JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
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2020
·Vol. 31
·期 6
·1216-1224
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IF 1.399
Han Qing,Wei Lanlan,Deng Guozhe,Sun Ying,Deng Jianjun,Tang Zigang,Fan Jinhui,Wang Xia,Kang Xuejun
The detection of vitamin D in complex samples is challenging because of the instability of vitamin D in sample preparation. To resolve this problem, packed-fiber solid-phase extraction (PFSPE) has been successfully developed for the pre-treatment of samples containing vitamin D2 (D2) and vitamin D3 (D3) in dairy products. Based on PFSPE, vitamin D could avoid oxidation because of the shorter extraction time. The adsorbent materials, polystyrene/polypyrrole (PS/PPy) nanofibers, were prepared by electrospinning of PS and in situ polymerization of PPy on the surface of PS nanofibers. The linearity was within the range of 1-2000 ng mL−1 in dairy solution, and the recoveries were 91.9-109.1% with a relative standard deviation (RSD) < 13.6%. Therefore, the prepared method could be used for the detection of D2 and D3 in dairy products.
研究领域:
分析化学
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食品科学
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ACS Applied Materials & Interfaces
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2022
·
IF 10.383
Pengfei Shan,Yingwen Lu,Weilin Lu,Xiangping Yin,Haiwei Liu,Daai Li,Xiaoyue Lian,Weiping Wang,Zhongyu Li,Zhihui Li
The low utilization efficiency of pesticides exerts an adverse impact on the environment and human health. Polymer-related controlled-release nanosized pesticide systems provide a promising and efficient way to overcome the problem. In this work, a biodegradable and light-responsive amphiphilic polymer was synthesized via 1,1,3,3-tetramethylguanidine-promoted polyesterification under mild conditions (low temperature, no vacuum, and no inert gas protection). We used this polymer to fabricate a light-triggered controlled-release nanosized pesticide system. The herbicide, 2,4-dichlorophenoxyacetic acid (2,4-D), was selected as a model drug to show its potential as a controlled-release pesticide system. It was found that the 2,4-D-loaded polymeric nanoparticles were stable without the treatment of UV, while the release rate of 2,4-D from the nanoparticles gradually increased after treatment with UV light. Pot trial showed that the 2,4-D-loaded polymer nanoparticles showed a good herbicidal effect. Finally, toxicity studies suggested that the polymer can reduce toxicity to nontarget organisms.
研究领域:
环境科学
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材料科学
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农业科学
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FOOD CHEMISTRY
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2020
·
IF 6.306
Yu Xu,Ziyi Liu,Zhaoye Liu,Zhihui Feng,Liang Zhang,Xiaochun Wan,Xiaogen Yang
During manufacturing processes and in the storage period of tea, amino acids may undergo enantiomeric isomerization, converting their l - to d -forms. To examine the hypothesis, a method was developed for the analysis of the enantiomers in tea leaves. After enriched by ion-exchange solid-phase extraction, the enantiomeric pairs were separated by a chiral high performance liquid chromatography (HPLC) and subsequently detected and identified by using a high resolution quadrupole time-of-flight mass spectrometry (QTOF MS). Only l -forms of amino acids were found in fresh tea leaves. A total of 11 d -amino acids were found in 19 tea samples, ranging from trace amount to 43 µg/g. The results indicated that the enantioisomerization of amino acids occurred in post-harvest tea leaves, and affected by process conditions and storage time.
研究领域:
食品科学
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分析化学
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农业化学
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2022
·
IF 5.895
Fang Fu,Yulin Fan,Langqiu Chen,Jing Zhang,Jiping Li,Jingyi Liao,Guochao Zhang
A series of nonionic disaccharide-based surfactants alkyldi(oxyethylene) β-d-maltosides (4a–4h, n = 6–16) were synthesized, and their physicochemical properties were further investigated. Six β-D-maltosides (4c–4h, n = 8–16) exhibited a fan-shaped texture feature, whereas hexyldi(oxyethylene) β-D-maltoside (4a) had the strongest hygroscopicity. Owing to the incorporation of the hydrophilic dioxyethyl spacer (−(OCH2CH2)2−), the related water solubility improved significantly. Tetradecyldi(oxyethylene) β-D-maltoside (4g) had good water solubility, whereas hexadecyldi(oxyethylene) β-D-maltoside (4h) had weak water solubility. Meanwhile, the surface tension of β-D-maltosides (4a–4g, n = 6–14) had a decreasing tendency with increasing the alkyl chain length, whereas 4g had the best surface activity. Furthermore, decyldi(oxyethylene) β-D-maltoside (4e) had the best foaming ability and foam stability. Dodecyldi(oxyethylene) β-D-maltoside (4f) had the best emulsifying property in the rapeseed oil/water system. In contrast, both ammonium dodecyl sulfate (NH4DS)/4f and cetyltrimethylammonium chloride (CTAC)/4f binary surfactant systems showed a synergistic effect in surface activity because the CCMC/CMCidmix was <1. NaCl impacted the surface activity of the aqueous 4f solution through salt–surfactant synergistic effects. The results showed that such surfactants should have potential applications in the related field in the future.
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JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2017
·
IF 1.9
Li Xu,Caifeng Wan,Jing Du,Hongli Li,Xuesong Liu,Hong Yang,Fenghua Li
Breast cancer is the leading cause of cancer-related deaths in women and earlier detection can substantially reduce deaths from breast cancer. Polymers with targeted ligands are widely used in the field of molecular ultrasound imaging and targeted tumor therapy. In our study, the nanotheranostic agent was fabricated through filling perfluoropropane (C3F8) into poly(d,l-lactic-co-glycolic acid) nanoparticles (PLGA NPs), followed by the formation of gold nanoshell on the surface, then conjugated with anti p53 antibody which has high specificity with the p53 protein overexpressing in breast cancer. The average diameter of the gold nanoshelled PLGA NPs carrying anti p53 antibody (p53-PLGA@Au NPs) was 247 ± 108.2 nm. The p53-PLGA@Au NPs had well-defined spherical morphology and hollow interiors observed by electron microscope, and had a good photothermal effect under the irradiation of an 808 nm laser. The results of laser scanning confocal microscope (LSCM) and flow cytometer (FCM) indicated the specific targeting of p53-PLGA@Au NPs conjugating with breast cancer MCF-7 cells overexpressing p53 protein in vitro. Also the ultrasound imaging experiments in vitro showed that p53-PLGA@Au NPs were suitable for ultrasound contrast imaging. In conclusion, the p53-PLGA@Au NPs are demonstrated to be novel targeted UCAs and may have potential applications in the early diagnosis and targeted near-infrared (NIR) photothermal therapy of breast cancer in the future.
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Oxidative Medicine and Cellular Longevity
·
2022
·
IF 7.31
Debo Gao,Pingli Li,Fei Gao,Yangjun Feng,Xiaolin Li,Delong Li,Yuqin Li,Yuliang Xiao
Previous studies have demonstrated that both CS and LiCl possess anti-Alzheimer's disease (AD) activities. We prepared chondroitin sulfate-Li (CS-Li) and investigated its effect on AD and explored the possible mechanisms both in vitro and in vivo . We found that CS-Li could inhibit amyloid β (A β ) aggregation and protect SH-SY5Y cells from A β 1-42 -induced cytotoxicity in vitro . In D-gal and AlCl 3 -induced AD mouse model, CS-Li improves the spatial learning and memory abilities of AD mice, reverses the nuclear pyknosis and cell edema, and increases the survival rate of neurons in hippocampus of mice. Moreover, CS-Li significantly increased the levels of GSH-Px, Na + /K + -ATPase, and ChAT and decreased the levels of MDA and AchE in AD mice. Western blot results demonstrated that CS-Li could decrease the hyperphosphorylation of tau (Ser396/Ser404) by regulating the expression of p-GSK-3 β (Ser9) and PP2A and inhibit the expression of proinflammatory factors through inhibiting NF- κ B nuclear translocation by activating the MAPK signaling pathways. In a word, CS-Li can delay AD development through multitarget processes, including A β aggregation inhibition, oxidative stress damage, tau hyperphosphorylation, and inflammatory response, thereby improves learning and memory abilities.
研究领域:
神经科学
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药理学
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分子生物学
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细胞生物学
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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2026
·
IF 2.5
Jing Wang,Xintong Chen,Yuanyu Tang,E. Pang,Duo Xia,Yongzhi Chen,Dan He,Kuansong Wang
Phototherapy has gained considerable attention in cancer treatment. Molecules with pronounced near-infrared (NIR) absorption are particularly advantageous for laser-induced phototherapy, as their NIR absorption enables deep tissue penetration while minimizing incidental damage to healthy tissues. In this study, we rationally designed and synthesized a non-fused ring A-D-A-type dye (T8IC4F) exhibiting both NIR absorption and fluorescence properties. Through self-assembly of T8IC4F with DSPE-PEG-NH 2 , water-dispersible nanoparticles (NPs) designated as C4@PEG were fabricated. The resulting C4@PEG NPs exhibit NIR absorption and NIR-II fluorescence properties and demonstrate significant therapeutic efficacy. Upon 808 nm laser irradiation (1 W·cm −2 ), these NPs exhibit a singlet oxygen ( 1 O 2 ) quantum yield of 25.9% and a photothermal conversion efficiency of 61%. These properties enable them to mediate both photodynamic and photothermal therapy, leading to robust antitumor efficacy. Moreover, C4@PEG NPs induce immunogenic cell death, facilitate the release of tumor antigens, and activate an antitumor immune response. These findings suggest that C4@PEG NPs could be applied in cancer phototherapy and immunotherapy.
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Pharmaceuticals
·
2026
·Vol. 19
·期 9
·1336
·
IF 5.7
Shini Zhang,Xiao-Li Luo,Hangxing Yang,Ganghua Huang,Jing Leng,Tao Yang
Background:Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder for which effective treatments remain limited. Liubao tea, a distinctive post-fermented dark tea, develops unique aged and areca nut aromas through prolonged storage. However, comprehensive studies on its anti-Alzheimer’s disease effects are lacking. This study aimed to identify the bioactive constituents of Liubao tea with varying storage durations and aroma profiles, and to further evaluate its neuroprotective potential against Alzheimer’s disease.Methods:Chromatography and spectrophotometry were employed to quantitatively determine the primary bioactive components in various Liubao tea samples. A D-galactose-induced Alzheimer’s disease zebrafish (Danio rerio) model was established to evaluate the neuroprotective effects of the aqueous extract of Liubao tea.Results:The contents of theabrownins, theaflavins, tea pigments, and catechins showed potential associations with the anti-AD capacity of Liubao tea. Variations in these bioactive components appeared to correlate with the neuroprotective activity.Conclusions:This study elucidates the anti-AD potential of aged Liubao tea and associates its characteristic constituents with neuroprotective effects. The findings provide essential theoretical support for developing Liubao tea as a promising natural product candidate worthy of further anti-AD research.
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Brazilian Journal of Pharmaceutical Sciences
·
2023
·
IF 1.3
Mei Xuejiao,Lu Dingqiang,Yan Xiangping
L-Malic acid is the Active Pharmaceutical Ingredient of the latest generation of compound electrolyte injection (STEROFUNDIN ISO, Germany) and plays a very important role in the rescue of critically ill patients. The optical purity of L-malic acid is a Critical Quality Attributes. A new reversed-phase high performance liquid chromatography (RP-HPLC) method for pre-column derivatization of D-malic acid enantiomer impurity in L-malic acid bulk drug was established. The derivatization reaction was carried out using (R)-1-(1-naphthyl)ethylamine ((R)-NEA) as a chiral derivatization reagent. The Kromasil C18 column was used with a detection wavelength of 225 nm, a flow rate of 1.0 mL·min-1, and a column temperature of 30 °C. The mobile phase was acetonitrile-0.01 mol·L-1 potassium dihydrogen phosphate solution (containing 20 mmol·L-1 sodium heptanesulfonate, adjusted to pH 2.80 with phosphoric acid) (at a ratio of 45:55) and the resolution of D-malic acid and L-malic acid derivatization products reached 1.7. The proposed method possesses the advantages of simple operation, mild conditions, stable derivatization products and low cost. Also it gave better separation and was more accurate than previous methods.
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Polymers
·
2022
·Vol. 14
·期 12
·2317
·
IF 4.967
Juliene Oliveira Campos de França,Deborah da Silva Valadares,Mateus Freitas Paiva,Sílvia Cláudia Loureiro Dias,José Alves Dias
Poly(lactic acid) (PLA) is an important polymer that is based on renewable biomass resources. Because of environmental issues, more renewable sources for polymers synthesis have been sought for industrial purposes. In this sense, cheaper monomers should be used to facilitate better utilization of less valuable chemicals and therefore granting more sustainable processes. Some points are raised about the need to study the total degradability of any PLA, which may require specific composting conditions (e.g., temperature, type of microorganism, adequate humidity and aerobic environment). Polymerization processes to produce PLA are presented with an emphasis on D,L-lactic acid (or rac-lactide) as the reactant monomer. The syntheses involving homogeneous and heterogeneous catalytic processes to produce poly(D,L-Lactic acid) (PDLLA) are also addressed. Additionally, the production of blends, copolymers, and composites with PDLLA are also presented exemplifying different preparation methods. Some general applications of these materials mostly dedicated to the biomedical area over the last 10–15 years will be pointed out.Keywords:poly(lactic acid)-PLA;polymerization based on D,L-lactic acid;D,L-lactide;stereo polymerization of D,L-lactic acid;blends of PLA;poly(DL-lactide-co-polymer);composites of PDLLA
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NEW JOURNAL OF CHEMISTRY
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2020
·Vol. 45
·期 3
·1721-1726
·
IF 3.288
Yin Zheng,Jiabing Chen,Youluan Lu,Xinjian Song,Zhen Shi
Three-dimensional interconnected porous carbon nanosheets were prepared through pyrolyzing sodium D-isoascorbic acid, and were thoroughly characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD). The specific surface area and pore size distribution of the porous carbon nanosheets were characterized by N2 adsorption desorption. The thickness of the carbon nanosheet was measured by atomic force microscopy (AFM). An electrochemical sensor was fabricated by the modification of the porous carbon nanosheets onto a glassy carbon electrode surface. The electrochemical behaviors of hydroquinone (HQ) and catechol (CA) on the electrochemical sensor were investigated by cyclic voltammetry and differential pulse voltammetry. Under the optimized conditions, the peak currents were found to be linear to the HQ and CA concentrations in the range from 0.4 to 20 μmol L−1, and the detection limits were 0.028 μmol L−1 (HQ) and 0.035 μmol L−1 (CA), respectively.
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DYES AND PIGMENTS
·
2014
·
IF 3.468
Xu-Feng Zang,Teng-Long Zhang,Zu-Sheng Huang,Zafar Iqbal,Dai-Bin Kuang,Lingyun Wang,Herbert Meier,Derong Cao
Three organic dyes with double D–A system were synthesized and applied in the dye-sensitized solar cells. These dyes contain phenothiazine as an electron donor and cyanoacetic acid as an acceptor/anchor. Linkages were incorporated at the ortho-, meta- and para-positions and their impact on the performance of photovoltaic was observed. Among them, the dye with a para-position linkage exhibited the highest short-circuit photocurrent density (12.26 mA cm −2 ) and open-circuit photovoltage (756 mV), leading to the best overall efficiency (6.14%) due to better light harvesting capacity under standard global 1.5 AM conditions. Under similar measuring conditions the dyes with ortho and meta-position linkage delivered sunlight to electricity conversion efficiencies of 5.25% and 5.85% respectively. The result shows the position isomer of the linkage units influences the photophysical characteristics, dye loading on the film and electron lifetime .
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危险品化学品经营许可证（带存储）