sole carbon source, the highest abundance in rumen and intestinal microbes was found in the Proteobacteria phylum. The strains of third generation of the rumen contents were mainly attributed to the genera Brevundimonas and Pseudomonas , and the dominant genera in intestine were Ochrobactrum , Bacillus , and Pseudomonas . Microorganisms were further isolated and purified from the third generation cultures. These 27 strains from the rumen (L1–L27) and 23 strains from the intestine (C1–C23) were obtained. Among them, four strains with the most effective degrading abilities were as follows: L6 (28.55% of IQ degrading rate) and C1 (25.19%) belonged to the genus Ochrobactrum , L15 (23.41%) belonged to the genus Pseudomonas , and C16 (20.89%) were of the genus Bacillus . This study suggested the application of abundant microbial resources from camels' digestive tract to biodegrade foodborne toxins.
研究领域:
微生物学
·
环境科学
·
食品科学
·
毒理学
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DOI
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 2
·1-12
·
IF 5.3
Wang Xiaoying,Yuan Wei,Kuang Yijing,Chen Xuyuan,Wang Xiaoning,Zhang Xiaoyu
A ratiometric electrochemical immunosensor is proposed for simultaneous detection of cellular-myelocytomatosis oncoprotein (C-myc) and B-cell lymphoma 2 (Bcl-2) via the potential-resolved strategy. It relied on multi-role co-loaded alloy composites (CLACs) and poly(3,4-ethylenedioxythiophene) (PEDOT)-graphene oxide (GO)-multiwalled carbon nanotubes (MWCNTs) (PGM) modified electrodes. CLACs with good catalytic and enzyme-like properties were synthesized in one step by loading tetramethylbenzidine (TMB) or methylene blue (MB) into Pt-Pd alloy and used as label materials. After immunological reactions, CLACs showed distinguishable dual differential pulse voltammetry signals at − 0.26 V and 0.38 V, corresponding to C-myc and Bcl-2, and the PGM had an electrochemical signal at 1.2 V, which could be used as a reference signal to construct a ratiometric sensor. CLACs had a satisfactory synergistic effect with the PGM, and eventually achieved quadruple signal amplification. Thus, benefiting from multiple magnification and ratiometric self-calibration functions, sensitive detections of C-myc and Bcl-2 were achieved, with detection limits as low as 0.5 and 2.5 pg mL −1 , respectively. Additionally, when the designed method was applied to blood samples from lymphoma patients, results consistent with the ELISA kit were obtained. This will open avenues for constructing multiple protein detection sensors. Graphical abstract
研究领域:
生物分析化学
·
电化学
·
生物传感器
·
癌症诊断
·
纳米材料
·
免疫传感
·
分析化学
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DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2019
·
IF 4.561
Pan Zhang,Lemeng Wang,Chunjie Lu,Mengying Li,Shujun Yu,Dong Fu
The surface tensions of 2‑diethylaminoethanol (DEAE)‑ N ‑(2‑aminoethyl)ethanolamine (AEEA), DEAE‑ N ‑methyl‑1,3‑propane‑diamine (MAPA) and DEAE‑1,4‑butanediamine (BDA) aqueous solutions have been measured by using the BZY-1 surface tension meter. The mass fractions of DEAE and AEEA/MAPA/BDA respectively ranged from 0.300 to 0.500 and 0.050 to 0.150. The temperature ranged from 303.2 K to 323.2 K. A thermodynamic equation was proposed to model the surface tension and the calculated results agreed well with the experiments. The effects of temperature and mass fraction of amines on the surface tension were demonstrated on the basis of experiments and calculations. The surface thermodynamics including surface enthalpy and surface entropy of blended amine aqueous solutions were also determined, and their temperature and mass fraction dependences were analyzed.
研究领域:
物理化学
·
溶液化学
·
热力学
·
表面科学
·
化工材料
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DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2017
·
IF 2.323
Ying Zhang,Xiong Zheng,Yutian Chen,Maogang He
The thermal diffusivities of 2-ethoxy-2-methylpropane (ETBE) and 2-methoxy-2-methylbutane (TAME) (mass purity > 0.990, GC) were measured by the dynamic light scattering method. The investigated p–T regions are T = (293 to 523) K and p = (4 to 10) MPa, including saturated liquid, saturated vapor, and liquid. The expanded relative uncertainty in thermal diffusivity was estimated to be less than 2.4% over the whole investigated range. The influences of temperature and pressure on thermal diffusivity were presented. The empirical correlation of thermal diffusivities for both saturated liquid/vapor and liquid were also proposed with absolute average relative deviations (AARDs) of 0.22 and 0.26% for saturated-liquid ETBE and TAME, 0.13 and 0.20% for saturated-vapor ETBE and TAME, and 0.23 and 0.69% for liquid ETBE and TAME, respectively.
研究领域:
热物理
·
化学工程
·
物理化学
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DOI
高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
·
2018
·
IF 2.179
Yun-Xiang Ma,Ya-Ping Gong,Chun-li Hu,Jiang-Gao Mao,Fang Kong
Three new d 10 transition metal selenites containing PO 4 tetrahedron, namely, Cd 7 (HPO 4 ) 2 (PO 4 ) 2 (SeO 3 ) 2 ( 1 ), Cd 6 (PO 4 ) 1.34 (SeO 3 ) 4.66 ( 2 ) and Zn 3 (HPO 4 )(SeO 3 ) 2 (H 2 O) ( 3 ), have been synthesized by hydrothermal reaction . They feature three different structural types. Compound 1 exhibits a novel 3D network composed of 3D cadmium selenite open framework with phosphate groups filled in the 1D helical tunnels. The structure of compound 2 displays a new 3D framework consisted of 2D cadmium oxide layers bridged by SeO 3 and PO 4 groups. Compound 3 is isostructural with the reported solids of Co 3 (SeO 3 ) 3-x (PO 3 OH) x (H 2 O) when x is equal to 1.0. Its structure could be viewed as a 3D zinc oxide open skeleton with SeO 3 and HPO 4 polyhedra attached on the wall of the tunnels. They represent the only examples in metal selenite phosphates in addition to the above cobalt compounds. Optical diffuse reflectance spectra revealed that these solids are insulators, which are consistent with the results of band structure computations based on DFT algorithm.
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产品关联
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高影响因子
ACS Applied Nano Materials
·
2023
·
IF 5.9
Shanyi Wang,Weihao Jin,Yujia Wu,Wanzhen Li,Yugui Tao,Jun Wang,Kai Yang,Weiwei Zhang,Lin Gui,Fei Ge
Drug-resistant bacterial infections pose a significant threat to global public health. Furthermore, the formation of biofilms makes traditional antibiotic treatments significantly less effective in killing multidrug-resistant (MDR) bacteria. In this work, we prepared a molybdenum disulfide (MoS2) nanosphere-based nanocomposite that utilized both photothermal therapy (PTT) and chemodynamic therapy (CDT) for effectively eradicating biofilms. A layer of manganese dioxide (MnO2) was adsorbed onto the surface of the MoS2 nanospheres by redox and electrostatic adsorption methods, and the resulting MoS2/MnO2 were loaded with 2,2′-azobis[2-(2-imidazolin-2-yl)propane]-dihydrochloride (AIPH) to form the MoS2/MnO2-AIPH nanocomposite (MMA). The microenvironment of biofilms is slightly acidic, lacks oxygen, and has a high concentration of glutathione (GSH). The MnO2 was capable of reacting with GSH to deplete it while also generating •OH radicals for CDT. In the presence of NIR light (808 nm), the temperature increase brought about by PTT further enhanced the CDT efficacy synergistically. The results showed that the photothermal conversion efficiency of the MMA was 40.5% at a concentration of 100 μg/mL, and the biofilm eradication rate of both MDR Escherichia coli and MDR Staphylococcus aureus was above 90%. The high bacterial inhibition rate (above 96%), as well as the excellent biosafety and biocompatibility of the MMA nanocomposite enabled it to effectively promote wound healing, which has significant implications in treating bacterial infections and promoting wound healing in clinical settings.
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高影响因子
Journal of Materials Chemistry C
·
2018
·Vol. 7
·期 1
·119-132
·
IF 5.976
Xue-Peng Wei,Rui-Qian Zhang,Le-Bin Wang,Yan-Ling Luo,Feng Xu,Ya-Shao Chen
With the increasing development of science and technology, food analysis and detection techniques are continouosly being updated, consummated, and are booming. To meet the demands for high efficiency, speediness, and accuracy in food detection, new rapid detection technology needs to be developed for ensuring food safety and human heath. For this purpose, multi-walled carbon nanotubes decorated with gold nanoparticles-grafted poly(2-methacryloyloxyethyl ferrocenecarboxylate) (MWCNTs@Au-g-PMAEFc) nanohybrids were prepared through ATRP of MAEFc, with the MWCNTs@Au nanocomposites prepared via an in situ reduction route. The chemical structure and composition of the nanohybrids were characterized by 1H NMR, FTIR, Raman, XRD, TGA, UV-vis, and XPS techniques. The dispersion behavior and morphologies were investigated by UV-vis, TEM, and SEM observations. The electrochemical properties were studied by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The experimental results indicated that the nanohybrid-modified electrodes possessed clearly improved electrochemical properties and good reversibility of the redox process, which could be tuned by altering the composition proportions, including the mass ratios of MWCNTs to Au NPs, and the graft percentage of PMAEFc chain segments. The resultant modified electrode sensors could efficiently detect trace poisonous and harmful pesticide residues, and presented a good linear relationship between the concentration and the peak currents, giving a low limit of detection of about 2.7 × 10−8 mol L−1. The developed nanohybrids could therefore be fabricated into electrochemical sensors to detect trace pesticide for ensuring food safety.
研究领域:
材料科学
·
分析化学
·
食品安全
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DOI
高影响因子
危险品化学品经营许可证（带存储）