Laser & Photonics Reviews
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2025
·
IF 10
Di Liu,Pengwei Duan,Junjie Chen,Ming Mu,Yumei Yang,Fuqiu Ma,Bing Zhao,Wei Song
Understanding atomic orbital-level interactions at material-molecule interfaces is crucial for advancing surface-enhanced Raman spectroscopy (SERS). While conventional mechanisms focus on electromagnetic effects or interfacial charge transfer (CT), the role of orbital hybridization in multimetallic systems remains underexplored. Here, a d-band-mediated CT mechanism is proposed through the engineering high-entropy alloy aerogels (HEAAs). A face-centered cubic AuAgCuMnInBi HEAAs synthesized via one-step coreduction achieves ultrasensitive SERS detection of crystal violet. Density of states analyses reveal that Mn-3d orbitals bridge electron reservoirs (Au/Ag/Cu) and In/Bi-p orbitals, enabling efficient charge delocalization. Voltage-tunable SERS signals in MnInBi subsystems confirm d-band-dependent CT enhancement. Beyond molecular sensing, this mechanism allows direct capture of reactive intermediates (OH·, O 2 · – ) and 5 n M uranium detection, bridging SERS enhancement dynamics with catalytic pathway elucidation. These findings establish d-band engineering as a paradigm for designing multifunctional SERS substrates, bridging atomic-scale electronic interactions with ultrasensitive sensing and catalytic mechanism elucidation.
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NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Jianhong Jia,Hui Zhang,Jian Huang,Xiangxiang Zhou,Endian Su,Mingyan Li,Ran Yao,Jiahui Chu,Debo Ding,Yun-Fang Yang,Yuanbin She
In this work, three series of 12 novel donor-acceptor (D-A) pyrazine derivatives (B/S/J series) were designed and synthesized via a molecular engineering strategy. The B series was constructed based on the fundamental framework; the S series introduced triphenylamine with stronger electron-donating ability on the basis of the B series to enhance intramolecular charge transfer (ICT); while the J series modified the molecular structure by incorporating methoxybenzene, altering the electron cloud distribution and optimizing the molecular architecture. The systematic investigation revealed that structural tuning significantly influences their third-order nonlinear optical (NLO) properties. Both experimental and theoretical studies demonstrated that the synergistic effect between triphenylamine donors and nitrobenzene acceptors effectively enhances ICT. Specifically, compound S-series exhibits exceptional third-order nonlinear polarizability (S-2, χ_I^((3) ) = 35.18×10⁻¹³ esu) and second-order hyperpolarizability (S-4, γ = 7.93×10⁻³³ esu) in solution state. Through solid-state doping optimization (Polymethyl methacrylate (PMMA) composite films), the NLO performance was enhanced by three orders of magnitude (β = 27.84×10⁻⁹ m/W), providing a new paradigm for designing high-stability organic NLO materials. In this study, UV-Vis absorption spectroscopy and fluorescence spectroscopy were employed to investigate the ICT process; cyclic voltammetry was used to explore the electrochemical behavior; the Z-scan technique was applied to study the third-order NLO properties of the solutions at 532 nm; and density functional theory (DFT) calculations were utilized for theoretical verification, revealing the relationship between molecular structures and properties from multiple perspectives.
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JOURNAL OF CHROMATOGRAPHY A
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2025
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IF 4
Lei Ding,Chundan Ye,Junchen Zhu,Cuirong Sun
Chiral impurity analysis presents significant challenges due to limitations of detection methods. Levodopa (L-Dopa) is the primary medication for Parkinson's disease treatment for over 50 years. However, the detection of its chiral impurity is difficult due to the similarity of polarity. This study presents a novel analytical method for the quantitative detection of trace amount of D-Dopa, as well as other three impurities. The method demonstrated excellent chromatographic resolution for D-Dopa and L-Dopa (resolution = 4.15) and achieved a derivatization efficiency of 97% using a chlorine-labeled chiral probe (D-BPCl) for chemical derivatization, followed by analysis with liquid chromatography-tandem mass spectrometry (LC-MS/MS) on a conventional C18 column. Meanwhile, D-BPCl showed strong chiral selectivity on D-Dopa, and the ratio of mass spectrometric response for labeled D-Dopa to that of L-enantiomers was 2.78-fold under the same condition. The developed method demonstrates high sensitivity with detection limits of 7.88 μ g L -1 for D-Dopa, and 9.85 μ g L -1 for L-Dopa, with good linearity for every analyte (R 2 > 0.99), recoveries ranging from 94.1% to 106.8%, and high repeatability with relative standard deviation (RSD) values predominantly below 5%. Then the method was applied to analyze fifteen batches of levodopa tablets from five manufacturers. D-Dopa was successfully detected with the corresponding content ranging from 0.15% to 0.44%, which suggests that D-Dopa are more likely generated during the production process. The study underscores the significant safety concerns regarding Dopa-containing medications.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2024
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IF 5.7
Lichun Guo,Mengqing Zhang,Ying Fei,Wei Zhao
This study examines the inhibitory effects of a range of sweeteners on α-glucosidase. Our findings revealed that only one natural sweetener, namely, glycyrrhetinic acid 3-O-mono-beta-d-glucuronide (GAMG), derived from licorice, exhibited a mixed-type inhibition against α-glucosidase with a IC50 value of 0.73 ± 0.05 mg/mL. The fluorescence intensity of α-glucosidase was quenched by GAMG in the formation of an α-glucosidase–GAMG complex. GAMG has been shown to induce conformational changes in α-glucosidase, likely through hydrogen bonding, van der Waals force, and alkyl–alkyl interactions with amino acid residues, including Arg 281, Leu 283, Trp 376, Asp 404, Asp 443, Trp 481, Asp 518, Phe 525, Ala 555, and Asp 616. Additional animal validation experiments demonstrated that GAMG slowed starch digestion, thereby attenuating the postprandial glycemic response. Taken together, these findings provide evidence that GAMG is a natural sweetener with potent inhibitory activity that selectively targets α-glucosidase. This study supports the use of GAMG as a natural sweetener, which holds a high biological value and may be beneficial for managing postprandial hyperglycemia.
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Biotechnology Journal
·
2024
·Vol. 19
·期 9
·2400360
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IF 3.2
Yue Yan,Haodong Zhao,Dingyu Liu,Jie Zhang,Yuwan Liu,Huifeng Jiang
Global climate deterioration intensifies the demand for exploiting efficient CO 2 utilization approaches. Converting CO 2 to biorefinery feedstock affords an alternative strategy for third-generation biorefineries. However, upcycling CO 2 into complex chiral carbohydrates remains a major challenge. Previous attempts at sugar synthesis from CO 2 either produce mixtures with poor stereoselectivity or require ATP as a cofactor. Here, by redesigning glycolaldehyde synthase, the authors constructed a synthetic pathway for biorefinery feedstock D-xylulose from CO 2 that does not require ATP as a cofactor. The artificial D-xylulose pathway only requires a three-step enzyme cascade reaction to achieve the stereoselective synthesis of D-xylulose at a concentration of 1.2 g L −1 . Our research opens up an alternative route toward future production of chemicals and fuels from CO 2 .
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MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
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2024
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IF 2.3
Jun Meng,Bo Yang,Chang Shu,Shuai Jiang
Background Prostate cancer (PCa), a prevalent malignancy worldwide, is frequently identified in advanced stages due to the absence of distinctive early symptoms, thereby culminating in the development of chemotherapy-induced drug resistance. Exploring novel resistance mechanisms and identifying new therapeutic agents can facilitate the advancement of more efficacious strategies for PCa treatment. Methods Bioinformatics analysis was employed to investigate the expression of FOXG1 in PCa tissues. Subsequently, qRT-PCR was utilized to validate FOXG1 mRNA expression levels in corresponding PCa cell lines. FOXG1 knockdown was performed, and cell proliferation was assessed using CCK-8 assays, while cell migration and invasion capabilities were evaluated through wound healing and Transwell assays. Western blot and Seahorse analyzer were used to measure oxidative phosphorylation (OXPHOS) levels. Additionally, to explore potential approaches to alleviate PCa drug resistance, this study assessed the impact of biologically active saikosaponin-d (SSd) on PCa malignant progression and resistance by regulating FOXG1 expression. Results FOXG1 exhibited high expression in PCa tissues and cell lines. Knockdown of FOXG1 inhibited the proliferation, migration, and invasion of PCa cells, while FOXG1 overexpression had the opposite effect and promoted OXPHOS levels. The addition of an OXPHOS inhibitor prevented this outcome. Finally, SSd was shown to suppress FOXG1 expression and reverse docetaxel resistance in PCa cells through the OXPHOS pathway. Conclusion This work demonstrated that SSd mediated FOXG1 to reverse malignant progression and docetaxel resistance in PCa through OXPHOS.
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2021
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IF 4.291
Mengyang Lu,Qi Zhang,Zhicheng Zhang,Xueqi Wang,Bing Yan,Yongqian Wang
There are a variety of biological ion channels in organisms, which change under the influence of the environment and regulate the material transport at both ends of the biofilm. Inspired by this, a large number of studies on biomimetic nanochannels have been carried out. The lack of selective specificity and detection sensitivity are considered as main drawbacks in biomimetic nanochannels, and the combination of nanomaterials and biomimetic nanochannels is one of solutions. In this research, a confined self-assembly system composed of anodic aluminum oxide (AAO) templates and ZnS nanoparticles was fabricated by a negative pressure filtration method. Besides, L- Cysteine ( L- Cys) and D- Cysteine ( D- Cys) were modified into the confined self-assembly system by ultraviolet irradiation to enhance the sensitivity for biological molecules response. The confined self-assembly system showed specific selection of L- Cys and high sensitivity to biological molecules response. This work not only synthesized ZnS nanoparticles in biomimetic nanochannels controllably but also provided a new way of studying how to utilize nanomaterials to improve the response sensitivity of biomolecules in biomimetic nanochannels.
研究领域:
纳米技术
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仿生学
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材料科学
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生物传感
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Antioxidants
·
2022
·Vol. 11
·期 6
·1044
·
IF 7.675
Yuanying Li,Pengpeng Zhang,Zhoutong Sun,Huanhuan Li,Ran Ge,Xiang Sheng,Wuyuan Zhang
Calcitriol is an active analog of vitamin D3 and has excellent physiological activities in regulating healthy immune function. To synthesize the calcitriol compound, the concept of total synthesis is often adopted, which typically involves multiple steps and results in an overall low yield. Herein, we envisioned an enzymatic approach for the synthesis of calcitriol. Peroxygenase fromAgrocybe aegerita(AaeUPO) was used as a catalyst to hydroxylate the C-H bond at the C-25 position of alfacalcidol and yielded the calcitriol in a single step. The enzymatic reaction yielded 80.3% product formation in excellent selectivity, with a turnover number up to 4000. In a semi-preparative scale synthesis, 72% isolated yield was obtained. It was also found thatAaeUPO is capable of hydroxylating the C-H bond at the C-1 position of vitamin D3, thereby enabling the calcitriol synthesis directly from vitamin D3.Keywords:peroxygenases;oxyfunctionalization;active vitamin D;calcitriol;biocatalysis
研究领域:
生物化学
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药物合成
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酶工程
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
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2021
·Vol. 37
·期 2
·304-310
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IF 1.307
Wang Dong,Li Zhenwei,Zhang Qian,Liu Jie,Yang Yu,Han Jishu,Wang Lei
Silicon(Si) with high theoretical capacity has attracted tremendous attention as the next-generation anode material for Li-ion batteries, but the huge expansion during cycling restricts its practical application. Designing a low-cost, accessible robust network binder is a facile and effective approach to suppress the volume change effect and achieve the commercial application of Si anodes. Different previous studies focused on the network binder macromolecule main chain, this manuscript pays attention to the study of small-molecule cross-linker. Herein, cross-linked network binders using alginate acid and two kinds of cross-linkers, i.e., D -sorbitol and isosorbide(Alg-DS and Alg-IS binders) are synthesized. It was found that not only the chemical structure of the cross-linker but also the physicochemical property, such as melting point affect greatly the mechanical properties of the network binder. As a result, the Si anode with an Alg-DS binder dried below the melting point of DS shows the best cycling stability with a high capacity of 2249.8 mA·h/g and a retention rate as high as 95.9% after 100 cycles. This study gives a new view to design robust network binders for stable Si anodes.
研究领域:
材料科学
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电化学
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电池技术
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Journal of Materials Chemistry C
·
2025
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IF 5.1
Ji Qi,Pibin Bing,Lanju Liang,Xin Yan,Haiyun Yao,Zhenhua Li,Ziqun Wang,Zhongyang Li,Qing Liu,Guifang Wu
Trace biological solution detection is currently of great interest in the terahertz (THz) field. Graphene oxide (GO) is an amphiphilic graphene-like material with favorable biocompatibility, showing good potential applicability in THz liquid detection. In this work, a GO enhanced THz metamaterial liquid biosensor with a polyimide capillary as the microfluidic channel is proposed. The experimental results reveal that the capillary structure can avoid the large absorption of THz waves by controlling the amount of water. In the biosensor, GO is demonstrated to play an important role in enhancing the THz response, improving surface adsorption, and facilitating signal transmission. It is able to enhance the immobilization of D-Asp, which was confirmed by both Raman spectra and XRD scans, thus resulting in the structural changes of GO. The transmission amplitude variation of THz waves indicates that the electromagnetic response of GO varies with the adsorbed D-Asp concentration. The proposed biosensor achieves an ultra-low detection limit of 3 pg mL−1 and a maximum transmission change of about 12.5%. Thus, with their robust resistance to water interference and outstanding detection performance, the proposed biosensors show potential advantages for the expanded application of THz metamaterials in the ultra-sensitive detection of trace biological samples in liquid environments.
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APPLIED SURFACE SCIENCE
·
2019
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IF 5.155
Junjie Yang,Lei Liu
The friction influence of 2-D molybdenum disulfide (MoS 2 ) films deposited on different substrates (Si, SiO 2 and Al 2 O 3 ) by atomic layer deposition (ALD) has been investigated. All of the three substrates showed a trend of decreasing friction with increasing number of layers of MoS 2 , but the friction leveled off for more than 6 layers samples. Comparing these 2-D MoS 2 films with each other, MoS 2 on the Al 2 O 3 possesses the lowest friction, while MoS 2 on the Si possesses the highest one, owing to effect of substrate on the specific self-limiting reaction in ALD process. At the same time, the friction of the monolayer MoS 2 is strongest affected by sulfur deficient. As the number of layers increases, the influence of the substrate on the friction of MoS 2 can be approximately characterized by the work of adhesion. Greater work of adhesion corresponds to a higher friction force. When the thickness is more than 6 layers, the substrate effect disappears gradually. Moreover, the friction of 2-D MoS 2 could be controlled near linearly by changing plasma treatment time within the range from 1 to 20 s, which suggests a possible way for the friction control of 2-D MoS 2 on different substrate quasi-qualitatively or even qualitatively.
研究领域:
材料科学
·
纳米技术
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JOURNAL OF HAZARDOUS MATERIALS
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2021
·
IF 10.588
Xiaoju Yan,Shirong Cheng,Cong Ma,Junyu Li,Guodong Wang,Chengyu Yang
Sodium tetraborate pentahydrate (STB) was intercalated into graphene oxide (GO) nanosheets to form a nanocomposite (STB@GO). Subsequently, it was self-assembled on a substrate membrane to prepare STB@GO nanofiltration membrane. The properties of the STB@GO powder samples and the nanofiltration membrane were studied using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), contact angle (CA), and zeta potential . When the STB concentration was 1.0 g/L in the cross-linking reaction, the membrane was described as the STB 2 @GO membrane and exhibited a large interlayer space ( d -spacing = 1.347 nm), high hydrophilicity (CA = 22.2 ° ), and high negative potential (zeta = −18.0 mV). Meanwhile, the pure water flux of the membrane was significantly increased by 56.60% than that of the GO membrane. In addition, the STB 2 @GO membrane exhibited a favorable capability for dye rejection,98.52% for Evans blue (EB), 99.26% for Victoria blue B (VB), 91.94% for Alizarin yellow (AY), and 93.21% for Neutral red (NR). Furthermore, the STB 2 @GO membrane performed better in dye separation under various types and concentrations of dye, pH values, and ions in solution. Thus, this study provides a promising method for preparing laminated GO nanofiltration membranes for dye wastewater treatment .
研究领域:
材料科学
·
环境科学
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