CHINESE JOURNAL OF CHEMICAL ENGINEERING
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2020
·
IF 2.627
Pengze Zhang,Yangzhen Jin,Zhaobin Jiang,Guanqun Xie,Qunfeng Zhang,Xiaonian Li
Developing of non-metallic catalyst to replace metal catalyst is a meaningful and challenging direction. In this work, the non-metallic catalyst was synthetized successfully by loading ionic liquid onto the silica surface, which was applied for the gas-phase dehydrochlorination of 1, 1, 2, 2-tetrachloroethane. The 12%TPPC/SiO 2 (wt%) showed the best results with the conversion of 1, 1, 2, 2-tetrachloroethane reaching 100%. The selectivity of 1, 1, 2-trichloroethylene was 100%, and no deactivation was found during the evaluation period. The catalytic mechanism was investigated and possible reaction route was given, which was a reference for fabricating and design of solid base catalyst.
研究领域:
催化化学
·
环境科学
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DOI
高影响因子
CHEMICAL PAPERS
·
2014
·Vol. 69
·期 2
·325-338
·
IF 1.193
Jian Zhang,Tian-Qi Zhao,Yao Chen,Xiao-Dong Chen,Hai-Kun Chang,Yu-Min Zhang,Shu-Cheng Hua
A solvent-free microwave-assisted method for the synthesis of 2-substituted-4,5-di(2-furyl)-1H-imidazoles was developed. Imidazoles with moderate to good yields were produced by condensation of furil with aldehydes over acidic alumina impregnated with ammonium acetate, and they were characterized by FT-IR, HRMS, 1 H NMR and 13 C NMR spectroscopy. Crystal structure of 2,4,5- tri-2-furyl-1H-imidazole (I ) in the orthorhombic space group Pbca was reported, which showed more coplanarity than the reported crystal structure of I in the monoclinic space group Cc. Moreover, their luminescent properties were investigated. It was found that the organic small molecule compounds synthesized possess higher fluorescence quantum efficiency (up to 0.508) in a 0.1 M H 2 SO 4 aqueous solution dissolved in 0.5 mL of CH 3 OH; along with higher stability; also the emission of some compounds synthesized in the solution was sensitive to the polarity of the solvents.
研究领域:
有机化学
·
材料科学
·
光化学
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Mingxiao Feng,Qianyu Wang,Minzhen Lei,Dawei Zhang,Qian Yu,Chunyan Yan
Neuroinflammation is closely linked to Alzheimer's disease, where the deposition of amyloid-beta activates microglia, triggering multiple processes that lead to neuronal damage and cognitive decline. However, studies have shown that water extract of Pinellia ternata can improve cognitive function and reduce inflammatory response in the brain injury of mice. Herein, a water-soluble polysaccharide, PTTBP-2-2. with a molecular weight of 11.7 kDa, consisting of D-Glc, D-Gal, D-Xyl, and L-Ara, was isolated from P. ternata . Methylation analysis, partial acid hydrolysis, and nuclear magnetic resonance revealed that the of PTTBP-2-2 backbone consisted of →4)- α -D-Glc p -(1→, →4,6)- α -D-Glc p -(1→, and →6)- α -D-Gal p -(1 → residues, with side chains substituted at O -2, O -3, and O -6 positions of →4)- α -D-Glc p -(1→. In vitro experiments demonstrated that PTTBP-2-2 significantly reduced nitrous oxide levels in BV2 microglia cells and suppressed the expression of pro-inflammatory genes, including COX2 , iNOS , TNF-α , IL-1β , and IL-6 . These factors are key mediators of neuroinflammation. Mechanistic investigations revealed that the anti-neuroinflammatory activity of PTTBP-2-2 was mediated through the regulation of NF-κB and Nrf2/HO-1 signaling pathways. Overall, PTTBP-2-2 shows potential as a therapeutic agent for the treatment of neuroinflammation.
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PubMed
高影响因子
ANALYTICAL LETTERS
·
2010
·
IF 1.317
Shuhui Ma,Jigang Gao,Zhiqi Li,Jie Zhou
A new fluorescent probe, 2-(2-thienyl)benzothiazoline was synthesized. Its structure was characterized with elemental analysis, IR and 1H NMR. The fluorescent probe can be oxidized by to form a less fluorescent product. Based on this reaction, a spectrofluorometric method was developed to determine the content of superoxide anion radicals and superoxide dismutase activity. There was a good linear relationship with a correlation coefficient 0.9996 between the scavenging percentage of and SOD activity. The method was simple, selective, and sensitive. It was successfully applied to the determination of SOD activity in garlic and onion samples.
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高影响因子
Catalysis Science & Technology
·
2026
·
IF 4.2
Yujie Guo,Chengjie Li,Wenhui Zhang,Ruifang Liu,Xueli Du,Zhen Liu,Ying Zhang,Zi-Feng Yan
Atmospheric CO 2 concentrations are increasing rapidly, posing severe environmental challenges. Hydrogenation of CO 2 to methanol represents a promising strategy to reduce the content of CO 2 . While Cu-based catalysts have garnered significant attention, there are still problems such as low selectivity for methanol and poor stability. In this study, a highly dispersed Cu/ZnO-ZrO 2 catalyst was synthesized via a formamide-assisted co-precipitation method. Investigation of the ZrO 2 loading revealed that the Cu/ZnO-25%ZrO 2 catalyst exhibited optimal performance for CO 2 hydrogenation to methanol, achieving a CO 2 conversion of 6.7%, methanol selectivity of 85%, and a methanol space-time yield (STY) of 586.5 g MeOH •kg cat -1 •h -1 . The results demonstrate a strong interaction between Cu and the ZnO-25%ZrO 2 support surface, which predominantly stabilizes Cu in the Cu + state. Notably, these Cu + species remain stable even after reduction and reaction. This interaction not only ensures high catalytic activity but also confers excellent stability to the catalyst, as evidenced by the absence of deactivation over a 200-hour stability test.
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JOURNAL OF NON-CRYSTALLINE SOLIDS
·
2024
·
IF 3.2
Taiyu Duan,Yao Ji,Weichao Wang,Qinyuan Zhang
The 1.0 μm ultra-short pulse laser is distinguished by its high energy, short pulse width, and intense peak power density, serving various applications in materials processing and biomedicine. Yb ions play a crucial role in this wavelength range, yet achieving high doping levels in commercial Yb-doped silica fibers is challenging due to their dense network structure. Here, we present the design and fabrication of a fluorophosphate (FP) glass with high thermal shock stability (figure of merit is 0.95), achieved through thermodynamic prediction methods, ion field strength analysis, and glass structure theory. By modifying the composition of high-field-strength cations, we not only alter the fundamental properties of the glass but also enhance its thermomechanical performance. Specifically, Yb 3+ -doped Zn(PO 3 ) 2 -Ba(PO 3 ) 2 -AlF 3 -KF FP glass (Yb 10 -ZBAFP10) exhibits a high emission cross-section (0.74×10 −20 cm 2 at ∼1008 nm), a low level of minimum population inversion ( β min =0.09), and minimum pump intensity ( I min =1.75 kW/cm 2 ). Furthermore, it demonstrates a stable fluorescence lifetime within the temperature range of 298 ∼ 473 K. These findings highlight the potential of Yb 3+ -doped FP glass for applications demanding high thermal shock stability, particularly in high repetition rate ultra-short pulse laser systems.
研究领域:
光子学
·
材料科学
·
激光技术
·
玻璃物理
·
光学材料
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DOI
高影响因子
BIOCONJUGATE CHEMISTRY
·
2014
·
IF 4.821
Jinwen Li,Yanxia Zhou,Chengwei Li,Dishi Wang,Yajie Gao,Chao Zhang,Lei Zhao,Yushu Li,Yan Liu,Xinru Li
Dual endosomal pH-sensitive micelles were designed and fabricated to deliver doxorubicin (DOX) for treating breast cancer based on a poly(2-ethyl-2-oxazoline) (PEOz)–DOX (PEOz–hyd–DOX) conjugate. PEOz–hyd–DOX was successfully synthesized by connecting DOX to PEOz via an acid cleavable hydrazone linker and self-assembled into nanosized micelles, which further physically encapsulated DOX. The conjugate and DOX-loaded conjugate micelles displayed faster release of DOX at pH 5.0 than at pH 7.4. This pH-dependent release behavior might assist the quick diffusion of DOX from acidic endosomes or lysosomes and the intracellular transfer into the nucleus after internalization, which was confirmed by confocal laser scanning microscopy images. As expected, PEOz–hyd–DOX conjugate and DOX-loaded conjugate micelles maintained cytotoxicity of DOX. In addition, the dual endosomal pH-sensitive micelles were found to substantially enhance antitumor efficacy and reduce side effects compared with free DOX. Therefore, PEOz–hyd–DOX conjugate-based micelles might be potential drug delivery vehicles of DOX for safe and effective breast cancer therapy.
研究领域:
药用纳米技术
·
癌症药物递送
·
高分子化学
·
生物医学工程
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Yan Hao,Jing Qu,Lei Tan,Zunyi Liu,Yicheng Wang,Tingrui Lin,Hui Yang,Jing Peng,Maolin Zhai
An eco-friendly superabsorbent polymer (SAP) was prepared by grafting 2-acrylamido-2-methyl-1-propanesulfonic acid onto microcrystalline cellulose in lithium chloride/ N, N -dimethylacetamide system. The synthesized SAP (cellulose- g -PAMPS) was characterized by FTIR, TGA , SEM, 1 H NMR, 13 C NMR and XRD. The water absorption equilibrium of cellulose- g -PAMPS could be achieved within 10 min in distilled water. Moreover, the maximum water absorption capacities of cellulose- g -PAMPS in distilled water, 0.9 wt% NaCl solution and 3.2 wt% Na 2 CO 3 solution were 648.9, 298.4 and 207.3 g·g −1 , respectively. The water absorption behavior of cellulose- g -PAMPS was interpreted by the pseudo-second-order model. Furthermore, cellulose- g -PAMPS could be used in some extreme conditions due to its high acid and alkali resistance. The water retention rate of cellulose- g -PAMPS could be maintained above 90 % at 25 °C for 6 h. As a consequence, the synthesized SAP can be applied to increase the plant growth and survival time under drought conditions, even under saline alkali conditions.
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DOI
PubMed
高影响因子
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
·
2023
·
IF 7.8
Xiaoqin Niu,Kejian Chang,Wenduo Li,Haobin Hu
Polyethersulfone membrane is easy to be polluted, and the negative surface would help enhance improve the permeability and the anti-pollution performance; so how to anchor polymer brushes with negative groups to polyethersulfone membrane surface is a challenge. In this paper, polymer brushes of poly(2-acrylamide-2-methylpropanesulfonic acid sodium salt) is first grafted to carbon nanotubes to form an organic-inorganic hybrid additive, which is further anchored onto the membrane surface of polyethersulfone by blending method. The graft reaction is proceeded by surface initiated electrochemical atom transfer radical polymerization , where the introduction of electrochemical part is because it could help better control the growth of polymer brushes compared with the pristine atom transfer radical polymerization process. The carbon nanotubes grafted with poly(2-acrylamide-2-methylpropanesulfonic acid sodium salt) could anchor on the membrane surface because the there is a self-assemble process of organic-inorganic hybrid additive during phase inversion method, where the inorganic part carbon nanotubes firmly embedded into the membrane and the organic part can be fixed on membrane surface. The polyethersulfone membrane exhibits enhanced surface hydrophilicity , improved the permeability of the membrane, and good anti-fouling performance due to the negative charge and electrostatic repulsion brought by anionic surface of the modified membrane. When the mass of nanotubes grafted with poly(2-acrylamide-2-methylpropanesulfonic acid sodium salt) in the casting solution is 20 mg, the water flux can reach 365.5 L m −2 h −1 , and the rejection ratios of both BSA and CR are close to 100% with good flux recovery and anti-fouling effect performance.
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高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2023
·
IF 10.8
Deqing Lin,Xiaoning Xu,Lin Chen,Lei Chen,Mengyun Deng,Jinrun Chen,Zhibin Ren,Lei Lei,Jiaqing Wang,Jie Deng,Xingyi Li
Herein, we report a facile method for converting carboxylate-containing indomethacin (Idm) into a cyclooxygenase-2 (COX-2) selective inhibitor via the amidation of an unnatural peptide sequence (Nal-Nal-Asp). The resulting indomethacin amides ( i.e., Idm-Nal-Nal-Asp) have high selectivity for COX-2, and can self-assemble into a one-component supramolecular hydrogel that acts as a ‘self-delivery’ system for boosting anti-inflammatory efficacy. Self-assembled Idm-Nal-Nal-Asp hydrogel robustly inhibits COX-2 expression in lipopolysaccharide (LPS)-activated Raw 264.7 macrophages while also exhibits superior anti-inflammatory and antioxidant activities via reactive oxygen species (ROS)-related NF-κB and Nrf2/HO-1 pathways. Moreover, a rabbit model of endotoxin-induced uveitis (EIU) reveals that the Idm-Nal-Nal-Asp hydrogel outperforms clinically used 0.1 wt% diclofenac sodium eye drops in terms of in vivo anti-inflammatory efficacy via topical instillation route. As a rational approach to designing and applying COX-2 selective inhibitors, this work presents a simple method for converting non-selective nonsteriodal anti-inflammatory drugs (NSAIDs) into highly selective COX-2 inhibitors that can self-assemble into supramolecular hydrogel for anti-inflammation applications.
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PubMed
高影响因子
STARCH-STARKE
·
2021
·
IF 2.741
Meidong Li,Xiufang Huang,Qin Zhang,Yifeng Zhou,Kai Luo
Four new types of water-soluble polysaccharides are isolated from Cardamine hupingshanensis . Herein, this study examines C. hupingshanensis polysaccharide no. 2 (CHP-2) with a molecular weight of 21.75 kDa. Analysis revealed that CHP-2 is composed of d -glucuronic acid, d -galacturonic acid, glucose, galactose, and L-arabinose. It is speculated that the main connecting bond is →4)-α-D-Glc(p)-(1→), →t)-α-D-Glcp-(1→). Through perfusion experiments using streptozotocin-induced diabetic rats, oral CHP-2 solution is found to significantly reduce food intake, water intake, and fasting blood glucose levels, while increasing the weights of rats. In addition, CHP-2 significantly reduces the serum and liver malondialdehyde contents and increases the activity of the corresponding antioxidant enzymes. Moreover, the effect elicited by the CHP-2 solution is similar to that of phenformin hydrochloride solution. Hence, the results of this study suggest that CHP-2 exhibits blood sugar-lowering and anti-oxidation effects.
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FLUID PHASE EQUILIBRIA
·
2020
·
IF 2.838
Jinbei Yang,Shucui Han,Qiuju Xu,Meiqiong Yu
The density and viscosity of pure liquid 2, 4-dichlorofluorobenzene and 2, 6-dichlorofluorobenzene were measured in the temperature range of (318.15–348.15) K at the local atmospheric pressure of 99.8 kPa. The saturated vapor pressures of pure 2, 4-dichlorofluorobenzene and 2, 6-dichlorofluorobenzene and the isobaric vapor-liquid equilibria (VLE) data for the 2, 4-dichlorofluorobenzene + 2, 6-dichlorofluorobenzene binary system at atmospheric pressure were determined experimentally by a modified Rose still. The density values were accurately described by DIPPR equation. The viscosity data were well correlated using the Litovitz, Ghatee and VFT, and Andrade equations, and the VFT equation shows the best accuracy. Both Antoine and Riedel equations can well describe the relationship between saturated vapor pressure and temperature, which meet the requirements of engineering design. The Riedel equation is more accurate due to the lower average relative deviation. The VLE data were successfully correlated with NRTL and Wilson activity coefficient models, and the interaction parameters were obtained. The result indicates that there is no azeotrope in the binary mixture. The above thermodynamic properties of pure component and the VLE data presented are crucial for the design and operation of distillation for the isomeric mixture separation of 2, 4-dichlorofluorobenzene + 2, 6-dichlorofluorobenzene.
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