PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2018
·Vol. 20
·期 20
·14117-14123
·
IF 3.906
Jun Zhou,Yunyun Huang,Chaoyan Chen,Aoxiang Xiao,Tuan Guo,Bai-Ou Guan
Interfacing bio-recognition elements to optical materials is a longstanding challenge to manufacture sensitive biosensors and inexpensive diagnostic devices. In this work, a graphene oxide (GO) interface has been constructed between silica microfiber and bio-recognition elements to develop an improved γ-aminobutyric acid (GABA) sensing approach. The GO interface, which was located at the site with the strongest evanescent field on the microfiber surface, improved the detection sensitivity by providing a larger platform for more bio-recognition element immobilization, and amplifying surface refractive index change caused by combination between bio-recognition elements and target molecules. Owing to the interface improvement, the microfiber has a three times improved sensitivity of 1.03 nm/log M for GABA detection, and hence a lowest limit of detection of 2.91 × 10−18 M, which is 7 orders of magnitude higher than that without the GO interface. Moreover, the micrometer-sized footprint and non-radioactive nature enable easy implantation in human brains for in vivo applications.
研究领域:
生物传感器
·
光学材料
·
纳米技术
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2026
·
IF 13.2
Wenxin He,Qijun Song,Qingyuan Liu,Xingyue Chen,Shuyin Tan,Hongtao Zhang
In this study, bovine serum albumin-γ-cyclodextrin (BSA-CD) conjugate was prepared to explore its solubilization effect on Paclitaxel (PTX) and the underlying mechanism. The aqueous solubility studies revealed that when 0.1 mM BSA-CD conjugate was complexed with 4 mM PTX, the maximum aqueous solubility of PTX reached 34 mM, which was approximately 5-fold higher than that of the clinical formulation Abraxane™, with drug loading capacity increased by about 2.8-fold. In vitro release studies demonstrated that the inclusion complex exhibited a cumulative PTX release of approximately 14% over 72 h at pH 7.4 and approximately 23% at pH 5.5, indicating a pH-responsive release profile. MTT assays confirmed that the BSA-CD carrier was non-cytotoxic, and the inclusion complex at the concentration of 10 μM exhibited superior cytotoxicity against melanoma B16F10 cells compared to free PTX and Abraxane™. This study confirms that the BSA-CD conjugate, through the synergistic “dual encapsulation” effect of the BSA hydrophobic pocket and the γ-CD hydrophobic cavity combined with a moderately aggregated state modulated by specific ionic strength, significantly enhances the aqueous solubility and delivery efficiency of PTX, providing a novel and efficient carrier as well as new insights for the formulation optimization of hydrophobic anticancer drugs.
✓ 已验证
DOI
PubMed
高影响因子
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
·
2013
·
IF 0.601
Zhikui Yin,Bin Zheng,Fang Ai
Sulfonic acid functionalized nano γ-Al2O3 is easily prepared by the reaction of nano γ-Al2O3 with 1,3-propane sulfone. This reagent can be used as an eficient catalyst for the synthesis of thioamides. This new method consistently has the advantages of excellent yields and short reaction times. Further, the catalyst can be recovered for several times.
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2018
·
IF 3.909
Min Zhang,Junhui Yang,Qili Yang,Liulian Huang,Hui Wu,Lihui Chen,Cuicui Ding
The poly(γ-glutamic acid)-NHS (γ-PGA-NHS) esters were used to endow collagen with both of excellent water-solubility and thermal stability via cross-linking reaction between γ-PGA-NHS and collagen. In the present work, the effect of γ-PGA-NHS on the aggregation of collagen molecules was studied by fluorescence techniques. The fluorescence emission spectra of pyrene in collagen solutions and the intrinsic fluorescence emission spectra of collagen suggested different effects of γ-PGA-NHS on collagen molecules: inhibiting aggregation below critical aggregation concentration (CAC) and promoting aggregation above CAC. The two-dimensional (2D) fluorescence correlation spectra indicated that the intermolecular hydrogen bonding and cross-linking between γ-PGA-NHS and collagen would influence the aggregation of collagen molecules. By the ultra-sensitive differential scanning calorimeter (VP-DSC), it was found that the main denaturational transition temperature ( T m2 ) of modified collagen increased, while its calorimetric enthalpy changes (Δ H 2 ) decreased compared to those of native collagen, further indicating that the modification of γ-PGA-NHS influenced the aggregation of collagen molecules. The study provide useful information for the utilizing and or the processing of water-soluble collagen in aqueous solution in the fields such as cosmetics, health care products , tissue engineering and biomedical materials , etc.
✓ 已验证
DOI
高影响因子
AICHE JOURNAL
·
2022
·Vol. 69
·期 2
·e17973
·
IF 4.167
Hong Xu,Di Hu,Lu Lin,Man Zhang,Xin Li,Yongjian Zeng,Mahmoud Amer,Wenhao Luo,Kai Yan
The selective hydrogenation of biomass-derived levulinic acid (LA) to γ-valerolactone (GVL) is one of pivotal reactions in many of the biorefinery schemes for the production of value-added chemicals and biofuels. Herein, we have fabricated carbon-supported bimetallic NiCo catalysts based on the metal–organic framework (MOF) material via a pyrolysis method. The as-obtained Ni 1 Co 1 bimetallic catalyst outperforms monometallic counterparts in the catalytic performance of LA-to-GVL, with a nearly full conversion of LA and a GVL yield of 95.2%, in particular with an excellent catalyst stability up to seven consecutive runs at 160°C and 4 MPa H 2 . Based on a combined characterization study by employing advanced techniques, for example, extended x-ray absorption fine structure (EXAFS), high-angle annular dark-field scanning transmission electron microscopy (HADDF-STEM), and electron paramagnetic resonance (EPR), we reveal that the enhanced catalytic performance, in particular the excellent stability, could be attributed to the formation of the bimetallic alloys, which efficiently alleviates the metal leaching and sintering during catalysis.
✓ 已验证
产品关联
DOI
高影响因子
FUEL
·
2023
·
IF 7.4
Xiaoqi Wang,Xinhua Qi,Mo Qiu,Feng Shen,Jirui Yang,Boxiong Shen
Herein, a Ni/Ru bimetallic ordered mesoporous carbon (Ni/Ru@WOMC) was prepared through solvent evaporation induced self-assembly (EISA) method with walnut shell organosolv lignin as carbon precursor and Ni 2+ as crosslinking agent followed by impregnating small amount of Ru, where the mass ratio of Ni/Ru was about 10:1. The resulting material showed superior catalytic activity on hydrogenation of levulinic acid (LA) to γ-valerolactone (GVL). A nearly 100 % GVL yield could be obtained in 2-propanol solvent under mild conditions at a low reaction temperature of 80 °C in 4 h reaction time. The Ni/Ru@WOMC catalyst could be used at least 5 times without obvious loss of its catalytic performance, which can be ascribed to the confinement effect provided by their ordered mesoporous structure. This successful development of Ni/Ru@WOMC in the hydrogenation of LA to GVL opens up new opportunities for the catalytic application of lignin derived functionalized ordered mesoporous carbon in biomass transformation reactions.
✓ 已验证
产品关联
DOI
高影响因子
Inorganic Chemistry Frontiers
·
2022
·Vol. 10
·期 4
·1119-1126
·
IF 7.779
Xin Zhao,Chensheng Lin,Shunda Yang,Haotian Tian,Chao Wang,Tao Yan,Jian Zhang,Bingxuan Li,Ning Ye,Min Luo
A non-centrosymmetric metal-free thiophosphate, γ-P4S3I2, was successfully synthesized utilizing polymorphism strategy in this study. γ-P4S3I2 crystallized in the space group of P43 and featured paralleled (P4S3I2)n molecular clusters. Importantly, it exhibited promising nonlinear optical (NLO) performances, such as a phase-matchable second harmonic generation (SHG) efficiency (0.5 × AgGaS2), wide band gap (2.38 eV), large birefringence (0.118@2050 nm), and wide infrared transparency, suggesting that γ-P4S3I2 may be a potential IR NLO candidate.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF DAIRY SCIENCE
·
2022
·
IF 4.225
Xiankang Fan,Luyun Yu,Zihang Shi,Chunwei Li,Xiaoqun Zeng,Zhen Wu,Daodong Pan
ABSTRACT This study developed and characterized a γ-aminobutyric acid (GABA)-enriched yogurt fermented by Levilactobacillus brevis CGMCC1.5954. The GABA content in the yogurt was 147.36 mg/100 mL, which was 317.06% higher than that of the control group. Furthermore, there was a significant improvement in the aroma, hardness, adhesion, cohesiveness, and gelatinousness of yogurt. The chromatography and metabolomics analyses further confirmed the high GABA content in yogurt and its nutritional value, and the metabolic pathway for GABA production by L. brevis 54 was identified. A total of 58 volatile flavor compounds were identified using headspace solid-phase microextraction-gas chromatography-mass spectrometry, of which 2-nonanone and 2-heptanone may be responsible for the high odor score of GABA-enriched yogurt. This study developed a nutritious and unique GABA-enriched flavored yogurt, summarized the metabolic pathway of GABA, and provided a flavor fingerprint that could guide the production of specifically flavored yogurts.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2022
·
IF 6.364
Shenglin Kang,Xuetong Zhao,Jing Guo,Jie Liang,Jianjie Sun,Yang Yang,Lijun Yang,Ruijin Liao,Clive A. Randall
Thermal-assisted cold sintering process (TA-CSP) has been applied to fabricate high dense α-Al 2 O 3 ceramics with submicron grain sizes. The α-Al 2 O 3 (80 wt%) and γ-Al 2 O 3 (20 wt%) powders are firstly mixed and then cold sintered at 300 °C to produce a green bulk with a relatively high density of ∼ 86.9 %, and then later a second heat treatment (800–1350 °C) is applied to finally fabricate (∼ 98 % dense) α-Al 2 O 3 ceramics with grain sizes of 720 nm. A microstructural analysis with XRD and TEM suggests that the TA-CSP samples not only complete the final densification but also drive a phase transition of γ-Al 2 O 3 to α-Al 2 O 3 . To put into perspective the Hardness and Young's modulus of TA-CSP samples reach ∼ 14 GPa and ∼ 335 GPa, respectively, which is comparable to conventional sintered samples processed at higher temperatures of 1500–1700 °C. Therefore, it is feasible to utilize TA-CSP to prepare α-Al 2 O 3 ceramics with small grain sizes at low sintering temperatures .
✓ 已验证
产品关联
DOI
高影响因子
FUEL PROCESSING TECHNOLOGY
·
2022
·
IF 8.129
Yiwei Tang,Junyan Fu,Yicong Wang,Haixin Guo,Xinhua Qi
Hydrogenation of levulinic acid to γ-valerolactone is one of the important reactions for conversion of biomass into renewable fuels and chemicals. Ni-Zn non-noble bimetallic catalysts supported on ordered mesoporous carbon (Ni-Zn@OMC) were prepared by one-pot solvent evaporation induced self-assembly (EISA) method and used for hydrogenation of levulinic acid to γ-valerolactone (GVL) in water. A GVL yield of 93% was obtained over bimetallic Ni 1 -Zn 1 @OMC catalyst at 180 °C in 90 min reaction time, with a turnover frequency (TOF) of 686.4 h −1 . Compared with Ni@OMC, the incorporation of Zn metal leads to the formation of Ni-Zn alloy and high dispersion of Ni particle on the catalyst surface . NiO sites on the catalysts lowered competitive adsorption between H 2 and levulinic acid on Ni 0 sites, as well as the Ni-Zn alloy is beneficial to the activation of carbonyl group in levulinic acid, and they synergistically promote the hydrogenation of levulinic acid to 4-hydroxyvaleric acid (4-HVA). Zn content in the catalyst influences both the activity of Lewis acid sites and the ratio of Lewis acid to Brønsted acid sites, and the active sites of Ni δ– Zn δ+ can facilitates the weakening and cleavage of C-O in 4-HVA, both of them are beneficial to the dehydration of 4-HVA to GVL.
✓ 已验证
产品关联
DOI
高影响因子
Atmosphere
·
2022
·Vol. 13
·期 2
·333
·
IF 3.11
Chao Wang,Lingdong Kong,Shengyan Jin,Lianghai Xia,Jie Tan,Yuwen Wang
Soot and aged soot are often found to be mixed with atmospheric particles, which inevitably affect various atmospheric heterogeneous reactions and secondary aerosol formation. Previous studies have investigated the heterogeneous reaction of NO2with different types of soot, but there are few studies on the heterogeneous reaction of NO2with mixtures containing diesel soot (DS) or aged DS and mineral dust particles. In this study, the effects of DS and aged DS on the heterogeneous reaction of NO2on the surface of γ-Al2O3were investigated via in-situ diffuse reflectance infrared Fourier transform spectrometry (DRIFTS). The results showed that the DS or DS n-hexane extract significantly inhibited the formation of nitrate on γ-Al2O3particles and promoted the formation of nitrite. At 58% RH, with the increase of DS or DS n-hexane extract loading amount, the effect of DS or DS n-hexane extract on the formation of nitrate changed from promotion to inhibition, but DS or DS n-hexane extract always promoted the formation of nitrite. The results also showed that light was conducive to the formation of nitrate on the DS-γ-Al2O3or DS-n-hexane extract-γ-Al2O3particles. Furthermore, the influence of soot aging on the heterogeneous reaction of NO2was investigated under light and no light. In the dark, O3-aged DS-γ-Al2O3or O3-aged DS-n-hexane extract-γ-Al2O3firstly inhibited the formation of nitrate on the mixed particles and then promoted it, while the effect of aged DS on nitrite formation was complex. Under light, the O3-aged DS-γ-Al2O3firstly promoted the formation of nitrate on the mixed particles and then inhibited it, while the O3-aged DS-n-hexane extract-γ-Al2O3promoted the formation of nitrate on the mixed particles. Our results further showed that the production of nitrate on the O3-aged particles under light or no light was greater than that of the UV-nitrate-aged particles. This study is helpful to deeply understand the atmospheric chemical behavior of soot and the heterogeneous conversion of atmospheric NO2.Keywords:soot;NO2;heterogeneous reaction;aged soot;γ-Al2O3
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2022
·
IF 10.319
Kunpeng Qian,Shuang Li,Jianhui Fang,Yuhuan Yang,Shaomei Cao,Miao Miao,Xin Feng
Ti 3 C 2 T x MXenes with excellent metallic conductivity and flexibility have shown a promising prospect as electromagnetic interference (EMI) shielding materials. Ultrathin, hierarchical hybrid films were fabricated by using C 60 intercalating Ti 3 C 2 T x MXenes with the assistance of water-soluble γ -cyclodextrin (CD). The C 60 /CD complex was obtained by high-speed vibration milling using hydrophilic CD as dispersing agent. After thermal annealing treatment, the obtained hybrid film exhibited excellent EMI shielding (53.52±0.43 dB), hydrophobicity (water contact angle: 93.7°) and mechanical stability (over 0.9 million bending times). Taking advantage of the antioxidant of C 60 , the chemical durability of Ti 3 C 2 T x MXenes based hybrid films was also improved as expected. These results indicate that the well-designed hierarchical hybrid films with the intercalation of C 60 have promising potential for high-performance EMI shielding applications.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）