JOURNAL OF LOSS PREVENTION IN THE PROCESS INDUSTRIES
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2024
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IF 3.6
Chenyang Pu,Zhi Wang,Boren Zheng,Bin Zhang
1,2,4-Triazole is a common intermediate used in the synthesis of pesticides and medicine, and has a very wide range of applications. As a kind of polynitrogen heterocycles, 1,2,4-triazole will release a lot of heat during thermal decomposition. If there is no comprehensive understanding of its pyrolysis behavior, there will be a very large thermal safety risk in the process involving 1,2,4-triazole in industrial production. At the same time, the instability of the substance may be affected by the presence of impurities, and the existing research on this aspect is quite scarce. Therefore, it is very necessary to study the effect of adding other substances on the thermal decomposition of 1,2, 4-triazole. The thermal decomposition characteristics and thermal runaway behavior of 1,2, 4-triazoles were revealed by thermodynamic experiments and various kinetic theoretical methods. According to the risk matrix, the thermal runaway danger level of 1,2, 4-triazole was determined to be level Ⅲ, which was an unacceptable risk. The results show that 1,2, 4-triazole has a huge heat release and the effect of thermal runaway is serious. In this study, three substances involved in the industrial production of fluconazole and flutriafol mixed with 1,2, 4-triazole were selected to explore their influence on the thermal decomposition of 1,2, 4-triazole under non-working conditions. DSC and ARC experiments consistently showed that these three impurities could reduce the reaction heat release of 1,2, 4-triazole to varying degrees, and confirmed that these three impurities could reduce the risk of thermal runaway of 1,2, 4-triazole to varying degrees. Among them, sodium hydride has the most outstanding performance, both in terms of reducing reaction heat release and reducing adiabatic temperature rise. The results can provide reference for loss control of 1,2,4-triazole in industrial applications.
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Nutrition & Diabetes
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2024
·Vol. 14
·期 1
·1-9
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IF 4.6
Li Hui,Fang Yujiao,Wang Da,Shi Bowen,Thompson Garth J.
Background Quantitative mapping of the brain’s metabolism is a critical tool in studying and diagnosing many conditions, from obesity to neurodegenerative diseases. In particular, noninvasive approaches are urgently required. Recently, there have been promising drug development approaches for the treatment of disorders related to glucose metabolism in the brain and, therefore, against obesity-associated diseases. One of the most important drug targets to emerge has been the Glucagon-like peptide-1 (GLP-1) and its receptor (GLP-1R). GLP and GLP-1R play an important role in regulating blood sugar and maintaining energy homeostasis. However, the macroscopic effects on brain metabolism and function due to the presence of GLP-1R are unclear. Methods To explore the physiological role of GLP-1R in mouse brain glucose metabolism, and its relationship to brain function, we used three methods. We used deuterium magnetic resonance spectroscopy (DMRS) to provide quantitative information about metabolic flux, fluorodeoxyglucose positron emission tomography (FDG-PET) to measure brain glucose metabolism, and resting state-functional MRI (rs-fMRI) to measure brain functional connectivity. We used these methods in both mice with complete GLP-1R knockout (GLP-1R KO) and wild-type C57BL/6N (WT) mice. Results The metabolic rate of GLP-1R KO mice was significantly slower than that of WT mice ( p = 0.0345, WT mice 0.02335 ± 0.057 mM/min, GLP-1R KO mice 0.01998 ± 0.07 mM/min). Quantification of the mean [ 18 F]FDG signal in the whole brain also showed significantly reduced glucose uptake in GLP-1R KO mice versus control mice ( p = 0.0314). Observing rs-fMRI, the functional brain connectivity in GLP-1R KO mice was significantly lower than that in the WT group ( p = 0.0032 for gFCD, p = 0.0002 for whole-brain correlation, p < 0.0001 for ALFF). Conclusions GLP-1R KO mice exhibit impaired brain glucose metabolism to high doses of exogenous glucose, and they also have reduced functional connectivity. This suggests that the GLP-1R KO mouse model may serve as a model for correlated metabolic and functional connectivity loss.
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Journal of Global Antimicrobial Resistance
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2024
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IF 3.7
Xiaoqian Long,Feng Lin,Biao Tang,Fengcheng Miao,Zhiyu Li,Yao Shen,Hua Yang,Jiangang Ma
Objectives Acinetobacter indicus is an important pathogen of nosocomial infection. The purpose of this study was to analyze the resistance and transmission of A. indicus strain AIBD14 isolated from slaughterhouse environment. Methods A total of 96 environmental samples were collected from slaughterhouse. The antimicrobial susceptibility test was carried out by microbroth dilution method and E -test. Whole genome sequencing and bioinformatics analysis of the AIBD14 were performed, then S1-PFGE and southern blot verified the location of bla NDM-1 and tet (X6). Results The AIBD14 is resistant to meropenem but susceptibility to tigecycline, and coharboring bla NDM-1 and tet (X6). The bla NDM-1 is located on the pAIBD14-NDM-1 that cannot be transferred by conjugation. Specifically, bla NDM-1 is located on the transposon Tn 125 , and bla NDM-1 can be transferred to other species with the help of transposon. The genetic background of bla NDM-1 is "IS Aba125 - bla NDM-1 - ble MEL - dsbD - cutA - groES - groEL -insE-IS Aba125 ". pAIBD14-NDM-1 is classified into the GR31 plasmid based on the homology of the repB . Meanwhile, there are two XerC/D-like binding sites on the plasmid, which can mediate the transfer of resistance genes. The tet (X6) gene is located on the chromosome of AIBD14, its downstream is accompanied by the neglected macrolide resistance gene estT , and there is a single copy of the insertion element IS CR2 around tet (X6) as the genetic background "IS Aba4 -IS 3 -hp-hp- tet (X6)- estT - guaA -IS CR2 ". Conclusions This is the first report of the coexistence of tet (X6) and bla NDM-1 in the A. indicus , and it has the risk of horizontal transfer across multiple species. So strict monitoring the multiple-resistant bacteria in the industrial chain is necessary based on the "One Heath".
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JOURNAL OF ENTOMOLOGICAL SCIENCE
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2024
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IF 0.7
Gao Wenjia,Dong Pei-Pei,Abduriyim Shamshidin,Wang Xiushuang
Licorice of the taxonomic genus Glycyrrhiza is a traditional Chinese medicinal plant. Its large-scale cultivation is threatened by insect pests, including the whitefly Bemisia tabaci Gennadius (Hemiptera: Aleyrodidae). Our study (1) examined the preference of B. tabaci for G. uralensis Fischer ex de Candolle, G. glabra L., and G. inflata Batalin through caged trials; (2) identified the volatile organic compounds (VOCs) released by the three Glycyrrhiza species using headspace gas chromatography–mass spectrometry (HS-GC-MS); and (3) screened the olfactory behavior responses of B. tabaci to the key VOCs identified. The caged host preference trial showed that B. tabaci had a clear preference for G. uralensis over G. inflata and G. glabra . Through HS-GC-MS analysis, we identified 26, 33, and 31 VOCs from G. uralensis , G. glabra , and G. inflata , respectively. (3 Z )-Hexen-3-ene-1-yl acetate, trans -3-hexen-1-ol, cis -3-hexen-1-ol, 3-carene, and β-pinene were selected for further olfactory response assays on the basis of variable importance projection values and quantity differences. From these, we learned that cis -3-hexene-1-ol and trans -3-hexene-1-ol, abundant in G. uralensis , attract B. tabaci , whereas 3-carene and β-pinene, abundant in G. inflata , repel B. tabaci . The different VOCs from these three species of licorice may be primary factors affecting the preference for and feeding on cultivated licorice by B. tabaci . Our results will facilitate studies on the potential of using selected VOCs for managing B. tabaci , perhaps in push–pull strategies of their use against the pest.
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International Journal of Applied Ceramic Technology
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2018
·Vol. 15
·期 3
·783-791
·
IF 1.165
Yi Ding,Xinggui Long,Shuming Peng,Zhaoyi Tan,Dong Zhang,Xirui Lu
Ce-doped zirconia ceramics with general stoichiometry of Zr 1- x Ce x O 2 (0 ≤ x ≤ 1) have been obtained by substitution of Ce 4+ for Zr 4+ in ZrO 2 . The phase and microstructure evolutions of the ceramics were investigated, and the effects of composition, temperature, and pH value on the chemical durability of the ceramics were also studied. The results show that the phase transformation from monoclinic to tetragonal takes place at about x = 0.2, and from tetragonal to cubic at about x = 0.6. It is found that the increase in Ce content and/or sinter temperature promote the phase transformation. The leaching studies show that the normalized leaching rates of Ce (LR Ce ) increase with increasing Ce content. Moreover, LR Ce in acid solution are higher than those in neutral and alkaline solution. After 42 days, LR Ce is 10 −5 ~ 10 −7 g m −2 d −1 under all different leaching conditions, exhibiting their excellent chemical durability.
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APPLIED SURFACE SCIENCE
·
2026
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IF 6.6
Jiani Guo,Xin Song,Yan Su,Yiran Zou,Renke Kang,Shang Gao
Polarity-dependent CMP behavior of 4H-SiC Si-face and C-face is systematically investigated. • The C-face exhibits higher material removal rate and stronger oxidation tendency. • A thicker oxygen-rich reacted layer forms on the C-face during CMP. • Enhanced interfacial charge transfer promotes oxidant–surface interactions on the C-face. • First-principles calculations reveal the origin of polarity-dependent CMP behavior. Chemical mechanical polishing (CMP) of SiC is fundamentally limited by its high hardness and chemical inertness, as well as the pronounced polarity-dependent anisotropy between the Si-face (0 0 0 1) and C-face (0 0 0 −1). In this work, the intrinsic mechanism governing polarity-dependent oxidation and material removal of 4H-SiC is systematically investigated by combining CMP experiments, surface characterization, electrochemical analysis, and first-principles calculations.Under identical polishing conditions, the C-face exhibits a significantly higher material removal rate (1900 nm·h −1 ) and lower surface roughness (0.13 nm) compared to the Si-face (1000 nm·h −1 , 0.65 nm). Electrochemical results reveal faster oxidation kinetics on the C-face, which is further confirmed by the formation of a thicker oxide layer and enhanced oxygen-containing species. DFT calculations demonstrate that the C-face possesses higher surface energy, lower work function, and stronger charge transfer capability, leading to more favorable oxidant adsorption and interfacial reactions. These results reveal that the superior CMP performance of the C-face originates from its intrinsically enhanced electronic activity and oxidation-assisted removal capability. This work establishes a clear structure–property–performance relationship for polarity-dependent CMP of SiC and provides new insights for improving polishing efficiency and achieving wafer-level uniformity. Download: Download high-res image (234KB) Download: Download full-size image
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CARBOHYDRATE POLYMERS
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2023
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IF 11.2
Yazhen Wu,Xiaoxiao Li,Zhengyu Jin,Birte Svensson,Yuxiang Bai
How to improve the solubility of linear dextrins (LD) and retain their characteristic helix amphiphilic cavities with flexible embedding capability, is a question worth exploring without adding new chemical groups. The strategy presented in this study is to attach a highly flexible (α-1 → 6) glucochain at the reducing end of LD by preparing a new type of dextrin, referred to as single-arm linear dextrin (SLD). In the actual synthesis, an (α-1 → 6) linked oligosaccharide of DP ¯ 10.7 (PDI = 1.28) was formed by extension of glucose units onto sucrose (2 M) by using L940W mutant of the glucansucrase GTF180-ΔN firstly. Next using γ-CD as glucosylation donor γ-CGTase extended this (α-1 → 6) glucochain with (α-1 → 4) bonds. SLD is a chimeric glucosaccharide comprising an (α-1 → 4) linked part ( DP ¯ 10.5) attached to the nonreducing end of an (α-1 → 6) glucochain as verified by enzyme fingerprinting and 1 H NMR. Furthermore, SLD was validated to show greatly improved solubility and dispersibility of resveratrol in water, as indicated by a 3.12-fold enhancement over the solubility in the presence of 0.014 M SLD. This study provided a new strategy for solving the solubility problem of LD and opens possibilities for new design of the fine structure of starch-like materials.
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Frontiers in Pharmacology
·
2021
·
IF 5.811
Xiao Qing,Liu Qi-Meng,Jiang Ru-Chao,Chen Kai-Feng,Zhu Xiang,Ma Lei,Li Wei-Xi,He Fei,Huang Jun-Jun
Previous studies have indicated that α1D/1A antagonist naftopidil (NAF) suppresses prostate growth by decreasing cell proliferation without affecting apoptosis and prostate volume in benign prostatic hyperplasia (BPH). A NAF-derived α1D/1A antagonist 1- benzyl-N-(3-(4-(2-methoxyphenyl) piperazine-1-yl) propyl)-1H-indole-2- carboxamide (HJZ-12) has been reported from our laboratory, which exhibits high subtype-selectivity to both α1D- and α1A- AR (47.9- and 19.1- fold, respectively) with respect to a1B-AR in vitro. However, no further study was conducted. In the present study, a pharmacological evaluation of HJZ-12 in BPH was performed on an estrogen/androgen-induced rat BPH model and human BPH-1 cell line. In vivo, HJZ-12 exhibited better performance than NAF in preventing the progression of rat prostatic hyperplasia by not only decreasing prostate weight and proliferation (similar to NAF) but also, shrinking prostate volume and inducing prostate apoptosis (different from NAF). In vitro, HJZ-12 exhibited significant cell viability inhibition and apoptotic induction in BPH-1 cell line, without presenting cell anti-proliferation properties. Intriguingly, the role of HJZ-12 on cell viability and apoptosis was an α1-independent action. Furthermore, RNA-Seq analysis was applied to screen out six anti-apoptotic genes (Bcl-3, B-lymphoma Mo-MLV insertion region 1 [Bmi-1], ITGA2, FGFR3, RRS1, and SGK1). Amongst them, Bmi-1 was involved in the apoptotic induction of HJZ-12 in BPH-1. Overall, HJZ-12 played a remarkable role in preventing the progression of prostatic hyperplasia through α1-independent apoptotic induction, indicating that it will be a multi-target effective candidate for BPH treatment.
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Translational Psychiatry
·
2026
·
IF 7.5
Liu Yiran,Liu Xiao,Yin Xueyong,Li Yunluo,Yu Xiaohui,Nan Xinyu,Xue Jiping,Lu Hengtai,Li Bingyu,Zhou Fei,Liu Xiaoyu,Zhang Xiangyu,He Xiangjun,Yu Xi,Yan Shu,Li Yating,Wang Shuang,Gao Yuan,Liu Yifan,Kang Ying,Zhang Jingwen,Zhao Ye,Shi Haishui
Defensive aggression is an evolutionarily conserved instinct, and its dysregulation represents a common behavioral manifestation in multiple psychiatric disorders. Although glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used for metabolic diseases, their role in aggressive behavior remains unclear. Here, we employed behavioral assays, chemogenetics, immunofluorescence, pharmacological manipulations, and metabolomics to investigate the regulatory effects of GLP-1RA on defensive aggression in mice. Acute intracerebroventricular administration of GLP-1RA significantly suppressed defensive aggression without affecting locomotor activity or time spent in the center of the open field. c-Fos immunofluorescence indicated that this effect was associated with reduced neuronal activity in the dorsomedial periaqueductal gray (DMPAG). Chemogenetic activation of DMPAG neurons reversed the suppressive effect of GLP-1RA on defensive aggression, supporting a key regulatory role of this region. In a social isolation (SI) induced pathological aggression model, GLP-1RA alleviated excessive defensive aggression and modulated the metabolic state of the DMPAG. Notably, GLP-1RA restored levels of L-carnosine, a dipeptide with neuroprotective and anti-excitotoxic properties whose levels were reduced in SI mice. Carnosine infusion into the DMPAG suppressed defensive aggression in SI mice, whereas administration of the carnosine degrading enzyme CNDP2 attenuated the suppressive effect of GLP-1RA, supporting carnosine signaling as a functionally relevant downstream component. These findings identify a carnosine-associated pathway by which GLP-1RA regulates defensive aggression and highlight its therapeutic potential beyond metabolic regulation.
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Science Advances
·
2026
·Vol. 12
·期 30
·
IF 13.9
Jialu Li,Xue Han,Wenjie Wang,Jinhui Wang,Tingting Zhang,Yuting Wu,Guofeng Zhang,Bin Li,Changgang Yang,Wenli Guo,Mi Zhang,Ruiyun Chen,Chengbing Qin,Jianyong Hu,Zhichun Yang,Shaoding Liu,Yue Wang,Yunan Gao,Jie Ma,Liantuan Xiao,Suotang Jia
Colloidal quantum dots (QDs) are promising optical gain materials that require a reduction in the threshold to reach their full potential. While QD charging theoretically reduces the threshold to zero, its effectiveness has been limited by strong Auger recombination and unstable charging. In this study, we theoretically determine the optimal combination of charging number and Auger recombination to minimize the lasing threshold. Experimentally, we develop stable, self-charged perovskite quantum rods (QRs) as an alternative to QDs via the state engineering and Mn (manganese) doping strategy. A two-order-of-magnitude reduction in nonradiative Auger recombination enables QRs to support a charging number of up to 6. We then achieve QR liquid lasing with a sub- 1 / 10 exciton threshold (an average of 0.098 excitons per QR) using 5-nanosecond pulse pumping. This threshold is exceptionally low among all reported QD lasers. These achievements demonstrate the potential of specially engineered QRs as excellent gain media and pave the way for their applications.
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ACS Catalysis
·
2026
·
IF 13.6
Le Lin,Haoran Jia,Xiaohui Feng,Xiaoyuan Sun,Rentao Mu,Qiang Fu,Xinhe Bao
Selective hydrogenation reactions over oxide catalysts are crucial in a variety of energy and catalytic conversion processes, in which surface hydrogen species are vital while controllable H2 activation and hydrogenation are still challenging over the complex oxide catalysts. Here, combining multiscale theoretical simulations and surface science studies, we find a series of single-site Zn (Zn1) species that are well orderly dispersed onto spinel ZnCr2O4 surfaces under syngas conversion conditions. A pair of coordinatively unsaturated Zn1 sites with specific spatial proximity (termed geminal-Zn1+1) facilitates H2 homolysis into hydrides, which even occurs below 123 K. Intriguingly, the geminal-Zn1+1 confined on ZnCr2O4(110) can stabilize both hydride species (as high as 673 K) and related formaldehyde intermediates, which enables controllable CO hydrogenation to ketene via a synergistic H- and CO-assisted CO activation mechanism instead of deep hydrogenation to methanol. Such coordinatively unsaturated geminal-atom (M1+1) confined by the oxide surface is expected to be generalized to more application scenarios of oxide-catalyzed H2 homolysis and selective hydrogenation catalysis.
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Molecular Catalysis
·
2026
·
IF 4.3
Xiaoni Wang,Tie Li,Yuyun Ma,Lulu Xu,Bo Wang,Shuo Tao
Selective hydrogenation of cinnamaldehyde (CAL) to cinnamyl alcohol (COL) presents a significant challenge owing to the thermodynamically unfavorable hydrogenation of the carbonyl (C═O) over the olefinic (C═C) bond. Herein, we report the rational design of silicate-1 (S-1) anchored PtCo catalysts (PtCo@S-1) synthesized via a sequential hydrothermal-impregnation method. Notably, the 4Pt1Co@S-1 catalyst exhibited superior catalytic performance, achieving a high COL selectivity of 92% at a near-complete CAL conversion of 98.2%. Furthermore, the catalyst exhibits robust stability with only slight fluctuations after five cycle tests. Beyond CAL hydrogenation, the developed catalyst is also applicable to the chemo-selectivity hydrogenation of other α, β-unsaturated aldehydes to the corresponding α, β-unsaturated alcohols during the substrate-extending hydrogenation tests. Experiments and theoretical calculations reveals the presence of CoSiO 2 species critically modifies the geometric and electronic structure of the Pt metallic active sites. This modification promotes the preferential adsorption and activation of the C═O bond, thereby significantly enhancing selectivity towards COL.
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