INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Ding Wang,Yaoqing Chu,Shuiping Liu,Lianjiang Tan
Vessel normalization has proved imperative in tumor growth inhibition. In this work, biopolymer-based hybrid nanospheres capable of normalizing blood vessels were designed to improve the therapeutic effect of chemotherapeutic drugs. Zn 0.4 Fe 2.6 O 4 nanoparticles (ZFO NPs) were synthesized, and were encapsulated in cross-inked chitosan (CS) along with a nitric oxide (NO) precursor, DETA NONOate, forming hybrid ZFO/NO@CS nanospheres highly stable in physiological environment. The structure, morphology and size of the nanospheres were characterized. The ZFO/NO@CS nanospheres could release NO under acidic conditions typical of intratumoral and intracellular environment. The results of related factors expression, wound healing and tube formation assays demonstrated that both the encapsulated ZFO NPs and the released NO were able to inhibit angiogenesis in tumors. The ZFO/NO@CS nanospheres enhanced the antitumor efficacy of the chemotherapeutic drug DOX by normalizing tumor vessels, as evidenced by in vivo experiments for CT26 tumor-bearing mice. By analyzing the contents of Fe in the tumor and different organs, the nanospheres were found to accumulate primarily at the tumor site. The blood analysis showed little side effect of the nanospheres. The ZFO/NO@CS nanospheres have great potential in improving tumor therapeutic effect when used in combination with chemotherapeutic drugs.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2024
·Vol. 25
·期 15
·8125
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IF 4.9
Taoyang Cai,Shangjie Ge-Zhang,Chang Zhang,Pingxuan Mu,Jingang Cui
Transparent films with excellent antibacterial properties and strong mechanical properties are highly sought after in packaging applications. In this study, Ag/SiO2nanoparticles were introduced into a mixed solution of chitosan (CS) and polyvinyl alcohol (PVA) and a Ag/SiO2-CS-PVA transparent film was developed. The excellent properties of the film were confirmed by light transmittance, water contact angle tests and tensile tests. In addition, for the antibacterial test, the antibacterial properties of the sample against Gram-negative bacteria (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus) were explored, and the average size of the bacteriostatic circle was measured by the cross method. The final results show that Ag/SiO2-CS-PVA transparent film has the advantages of good antibacterial properties, high transparency and high mechanical strength.
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Nanoscale
·
2024
·
IF 5.8
Xiaodong Yu,Jihao Fan,Shengquan Zheng,Linlin Ma,Xiaojing Liu,Yue Wu,Chuangqi Zhao,Lei Jiang
High strength/toughness nanocomposites are increasingly in demand due to the development needs of high-end applications. However, the aggregation and random orientation of nanofillers and the weak crosslinking of the polymer matrix lead to the degradation of the mechanical properties of nanocomposites. Here, we present a strategy to prepare chitosan-based nanocomposites with aligned nanosheets via the in situ photo-crosslinking of modified chitosan. The well-dispersed and highly aligned nanosheets, as well as the dense covalently crosslinked network between the modified chitosan chains, effectively improve the mechanical properties of the prepared nanocomposites. For example, the chitosan-based nanocomposite films exhibit a tensile strength of up to 340.6 ± 13.4 MPa, a Young's modulus of 8.2 ± 0.2 GPa and a toughness of 22.0 ± 2.5 MJ m−3, which are 4.2, 4.8 and 1.8 times higher, respectively, than those of pure chitosan films. Moreover, the thermal decomposition temperature of the chitosan-based nanocomposite films reaches 286.8 °C, which is 48.5 °C higher than that of pure chitosan films. We consider that our strategy, which constructs a crosslinked chitosan structure with aligned nanofillers, could lead to the development and application of the bio-based composites with excellent mechanical properties.
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BIOMACROMOLECULES
·
2025
·
IF 5.4
Hongyan Wang,Lin Shi,Zhongxu Zhang,Long Chen,Xinli Xu,Weiwei Ding,Chuntao Chen,Dongping Sun
Managing uncontrolled and noncompressible bleeding presents a major challenge in emergency trauma care. Methods to halt bleeding quickly and efficiently, without applying direct pressure on the wound, have become a key focus of research. Herein, a novel fructose-modified chitosan/gelatin composite sponge has been developed, exhibiting high elasticity, low rebound pressure, and excellent cell compatibility. This material can rapidly return to its original form in around 1.5 s after being compressed by 80% upon contact with water. Additionally, experimental results from a rat liver wound model demonstrated that it exhibited a clear hemostatic effect. The hemostatic time was shortened from 204 ± 15.35 s to 53.3 ± 6.54 s, and the blood loss was reduced from 867 ± 153.15 mg to 187 ± 61.06 mg. Moreover, it can promote tissue healing by inhibiting the production of inflammatory factors including TNF-α, MCP-1, and IL-6. This material offers an effective solution for noncompressible tissue injuries.
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CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Fang Liu,Yinchun Liu,Youli Guo,Jianrui Liu,Jingwen Dong,Tengbin Wang,Di Hao,Yongqin Zhang
We developed and validated a novel Fourier transform infrared (FTIR) method to determine the degree of molar substitution (MS) for hydroxypropyl chitosan (HPCS) using nuclear magnetic resonance ( 1 H NMR) as a reference, and investigated the factors influencing the MS assay. Through extensive screening of integration methods for candidate bands in the FTIR spectrum of HPCS using 20 HPCS samples with degrees of acetylation (DA) ranging from 0.003 to 0.139, we found that when using band area at 2970 cm −1 as a probe integral, the MS values obtained via the 1 H NMR method exhibited linear correlations (R 2 > 0.98) with at least 16 integral ratios derived from their FTIR spectra. The optimal reference bands with high reliability are located at 3440 cm −1 and 1415 cm −1 , with R 2 exceeding 0.99 and a MS range of 0.17–1.92. The band at 2875 cm −1 is less affected by the trace moisture present in HPCS samples than the others. The results of the method validation demonstrated a mean recovery of 98.9 ± 2.8 % and an RSD below 10 %, suggesting a simple, robust, and highly accurate and precise method. This method could be extendable for the determination of the MS of insoluble HPCS derivatives and other hydroxypropylated polysaccharides .
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Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Meng Pan,Zonghao Tang,Jianbing Tu,Zhengchao Wang,Qinhui Chen,Rongdong Xiao,Haiqing Liu
Quick hemostats for non-lethal massive traumatic bleeding in battlefield and civilian accidents are important for reducing mortality and medical costs. Chitosan (CS) has been widely used as a clinic hemostat. To enhance its hemostatic efficiency, Zn 2 + in the form of zinc alginate (ZnAlg) was introduced to CS to make porous CS@ZnAlg microspheres with ZnAlg component on the surface. Such microspheres were prepared by successive steps of micro-emulsion, polyelectrolyte adhesion, and thermally induced phase separation. Their structure and hemostatic performance were analyzed by SEM, FT-IR, XPS and a series of in vitro hemostatic experiments including thromboelastography analysis. The composite microspheres had an outer and internal interconnected porous structure. Their size, surface area, and water absorption ratio were ca. 70 μm, 48 m 2 /g, and 1850%, respectively. Compared to the neat chitosan microspheres, the CS@ZnAlg microspheres showed shorter onset of clot formation, much faster in vitro and in vivo whole blood clotting, bigger clot, less blood loss, and shorter hemostatic time in the rat liver laceration and tail amputation models. The synergetic hemostatic effects from (1) the electrostatic attraction between chitosan component and red blood cells, (2) the activation of coagulation factor XII by Zn 2 + of zinc alginate component, and (3) physical blocking by microsphere matrix, contributed to the enhanced hemostatic performance of CS@ZnAlg microspheres.
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CARBOHYDRATE POLYMERS
·
2017
·
IF 4.811
Yongli Zhang,Xingrui Wang,Chen Xu,Weiwei Yan,Qiang Tian,Zhiming Sun,Hongduo Yao,Jianping Gao
Hydrophobic and dispersible functionalized reduced graphene oxide (FrGO) was employed to prepare chitosan gel droplets by crosslinking an inverse Pickering emulsion. The emulsion was prepared using toluene as the continuous phase and a chitosan aqueous solution as the dispersed phase. The effects of the FrGO concentration and the water/oil ratio on the chitosan droplet morphology were studied. At appropriate concentrations, the FrGO acted as a stabilizer and chitosan gel droplets were formed. Decreasing the FrGO concentration or increasing the water/oil ratio was unfavorable to the formation of chitosan droplets. Using this method, drug loaded chitosan gel droplets (microgels) were prepared and their release profiles as well as the factors that influence the drug release were investigated.
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2018
·
IF 4.61
Chunzhen Fan,Kan Li,Yi He,Yalin Wang,Xufang Qian,Jinping Jia
Although many magnetic chitosan materials have been prepared for adsorption of metal ions , there is no standard method for comprehensive evaluation of material performance. The common practice simply compares either adsorption capacity (Q) or saturation magnetization (M s ) of interested materials; however, these two important parameters often work in opposite way. This study aims to establish two methods for evaluation of the overall performance of magnetic materials. The proposed methods consider both heavy metal ion adsorption capacity and magnetic recovery of the material after use. The first method introduces adsorption recovery index (ARI, ARI = Q t ), which is calculated using Q and recovery time (t) needed for achieving 98% material recovery. Higher ARI value shows better performance of a magnetic material. The second method uses effort-vector data visualization, in which the position of a magnetic material is shown on a coordinate depicted using normalized Q and M s value. The distance of the data point to the target (ideal Q and M s value) indicates the performance of the material. The shorter the distance, the better the overall performance is. Two series of MCBs with different Fe 3 O 4 chitosan mass ratios were prepared by using embedding method and chemical co-precipitation method respectively. They were used as model compounds for investigation of the feasibility of the proposed evaluation methods through adsorption of various metal ions (Ag + , Cu 2+ , Hg 2+ , Cr 3+ and Cr 6+ ) and MCBs recovery test. The best performers were able to be identified by using both methods and the results agreed with each other. Compared with ARI, the effort-vector data visualization was more straightforward and easier to use. This method was successfully applied to evaluate a wide selection of magnetic materials, including those prepared in this work and reported from literatures, for their overall performance.
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Polymers
·
2025
·Vol. 17
·期 3
·387
·
IF 4.9
Rong Sun,Liangliang Li,Jiangjie Zhou,Yongfeng Zhang,Haiya Sun,Datong Zhang,Qi Wu
Zein exhibits excellent biodegradability, thermal stability, UV resistance, and water barrier properties, making it a promising candidate for food packaging applications. However, pure zein films suffer from brittleness and poor mechanical strength, which limit their practical use. In this study, a unique bilayer packaging film (ZP/P-C) was developed using a layer-by-layer solution casting technique, where hydrophobic zein was coated onto a polyvinyl alcohol and chitosan composite layer (P-C). Incorporating PEG400 into the zein layer improved the interfacial compatibility of the bilayer film, increasing its uniformity and toughness. The resulting bilayer films demonstrated enhanced mechanical properties, flexibility, and water vapor barrier performance. Specifically, the ZP7.5/P-C bilayer film showed an elongation at break of 68.74% and a modulus of elasticity of 187.19 MPa. It had a water vapor permeability of 6.60 × 10−11g·m·m−2·s−1·Pa−1and provided near-complete UV protection within the 200–350 nm range. Furthermore, an intelligent detection bilayer film was created by integrating anthocyanin extract into the zein layer. Adding anthocyanin improved the film’s antioxidant properties and allowed it to respond colorimetrically to total volatile basic nitrogen. The bilayer film ZPBA1.0/P-C displayed an excellent antioxidant activity (45.8%) and remarkable color change (ΔE = 20.2) in response to ammonia, effectively indicating shrimp spoilage in 48 h (ΔE > 10). This investigation spotlights the potential of zein-based bilayer films in active and intelligent food packaging, offering innovative strategies to improve food safety and extend the shelf life of perishable goods.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Yunfeng Xu,Xiaoxun Huang,Chuyin Liu,Dongning Kong,Guangren Qian
Arsenic (As) contamination of soils adversely affects human health and ecosystems and is an environmental issue of serious concern worldwide. Efficient and economical remediation methods are urgently needed. In this research, a chitosan-modified scrap iron filings (CFF) composite was prepared by using industrial scrap iron filings and chitosan to stabilize As-contaminated soil. The optimal modification conditions were explored, and CFF was applied to As-contaminated soil to investigate its remediation effect and stabilization mechanism. The results showed that the optimal preparation conditions of CFF were chitosan concentration of 3.75 % (w/w), chitosan to scrap iron filings ratio of 1:1, optimal modification temperature of 40 °C, iron filings particle size of 35–80 mesh, and 10 % glutaraldehyde crosslinking for 6 h, and the stabilization efficiency of As was 73.98 %. The adsorption behavior of CFF was consistent with the pseudo-second-order kinetic model and the Langmuir isotherm model, and the best adsorption effect was achieved at pH = 5–6. The possible mechanisms of As stabilization by CFF were surface complexation, hydrogen bonding synergy, precipitation, electrostatic attraction, and van der Waals forces.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Que Bai,Fangfang Hu,Siyuan Gou,Qian Gao,Shihao Wang,Wenhui Zhang,Yanni Zhang,Tingli Lu
The damaged skin for some reasons is vulnerable to invasion by bacteria and other harmful microorganisms, leading to delay of the wound healing. In order to promote the infected wound healing, curcumin was loaded with chitosan-based hydrogel was formed through phenylborate ester bonding and its properties and effects on the S. aureus -infected wound healing was tested. It was found the hydrogel showed good antioxidation on the intracellular reactive oxygen species, inhibition on the growth of S. aureus , and acceleration the infected skin healing. The ablity of hydrogel due to its regulating inflammation, promoting angiogenesis and collagen synthesis in the wound site. This research work suggested that the developed multifunctional hydrogel might be a beneficial treatment for the infected wound healing.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Xinxin Wang,Ruixue Meng,Shiyong Zhao,Zhenyu Jing,Yonghui Jin,Jie Zhang,Xinxin Pi,Qiuju Du,Long Chen,Yanhui Li
Radioactive iodine is considered one of the most dangerous radioactive elements in nuclear waste. Therefore, effective capture of radioactive iodine is essential for developing and using nuclear energy to solve the energy crisis. Some materials that have been developed for removing radioactive iodine still suffer from complex synthesis, low removal capacity, and non-reusability. Herein, covalent organic framework (COF)/chitosan (CS) aerogels were prepared using vacuum freeze-drying, and the COF nanoparticles were tightly attached on the green biomass material CS networks. Due to the synergistic effect of both COF and CS, the composite aerogel shows a three-dimensional porous and stable structure in the recycle usage. The COF/CS aerogel exhibits excellent iodine adsorption capacity of 2211.58 mg g −1 and 5.62 g g −1 for static iodine solution and iodine vapor, respectively, better than some common adsorbents. Furthermore, COF/CS aerogel demonstrated good recyclability performance with 87 % of the initial adsorption capacity after 5 cycles. In addition, the interaction between iodine and imine groups, amino groups, and benzene rings of aerogel are the possible adsorption mechanisms. COF/CS aerogel has excellent adsorption properties, good chemical stability, and reusable performance, which is a potential and efficient adsorbent for industrial radioactive iodine adsorption from nuclear waste.
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