ACTA BIOCHIMICA ET BIOPHYSICA SINICA
·
2024
·
IF 3.3
Yao Deng,Yujie Li,Mingyue Yang,Yang Gao,Xuling Luo,Hanbin Chen,Meng Guo,Xuefeng Yang,Yongzhang Liu,Jun He,Bin Lu,Naxin Liu
Hepatocellular carcinoma (HCC) is one of the most prevalent and deadly cancers in the world, which is frequently diagnosed at a late stage. HCC patients have a poor prognosis due to the lack of an efficacious therapeutic strategy. Approved drug repurposing is a way for accelerating drug discovery and can significantly reduce the cost of drug development. Carfilzomib (CFZ) is a second-generation proteasome inhibitor, which is highly efficacious against multiple myeloma and has been reported to possess potential antitumor activities against multiple cancers. However, the underlying mechanism of CFZ on HCC is still unclear. Here, we show that CFZ inhibits the proliferation of HCC cells through cell cycle arrest at the G2/M phase and suppresses the migration and invasion of HCC cells by inhibiting epithelial-mesenchymal transition. We also find that CFZ promotes reactive oxygen species production to induce endoplasmic reticulum (ER) stress and activate JNK/p38 MAPK signaling in HCC cells, thus inducing cell death in HCC cells. Moreover, CFZ significantly inhibits HCC cell growth in a xenograft mouse model. Collectively, our study elucidates that CFZ impairs mitochondrial function and activates ER stress and JNK/p38 MAPK signaling, thus inhibiting HCC cell and tumor growth. This indicates that CFZ has the potential as a therapeutic drug for HCC.
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高影响因子
Small
·
2024
·
IF 13
Weijin Yang,Cheng Bu,Min Zhao,Yafei Li,Shihai Cui,Jing Yang,Hongzhen Lian
In this work, novel ternary composite ZIF-67/Ag NPs/NaYF 4 :Yb,Er is synthesized by solvothermal method. The photocatalytic activity of the composite is evaluated by sulfadiazine (SDZ) degradation under simulated sunlight. High elimination efficiency of the composite is 95.4% in 180 min with good reusability and stability. The active species (h + , ·O 2 − and ·OH) are identified. The attack sites and degradation process of SDZ are deeply investigated based on theoretical calculation and liquid chromatography-mass spectrometry analysis. The upconversion mechanism study shows that favorable photocatalytic effectiveness is attributed to the full utilization of sunlight through the energy transfer upconversion process and fluorescence resonance energy transfer. Additionally, the composite is endowed with outstanding light-absorbing qualities and effective photogenerated electron–hole pair separation thanks to the localized surface plasmon resonance effect of Ag nanoparticles. This work can motivate further design of novel photocatalysts with upconversion luminescence performance, which are applied to the removal of sulphonamide antibiotics in the environment.
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高影响因子
ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Ziying Wang,Xinyu Li,Sihan Yang,Xuejiao Wang,Ji-Guang Li
The development of upconversion (UC) luminescent materials with negative thermal expansion (NTE) is of great importance to achieve high-performance temperature sensing. However, simultaneously enhancing UC luminescence and moisture resistance to overcome performance limitations remains a major challenge. In this work, an aliovalent cation substitution strategy is designed in which (NaMg)3+, (KMg)3+, and (RbMg)3+ are used to replace the Sc3+ in Sc2Mo3O12: Yb, Er phosphor, leading to significant structure transformation and remarkable enhancement in luminescence and moisture resistance. Among them, NaMgScMo3O12: Yb, Er exhibited a 29-fold enhancement in emission intensity and an increase in the water contact angle from 22.15° to 29.25°. Due to the efficient energy transfer induced by NTE effect, the emission intensity of NaMgScMo3O12: Yb, Er is 17 times higher than that of Sc2Mo3O12:Yb, Er at 548 K. The temperature sensing capability of NaMgScMo3O12: Yb, Er is investigated using the fluorescence intensity ratio (FIR) technique, revealing a maximum relative sensitivity (SR) of 1.17% K–1 (323 K). Furthermore, a superhydrophobic flexible film (water contact angle of 134.68°) temperature sensor is fabricated for monitoring ceramic heating element, achieving a low temperature uncertainty of 0.23–1.12 K. This work provides an approach for temperature sensing with NTE luminescent materials.
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Journal of Materials Chemistry C
·
2026
·
IF 5.1
Yuanhao Chen,Xiaoshan Zhang,Yirong Liu,Haisheng Liu,Dechao Yu,Dawei Zhang
Gadolinium gallium garnet has been emerging as a starlet for preparing efficient luminescent materials, while via crystal field engineering the luminescence properties of rare-earth activator in its solid solution phosphors were scarcely explored. In this work, Er 3+ -doped Gd 3 Zn x Ga 5-2x Ge x O 12 (GZG 5- 2x G:Er 3+ ) solid solutions were prepared by high-temperature solid-state reaction, where a hetero-valent co-substitution strategy was implemented via introducing Zn 2+ /Ge 4+ pair to replace 2 Ga 3+ sites. X-ray diffraction Rietveld refinements confirm all samples crystallized into pure garnet phase. Upon 381 nm excitation, Er 3+ concentration was spectrally optimized to be about 10%, substituting the Gd 3+ sites, and via the Zn 2+ /Ge 4+ co-substitution, luminescence intensity of GZG 2 G:10%Er 3+ increases by more than 3 times in comparison with that of the baseline GZGG:10%Er 3+ sample. All the GZG 5-2x G:10%Er 3+ solid solution samples color in bright green under illumination using an ultraviolet ~ 365 nm lamp.Thermometric properties of Er 3+ 2 H 11/2 -4 S 3/2 thermally coupled levels of were systematically studied on basis of fluorescence intensity ratio principle. The GZG 5-2x G:10%Er 3+ all can perform temperature sensing over a wide temperature range of 298-573 K with a maximum relative sensitivity (S r ) above 1.20% K -1 and an applicable minimum temperature resolution (δT) around 0.4 K. Continuous exploration of solid solution-manipulating luminescent properties would develop novel thermometry probes (particularly for activator with spin-allowed transitions) with higher S r and smaller δT for practical optical temperature sensing.
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高影响因子
Journal of Functional Foods
·
2026
·
IF 3.9
Ying Zhang,Xue Zhang,Qiu Zhong,Mingyue Yu,Qianfei Wei,Caiping Xu,Yuecheng Liu,Yi Zhao,Yi Wu,Xin Wu,Yanyun Che
Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is becoming increasingly prevalent worldwide. It has a complex, multifactorial pathogenesis and limited therapeutic efficacy. Emerging evidence indicates that Phyllanthus emblica polyphenols (PEP) exert protective effects against UC. However, its precise molecular mechanisms have yet to be fully elucidated. In this study, 71 polyphenolic compounds were identified from PEP using UPLC-Q-Exactive Orbitrap/MS, including 8 flavonoids, 27 phenolic acids, and 2 lignans. The symptoms of UC in mice were significantly reduced by PEP when induced with dextran sulfate sodium (DSS). Histological and biochemical analyses revealed that PEP ameliorated mucosal damage, restored goblet cell numbers, and enhanced the expression of tight junction (TJ) proteins, indicating improved intestinal barrier integrity. This restoration of barrier function was associated with the attenuation of endoplasmic reticulum (ER) stress, evidenced by the downregulation of the ATF4/eIF2α/CHOP signaling pathway, and a concurrent reduction in intestinal epithelial cell apoptosis involving the modulation of the Bax/Bcl-2 balance and Caspase 3 expression. In parallel, gut microbiota analysis showed that PEP restored microbial community structure, increasing the relative abundance in a higher Firmicutes/Bacteroidetes ratio. Furthermore, PEP enhanced short-chain fatty acid (SCFA) production, particularly acetic, propionic, isobutyric, and isovaleric acids, which were positively correlated with beneficial bacterial taxa. Collectively, these findings demonstrate that PEP exerts therapeutic effects against UC by modulating the interplay between intestinal barrier integrity, ER stress, the apoptotic pathway, and the gut microbiota-SCFA metabolism axis.
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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2021
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IF 5.302
He Junjie,He Guo,Liu Jing,Tao Jingchao
High-entropy ceramics exhibit great application potential as thermal barrier coating (TBC) materials. Herein, a series of novel high-entropy ceramics with RE 2 (Ce 0.2 Zr 0.2 Hf 0.2 Sn 0.2 Ti 0.2 ) 2 O 7 (RE 2 HE 2 O 7 , RE = Y, Ho, Er, or Yb) compositions were fabricated via a solid-state reaction. X-ray diffraction (XRD) and energy dispersive spectrometry (EDS) mapping analyses confirmed that RE 2 HE 2 O 7 formed a single defect fluorite structure with uniform elemental distribution. The thermophysical properties of the RE 2 HE 2 O 7 ceramics were investigated systematically. The results show that RE 2 HE 2 O 7 ceramics have excellent high-temperature phase stability, high thermal expansion coefficients (10.3–11.7 × 10 −6 K -1 , 1200 ℃), and low thermal conductivities (1.10-1.37 W m -1 K -1 , 25 ℃). In addition, RE 2 HE 2 O 7 ceramics have a high Vickers hardness (13.7–15.0 GPa) and relatively low fracture toughness (1.14-1.27 MPa m 0.5 ). The outstanding properties of the RE 2 HE 2 O 7 ceramics indicate that they could be candidates for the next generation of TBC materials.
研究领域:
材料科学
·
陶瓷
·
热工工程
·
高温材料
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高影响因子
Small
·
2026
·
IF 11.8
Wuxi Zhang,Jianyu Li,Yangke Cun,Xinmin Bai,Yingzhu Zi,Zan Xu,Jianbei Qiu,Zhaoyu Ma,Junying Zhang,Zhengwen Yang
Most widely-studied semiconductor catalysts have low efficiency in utilizing near-infrared (NIR) light in the solar spectrum, while also facing major issues such as slow charge-carrier migration rate and lack of active sites that limit photocatalytic performance. Here, a new strategy to promote the solar-light driven photocatalytic activity of ZnIn 2 S 4 was proposed by introducing Rh single atom (SAs) into CeO 2 :Yb,Er/ZnIn 2 S 4 with photo-thermo-electric effects. The introduction of Rh SAs into ZnIn 2 S 4 effectively suppresses charge recombination, and improves reaction rate through photo-thermal effect. CeO 2 :Yb, Er converts NIR light into visible light via up-conversion photo-optical processes and generates high-energy electrons via two-photon photo-electronic process, both of which can activate ZnIn 2 S 4 . Large contact area and strong interface electric field between CeO 2 and ZnIn 2 S 4 enhance photo-electric conversion efficiency. The CeO 2 :Yb,Er/Rh-ZnIn 2 S 4 exhibits a hydrogen production rate of up to 99.68 mmol·g −1 ·h −1 at 10°C and 148.06 mmol·g −1 ·h −1 with non-temperature-controlled conditions. Under mild conditions, the photocatalysts can convert glucose into high-value-added chemicals (e.g., arabinose) while simultaneously generating hydrogen. This work provides a new strategy to improve NIR light utilization efficiency and enhance charge-carrier separation capability through photo-thermo-electric effects, promoting the production of green hydrogen and biomass conversion into high-value-added chemicals.
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高影响因子
BIOCHEMICAL PHARMACOLOGY
·
2022
·
IF 6.1
Yi Li,Wenyan She,Tangxi Guo,Tianhe Huang,Yixin liu,Pan Liu,Xiaoran Xu,Xinyu Wang,Miao Wang,Chaochao Yu,Yi Liu,Yongchang Wei
Developing novel drugs for gastric cancer (GC) is greatly needed, and a reactive oxygen species (ROS)-modulating strategy has been demonstrated to be useful for cancer treatment. However, no organic arsenical-derived ROS-modulating drug has been developed in GC. Here, we constructed ACZ2 and investigated its efficacy and potential mechanism for GC in vitro and in vivo. Our data showed that ACZ2 could inhibit GC proliferation and cause G2/M phase arrest. Moreover, ACZ2 induced ROS accumulation by depleting glutathione (GSH) and TrxR1, triggering a subsequent ER stress response by activating the PERK/EIF2/ATF4/CHOP signalling pathways, which is a crucial step for ACZ2-mediated apoptosis and autophagy. Vitally, ROS scavenger (NAC) and ER stress inhibitor (4PBA) reversed ACZ2/ROS/ER stress-mediated apoptosis and autophagy. Our in vivo results clearly demonstrated that ACZ2 suppressed tumour growth in a GC xenograft model. Collectively, our data indicated that ACZ2 is a potential agent against GC.
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BIOMEDICINE & PHARMACOTHERAPY
·
2022
·
IF 7.419
Kai Zhou,Hua Chen,Xiao-yu Wang,Yan-mei Xu,Yu-feng Liao,Yuan-yuan Qin,Xue-wan Ge,Ting-ting Zhang,Zhong-lin Fang,Bei-bei Fu,Qing-Zhong Xiao,Feng-qin Zhu,Si-rui Chen,Xue-sheng Liu,Qi-chao Luo,Shan Gao
Background and purpose Xin-Ji-Er-Kang (XJEK) is traditional Chinese formula presented excellent protective effects on several heart diseases, but the potential components and targets are still unclear. The aim of this study is to elucidate the effective components of XJEK and reveal its potential mechanism of cardioprotective effect in myocardial ischemia-reperfusion (MIR) injury. Experimental approach Firstly, the key compounds in XJEK, plasma and heart tissue were analyzed by high resolution mass spectrometry. Bioinformatics studies were also involved to disclose the potential targets and the binding sites for the key compounds. Secondly, to study the protective effect of XJEK on MIR injury and related mechanism, mice subjected to MIR surgery and gavage administered with XJEK for 6 weeks. Cardiac function parameters and apoptosis level of cardiac tissue were assessed. The potential mechanism was further verified by knock down of target protein in vitro. Results Pharmacokinetics studies showed that Sophora flavescens alkaloids, primarily composed with matrine, are the key component of XJEK. And, through bioinformatic analysis, we speculated JAK2 could be the potential target for XJEK, and could form stable hydrogen bonds with matrine. Administration of XJEK and matrine significantly improved heart function and reduced apoptosis of cardiomyocytes by increasing the phosphorylation of JAK2 and STAT3. The anti-apoptosis effect of XJEK and matrine was also observed on AC16 cells, and could be reversed by co-treatment with JAK2 inhibitor AG490 or knock-down of JAK2. Conclusion XJEK exerts cardioprotective effect on MIR injury, which may be associated with the activation of JAK2/STAT3 signaling pathway.
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OPTICAL MATERIALS
·
2022
·
IF 3.754
Fenglei Sun,Zhenlei Yuan,Peng Guo,Haifeng Zhou,Jiaxuan Wang,Chuan Liao,Caoyuan Niu,Guangjun Zhou,Xiaoqiang Yu
In this study, we designed a dual functional nanosensor for detecting Cr (Ⅲ) and sodium tripolyphosphate (STPP) based on fluorescence resonance energy transfer (FRET) mechanism between amine functionalized upconversion nanoparticles (UCNPs) and gold nanoparticles (AuNPs), where UCNPs serve as energy donor and aggregated AuNPs as energy acceptor. UCNPs have red emission at 654 nm under 980 nm laser excitation and monodispersed AuNPs show strong absorbance around 520 nm. Monodispersed AuNPs form aggregate easily in the presence of Cr (Ⅲ), which leads to the red-shift of the absorption of AuNPs and quenches the red emission of UCNPs. In the presence of STPP, the formation of Cr (Ⅲ)-STPP complex weakens the aggregation extent of AuNPs and the red emission of UCNPs increases. Therefore, the content of Cr (Ⅲ) and STPP could be detected in wide range according to the linear variety of fluorescence intensities of UCNPs at 654 nm with the detection limits of 0.44 μM and 0.54 μM for detecting Cr (Ⅲ) and STPP, respectively. In addition, due to the high selectivity and accuracy for the detection of STPP, this nanosensor can be utilized to determine STPP in green tea drink and drinking water.
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高影响因子
DALTON TRANSACTIONS
·
2021
·Vol. 50
·期 22
·7826-7834
·
IF 4.39
Xiangyu Zhang,Jialing Wu,Peng Wang,Jie Gao,Feng Gao,Dangli Gao
The majority of the fabrication procedures of lanthanide-doped materials involve thermal treatment that often results in crystallite regrowth, stabilizing the specific crystal structure and resulting in luminescence enhancement. The efficiency and intensity of up-conversion luminescence are closely related to the structure and synthesis process of the materials. Herein, well-crystallized and pure tetragonal NaY(MoO4)2 microcrystals with a uniform octahedral shape have been successfully synthesized via an environmentally friendly hydrothermal method, followed by annealing treatment. The phases, structures, morphologies, and compositions of the synthesized products annealed at 500–1000 °C remain unchanged, indicating high thermal stability. Furthermore, the NaY(MoO4)2:Yb3+/Er3+ microcrystals exhibit strong green emission when irradiated using infrared (980 nm) or ultraviolet (378 nm) wavelengths. Upon 980 nm excitation, up to 37-fold luminescence enhancement is achieved when the samples are annealed at about 700 °C. Interestingly, the high colour purity of the strong green emission is not only independent of the dopant concentration and heat treatment temperature, but it is also independent of the excitation conditions, including power and wavelength, and this makes it particularly suitable as a green safety signal light and luminescent security ink in paintings. As-prepared safety inks with NaY(MoO4)2:Yb3+/Er3+ microcrystals were used for visual fingerprint recognition printed on A4 paper with three-level fingerprint security features, significantly increasing the difficulty of illegal imitation and enhancing the levels of anti-counterfeiting.
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CHEMOSPHERE
·
2020
·
IF 5.778
Jiawei Lei,Pingzhou Duan,Weijun Liu,Zhirong Sun,Xiang Hu
Due to the potential threatening of antibiotics in aqueous environment, a novel electro-oxidation (EO) — electro-Fenton (EF) —persulfate (PS) system with the addition of peroxydisulfate and Fe 2+ was installed for the degradation of cefotaxime. Ti/CNT/SnO 2 –Sb–Er with an ultra-high oxygen evolution potential (2.15 V) and enhanced electrocatalytic surface area was adopted as anode. The OH production and electrode stability test demonstrated great improvement in the electrochemical performances. Ni@NCNT cathode was tested with higher H 2 O 2 generation by the presence of nitrogen functionalities due to the acceleration of electron transfer of O 2 reduction. Experiment results indicated CNT and ErO 2 modification increased the molecular and TOC removal of cefotaxime. Coupling processes of EO-EF and EO-PS both resulted in shorter electrolysis time for complete cefotaxime removal, however, the mineralization ability of EO-PS process was lower than EO-EF, which might result from the immediate vanishing of PS. Thus, a further improved treatment EO-EF-PS system achieved an 81.6% TOC removal towards 50 mg L −1 cefotaxime after 4 h electrolysis, under the optimal working condition Fe 2+ = PS = 1 mM. The influence of current density and initial concentration on the performance of all processes was assessed. Methanol and tert-butanol were added in the system as OH and SO 4 − scavengers, which illustrating the mechanism of EO-EF-PS oxidizing process was the result of the two free radicals. Major intermediates were deduced and the degradation pathway of cefotaxime was analyzed. This research provides a potential coupling process with high antibiotic removal efficiency and effective materials for practical uses.
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