MOLECULAR CRYSTALS AND LIQUID CRYSTALS
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2020
·
IF 0.512
Yang Yun-Xia,Xia Shi-Ying,Zhang Hai-Xia,Niu Hui-Hui
Three complexes of (CH3)4N+·(C15H15O2)2H-·H2O (1), (CH3)4N+·C15H15O2-·H2O (2), and 2(C2H5)4N+·2C15H15O2-·C15H16O2·3H2O (3) have been prepared under the similar conditions by using 2, 2’-bis (4-hydroxyphenyl) propane as the host and tetraalkylammonium as the guest. Then, the complexes were characterized by X-ray single crystal diffraction. The results show that 1 and 2 are two polymorphs, and in complex 3, only the magnitude of the template is different from the former two complexes. Although, the hydrogen bonding of three compounds are all related to the traditional O-H…O hydrogen bonds between the phenolic hydroxyl groups and water molecules, they eventually form various channel frameworks with different shape of cavities, such as the peanut-like channels in complex 1, the cross-shape in complex 2, and varied hexagonal-shape and tetragonal-shape cavities in complex 3. And the corresponding guest cations are contained in these channels to build the related stable crystal structures. Obviously, 2,2’-bis (4-hydroxyphenyl)propane, as a more flexible “V” type host molecule with terminal hydroxyl groups, can interact with tetraalkylammonium template and the auxiliary water molecules to construct different host lattices, showing excellent ability of forming hydrogen bonds.
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TOXICON
·
2020
·
IF 2.201
Lingchen Yang,Di Tu,Yingxin Wu,Wei Liu,Yi Hu,Tanbin Liu,Lei Tan,Yalan Li,Hongyu Lei,Yang Zhan,Naidong Wang,Zhibang Deng,Shiyin Guo,Aibing Wang
T-2 and HT-2 widely found in food products can seriously affect human and animal health. In this study, sterilized corn was inoculated with F. poae and incubated to allow fungal growth before being examined via liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) to determine the concentrations of T-2/HT-2. Broilers were then fed with a mix of moldy corn and normal feed at different ratios to obtain different toxin doses. After 35 days, the contaminated feed was replaced with mycotoxin-free feed and the distribution and concentration of residual toxins in the tissues and organs of the chickens were examined at different time points. The results showed that at the time of feed replacement (0 h), T-2 residue was present at significantly higher concentrations in the lungs and small intestines than in other tissues ( P < 0.05). In addition, T-2 concentrations increased in a dose-dependent manner in the tissues of chickens in the low-, medium-, and high-dose groups; however, the differences in concentration between the groups were not statistically significant. The HT-2 content (0 h) in the livers and small intestines was significantly higher than that in other tissues ( P < 0.05). At 48 h post-feed replacement, the concentration of T-2 dropped below detectable levels in all tissues while HT-2 could still be detected at 192 h post-feed replacement. Thus, this study reveals the distribution and persistence of residual T-2/HT-2 from moldy feed in broilers, providing a reference for the detection of these toxins in animal-derived food products and a theoretical basis for formulating food-safety and quality standards.
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MOLECULAR AND CELLULAR ENDOCRINOLOGY
·
2019
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IF 3.693
Wen Qi,Liting Zhou,Tianye Zhao,Shuang Ding,Qi Xu,Xu Han,Yaming Zhao,Xinyue Song,Tianyang Zhao,Xiaohan Zhang,Lin Ye
Background Mono-2-ethylhexyl phthalate (MEHP), an important metabolite of di (2-ethylhexyl) phthalate (DEHP), can induce lipid metabolic disorder . Previous studies have shown that MEHP promotes 3T3-L1 cell differentiation ; however, the underlying mechanism is unclear. The present study was performed to investigate the effect of the TYK-2/STAT-3 pathway on lipid accumulation induced by MEHP. Methods A 3T3-L1 precursor adipocyte differentiation model was exposed to MEHP. 3-Isobutyl-1-methylxanthine (IBMX), dexamethasone (DEX), and insulin were used to establish the 3T3-L1 precursor adipocyte differentiation model. Then the model cells were exposed to MEHP for 8 d. The lipid droplet formation in 3T3-L1 cells was determined with Oil-Red-O staining, and isopropyl alcohol was used to extract the lipid droplets for quantification. Flow cytometry was used to detect the intracellular reactive oxygen species (ROS) and mitochondrial membrane potential . Quantitative real-time polymerase chain reaction (qPCR) was used to detect mRNA expression, and western blotting was used to detect the expression of proteins encoded by TYK-2/STAT-3 pathway genes and adipogenesis-related genes. Results MEHP treatment , compared with the control treatment, significantly promoted the differentiation of 3T3-L1 cells and increased the expression of STAT-3 mRNA and protein and P-STAT3 protein in the cells. In addition, MEHP down-regulated the phosphorylation of STAT-3 in mitochondria. MEHP was found to influence the mitochondrial membrane potential and intracellular ROS levels. Conclusion MEHP may affect adipocyte differentiation and lead to lipid accumulation through the TYK-2/STAT-3 pathway.
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高影响因子
POLYMER BULLETIN
·
2014
·Vol. 71
·期 7
·1797-1811
·
IF 1.491
Chen Haochuan,Jiao Jiao,Zhao Changwen,Ma Yuhong,Ma Wenchao,Yang Wantai
Organotellurium compounds-mediated living radical polymerization (TERP) is one of the most robust tools of living free radical polymerizations (LRP). However, synthesis and purification of organotellurium compounds are time-consuming and to be operated in an inert atmosphere due to their extreme sensitivity to trace oxygen. In this article, a simple process of TERP, operating in open air, has been reported. It has demonstrated that the crude organotellurium compound, ethyl 2-phenyltellanyl-2-methylpropionate, could mediate 2,2′-azobis (isobutyronitrile) initiated styrene (St) and butyl acrylate (BA) polymerization as an LRP system. For the bulk and solution polymerization of St and the solution polymerization of BA, the molecular weights of produced polymers increased linearly with the monomer conversions. During the same time, the molecular weight distributions kept under 1.3. The UV–vis spectrum showed that the PS polymer chain bearing C-TePh end group. With the sequential monomer addition technique, a clean diblock polymer of PS- b -PBA was also obtained.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2017
·Vol. 134
·期 47
·45532
·
IF 1.86
Yanfei Zhang,Hongwei Zhou,Li Wang,Wenyuan Jiang,Mark D. Soucek,Ying Yi
Crosslinked castor oil (CO)-based waterborne polyurethane was synthesized from CO, polycarbonate diol, isophorone diisocyanate, 2,2-dimethylol propionic acid, and 2-amino-2-(hydroxymethyl)-1,3-propanediol (THAM) using pre-polymer process. Fourier transform infrared spectroscopy, X-ray diffraction, and transmission electron microscopy were utilized to characterize the above-synthesized polyurethane. The effect of THAM content was studied on particle size, zeta potential, thermogravimetric analysis, differential scanning calorimetry, tensile tests, and contact angle measurement. Results showed that, with the increase of THAM content, the particle size increases and the thermal stability increases. Furthermore, as the THAM content increased from 0% to 1.5%, tensile strength increased from 9.5 to 16.3 MPa, contact angle increased from 67.8° to 87.4°, and bibulous rate decreased from 13.4% to 6.1%, the elongation at break dropped from 154.8% to 37.9%, respectively. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 45532.
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SCIENCE OF THE TOTAL ENVIRONMENT
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2024
·
IF 8.2
Shasha Fang,Yue Geng,Lu Wang,Jun Zeng,Shimin Zhang,Yucheng Wu,Xiangui Lin
Polybrominated diphenyl ethers (PBDEs) are persistent pollutants that may undergo microbial-mediated debromination in anoxic environments, where diverse anaerobic microbes such as methanogenic archaea co-exist. However, current understanding of the relations between PBDE pollution and methanogenic process is far from complete. To address this knowledge gap, a series of anaerobic soil microcosms were established. BDE-47 (2, 2′, 4, 4′-tetrabromodiphenyl ether) was selected as a model pollutant, and electron donors were supplied to stimulate the activity of anaerobes . Debromination and methane production were monitored during the 12 weeks incubation, while obligate organohalide-respiring bacteria (OHRBs), methanogenic, and the total bacterial communities were examined at week 7 and 12. The results demonstrated slow debromination of BDE-47 in all microcosms, with considerable growth of Dehalococcoides and Dehalogenimonas over the incubation observed in most BDE-47 spiked treatments. In addition, the accumulation of intermediate metabolites positively correlated with the abundance of Dehalogenimonas at week 7, suggesting potential role of these OHRBs in debromination. Methanosarcinaceae were identified as the primary methanogenic archaea, and their abundance were correlated with the production of debrominated metabolites at week 7. Furthermore, it was observed for the first time that BDE-47 considerably enhanced methane production and increased the abundance of mcrA genes, highlighting the potential effects of PBDE pollution on climate change. This might be related to the inhibition of reductive N- and S-transforming microbes, as revealed by the quantitative microbial element cycling (QMEC) analysis. Overall, our findings shed light on the intricate interactions between PBDE and methanogenic processes, and contribute to a better understanding of the environmental fate and ecological implication of PBDE under anaerobic settings.
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INTERNATIONAL IMMUNOPHARMACOLOGY
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2024
·
IF 4.8
Li Guo,Sai Zhang,Cong Zhang,Shuang Ren,Zihan Zhou,Fengyuan Wang,Yuexuan Wang,Qiqi Chen,Yubing Wang,Wen-Hui Lee,Kui Zhu,Di Qin,Yuanyuan Gao,Tongyi Sun
Inflammatory pain is a chronic pain caused by peripheral tissue inflammation, seriously impacting the patient’s life quality. Cinobufacini injection, as a traditional Chinese medicine injection preparation, shows excellent efficacy in anti-inflammatory and analgesic treatment in patients with advanced tumors. In this study, a novel analgesic peptide CI5 with anti-inflammatory and analgesic bio-functions that naturally presents in Cinobufacini injection and its regulatory mechanism are reported. Our results showed that the administration of CI5 significantly relieved the pain of mice in the acetic acid twisting analgesic model and formalin inflammatory pain model. Furthermore, CI5 effectively reduced the inflammatory cytokines (IL-6, TNF-α and IL-1β) and inflammatory mediator (PGE2) expressions, and prevented the carrageenan-induced paw edema in mice. Further LC-MS/MS results showed the anti-inflammatory and analgesic bio-functions of CI5 depended on its interaction with the Rac-2 protein upstream of ERK1/2 and the inflammatory signaling pathway (ERK1/2/COX-2 axis). In summary, CI5, as a novel natural candidate identified from Cinobufacini injection, showed substantial clinical promise for inflammatory pain treatments.
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Marine Drugs
·
2024
·Vol. 22
·期 11
·513
·
IF 4.9
Xiaohan Zang,Yongcheng Wang,Cong Han,Lishuang Cui,Haojie Liu,Shuimiao Tian,Kechun Liu,Peihai Li,Chen Sun,Qing Xia,Yun Zhang
Hyperlipidemia and consequent endothelial inflammation, along with foam cell generation, promote the progression of atherosclerosis (AS). Here, we aimed to investigate the effects of 2-acetamidophenol (2-AAP), which was selected by zebrafish phenotypic screening, in alleviating AS by relieving hyperlipidemia and inhibiting foam cell formation, as well as the underlying mechanisms. In a zebrafish hyperlipidemia model, 2-AAP increased lipid-lowering efficacy; alleviated TC, TG, LDL-C, and MDA levels; elevated HDL-C and T-SOD levels; significantly improved intravascular macrophage aggregation; and improved blood flow. In an ox-LDL-induced RAW264.7 model, 2-AAP inhibited lipid phagocytosis in RAW264.7 cells; reduced the intracellular TC, TG, FC, and CE contents; and decreased the CE/TC ratio, thus slowing foam cell generation. In addition, 2-AAP alleviated intracellular ROS and ferrous ion accumulation in RAW264.7 cells, reduced the MDA content, and increased GPX4 viability. Furthermore, transcriptome analyses and gene expression validation showed 2-AAP treatment upregulates genes related to GSH synthesis and transport, such as gclc, gclm, gss, and gpx4a, and enhanced the expression levels of genes involved in the storage and transportation of iron ions, such as fpn1, fth, and g6pd, indicating that 2-AAP dramatically regulated the ferroptosis and glutathione metabolic pathways. Overall, our study demonstrated that 2-AAP demonstrated potential in AS by alleviating hyperlipidemia and attenuating the ferroptosis pathway and provided evidence supporting the future application of 2-AAP in AS treatment.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-9
·
IF 14.7
Liu Wei,Yu Jiage,Li Tianshui,Li Shihang,Ding Boyu,Guo Xinlong,Cao Aiqing,Sha Qihao,Zhou Daojin,Kuang Yun,Sun Xiaoming
Low-energy consumption seawater electrolysis at high current density is an effective way for hydrogen production, however the continuous feeding of seawater may result in the accumulation of Cl − , leading to severe anode poisoning and corrosion, thereby compromising the activity and stability. Herein, CoFeAl layered double hydroxide anodes with excellent oxygen evolution reaction activity are synthesized and delivered stable catalytic performance for 350 hours at 2 A cm −2 in the presence of 6-fold concentrated seawater. Comprehensive analysis reveals that the Al 3+ ions in electrode are etched off by OH − during oxygen evolution reaction process, resulting in M 3+ vacancies that boost oxygen evolution reaction activity. Additionally, the self-originated Al(OH) n − is found to adsorb on the anode surface to improve stability. An electrode assembly based on a micropore membrane and CoFeAl layered double hydroxide electrodes operates continuously for 500 hours at 1 A cm −2 , demonstrating their feasibility in brine electrolysis.
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Results in Engineering
·
2025
·
IF 7.9
Jingjing Xiao,Li Li,Zhengwen Li,Mengjia Hu,Sisi Liu,Jia Tu,Baining Lin,Hongqing Wang,Zhihong Xiao,Rukuan Liu,Xiaoyu Cao
To efficiently enrich uranyl ions, a novel extractant, dialkyl-(2-amino-2-(hydroxyimino) ethyl) phosphonate (DAAHEP), was firstly synthesized by modifying dibutyl butylphosphonate (DBBPP) with amidoxime groups. Under optimized experimental conditions, the extraction efficiency of uranyl ions by dihexyl-(2-amino-2-(hydroxyimino) ethyl) phosphonate (DHAHEP) and dibutyl-(2-amino-2-(hydroxyimino) ethyl) phosphonate (DBAHEP) reached 98.1 % and 87.0 %, respectively, which were much higher than the extraction efficiency of 70.6 % by DBBPP. Extraction saturation capacity results indicated that the saturation capacity of DHAHEP continuous extraction can reach 584.3 % after 8 times of extraction. Reusability and selectivity experiment demonstrated that DHAHEP exhibited excellent selectivity for uranyl extraction and achieved about 85% extraction efficiency after 4 consecutive extraction-strip cycles. Extraction mechanism studies further revealed that DHAHEP complexed with uranyl ions in a 1:1 ratio via C(=N-OH)-NH 2 and P=O groups. Furthermore, the production cost of DHAHEP is about one-tenth of that of DBBPP, indicating its potential for industrial application.
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NEUROCHEMICAL RESEARCH
·
2022
·Vol. 48
·期 2
·658-670
·
IF 4.414
Yang Jinghui,Guo Qian,Wang Lu,Yu Shan
Cerebral ischemia reperfusion injury (CIRI) is the commonest cause of brain dysfunction. Up-regulation of POU domain class 2 transcription factor 2 (POU2F2) has been reported in patients with cerebral ischemia, while the role of POU2F2 in CIRI remains elusive. Middle cerebral artery occlusion/reperfusion (MCAO/R) in mice and oxygen and glucose deprivation/reperfusion (OGD/R) in mouse primary cortical neurons were used as models of CIRI injury in vivo and in vitro. Lentivirus-mediated POU2F2 knockdown further impaired CIRI induced by MCAO/R in mice, which was accompanied by increased-neurological deficits, cerebral infarct volume and neuronal loss. Our evidence suggested that POU2F2 deficiency deteriorated oxidative stress and ferroptosis according to the phenomenon such as the abatement of SOD, GSH, glutathione peroxidase 4 (GPX4) activity and accumulation of ROS, lipid ROS, 4-hydroxynonenal (4-HNE) and MDA. In vivo, primary cortical neurons with POU2F2 knockdown also showed worse neuronal damage, oxidative stress and ferroptosis. Sestrin2 (Sesn2) was reported as a neuroprotection gene and involved in ferroptosis mechanism. Up-regulation of Sesn2 was observed in the ischemic penumbra and OGD/R-induced neuronal cells. Further, we proved that POU2F2, as a transcription factor, could bind to Sesn2 promoter and positively regulate its expression. Sesn2 overexpression relieved oxidative stress and ferroptosis induced by POU2F2 knockdown in OGD/R-treated neurons. This research demonstrated that CIRI induced a compensatory increase of POU2F2 and Sesn2. Down-regulated POU2F2 exacerbated CIRI through the acceleration of oxidative stress and ferroptosis possibly by decreasing Sesn2 expression, which offers new sights into therapeutic mechanisms for CIRI.
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JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
·
2015
·Vol. 53
·期 11
·1305-1309
·
IF 3.113
Yuanyuan Xu,Jinming Sun,Hou Chen,Liangjiu Bai,Qian Tao,Lili Yu,Yating Wang
2-Cyanoprop-2-yl dithionaphthalenoate (CPDN) was successfully used as the chain transfer agent to prepare polyacrylonitrile in combination with manganese(III) acetylacetonate (Mn(acac) 3 ) as the initiator. The novel polymerization exhibited well “living”/controlled characteristics. The polymerization behavior was revealed to comply with features of reversible addition–fragmentation chain transfer polymerization process. Mn(acac) 3 played a key role as the initiator rather than the radical trapping agent in polymerization and exhibited better control performance than azo-initiator. The narrowest molecular weight distribution was 1.31 under the condition of [AN] 0 :[Mn(acac) 3 ] 0 :[CPDN] 0 = 200:1:0.025 and AN:DMF = 1:1 (V/V). Various feed ratios of Mn(acac) 3 and CPDN were also investigated in detail. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015 , 53 , 1305–1309
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危险品化学品经营许可证（带存储）