ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Li Yang,He Wang,Abu Musa Abdullah,Chuizhou Meng,Xue Chen,Anqi Feng,Huanyu Cheng
Wearable electrochemical sensors provide means to detect molecular-level information from the biochemical markers in biofluids for physiological health evaluation. However, a high-density array is often required for multiplexed detection of multiple markers in complex biofluids, which is challenging with low-cost fabrication methods. This work reports the low-cost direct laser writing of porous graphene foam as a flexible electrochemical sensor to detect biomarkers and electrolytes in sweat. The resulting electrochemical sensor exhibits high sensitivity and low limit of detection for various biomarkers (e.g., the sensitivity of 6.49/6.87/0.94/0.16 μA μM–1 cm–2 and detection limit of 0.28/0.26/1.43/11.3 μM to uric acid/dopamine/tyrosine/ascorbic acid) in sweat. The results from this work open up opportunities for noninvasive continuous monitoring of gout, hydration status, and drug intake/overdose.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 31
·14726-14732
·
IF 3.3
Lingting Huang,Yuqing Ren,Zhen Yang,Ruijin Zeng,Dianping Tang
Based on the electro-oxidation mode, electrochemical sensors provide an appealing evaluation tool for uric acid (UA) detection. However, improvements in the field of high-performance electrocatalysts remain necessary to enable wide-range and ultrasensitive detection of UA in this way. In recent years, the research and development of thermally treated metal (M) and nitrogen (N) co-doped carbon (M–N–C) catalysts, along with the usage of metal–organic framework materials as precursors, has substantially increased the performance of non-precious metal oxygen reduction catalysts, rendering them a potential species of the active substance. In this work, we synthesized cobalt metal-embedded nitrogen-doped carbon frameworks (Co–CN) through a host–guest synthetic strategy. An electrochemical sensing system was constructed for the accurate detection of UA molecules utilizing the excellent UA electrooxidation performance of Co–CN. The electro-oxidation reaction exhibits double electron/double proton transfer, and a response current signal can be obtained using differential pulse voltammetry (DPV), establishing a correlation between the measured UA concentration and the strength of the DPV current. The target UA concentration and DPV current density exhibited a dose-dependent relationship with a dynamic range of 2–120 μM and a limit of detection of 0.55 μM. During measurement, this sensing approach revealed good accuracy, high specificity, and adequate storage stability. It is worth noting that this detection system introduces a fresh approach for the development of sensitive, portable, and reasonably priced human metabolite analysis in wearable health monitoring devices.
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2023
·
IF 5.9
Junru Li,Yunqi Huang,Yanli Zhou,Hui Dong,Haoyuan Wang,Haoran Shan,Yifei Li,Maotian Xu,Xiaobing Wang
The conductive metal–organic framework (CMOF) is a promising application nanomaterial for the construction of electrochemical sensors. Three two-dimensional conductive M3(HHTP)2 materials with larger aspect ratios were prepared by a one-pot method using acetate-based metals (Cu, Ni, Co) and 2,3,6,7,10,11-hexahydroxytriphenylene (HHTP) with the introduction of N,N-dimethylformamide (DMF) as the limiting reagent. Compared with Ni3(HHTP)2 and Co3(HHTP)2, Cu3(HHTP)2 had a larger double capacitance, pore size, specific surface area, and smaller resistance. As a result, Cu3(HHTP)2 provided greater catalytic oxidation active surface area and charge transfer efficiency for malachite green (MG) detection. Hence, Cu3(HHTP)2 efficiently catalyzed MG oxidation and significantly improved the sensitivity of MG detection. Meanwhile, the oxidation current signal from the copper of Cu3(HHTP)2 was used as an internal reference signal to form a ratiometric electrochemical sensor with an MG oxidation current signal, which effectively reduced the external interference. The constructed electrochemical assay for MG detection displayed broad linearity (5–1000 nM) with a detection limit of 1.34 nM. In the meantime, MG residues in fish was evaluated and high reliability was obtained, confirming the feasibility of this valuable method for food safety and health evaluation of aquatic products.
✓ 已验证
产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Zhen Lin,Chuangui Cai,Wei Chen,Qian Deng,Jialin Yang,Kaiyuan Huang,Haohua Deng,Xinhua Lin,Wei Chen,Wensong Yao
Chemiluminescence (CL) intensity of luminol-H 2 O 2 system was dramatically enhanced by cetyltrimethylammonium bromide (CTAB) micelle-mediated 6-aza-2-thiothymine-protected gold nanoclusters (ATT-AuNCs). It is proved that spherical micelles of CTAB in aqueous solution improved the dispersity of ATT-AuNCs, thus enhancing their catalytic activity, which brought in the increased CL intensity of luminol-H 2 O 2 system. Carbazochrome sodium sulfonate (CSS) with a hemostatic containing tetrahydroindole structure broke the spherical micelles and notably quenched the CL intensity of luminol-H 2 O 2 -CTAB-ATT AuNCs system. Based on these results, a simple, fast, and sensitive CL method has been developed for the detection of CSS with a linear range of 0.25–25 μM and a detection limit of 0.11 μM. The method has also been successfully applied to the determination of CSS in serum with satisfied recoveries in the range of 89.6 % to 103.7 %. This study not only provides an effective approach for CSS detection but also paves the way for AuNCs-based CL applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Jin Yuan Zhang,Ying Zhang,Yu Zou,Ze Li Bo Xu,Bo Zhang,Wang Ren
In this study, a facile fluorescence-scattering ratiometric sensor was designed for visual and selective detection of levodopa (LD) via a clever physicochemical modulation scheme. The alkalized products of LD can rapidly react with polyethyleneimine (PEI) to exhibit an intense blue fluorescence and decrease the second-order scattering (SOS) signal of PEI. As the concentration of LD increased, the fluorescence intensity at 420 nm increased and the SOS intensity at 675 nm decreased synchronously. Thus the fluorescence-scattering ratiometric sensor was constructed by virtue of the two simultaneously changed signals. Furthermore, red light-emitting Au nanoclusters (AuNCs) were added into the above mixture solution to enlarge the SOS signal and provide a stable red background fluorescence. The intensity ratio of fluorescence to SOS ( F /( S / S blank )) is linear dependent on C LD in the wide range of 50.0–––30000.0 nM, and LD as low as 50.0 nM can be identified with the naked eye via change of fluorescence color. The developed ratiometric sensor is smart, simple and efficient, and has been applied to the convenient assay of LD in real samples. The proposed physicochemical modulation strategy provides a new and facile path for selectively and visually identifying the target from its analogues.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Jiaojiao Jiang,Zhixuan Zhang,Zhiqi Liang,Wenying Chen,Manfei Zhong,Kai Xu,Zhouling Wu
The crystalline structure of catalyst surfaces has an important effect on the catalytic activity. However, the crystal plane effects of Co 3 O 4 catalysts towards H 2 O 2 activation are rarely reported. In this work, Co 3 O 4 hexagon nanosheets, nanosheets, nanorods and nanocubes with respective {1 1 1}, {1 1 2}, {1 1 0} and {0 0 1} dominant exposed facets were synthesized by hydrothermal synthesis, and the crystal plane effects of these Co 3 O 4 nanocrystals were compared with respect to their viability as potential for non-enzymatic H 2 O 2 sensors. Co 3 O 4 as a hexagonal nanosheet with a {1 1 1} crystal plane exhibited the best performance for H 2 O 2 detection, and exhibited a fast response of 3 s, a wide linear range from 0.0005 ∼ 8.5 mM with sensitivity of 1160.2 μA·mM -1 cm - 2 , and detection limit of 0.049 μM. Overall, the H 2 O 2 detection performance of Co 3 O 4 with different exposed facets was ranked as {1 1 1} > {1 1 2} > {1 1 0} > {0 0 1}, which is consistent with the proportion of surface Co 3+ , indicating that the surface Co 3+ exhibit higher activity for H 2 O 2 oxidation. This study indicates that tuning of thecrystal plane of nanocrystals is important to enhancement of non-enzymatic H 2 O 2 detection, and provides an important constraint when developing high efficiency catalysts for non-enzymatic electrochemical H 2 O 2 sensors.
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2023
·Vol. 191
·期 1
·1-11
·
IF 5.7
Shi Fengna,Hu Sheng,Li Jingfang,Wang Fang,Chen Naipin
A novel, green, and facile approach has been developed to construct an ultrasensitive flexible enzyme-less electrochemical sensor on the basis of chitosan and graphene oxide composites decorated with Cu nanoparticles supported on nickel foam (Nif/Cs/GO@Cu), in which GO functions as the intermediate between Nif and Cu nanoparticles. The Nif/Cs/GO@Cu sensing platform was successfully fabricated by the drop casting method to load Cs/GO onto Nif followed by an additionally electrodeposition to support Cu nanoparticles on Nif/Cs/GO. Impressively, the Nif/Cs/GO@Cu exhibited much higher electrocatalytic activity for glucose and UA oxidation as compared to that of Nif or Nif@Cu. For glucose and UA at about 0.6 V and 0.1 V (vs. Ag/AgCl), linearity could be obtained in the concentration ranges 5 µM–4 mM and 5–345 µM; the sensitivities were 16 and 2.5 µA µM −1 cm −2 , and the detection limits 83 nM and 0.3 µM, respectively. The improved performance of the composite electrode was ascribed to the synergistic effect of Cu nanoparticles, Nif and GO, in which GO provides high electron conductivity and large surface area to prevent the agglomeration of Cu nanoparticles; Cu nanoparticles and Nif offer abundant active sites towards analytes oxidation. Additionally, the method was applied to determine both analytes successfully in blood serum samples with excellent recovery and also opens up an attractive route to potential applications of the flexible nickel foam-based electrochemical sensor. Graphical Abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY COMMUNICATIONS
·
2023
·
IF 3.8
Minghui Chen,Chen Wang,Fei Chen,Hongjie Li,Yunpeng Wang,Haitao Ma
A highly sensitive and precise electrochemical biosensor for glucose detection was developed by coupling synergetic catalysis of Cu-Zn-Ni oxide films. To enhance the catalytic performance of alloy, potentials between −0.5 V and 1.5 V are selected for potentiostatic oxidation. Notably, the oxidation process reveals the influence of Cl − in the electrolyte, leading to electrode surface etching, with increasing etching and grain boundary collapse at higher potentials. The electrochemical performance of the electrode was comprehensively evaluated using cyclic voltammetry (CV) and amperometric response in alkaline conditions. The catalytic electrode has an impressive linear response in the concentration range of 0.1 ∼ 1.0 mM glucose, with a sensitivity of 3775.11 μA·mM −1 . Furthermore, the electrode exhibits remarkable stability and anti-interference properties, rendering it suitable for non-enzymatic glucose sensing applications.
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Xin Chen,Xiao-Zhen Feng,Tao Zhan,Yu-Ting Xue,Hai-Xiang Li,Guo-Cheng Han,Zhencheng Chen,Heinz-Bernhard Kraatz
Three enzyme-free electrochemical glucose (GLU) sensors with bimetallic structures were constructed by electrodeposition of gold and copper nanoparticles (AuNPs/CuNPs), nickel and copper nanoparticles (NiNPs/CuNPs), and a copper-based metal-organic framework (Cu-MOF) combined with PtNPs , respectively. Amongst, the Cu-MOF/PtNPs on a gold electrode (GE) exhibited the best catalytic performance for GLU oxidation due to the synergistic amplification. The relevant electrochemical behaviour of GLU showed that two OH - and two electrons were involved in the process. The differential pulse voltammetry (DPV) enables the establishment of linearity in the concentration of 0.40–25.00 mM, with a detection limit (LOD) of 0.06 mM and a sensitivity of 158.41 µA·mM −1 cm −2 . In addition, the Cu-MOF/PtNPs/GE sensor was used to detect GLU in oral liquid as well as human serum samples with a recovery rate of 97.00–103.98% and RSD less than 3.59%. Finally, a portable electrochemical detection system based on the STM32F103C8T6 microcontroller , obtained a GLU concentration 5.24 mM while detecting in a diluted injection where the value 5.40 mM was recorded by a commercial meter to show the system has very broad application prospects in the point-of-care setting.
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Fang Wang,Fengna Shi,Jingfang Li,Naipin Chen,Cheng Chen,Ziqi Xu,Jiajun Wang
It is extremely important to simultaneously detection different biomarkers in various biological systems. Hereby, we have developed an original flexible nonenzymatic glucose and uric acid sensor using carbon cloth loaded with copper microspheres (Cu MSs) and ZnO nanoparticles decorated single-walled carbon nanotubes (Cu MSs/ZnO@CNTs/CC). Firstly, ZnO@CNTs was synthesized via sol–gel method, and then Cu MSs were uniformly electrodeposited on ZnO@CNTs/CC substrate rapidly. Morphological and compositional characteristics were examined to confirm the successful decoration of Cu microspheres and ZnO nanoparticles. Importantly, the nanocomposite electrode displayed remarkable electrocatalytic activity for glucose and UA, including wide linear detection range, low detection limit, outstanding sensitivity, respectively. Moreover, the nanostructure biosensor exhibited fast response time (0.1 s) and favorable long-term stability, which are attributed to synergistic catalytic effects: (a) the large specific surface area of CNTs offered abundant sites for the decoration of ZnO nanoparticles, and (b) the rough nanosheets assembled Cu microspheres could expose plentiful active sites. Finally, in practical serum samples, the sensor also exhibits considerably favorable precision and accuracy. As such, the novel flexible Cu MSs/ZnO@CNTs/CC sensor developed with economical and efficient preparation method provided a new easy and sensitive platform for glucose and UA determination in real application.
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2023
·
IF 5.9
Jingwen Feng,Jinjuan Gao,Wen Yang,Yaru Li,Jian Shi,Cong Liu,Mingshun Jiang,Shouzhen Jiang
Two-dimensional (2D) metal–organic frameworks (MOFs) have promising applications in surface plasmon resonance (SPR) sensing for their intriguing exciton migration and visible light-near infrared absorption properties. In this study, an effective biosensing structure comprising 2D Cu-TCPP MOF nanosheet-capsulated Au film was developed, such that lower molecular-weight dopamine with small changes of refractive index can be identified on the fiber-optic platform. The large areas of ultrathin 2D Cu-TCPP MOF nanosheets were well prepared, the experimental results indicated that the sensitivity (48%) and figure of merit (18%) were increased notably compared with the bare Au film. Moreover, the finite element method was adopted to numerically analyze and verify the excellent charge-transfer ability of MOF nanosheets and the bidirectional gain properties between MOF nanosheets and Au films. Furthermore, the sensitivity [1.24 nm/log(M)] and selectivity of the dopamine were significantly enhanced with a low limit of detection of 1.50 × 10–13 M and linear response with a wide range of concentrations from 5 × 10–12 M to 5 × 10–7 M through ssDNA surface modification and conformation amplification. As revealed by the above-mentioned results, the Cu-TCPP/Au/SMF biosensor can serve as a promising nanoplatform for clinical diagnosis and medical assessment.
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2023
·
IF 6.2
Yanping Zhao,Xu Geng,Xiaoling Zhou,Li Xu,Shuai Li,Zhengqiang Li,Yi Guo,Chen Li
Pyruvate participates in diverse metabolic pathways in the body and is normally present in human blood at 40–120 μM, with concentrations outside this range associated with various diseases. Therefore, accurate and stable blood pyruvate level tests are necessary for effective disease detection. However, traditional analytical techniques require complicated instrumentation and are time consuming and expensive, prompting researchers to develop improved methods based on biosensors and bioassays. Here, we designed a highly stable bioelectrochemical pyruvate sensor affixed to a glassy carbon electrode (GCE). To maximize biosensor stability, 0.1 U of lactate dehydrogenase was affixed to the GCE using a sol-gel process, resulting in generation of Gel/LDH/GCE. Next, 2.0 mg/mL AuNPs-rGO was added to enhance current signal strength, resulting in generation of the bioelectrochemical sensor Gel/AuNPs-rGO/LDH/GCE. AuNPs-rGO synthesized in advance was verified as correct using transmission electron microscopy and UV–Vis, Fourier-transform infrared and X-ray photoelectron spectroscopy. Pyruvate detection conducted via differential pulse voltammetry in phosphate buffer (pH 7.4, 100 mM) at 37 °C for 1–4500 μM pyruvate provided detection sensitivity as high as 254.54 μA/mM/cm 2 . The reproducibility, regenerability and storage stability were analyzed with the relative standard deviation of 5 bioeletrochemical sensors detection was 4.60% and biosensor accuracy after 9 cycles was 92%, with accuracy remaining at 86% after 7 days. In the presence of D-glucose, citric acid , dopamine, uric acid and ascorbic acid , the Gel/AuNPs-rGO/LDH/GCE sensor exhibited excellent stability, high anti-interference ability and better performance than conventional spectroscopic methods for detection of pyruvate in artificial serum.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）