Food Bioscience
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2025
·
IF 5.9
Zhuo Xu,Bin Wu,Chunhua Wu,Qian Chen,Kaimeng Xu,Zhengjun Shi,Xiaoping Rao,Yanfei Niu
In order to obtain natural bio-antimicrobial agents with better antifungal activity, the present study compared the antifungal properties of different structural natural resin acid derivatives (dehydroabietic acid (DHA), acrylpimaric acid (APA), and maleopimaric anhydride (MPA)) grafted with chitosan C 2 -OH and investigated the relationship between structure and activity. The structures of the derivatives were determined by FTIR and 1 H NMR. The antifungal properties were determined by mycelial growth rate method. The results demonstrated that CS-DHA (CSDA) exhibited the capacity to inhibit the majority of the tested fungi with notable efficacy, with an optimal antifungal effect observed at 97.53% against Alternaria solani . CS-APA (CSAA) demonstrated a comparatively weaker antifungal effect in comparison to CSDA, yet it exhibited a stronger effect when compared to CS-MPA (CSMA). SEM, TEM and relative permeability of cell membranes proved that the derivatives inhibited fungal growth by destroying the cell wall structure. The in vivo experiments proved that the derivatives all have the effect of protecting chili peppers, which has some application prospects. The best curative effect of CSAA on chili was observed at 1.5 mg/mL concentration (21.04%). At 3 mg/mL concentration, CSDA showed the best protective effect (29.48%) against chili peppers, which was closest to the effect of Imazalil at the same concentration. Meanwhile, the three derivatives had good preservation effect on cherry tomatoes, and the longest one could extend the shelf life by 6 days.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2017
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IF 3.671
Yang Liu,Peihong Ji,Huilin Lv,Yong Qin,Linhong Deng
Gentamicin modified chitosan film (CS-GT) was produced using a three-step procedure comprising: (i) the chitosan solution was air-dried to form a chitosan (CS) film, (ii) using citric acid to generate the amide and carboxyl groups on the surface of CS, (iii) the CS with surface carboxyl groups was modified by grafting of gentamicin. After modification, this CS-GT film has excellent hydrophilicity and biocompatibility. It is very evident that the gentamicin grafting treatment significantly improves the antibacterial properties of the CS film. Our preliminary results suggest that this novel gentamicin modified chitosan film, which can be prepared in large quantities and at low cost, should have potential application in biomedical applications.
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Desalination and Water Treatment
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2025
·
IF 1
Yunlong Zhao,Hao Peng,Lei Zhang,Wanwan Fu,Man Zhang,Zhishan Chen,Longfei Li,Yutao Chen
As a new type of polymer functional material, magnetic chitosan has been widely used in wastewater treatment. In this study, magnetic chitosan microspheres (MCMs) were prepared by reversed-phase microemulsion cross-linking technology, and the adsorption capacity of MCMs to organic pollutants with high chemical oxygen demand (COD) in coking wastewater was studied. Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM) and energy dispersive spectrometer (EDS), brunauer - emmett - teller (BET), vibrating sample magnetometer (VSM) were characterized. The effects of Fe 3 O 4 magnetic nanoparticles (MNPs), pH and the amount of adsorbent on the adsorption properties of MCMs were investigated. The following conclusions are obtained: the MCMs prepared in this study are successfully encapsulated, and the MCMs have good magnetic properties; Meanwhile, the removal performance of COD is higher. When the addition amount of Fe 3 O 4 is 10 % of the mass fraction of chitosan, the maximum adsorption amount of COD by MCMs can reach 261.82 mg/g under the conditions of pH 7.5, reaction temperature 298 K and adsorption time 42 h. The adsorption kinetics can be described by a quasi-second-order kinetic model. In addition, after 4 times of adsorption-desorption processes, the adsorbent still has more than 40 % COD adsorption, and has good adsorption performance. In general, because of the high adsorption efficiency, strong regeneration and excellent magnetic separation performance, MCMs have practical application potential in sewage treatment, biomedicine and other fields.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Zhaoqian Fan,Kun Gao,Linsong Wang,Yukun Qin,Song Liu,Ronge Xing,Huahua Yu,Kecheng Li,Pengcheng Li
Chitosan oligosaccharide (COS) modification is a feasible way to develop novel green nematicides. This study involved the synthesis of various COS sulfonamide derivatives via hydroxylated protection and deprotection, which were then characterized using NMR, FTIR, MS, elemental analysis, XRD, and TG/DTG. In vitro experiments found that COS-alkyl sulfonamide derivatives ( S6 and S11 – S13 ) exhibited high mortality (>98 % at 1 mg/mL) against Meloidogyne incognita second-instar larvaes (J2s) among the derivatives. S6 can cause vacuole-like structures in the middle and tail regions of the nematode body and effectively inhibit egg hatching. In vivo tests have found that S6 has well control effects and low plant toxicity. Additionally, the structure-activity studies revealed that S6 with a high degree of substitution, a low molecular weight, and a sulfonyl bond on the amino group of the COS backbone exhibited increased nematicidal activity. The sulfonamide group is a potential active group for developing COS-based nematicides.
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JOURNAL OF NANOPARTICLE RESEARCH
·
2024
·Vol. 27
·期 1
·1-14
·
IF 2.1
Zhang Ziying,Liu Feng,Li Jiale,Wang Bing
Photothermal therapy (PTT), as a non-invasive and selective treatment strategy, has garnered extensive research interest. Photothermal agents (PTAs) are critical components of PTT, whose light-absorbing and thermosensitive properties enable effective conversion of light energy into heat, creating localized high-temperature regions. However, PTAs often face challenges with degradation in vivo, and standalone PTT is insufficient for complete tumor cell ablation. In this study, we successfully developed a biodegradable nanoplatform for synergistic photothermal-photodynamic therapy. This platform is based on degradable antimonene nanosheets, further functionalized with a chitosan coating, and loaded with the photosensitizer Ce6. In vitro experiments demonstrated that this nanoplatform exhibits excellent biocompatibility and biodegradability. Upon laser excitation, the platform induces localized thermal effects for cell ablation and promotes reactive oxygen species generation, leading to superior anti-tumor efficacy compared to monotherapies. These findings suggest that this multifunctional nanoplatform can significantly enhance the therapeutic efficiency of synergistic phototherapy, presenting a promising candidate for cancer treatment.
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ACS Sustainable Chemistry & Engineering
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2025
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IF 7.3
Qingqing Tao,Xinbo Wang,Ruoxin Du,Chi Man Leong,Matthew Y. Lui
Several insects hold great promise as vital organisms of the future due to their ability to eliminate various types of organic waste under benign conditions while serving as nutritious protein sources for humans and other animals. During their lifecycle, insects produce a significant volume of excrement, commonly known as frass. The utilization or valorization of insect frass is crucial for ensuring the sustainability of insect-related biodegradation processes. In this paper, we present a seamless process for upgrading insect frass. Specifically, we demonstrate that mealworm (Tenebrio molitor) frass, produced through the biodegradation of plastic (polystyrene) or food waste (shrimp shells), can be straightforwardly used to produce high-quality chitin and chitosan, two essential biopolymers. Depending on the insect feed, chitin and chitosan can be isolated with high purity and N-acetylation, exhibiting physicochemical properties similar to those of commercially obtained products through either acid/base treatment or ionic liquid treatment. Moreover, unlike extraction from other major sources, these carbohydrates can potentially be isolated in a one-pot process with good purity using only base treatment, without the need for corrosive acid solutions for demineralization. These findings suggest that insect frass could serve as a more sustainable source of these two crucial biomaterials.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Jiajia Lan,Hai Wang,Shiming Feng,Lingyan Zou,Yuxing Chen,Xinbao Guo,Airong Xu
The chitosan-based hydrogel sensor with successful integration of robust mechanical performances, simultaneously anti-freezing/drying environments and excellent biocompatibility still remains challenged. To overcome this challenge, here, a superhydrogen-bond networks (SHBNs) strategy was presented to assemble a novel chitosan-based hydrogel sensor CS/PVA/GL (chitosan/polyvinyl alcohol/glycerol) which exhibits excellent mechanical performances (e. g. load capacity of 60 kg) and 99 % cell viability. Moreover, the hydrogel has exceptional anti-freezing capacity with −100 °C glass transition temperature. Even after going through freezing at −75 °C, it still displays good flexibility, conductivity and mechanical performances. Interestingly, after 60 days of dryness, it still possesses very good flexibility. Importantly, its anti-freezing capacity is nearly close to that before being dried, and the mechanical properties are higher than those before being dried, indicating its excellent anti-drying capacity. With these prominent advantages, after being assembled into a hydrogel sensor, it can monitor human action signals, and be used as bionic skin to write the words “engineer” and “function” on the screen of a mobile phone. The engineering concept developed in this work can provide a valuable insight into constructing high-performance chitosan-based hydrogel sensors which can satisfy real-time tasks regardless of in extremely low temperature and long-term open environments.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Jiuxiao Dong,Hongzhi Liu
A novel water-soluble silsesquioxane precursor (DEA-GSQ) was prepared by the nucleophilic substitution reaction of diethanolamine (DEA) with glycidyloxypropyl substituted silsesquioxane (GSQ). DEA-GSQ can be used to crosslink chitosan to prepare hybrid aerogels (DGCA). The hybrid aerogels were fully characterized using Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, compression performance test and Mercury intrusion porosimetry. The hybrid aerogel shows selective adsorption for Au(III) with the saturated adsorption capacity of 918.16 mg/g at pH = 6. Pseudo-second-order model and Langmuir model could describe the adsorption process well. It was found that Au(III) was mostly reduced to Au(0) by C N bond during the adsorption process. Furthermore, an adsorption device was designed to remove Au(III) based on this hybrid aerogel, laying the foundation for the adsorption of Au(III) in practical applications.
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JOURNAL OF MATERIALS SCIENCE
·
2024
·Vol. 59
·期 23
·10419-10431
·
IF 3.5
Wang Feng,Li Fang,Zhang Zhibin,Liang Mengdi,Zhang Bei,Qi Ning,Zhang Xicheng,Li Gang
Abdominal aortic aneurysm (AAA) is a common vascular disease that has attracted widespread attention due to its characteristic of being asymptomatic and high mortality rate. In this study, we present a novel woven vascular stent-graft, which can improve thrombus formation resulting from excessive smooth muscle cell proliferation following blood vessel stent implantation. To achieve this, we adopted the orthogonal design method to optimize the production process parameters and then coated the surface of the woven stent with chitosan/heparin using a layer-by-layer self-assembly technique based on the electrostatic binding principle, and the performance of the stent before and after modification was comprehensively evaluated. The results demonstrated that the coating had no impact on the mechanical properties, wall thickness, and cross-sectional water permeability of the membranes. Remarkably, the release rate of heparin reached as high as 90.88% at 216 h, effectively inhibiting the growth of smooth muscle cells. In conclusion, the new woven polyester vascular stent-graft provides a potential application prospect for the treatment of AAA.
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ACS Applied Polymer Materials
·
2024
·
IF 4.4
Chenxin Zhong,Ran Wang,Zhiqian Zhang,Haijiao Xie,Zhengjie Tang,Zhangkang Wu
Trees are abundant in resources, and functionalization can endow wood with diverse properties, expanding its application potential. Chitosan is frequently utilized for functionalized wood, and various lignocellulose-chitosan composites with intricate structures, morphologies, and anisotropies can be produced through a bottom-up assembly. Nevertheless, the physical interactions among the components of lignocellulose and alkaline polysaccharides remain inadequately understood. This study systematically examined the intermolecular forces between chitosan and the principal components of lignocellulose, hemicellulose, and lignin to clarify the nature of their interactions. Through a combination of adsorption experiments, isotherm modeling, and density functional theory (DFT) simulations, distinct interaction mechanisms governing these systems were identified. Results reveal that chitosan adsorption on wood fibers is heterogeneous and results in multilayer structures with different binding affinities. Lignin exhibits monolayer adsorption dominated by electrostatic and hydrophobic interactions, while cellulose and xylan exhibit mixed monolayer-multilayer adsorption primarily driven by hydrogen bonding. These molecular-level insights offer a solid theoretical foundation for the design, self-assembly, and production of chitosan/lignocellulose composites, promoting the advancement of biobased materials with customized properties.
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Journal of Renewable Materials
·
2025
·
IF 2.115
Tingqiang Yan,Xiaodong Wang,Yingjie Qiao
Polylactic acid (PLA), a biodegradable polymer, exhibits superior mechanical strength and processability. However, its broader adoption is hindered by inherent brittleness, low hydrophilicity, and sluggish crystallization kinetics. Chitosan (CS), a natural polysaccharide renowned for its biocompatibility and biodegradability, offers potential to address these limitations. While both materials have garnered significant attention in materials science, research on their integration via melt blending and the resulting performance enhancements for food-contact plastics remains understudied. This research comprehensively explores how different levels of CS content, from 0% to 10%, impact the characteristics of chitosan/polylactic acid (CS/PLA) composites. It specifically analyzes the influence of various CS concentrations on the mechanical attributes, crystallization behavior, thermomechanical properties, and rheological performance of these composites. The study concludes that a CS content of 4% in the CS/PLA composite results in the best overall properties. At this point, its elongation at break and impact strength reached their maximum values (16.16% and 20.63 kJ/m²), representing increases of 23.9% and 15.7% compared to pure PLA. At this particular concentration, CS is evenly distributed throughout the PLA matrix, acting as a heterogeneous nucleating agent. It facilitates the crystallization of the composite material and offers effective reinforcement. This study presents a promising approach for developing environmentally friendly and sustainable alternatives to fossil-based plastics, highlighting significant research value and practical application potential.
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JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Lijuan Cheng,Xiaolong Xu,Yurong Jiang,Shiyu Zhang,Kai Xu,Hui Wang,Xianjuan Zhang,Runnan Zhang,Zhongyi Jiang
Surface segregation as a simple and efficient method for in situ membrane surface modification, has distinct advantages in constructing antifouling membranes. In this study, two chitosan derivatives, carboxymethyl chitosan (CMC) and chitosan quaternary ammonium salt (HACC), are selected as surface modifiers to fabricate antifouling poly (ether sulfone) (PES) membrane for oil-water filtration. The addition of CMC and HACC can regulate the phase inversion process to acquire membranes with high porosity. During the phase inversion process, CMC and HACC can in situ crosslink the polyvinylpyrrolidone (PVP) segregation agent by hydrogen bonds at the water-polymer interface, constructing a hydrophilic and underwater superoleophobic modification layer on the membrane surface. Specifically, the CMC-modified membrane exhibits enhanced water permeance from 339 to 635 Lm -2 h -1 bar -1 and antifouling performance with 98% flux recovery and 7% total flux decline. Furthermore, the membrane shows satisfying long-term performance stability in industrial oily wastewater treatment with the permeance maintained above 400 Lm -2 h -1 bar -1 within 10-hour continuous filtration. The study provides a facile strategy to in situ fabrication of oil-water separation membranes with excellent antifouling performance, which displays application potential in practical oily wastewater treatment.
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