ACS Nano
·
2022
·
IF 18.027
Shanshan Liu,Bingnan Wang,Yuewen Yu,Yubo Liu,Zeyan Zhuang,Zujin Zhao,Guangxue Feng,Anjun Qin,Ben Zhong Tang
Photodynamic therapy as an emerging phototheranostic approach holds great potential for antibacterial treatment, but is limited by compromised reactive oxygen species (ROS) generation in an aggregate and hypoxic microenvironment. Herein, we report a molecular cationization approach to boost the ROS, especially type I ROS generation of aggregation-induced emission (AIE) photosensitizers for photodynamic treatment of drug-resistant bacteria. Such cationization reinforces the electron-accepting ability of the cationic moiety, promotes intersystem crossing (ISC), and increases electron separation and transfer processes. The resultant CTBZPyI exhibits largely enhanced ROS generation ability with predominant hydroxyl radical generation over its neutral counterpart in aggregate. Moreover, cationization also confers CTBZPyI with the bacterial binding ability and a moderate bacterial inactivation ability in the dark. Further light irradiation leads to superb antibacterial performance, which largely promotes the healing process of a MRSA-infected wound. Such a cationization strategy is expected to be a general strategy for the design of highly effective type I photosensitizers for bacterial infection treatment.
✓ 已验证
DOI
PubMed
高影响因子
Applied Sciences-Basel
·
2024
·Vol. 14
·期 11
·4537
·
IF 2.5
Yang Li,Yang Zhang,Jianping Gao,Shuguang Liao,Guifeng Zhang
Acute and chronic liver failure are clinically significant conditions, and the artificial liver support system (ALSS) is emerging as a novel and effective approach for the clinical management of liver failure. Within this framework, scaffold materials occupy a pivotal position as integral components of the bioreactor. Elevating the performance capabilities of these scaffolds not only augments the therapeutic efficacy of the artificial liver but also lays the groundwork for refining and selecting large-scale hepatocyte culture models. In this study, we introduced a novel hepatocyte scaffold material designated as PET-COL, crafted by coating polyethylene terephthalate (PET) with collagen. This involved a sequence of modifications, including alkaline hydrolysis, EDC/NHS activation and crosslinking, as well as collagen conjugation. The physicochemical attributes of the scaffold were thoroughly characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), second harmonic generation (SHG), water contact angle measurements, and high-performance liquid chromatography–mass spectrometry (HPLC-MS). Furthermore, an investigation into the material’s biological properties was conducted that encompassed SEM (HepaRG growth), fluorescence staining (assessment of cell viability), staining by trypan blue (HepaRG counting), CCK-8 (proliferation of cells), biochemical testing, and immunosorbent assay. Our findings revealed that collagen was covalently bonded to the PET surface, leading to a substantial enhancement in the material’s hydrophilicity (p< 0.001). The quantity of collagen coating was determined to be precisely 33.30 μg per scaffold. Human liver progenitor HepaRG cells thrived on the PET-COL material. Compared with the untreated group, cell viability, albumin secretion, urea synthesis, and the expression levels of CYP3A4 and CPS1 increased significantly (p< 0.001), demonstrating remarkable biological vitality. The PET-COL scaffold, as developed in this study, holds immense potential for application in bioartificial livers.
✓ 已验证
产品关联
DOI
高影响因子
FITOTERAPIA
·
2024
·
IF 2.5
Lin Zhu,Yongle Yu,Youfu Ma,Yenong Shi,Jamal Alzobair Hammad Kowah,Lisheng Wang,Mingqing Yuan,Xu Liu
Sophoridine, which is derived from the Leguminous plant Sophora alopecuroides L., has certain pharmacological activity as a new anticancer drug. Herein, a series of novel N-substituted sophoridine derivatives was designed, synthesized and evaluated with anticancer activity. Through QSAR prediction models, it was discovered that the introduction of a benzene ring as a main pharmacophore and reintroduced into a benzene in para position on the phenyl ring in the novel sophoridine derivatives improved the anticancer activity effectively. In vitro, 28 novel compounds were evaluated for anticancer activity against four human tumor cell lines (A549, CNE-2, HepG-2, and HEC-1-B). In particular, Compound 26 exhibited remarkable inhibitory effects, with an IC 50 value of 15.6 μM against HepG-2 cells, surpassing cis-Dichlorodiamineplatinum (II). Molecular docking studies verified that the derivatives exhibit stronger binding affinity with DNA topoisomerase I compared to sophoridine. In addition, 26 demonstrated significant inhibition of DNA Topoisomerase I and could arrest cells in G 0 /G 1 phase. This study provides valuable insights into the design and synthesis of N-substituted sophoridine derivatives with anticancer activity.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Yu Han,Jun Li,Shuhuan Hao,Wan-Zhen Fo,Liwen Cao,Mengjiao Li,Yanan Liu,Jianhua Zhang
Photonic synaptic transistors, designed to emulate the multispectral light detection of retinal neurons, play a pivotal role in advancing artificial vision systems capable of full-color image recognition. However, their limited sensitivity to weak and multispectral light significantly hampers their application in full-color image capture and recognition. In this work, a p-i-n structured synaptic transistor is introduced that improves weak light sensitivity and enhances synaptic performance by addressing interface issues. By integrating P3HT/LiF/InZnGdO nanofibers as p-i-n structure, the spectral response is successfully broadened from visible to near-UV region, achieving sensitivity to light intensities as low as 0.05 mW cm −2 . The device exhibits remarkable PPF characteristics across the wavelength range of 395–633 nm, with the PPF index showing a maximum increase of 84% compared to the single InZnGdO nanofiber device. Additionally, multiple neural networks are constructed with data from the synaptic transistor array driven by wavelength-tunable synaptic plasticity to validate the device's feasibility in various application scenarios. The proposed device achieved a recognition accuracy of up to 95.26% for high-precision full-color images based on the public CIFAR-10 dataset. This p-i-n structure offers a novel pathway to enhance the synaptic performance of metal oxide-based synaptic transistors, advancing the development of next-generation artificial vision.
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2021
·Vol. 31
·期 32
·2101637
·
IF 18.808
Xudong Hu,Yang Zhao,Seung Joon Yoo,Xin Li,Xiaojun Zeng,Chunming Zheng,Xiaohong Sun,Galen D. Stucky
Sodium-metal batteries (SMBs) employing transition-metal-free cathodes are of great importance for energy storage applications that require low cost and high energy density. A strategy to enhance the energy density of transition-metal-free-cathode SMBs by transforming the electrolyte from a dead mass to an energy-storage contributor is reported. NaI is used for the partial substitution of NaClO 4 in the electrolyte and thus provides the additional electrochemistry of I 3 − /I − redox couple to enhance battery performance. Graphene oxide (GO) encapsulated mesoporous (10 nm) carbon spheres (N-MCS@GO) that are nitrogen-doped (15.71 at%) are fabricated as the cathode for the I 3 − /I − redox enhanced SMBs. It is experimentally demonstrated that: the mesoporous structure increases the capacitive energy storage by providing a substantial interface that enhances the electrochemistry of I 3 − /I − redox couples; and encapsulation of the mesoporous carbon spheres with GO suppresses self-discharge and increases Coulombic efficiencies from 70.4% to 91.9%. In full-cell configuration, N-MCS@GO working with the NaI-activated electrolyte can deliver a capacity of 279.6 mAh g −1 with an energy density of 459.2 Wh kg −1 in 0.5–3 V at 200 mA g −1 . I 3 − /I − redox in the full cell maintains its activity without obvious decay after 1000 cycles at 1 A g −1 , highlighting the practical application of the I 3 − /I − redox enhanced SMBs.
✓ 已验证
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2019
·
IF 6.35
Qinlei Liu,Yao Lin,Jing Xiong,Li Wu,Xiandeng Hou,Kailai Xu,Chengbin Zheng
A disposable, instrument-free, height readout paper-based analytical device (HR-PAD) based on a paper strip inkjet-printed with CdTe quantum dots (QDs) was developed for the sensitive speciation analysis of Ag+ and silver nanoparticles (AgNPs). When the paper strip is immersed into a sample solution, capillary action draws it through the surface and any Ag+ in the solution quenches the fluorescence of CdTe QDs via a cation exchange reaction between Ag+ and the CdTe QDs, with the height of the quenched band being proportional to the concentration of Ag+. In contrast, fluorescence quenching cannot be observed when only AgNPs are present in solution. Thus, the concentration of AgNPs can be obtained by subtracting the Ag+ content from the total silver determined by the HR-PAD after digestion with HNO3. Under optimized conditions, the methodology provides high selectivity, sensitivity, and accuracy for the detection of Ag+ or AgNPs in various samples, even at concentrations as low as 0.05 mg L–1. Precisions of 4.5% and 2.2% RSDs were achieved at concentrations of 1 mg L–1 and 7 mg L–1 of Ag+, respectively. Compared to conventional methods, this approach is inexpensive and user-friendly and eliminates the need for expensive and sophisticated detection instruments. The practicality of the method was demonstrated via the speciation analysis of AgNPs and Ag+ in river water and 12 commercial products with satisfactory results.
✓ 已验证
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2022
·
IF 11.504
Laiming Zhang,Jiaqi Zheng,Yi Wang,Xingqian Ye,Shiguo Chen,Haibo Pan,Jianle Chen
Rhamnogalacturonan-I (RG-I) was considered to be incompatible with gel formation. Due to its important health benefits, our previous study reported synergistic gelation of RG-I enriched pectin from citrus membranes with sequential acidic and alkaline treatment. In the present study, we further fabricated RG-I enriched pectin-based emulsion gels with the synergistic gelation for hydrophobic bioactive encapsulation. The effect of oil fraction and interfacial compositions including pectin itself and Tween 20 on the physical properties and delivery characteristics of emulsion gels was investigated. As to interfacial compositions, pectin reduced syneresis and swelling ratio and increased water holding capacity . Oil fraction had no marked influence on syneresis and swelling ratio, but significantly increased water holding capacity. Particularly, all the emulsion gels showed an elastic behavior and a full structure recovery after shearing. Increase in pectin instead of Tween 20 onto the surface of oil droplets and oil fraction markedly improved their gel strength. Curcumin was encapsulated within the oil phase of emulsion gels. Improvement in gel strength provided enhanced protection of curcumin against heat-induced degradation. In vitro digestion revealed that interfacial compositions decelerated curcumin release by increasing the proportion of pectin onto the surface, but didn't change its bioaccessibility eventually. Increase in oil fraction accelerated curcumin release, but reduced its bioaccessibility. Overall, fabrication of RG-I enriched pectin-based emulsion gel with pectin itself as interfacial composition and low oil fraction would contribute to improving curcumin bioavailability for its sustained release, which should be further validated in vivo .
✓ 已验证
DOI
高影响因子
FUEL PROCESSING TECHNOLOGY
·
2023
·
IF 7.5
Dingshan Cao,Cong Luo,Tong Luo,Zhaowei Shi,Fan Wu,Xiaoshan Li,Ying Zheng,Liqi Zhang
One of the research priorities in dry reforming of methane (DRM) technology is the development of highly active and stable catalysts. Using crystalline oxides as catalyst precursors is an effective catalyst optimization scheme for DRM. Therefore, the application of La 2 NiO 4 perovskite in DRM was systematically studied, including preparation, characterization, carbon deposition properties, regeneration properties, and B-site doping, etc. This paper is the first part, the effects of preparation methods (sol-gel, co-precipitation, hydro-thermal, and solid-state methods) on the physicochemical properties and DRM performance of La 2 NiO 4 samples were investigated, and the relationship between materials' structure and their catalytic performance was analyzed. The results showed that compared with the samples prepared by the hydro-thermal and co-precipitate methods, the sample prepared by the sol-gel method exhibited the highest conversion of CH 4 and CO 2 (91.4% and 91.5%, respectively) and the best carbon resistance in DRM, which were mainly attributed to its richer microstructure, higher reducibility and basicity . While the lowest DRM performance of the sample prepared by the solid-state method was mainly due to the small amount of reduced amorphous NiO and the weak reducibility of the perovskite phase in this sample, resulting in the inability of perovskite in-situ decomposition under the DRM atmosphere.
✓ 已验证
DOI
高影响因子
Nanomaterials
·
2022
·Vol. 12
·期 23
·4166
·
IF 5.719
Min Zhang,Hongmei Yu,Xiaodan Tang,Xiuhui Zhu,Shuping Deng,Wei Chen
Sudan dyes are strictly prohibited from being added to edible products as carcinogens and tetracycline hydrochloride (TC) remaining in animal-derived food may cause harm to the human body. Therefore, it is necessary to establish a high-sensitivity, simple and convenient method for the detection of Sudan dyes and TC in foods for safety purposes. In this work, multifunctional blue fluorescent carbon dots (B-CDs) were prepared by a one-step hydrothermal synthesis using glucose as the carbon source. The results show that the fluorescence intensity of B-CDs was significantly affected by the acidity of the solution and can be quenched by Sudan I, IV and TC through selective studies. Interestingly, the fluorescence quenching intensities of B-CDs have a good linear relationship with the concentration of Sudan I and IV at pH = 3–7. The wide range of pH is beneficial to broaden the application of B-CDs in a practical samples analysis. The method has been successfully applied to real food samples of tomato paste, palm oil and honey, and the detection limits are 26.3 nM, 54.2 nM and 31.1 nM for Sudan I, Sudan IV and TC, respectively. This method integrates Sudan dyes and TC into the same multifunctional B-CDs, which shows that the sensor has a great potential in food safety detection.
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry C
·
2021
·Vol. 9
·期 16
·5469-5477
·
IF 7.393
Hao Cai,Shengqiang Liu,Zhen Song,Quanlin Liu
The practical application of near-infrared (NIR) phosphors is hindered due to their limited light emitting region and narrow bandwidth. Here, we report a series of Cr3+-doped olivine phosphors, (Mg1−xLix)(Mg1−xScx)GeO4:Cr3+, with tunable luminescence from NIR-I to NIR II based on crystallographic site engineering. By using a [Li+–Sc3+] unit substituting for a [Mg2+–Mg2+] unit, the NIR luminescence can be largely tuned from 940 nm to 1110 nm, and the corresponding FWHM can be modified from 236 to ∼300 nm. The internal quantum efficiency (IQE) and external quantum efficiency (EQE) of Mg2GeO4:1% Cr3+ were measured to be 48.19% and 16.38%, respectively. The photoluminescence of the phosphors matches well with the absorption of several functional groups. By measuring the NIR absorption of different liquids illuminated by NIR light from our phosphors, qualitative and quantitative analysis can be realized. These results suggest that the super-broad NIR luminescence of (Mg1−xLix)(Mg1−xScx)GeO4:Cr3+ has potential applications as light sources for nondestructive food analysis.
✓ 已验证
DOI
高影响因子
Sensing and Bio-Sensing Research
·
2025
·
IF 4.9
Yue He,Xinyue Qu,Tingting Lan,Mingxing Yu,Xu Duan,Ruyi Chen,Junhao Wu,Zhihong Wang,Deling Kong,Zhongyang Shen,Shuang Yang,Chunlei Zhou,Tao Ming
As a key biomarker in clinical diagnostics, cardiac troponin I facilitates the early diagnosis of acute myocardial infarction. This study developed a rapid quantitative method for detecting cardiac troponin I in blood, aiming to establish its quantitative correlation with myocardial infarction area by accurately quantifying the serum cTnI concentration in patients suffering from acute myocardial infarction. We utilized a cTnI-specific aptamer as the recognition element. Gold nanoparticles exhibit salt-induced aggregation with visible color change. The aptamer protects gold nanoparticles from high-salt aggregation. Through systematic optimization, we established a gold nanoparticle-based colorimetric assay leveraging this anti-aggregation mechanism. Results demonstrated that under optimal conditions—200 mM NaCl and 800 nM aptamer concentration—the developed assay exhibited a promising linear response (R 2 = 0.942) across a cardiac troponin I concentration spanning from 0.1 to 0.8 μg/mL. According to the standard calibration method, the detection limit was estimated as 0.1 μg/mL. We observed recovery rates ranging from 105.6 % to 118.5 %. This research presents a highly sensitive, specific, and rapid point-of-care detection methodology for cardiac troponin I, offering enhanced field-testing efficiency and providing a low-cost alternative for serum cardiac troponin I detection. Moreover, it lays the groundwork for the development of a novel methodology enabling dynamic and quantitative assessment of infarct size in patients suffering from myocardial infarction.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Jian Wang,Yueyang Xu,Erjian Huang,Liming Kong,Jie Li,Yongping Zeng
The combustion of thiophene sulfides in fuel leads to the release of sulfur oxides (SO x ), which pose significant threats to both ecological systems and human health. Adsorption desulfurization has gained considerable attention from researchers due to its mild operating conditions, low production costs, and minimal impact on octane number. This study investigates the use of Cu-BTC as a platform for developing a novel adsorbent aimed at efficiently removing thiophenic compounds from fuel. Aluminum atoms were incorporated into the framework of Cu-BTC to create micro/mesoporous Al/Cu-BTC. Subsequently, the π-complexation adsorbent Al/Cu(I)-BTC, featuring Lewis acid sites, was synthesized through the in-situ reduction of Al/Cu-BTC using sodium thiosulfate. The adsorption properties of Al/Cu(I)-BTC for thiophene were assessed through both batch and breakthrough experiments. Al/Cu(I)-BTC-0.10(0.28) demonstrated exceptional adsorption performance. The static and dynamic adsorption capacities of thiophene at 500 and 200 ppm were 18.54 mg S/g and 9.49 mg S/g, respectively. Importantly, the adsorption capacity of Al/Cu(I)-BTC-0.10 (0.28) for thiophene in fuel containing 500 ppm sulfur remained at 15.45 mg S/g after six regeneration cycles. In the competitive adsorption of toluene, the adsorption capacity of the adsorbent for thiophene in the fuel containing 200 ppm sulfur was 7.84 mg S/g.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）