Journal of Renewable Materials
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2025
·
IF 2.115
Tingqiang Yan,Xiaodong Wang,Yingjie Qiao
Polylactic acid (PLA), a biodegradable polymer, exhibits superior mechanical strength and processability. However, its broader adoption is hindered by inherent brittleness, low hydrophilicity, and sluggish crystallization kinetics. Chitosan (CS), a natural polysaccharide renowned for its biocompatibility and biodegradability, offers potential to address these limitations. While both materials have garnered significant attention in materials science, research on their integration via melt blending and the resulting performance enhancements for food-contact plastics remains understudied. This research comprehensively explores how different levels of CS content, from 0% to 10%, impact the characteristics of chitosan/polylactic acid (CS/PLA) composites. It specifically analyzes the influence of various CS concentrations on the mechanical attributes, crystallization behavior, thermomechanical properties, and rheological performance of these composites. The study concludes that a CS content of 4% in the CS/PLA composite results in the best overall properties. At this point, its elongation at break and impact strength reached their maximum values (16.16% and 20.63 kJ/m²), representing increases of 23.9% and 15.7% compared to pure PLA. At this particular concentration, CS is evenly distributed throughout the PLA matrix, acting as a heterogeneous nucleating agent. It facilitates the crystallization of the composite material and offers effective reinforcement. This study presents a promising approach for developing environmentally friendly and sustainable alternatives to fossil-based plastics, highlighting significant research value and practical application potential.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Qingqing Liu,Yue Tang,Mingming Xiong,Yunting Yang,Yanting Liu,Zhengping Duan,Wei Luo,Yisha Xie,Yongjun Yuan
Lipase is widely used in the food industry, but its catalytic efficiency is limited by the insufficient enzyme-substrate contact. To address this issue, chitosan-zein complex particles immobilized lipase (CZPs-lipase) and the corresponding Pickering emulsion catalytic system (PEC) were fabricated. The results showed that the incorporation of zein increased the three-phase contact angle of the particles and decreased the particle size, facilitating lipase immobilization. However, the reduced ζ-potential of the particles was unfavorable for the lipase immobilization by electrostatic adsorption. As a compromise, the maximum immobilized lipase activity was obtained at a chitosan:zein mass ratio of 1:2 (CZPs 1:2 -lipase). In addition, the PEC stabilized by CZPs-lipase had a significantly ( P < 0.05) smaller particle size than that stabilized by chitosan-lipase particles. Consequently, after 120 min of reaction, the hydrolysis rate of p-nitrophenol palmitate in the PEC stabilized by CZPs 1:2 -lipase was 1.66 and 3.67 times that of the free lipase emulsion and the free lipase biphasic catalytic system, respectively. Meanwhile, after 180 min of reaction, the hydrolysis rate of corn oil and soybean oil in the PEC reached 75.68 ± 1.85 % and 96.27 ± 2.26 %, respectively, significantly ( P < 0.05) higher than that in the free lipase emulsion. After five cycles, the relative hydrolysis rate remained at approximately 85 %. This efficient and PEC has considerable potential for applications in the food industry.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
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IF 8.5
Hermela Ejegu,Mengdi Xu,Charles Kumah,Yan Qingshuai,Biruk Fentahun,Sun Yifan,Binjie Xin,Guangniao Xu,Hua Shen
Biocompatible electrospun fibrous scaffolds that mimic the extracellular matrix (ECM) have significant potential in tissue engineering and wound healing applications. This study aimed to develop a novel scaffold by incorporating Discopodium penninervium (DP) leaf extract into chitosan-polyvinyl alcohol (CH-PVA) scaffolds via electrospinning and evaluate their biocompatibility, antibacterial properties, and efficacy in wound healing. Gas chromatography-mass spectrometry (GC–MS) analysis identified bioactive compounds in the DP extract, including phenolic acids, phytol, linolenic acid, and gamma-sitosterol, which are known for their anti-inflammatory, antioxidant, and skin-regenerative properties. The scaffolds exhibited a continuous, smooth, bead-free structure with fiber diameters ranging from 186 ± 24.1 nm to 236 ± 14.22 nm. Crosslinking (CL) with glutaraldehyde enhanced hydrophilicity, water absorbency, and biodegradability. Scaffolds with 2 % and 3 % DP extract demonstrated enhanced cell viability (up to 116.49 %) and improved antibacterial efficacy, with inhibition zones of 21 mm and 21.5 mm against E. coli and 21.2 mm and 21.8 mm against S. aureus , respectively, significantly outperforming the control group. In vivo studies showed accelerated wound closure (98 % within 15 days) compared to untreated controls (85 %). Enhanced angiogenesis, re-epithelialization, and collagen deposition promoted faster healing, while modulation of IL-6 and TNF-α inflammatory markers balanced inflammation and tissue regeneration. These findings demonstrate the potential of DP-loaded CH-PVA scaffolds as innovative, sustainable, and effective wound dressings. Their enhanced healing properties and antibacterial performance present a promising solution for improving healthcare outcomes, particularly in resource-limited settings where affordable and accessible treatments are critically needed.
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高影响因子
CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Xiaoyue Xu,Liping Sun,Li Zhou,Yanju Cheng,Feng Cao
Chitosan oligosaccharide-valylvaline-stearic acid (CSO-VV-SA) nanomicelles were designed for topical ocular drug delivery, based on peptide transporter-1 (PepT-1) active targeting. Hydrogenated castor oil-40/octoxynol-40 (HCO-40/OC-40) mixed nanomicelles were also prepared according to Cequa, just approved by FDA. Both nanomicelles produced no significant cytotoxicity and difference in human corneal epithelial cells (HCEpiC) and human conjunctival epithelial cells (HConEpiC). The active transport of CSO-VV-SA nanomicelles by PepT-1 was illustrated in the inhibitory test. Ex vivo fluorescence images of frozen sections indicated that the nanomicelles entered the posterior segment mainly through conjunctival route. In vivo precorneal retention study suggested dexamethasone from both nanomicelles could be detected for more than 3 h in rabbit tears. In vivo distribution evaluation of rabbits’ eyes showed the delivering efficiency of CSO-VV-SA nanomicelles was not inferior to that of HCO-40/OC-40 mixed nanomicelles. These findings indicated that CSO-VV-SA nanomicelles could become promising candidates for further clinical application.
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FIBERS AND POLYMERS
·
2022
·Vol. 23
·期 10
·2707-2716
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IF 2.347
Zhu Shengyu,Pei Jiliu,Song Yukang,Liu Yu,Xue Feng,Xiong Xiaohui,Li Chen
This study aimed to improve the physicochemical properties of chitosan (CS) film by riboflavin (RF)-induced cross-linking under ultraviolet (UV) light for different times (0, 2, 4, 6 h). It was found that the water vapor resistance, tensile strength, optical property, and thermal stability of the film were significantly enhanced under RF-induced photo-crosslinking, especially when illuminated for 6 h. Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) verified the molecular bonding of CS and RF, as well as scanning electron microscope (SEM) showed a tighter and more uniform film structure was formed through UV crosslinking. Thus, the CS-RF films have the potential to replace petrochemical materials as a novel type of environmentally friendly packaging material.
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JOURNAL OF NANOPARTICLE RESEARCH
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2013
·Vol. 15
·期 9
·1-9
·
IF 2.175
Chen Zhanguang,Wang Zhen,Chen Xi,Xu Haixiong,Liu Jinbin
In this contribution, novel chitosan-stabilized gold nanoparticles (AuNPs) were prepared by mixing chitosan with citrate-reductive AuNPs under appropriate conditions. The as-prepared chitosan-stabilized AuNPs were positively charged and highly stably dispersed in aqueous solution. They exhibited weak resonance light scattering (RLS) intensity and a wine red color. In addition, the chitosan-stabilized AuNPs were successfully utilized as novel sensitive probes for the detection of heparin for the first time. It was found that the addition of heparin induced a strong increase of RLS intensity for AuNPs and the color change from red to blue. The increase in RLS intensity and the color change of chitosan-stabilized AuNPs caused by heparin allowed the sensitive detection of heparin in the range of 0.2–60 μM (~6.7 U/mL). The detection limit for heparin is 0.8 μM at a signal-to-noise ratio of 3. The present sensor for heparin detection possessed a low detection limit and wide linear range. Additionally, the proposed method was also applied to the detection of heparin in biological media with satisfactory results.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
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2025
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IF 3.9
Gao Yang,Gao Shan,Zhang Yunhua,Lyu Shaoyi,Wang Feijun
Reuse of dye-containing wastewater for valuable products offers significant potential. Chitosan, a natural high-molecular-weight porous material, served as an effective carrier for dye molecules. This study uses chitosan to adsorb Congo Red, preparing hierarchical porous carbon materials, which are then applied in supercapacitors. The findings reveal that chitosan achieves an impressive adsorption capacity of 1450 mg g −1 for Congo Red. When the chitosan–Congo Red composite material-based carbon is used as the electrode material, it shows an outstanding specific capacitance of 318 F g −1 at a current density of 1 A g −1 . Furthermore, due to its high content of heteroatoms such as N, O, and S, the double-layer supercapacitor fabricated with this electrode material demonstrates a specific capacitance of 149.49 F g −1 at 1 A g −1 , with an energy density of 8.77 Wh kg −1 at a power density of 335.35 W kg −1 . These results highlight the considerable potential of this material after adsorption of dye-containing wastewater for applications in the energy storage field.
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
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2025
·
IF 8.4
Jin-Hyuk Choi,Mingi Ko,Soyeong Yoon,Narae Kim,Taesoon Jang,Myeongsong Lee,Jeong-Ann Park
A three-dimensional porous graphene oxide/chitosan (GO/CS) sponge (average pore size = 21.67 μm; pore size distribution = 0.75–319.26 μm, total pore area = 1.84 m 2 /g; and pH pzc = 5.76) was evaluated for the polystyrene (PS) NPs (hydrodynamic diameter = 31.1 ± 0.4 nm) removal from aqueous solutions. The adsorption kinetics followed a pseudo-second-order model, and intra-particle diffusion occurred in three distinct stages: film diffusion, pore diffusion, and surface sorption. Adsorption isotherms aligned best with the Langmuir model, indicating a maximum adsorption capacity of 33.30 mg/g. Thermodynamic analysis showed that PS NPs adsorption was spontaneous (ΔG° < 0) and endothermic (ΔH° > 0) within the temperature range of 283–293 K. FT-IR and XPS analyses confirmed that adsorption occurred through multiple mechanisms, including electrostatic attraction, hydrogen bonding, and π–π stacking. The adsorption behavior was significantly affected by pH, salinity, and competing ions. The highest adsorption capacity (17.99 mg/g) was observed at pH 5.5, which is close to the pH PZC (5.76) of the sponge, due to favorable electrostatic and hydrophobic interactions. As NaCl concentration increased, adsorption capacity remained stable up to 20 mM, but declined sharply above 100 mM due to PS NPs aggregation. Divalent cations, particularly Ca 2+ , significantly reduced adsorption by compressing the electrical double layer and enhancing aggregation, while monovalent cations and anions had minimal impact. The sponge was reusable after a simple squeeze-wash regeneration, achieving 83.12 % removal efficiency after 12 consecutive adsorption–desorption cycles. Compared to deionized water, real water samples exhibited similar or improved adsorption capacities, with the highest capacity observed in seawater (15.78 mg/g).
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BIOMACROMOLECULES
·
2025
·
IF 5.4
Yinsong Li,Zhuozheng Yu,Yang Wang,Shuhan Xu,Xiangrui Zheng,Yao Zhang
Cellulose-based materials have been widely studied due to their biodegradability and excellent mechanical strength. However, the intrinsic brittleness of cellulose limits its applications. In this study, the bacterial cellulose-chitosan films were prepared by a casting method. The cellulose films with ≤ 30% chitosan exhibited a simultaneous increase in strength and toughness. The slippage of cellulose chains and dense network structure contribute to the improved strength and toughness of the cellulose-chitosan films. Besides, coarse-grained molecular dynamics simulations were performed to investigate the effects of different molecular factors (i.e., chain length, molecular interaction strength, and density) on the mechanical properties of cellulose-chitosan films. These molecular factors exhibited opposite effects on the tensile strength and strain at break. In particular, modifying the density of cellulose-chitosan films could simultaneously improve the strength and toughness significantly without sacrificing the elastic modulus. The findings provide physical insights into the strengthening and toughening effects of the cellulose-chitosan films.
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JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
·
2023
·Vol. 106
·期 3
·877-894
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IF 2.5
Hao Pei Yan,Zhou Hui Yun,Ren Li Jun,Zheng Hui Jie,Tong Jia Nan,Chen Ya Wei,Park Hyun Jin
Abstract The chitosan hydrogel has been widely appraised for drug delivery systems. However, its long gel formation time, poor drug release effect, and low drug loading capacity for hydrophobic drugs limited its wide application. Herein, the β-cyclodextrin-grafted chitosan (CD-g-CS) with different degrees of substitution (DS) was successfully synthesized from O-p-toluenesulfonyl-β-cyclodextrin (Ts-CD) and chitosan (CS). The novel thermosensitive β-cyclodextrin-grafted chitosan/glycerophosphate (CD-g-CS/GP) hydrogels were prepared in the presence of αβ-glycerophosphate (GP). The CD-g-CS/GP hydrogels had a gel time of less than 6 min and performed great injection performance. In vitro release studies revealed that the hydrogels not only had a sustained release but also enhanced the solubility and bioavailability of curcumin (CUR). And the CD-g-CS/GP hydrogel had suitable swelling behavior, porosity, and degradation rate. In addition, the hydrogels exhibited good hemocompatibility. The evaluation of the antibacterial activity indicated that CUR@CD-g-CS/GP hydrogels were effective antibacterial materials for Staphylococcus aureus and Escherichia coli . In summary, the results suggested that the CD-g-CS/GP hydrogel might be used as a potential biodegradable smart drug-sustained release system for the controlled release of hydrophobic drugs, which has broad application prospects in the field of biomedicine. Graphical Abstract
Preparation of CUR@CD-g-CS/GP hydrogel. First, the prepared CD-g-CS was dissolved in 0.1 M HAc solution. The GP powder was dissolved in distilled water to prepare a GP solution of 50% (w/v). Next, the GP solution was added dropwise to the CD-g-CS solution and stirred in an ice bath. Finally, the CD-g-CS/GP hydrogel was obtained. The hydrogel-loaded CUR (CUR@CD-g-CS/GP) was prepared by adding CUR to the CD-g-CS solution. After incubation at 37 °C, the system changed from a sol to a gel state. The gel was placed in a release medium and the drug molecules were released from the system.
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JOURNAL OF MATERIALS RESEARCH
·
2018
·Vol. 33
·期 17
·2586-2597
·
IF 1.495
Haochao Huang,Haiwei Wu,Yongrui Huang,Shuangying Zhang,Yuetwai Lam,Ningjian Ao
N-(3-Carboxypropyl) triphenylphosphonium bromide chitosan (TPPB-CS) was synthesized and characterized by FTIR, 1H NMR spectrometer, and Zeta potential. TPPB-CS showed a selectivity-toxicity among cancer cell lines (MG-63 and HepG2 cells) and mouse embryonic fibroblast cells (NIH3T3 cells). A significant effect on inhibiting cell migration in HepG2 cells was observed in vitro, and TPPB-CS could effectively inhibit tumor growth in H22-bearing mice in vivo. Furthermore, the distribution of cell cycle, the level of reactive oxygen species (ROS), mitochondrial transmembrane potential (∆ψm), the expression of tumor necrosis factor α (TNF-α), and vascular endothelial growth factor (VEGF) were examined to investigate the antitumor mechanism of TPPB-CS. The results suggested that the antitumor activity of TPPB-CS may be attributed to delay the cell cycle in S phase, alter the ROS and ∆ψm level, as well as regulate the TNF-α and VEGF secretion. TPPB-CS can become a promising anticancer drug for clinical therapy.
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COMPOSITES COMMUNICATIONS
·
2022
·
IF 7.685
Qiaoyun Wu,Ling Wang,Peng Ding,Yaling Deng,Oseweuba Valentine Okoro,Amin Shavandi,Lei Nie
In this study, medical hydrogels (TGs) were fabricated based on thiolate-modified chitosan (TCS) and methacrylate gelatin (GelMA) using the Thiol-Michael addition reaction. The hydrogels were formed via the Michael reaction between TCS and GelMA and determined to have an equilibrium swelling rate of more than 1100% while simultaneously providing a moist environment for the wound, and limiting crust formation. The porosity of the prepared hydrogel was also shown to have a positive correlation with the concentration of the thiolated chitosan in the formulation. A positive correlation between hydrogel strain and stress properties and increasing concentrations of thiolated chitosan was also observed. The cytocompatibility of the prepared hydrogels was also tested and confirmed using CCK-8 assay after 5 days of culture, and the best antimicrobial properties were observed with the hydrogel containing TCS and GelMA in the mass ratio of 1:2. The present study was, therefore, able to highlight the potential of a simple and low-cost approach to developing cytocompatible hydrogels with antibacterial properties and tunable mechanical properties based on the well-studied GelMA. This study implies that the produced hydrogels can have future applications in fabricating skin wound healing dressings.
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