EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
·
2014
·Vol. 2015
·期 3
·631-637
·
IF 3.154
Laichun Luo,Lanlan Meng,Yangqiu Peng,Yongning Xing,Qi Sun,Zemei Ge,Runtao Li
Graphical A facile ZnCl 2 -promoted one-pot three-component synthesis of thiazolo[4,5- b ]pyridines and thieno[2,3- b :4,5- b′ ]dipyridines is described. This approach involves a tandem S N 2/Thorpe–Ziegler cyclization/Friedländer reaction to give fused pyridines in moderate to good yields. A ZnCl 2 -promoted one-pot synthesis of multisubstituted thiazolo[4,5- b ]pyridines and thieno[2,3- b :4,5- b′ ]dipyridines from mercaptonitrile salts, α-bromo ketones and ketones has been developed. This approach involves a tandem S N 2 alkylation/Thorpe–Ziegler cyclization/Friedländer reaction, which allows the creation of two hetero rings and four new bonds in a single operation. The reaction proceeds smoothly under solvent-free conditions to afford fused pyridines in moderate to good yields.
研究领域:
有机化学
·
药物化学
✓ 已验证
DOI
高影响因子
Environmental Science-Nano
·
2018
·Vol. 5
·期 3
·776-781
·
IF 6.087
Ruifen Jiang,Wei Lin,Jiayi Wu,Yaxin Xiong,Fang Zhu,Lian-Jun Bao,Jing You,Gangfeng Ouyang,Eddy Y. Zeng
Because of their large surface area and high hydrophobicity, nanoplastics (NPs) possess a large sorption capacity for and strong affinity to hydrophobic organic chemicals, which may substantially alter the environmental behavior, especially the bioaccumulation of hydrophobic organic compounds. The present study aims to examine the effects of nano-size polystyrene (PS) on the bioaccumulation of polychlorinated biphenyls (PCBs) in Daphnia magna. A novel passive dosing method was developed to quantify the accumulation of NPs in D. magna in different exposure suspensions with various NP concentrations during 2 h and 24 h exposure. Addition of NPs enhanced the amount of PCBs accumulated in D. magna by 1.4–2.6 times compared to no presence of NPs during 24 h exposure. The relative amounts of NP-bound PCBs accumulated in D. magna were 18% to 81% for different PCB congeners at various NP concentrations. The significance of different uptake pathways in the accumulation of PCBs in D. magna with the presence of NPs was found to relate to the chemical properties of PCBs, the ingestion rate of plastics and the exposure conditions. These results have justified additional research efforts toward investigating the fate and toxic effects of NP-bound contaminants ingested by organisms.
研究领域:
环境科学
·
生态毒理学
✓ 已验证
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2022
·
IF 10.753
Aixi Tang,Xiaochao Bi,Jiayu Du,La Rao,Vasanthakumar V.,Yi-bo Hu,Ming-Lai Fu,Wenjie Sun,Baoling Yuan
The effect of polyethylene microplastics (PE-MPs) on the disinfection of Escherichia coli ( E. coli ) by sodium hypochlorite was investigated in different pH value, ionic strength , and NOM concentration to illustrate the impact of MPs on the pathogenic bacteria disinfection efficiency in nature water environment. The results showed that PE-MPs tended to agglomerate rather than disperse due to their strong hydrophobicity in water. Within 30 s, about 1.5 log 10 of E. coli was adsorbed on the surface of PE-MPs, forming subsequent protection for E. coli . Thus, the presence of PE-MPs reduced the inactivation rate of E. coli . As for the particle-free solutions, the higher solution pH, the presence of natural organic matter (NOM), and the higher concentrations of cations (monovalent Na + and divalent Ca 2+ ) were confirmed as the major influencing factors decreasing the E. coli disinfection efficiency. However, due to the adsorption and protection of PE-MPs on E. coli , the influences of complex chemistry factors on the inactivation of E. coli were reduced. The inactivation of E. coli in PE-MPs (20 NTU) solution was 1 log 10 lower than that in particle-free solution under the same water quality conditions. Therefore, considering the complex water chemistry , the existence of MPs could be a potential challenge for disinfection efficiency in the water treatment plants .
研究领域:
环境科学
·
微生物学
✓ 已验证
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2021
·
IF 8.742
Ke Zheng,Shaoqi Zhou,Zuqin Cheng,Guoru Huang
Quaternized poly phenylene oxide (QPPO) was synthesised and used as a modifier material to blend with polyvinyl chloride (PVC) to cast the substrate for thin-film composite (TFC) forward osmosis (FO) membranes. The addition of QPPO improved the porosity, hydrophilicity , and morphology of the substrate, thereby weakening the internal concentration polarisation of TFC membranes . Furthermore, the introduction of QPPO improved the structure of the active layer , which led to higher water permeability. Moreover, the mechanical properties of the TFC membranes were significantly improved after the introduction of QPPO. As a result, introducing QPPO significantly increased the FO performance. In addition, the TFC membrane based on a 40% QPPO blend ratio exhibited optimal FO performance: a high water flux of 71.21 L h −1 m −2 and an extremely low specific reverse solute flux of 0.079 g L −1 under the active layer facing the draw solution (DS) mode by utilising 1 M NaCl as the DS and deionised (DI) water as the feed solution; this FO performance remained fairly stable during long-term operation. This study suggests that introducing QPPO into the substrate is a sensible strategy for fabricating high-performance TFC FO membranes.
研究领域:
材料科学
·
环境工程
✓ 已验证
DOI
高影响因子
CHEMOSPHERE
·
2022
·
IF 8.943
Xueke Liu,Peng Wang,Yiran Liang,Jing Zhan,Donghui Liu,Zhiqiang Zhou
Chlordane-related compounds are ubiquitously detected in the environment and can transfer and accumulate to animals through food chain to cause adverse effects . In this study, the dynamic distribution and the enantiomeric profile of chlordane-related compounds in laying hens over time were investigated. The effect of these compounds on immune-associated cells in the intestinal tract and histopathology in some tissues were also evaluated after long-term exposure. The chlordane-related compounds preferentially accumulated in fat, followed by the intestines, ovum, and egg yolk during long-term exposure. The metabolites heptachlor epoxide and oxychlordane were mainly formed in the liver of hens by epoxidation or hydroxylation . The high accumulation ratios of trans -nonachlor and MC5 were found in ovum and egg yolk after long-term exposure, implying a greater risk to the hens’ offspring. Chlordane-related compounds may cause abnormal lipometabolism and glycometabolism in liver of hens. Additionally, (−)-Cis-chlordane was dominant in all tissues of laying hens and its dominance increased over time. Conversely, (+)-isomer of metabolite oxychlordane was overwhelmingly dominant during the experiment. These findings about enantioselectivity , metabolic processes and toxicological effects are crucial in understanding the exposure risk of chlordane-related compounds.
研究领域:
环境科学
·
毒理学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Junjie Ding,Dajian Huang,Wenbo Wang,Yushen Lu,Wenkai Dong,Li Zong,Qin Wang,Aiqin Wang
Biopolymers have shown great application prospects due to their advantages of being biodegradable, renewable, non-toxic, safe and inexpensive. However, the innate hydrophilicity of biopolymers means the materials prepared from them easily swell or disintegrate in aqueous media, limiting their applications. Herein, on the basis of improving the mechanical performance of a sodium alginate/poly(vinyl alcohol) (SA/PVA) film by introducing palygorskite (Pal) nanorods , the hydrophobicity of the obtained SA/PVA/Pal film was improved further by surface coating with methyltrichlorosilane (MTCS) through a vapor deposition-surface polycondensation reaction. MTCS nanofilaments, with a size of approximately 50 nm, were formed on the film surface by the silanization reaction between MTCS and hydroxyls, resulting in an improvement in surface hydrophobicity characterized by a contact angle (111.8°) higher than that of SA/PVA/Pal film (72.7°). Therefore, the obtained films maintained their original shape and strength after soaking for a long time in aqueous solutions containing acid, alkaline, and electrolyte, also in organics, while the uncoated film dissolved quickly and lost its original shape. Moreover, the surface coating also increased the film's tensile strength from 11.43 to 28.69 MPa. This demonstrates a simple, universal and effective way to improve the resistance of biopolymer-derived materials to water and various chemicals.
研究领域:
材料科学
·
生物材料
✓ 已验证
DOI
高影响因子
BIOMACROMOLECULES
·
2022
·
IF 6.978
Xiaoyang Qiu,Zeke Li,Yanggui Wu,Wolfgang H. Binder,Senbin Chen,Jintao Zhu
Chemodynamic therapy (CDT) reflects an innovative cancer treatment modality; however, to enhance its relatively low therapeutic efficiency, rational combination with extra therapeutic modes is highly appreciated. Here, core-coordinated amphiphilic, elliptic polymer nanoparticles (Cu/CBL–POEGEA NPs) are constructed via the self-assembly of a glutathione (GSH)-responsive polymer–drug conjugate, bearing side-chain acylthiourea (ATU) motifs which behave as ligands capable of coordinating Cu(II), such a design is featured by combined chemo (CT)/CDT with dual GSH depletion collectively triggered by the Cu(II) reduction reaction and disulfide bond breakage. To do so, an amphiphilic random copolymer poly[oligo(ethylene glycol)ethyl acrylate-co-thiourea] [P(OEGEA-co-ATU)] is synthesized, followed by conjugation of chlorambucil (CBL) to ATU motifs linked via a disulfide bond, thus yielding the targeted P[OEGEA-co-(ATU-g-CBL)]. In such a system, hydrophilic POEGEA serves as the biocompatible section and ATU motifs coordinate Cu(II), resulting in core-coordinated elliptic Cu/CBL–POEGEA NPs. Benefitting from the GSH-induced reduction reaction, Cu(II) is converted into Cu(I) and subsequently react with endogenous H2O2 to create •OH, realizing GSH-depletion-promoted CDT. Additionally, the disulfide bond endows GSH-responsive CBL release and provokes further GSH decline, finally realizing combined CDT/CT toward enhancing antitumor outcomes, and in vitro as well as in vivo studies indeed reveal remarkable efficacy. Such a system can provide valuable advantages to create novel nanomedicines toward cascade antitumor therapy.
研究领域:
生物医学工程
·
肿瘤学
·
材料科学
✓ 已验证
DOI
高影响因子
Journal of Instrumentation
·
2023
·Vol. 18
·期 07
·P07039
·
IF 1.3
Ye Liang,Tong Xu,Jialiang Zhang,Shuo Li,Ming Qi,Zhe Wang
The lithium chloride aqueous solution has great potential to
be the detection medium of a novel solar neutrino detector. The
nuclide 7Li provides a charged-current interaction channel with a
high cross-section for the MeV-scale solar electron-neutrinos,
enabling measurement of the solar neutrino spectrum. This work
measures the optical properties and the light yields of a saturated
lithium chloride solution. After adsorption with activated carbon
and recrystallization, the solution shows little absorption in the
sensitive wavelength range of the bialkali photomultipliers. The
attenuation length is evaluated to reach 50 meters at 430 nm. In
addition to being a pure Cherenkov detector medium, a wavelength
shifter, carbostyril 124, is added to the LiCl aqueous solution. The
compatibility and the enhancement of the light yield are confirmed,
enabling the development of a water-based Cherenkov-enhanced
lithium-rich detector.
研究领域:
物理学
·
天文学
·
核科学
✓ 已验证
DOI
高影响因子
FOOD CONTROL
·
2021
·
IF 5.548
Weiwei Cheng,Qiaoyun Zhang,Di Wu,Yuling Yang,Yan Zhang,Xiaozhi Tang
3-monochloropropane-1,2-diol (3-MCPD) is a well-known heat-produced food contaminant, which has been reported to be carcinogenic, nephrotoxic, and reproductively toxic. In this study, a facile electrochemical sensor based on nanoporous gold (NPG) capped with molecularly imprinted polymer (MIP) was constructed for the rapid and selective determination of 3-monochloropropane-1,2-diol (3-MCPD). Firstly, NPG was fabricated on the electrode through coating the glass carbon electrode (GCE) surface with NPG film to provide an ideal substrate for polymerization of the MIP membrane and improve the electrocatalysis activity of the sensor. Then, the MIP membrane was constructed on the NPG surface via self-assembly by electropolymerization to realize selective recognition of target 3-MCPD molecules. As a consequence of the combined effect of NPG and MIP, the optimized molecularly imprinted polymer/nanoporous gold/glassy carbon electrode (MIP/NPG/GCE) sensor exhibited outstanding analytical performance towards 3-MCPD with a much wider linear range from 10 −16 to 10 −7 mol/L and fairly low detection limit of 3.5 × 10 −17 mol/L (S/N = 3). Meanwhile, the constructed electrochemical sensor presented outstanding specificity, anti-interference capability, and reproducibility. In order to demonstrate practical applicability, the MIP/NPG/GCE was applied for the detection of 3-MCPD in real soy sauce and satisfactory results were obtained with recovery rates ranging from 105.90% to 107.52%.
研究领域:
食品科学
·
分析化学
✓ 已验证
DOI
高影响因子
Cell Reports Physical Science
·
2023
·
IF 8.9
Akram Entezari,He Lin,Oladapo Christopher Esan,Weili Luo,Ruzhu Wang,Ruoyu You,Liang An
Dehumidification not only regulates the relative humidity (RH) of buildings with reduced cooling costs but also provides a potential drinking water source for residents. Desiccant-based dehumidification has a lower energy consumption than the condensation-based method; however, the former requires successive regeneration of used sorbents and is, therefore, bulky. In this study, by mimicking transpiration in trees, we propose a humidity pump (HP) that continuously dehumidifies rooms by creating a continuous driving force for water wicking. Meanwhile, we investigate the potential of the HP by combining it with atmospheric water harvesting systems. We use activated carbon-lithium chloride composites since they have proven to possess high sorption capacity and strong capillary effect. We develop a small prototype, and our results show that it can maintain the RH between 50% and 70% while producing 1.3–3.25 g water per day. By advancing these techniques, we create an opportunity for developing more energy-efficient humidity regulation and atmospheric water harvesting systems.
研究领域:
能源与环境工程
·
材料科学
✓ 已验证
DOI
高影响因子
LUMINESCENCE
·
2022
·Vol. 37
·期 11
·1873-1880
·
IF 2.613
Ping Yang,Wei Sun,Zikuan Zhang,Honglong Xing
As a type of nonmetals fluorescent reagent, the described chlorine phenol–formaldehyde resin (Cl–PFR) nanoparticles (NPs) were synthesized using a facile method. The as-synthesized Cl–PFR NPs can emit strong green fluorescence emission under 365 nm ultraviolet (UV) light irradiation. As mesoporous silica (MSN) NPs have a large specific area, strong adsorption, and uniform dispersion, MSN-coated Cl–PFR composites were prepared by mixing Cl–PFR and MSN NPs together. The as-synthesized multifunctional composites combining the advantages of the green fluorescence of Cl–PFR, and the strong adhesion of MSN was applied to detect potential fingerprints. Different base fingerprints (glass, paper, aluminium sheets, rough stones, tape) could be clearly observed in the presence of the Cl–PFR@MSN–NH 2 composites. Furthermore, fingerprints that had been aged for 3 months and washed with water several times could also be clearly displayed using the multifunctional composites. This study provided a simple, economical, and nontoxic fluorescent reagent for application in fingerprint detection.
研究领域:
材料科学
·
法医学
✓ 已验证
DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2020
·
IF 4.244
Wangxia Wang,Feng Gu,J.Y. Zhu,Kaiyong Sun,Zhaosheng Cai,Shufeng Yao,Wenjuan Wu,Yongcan Jin
Lignin valorization is significantly influenced by the degrees of lignin condensation measured by the amount of cleaved β O 4 ether linkages and interunit C C linkages formed during biomass fractionation. To minimize the cleavage of aryl ether and formation of C C linkages, a p–toluenesulfonic acid (p–TsOH)/choline chloride (ChCl) solvent system with hydrotropic properties was evaluated. The ChCl was chosen to control the H + concentration of the p–TsOH/ChCl solvent system. Compared with p–TsOH/H 2 O, the degradation of β O 4 was kept in a similar rate during p–TsOH/ChCl fractionation; however, the formation of C C linkage was slower. Under 75/25 p–TsOH/ChCl mass ratio at 80 °C for 20 min, 76.6 % of miscanthus lignin, with β O 4 content of 30.9 %, and 88.9 % of wheat straw lignin, with β O 4 content of 33.6 %, can be dissolved. In addition, the low polar and layered structure of hydrotropic p–TsOH/ChCl system has a strong ability to dissolve lignin, which resulted in lignin with larger particle size and lower surface charge. The results also indicated that lignin from p–TsOH/ChCl solvent system has great potential for lignin depolymerization to aromatics for valorization.
研究领域:
生物化学
·
可再生资源与环境科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）