COLLOIDS AND SURFACES B-BIOINTERFACES
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2022
·
IF 5.999
Xiaowei Yang,Zhihui Kuang,Xinmin Yang,Xin Hu,Peng Luo,Qi Lai,Bin Zhang,Xiaoyong Zhang,Yen Wei
Osteoporosis is an age-related metabolic disease of bone, resulting in bone pain and even bone fragility and brittle fracture . Inhibiting overactive osteoclasts while promoting osteoblast activity is an ideal way to treat osteoporosis. Previous studies have demonstrated that natural compounds , such as curcumin (Cur) have dual roles both in promoting bone formation and inhibiting bone resorption , making them promising candidates for osteoporosis treatment . However, their poor water solubility, high dosage of curative effect and significant toxicity to other organs have largely limited their clinical translations. In this study, a novel method was reported to conjugate Cur and poly(amidoamine) dendrimers (PAD) using hexachlorocyclotriphosphazene (HCCP) as the linkage through a one-pot reaction, forming stable and uniform Cur loaded nanospheres (HCCP-Cur-PAD, HCP NPs). Owing to the hydrophilicity of PAD and hydrophobicity of Cur, HCP NPs can self-assemble into nanoparticles with particle size of 138.8 ± 78.7 nm and display excellent water dispersity . The loading capacity of Cur can reach 27.2% and it can be released from HCP NPs with pH-responsiveness. In vitro experimental results demonstrated that the HCP NPs entered lysosomes by endocytosis and proved dual anti-osteoporosis effects of inhibiting osteoclasts and promoting osteoblasts.
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高影响因子
JOURNAL OF POLYMERS AND THE ENVIRONMENT
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2022
·Vol. 31
·期 1
·287-296
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IF 4.705
Xie Shiyu,Xu Bo,Yuan Li,Zhao Yaxin,Ma Na,Wang Yaomin,Liu Dagang,Xiang Aimin,Ouyang Yuge,Tian Huafeng
Zein as a natural protein had been widely used in various fields due to its biodegradability and biocompatibility. However, its sensitivity to humidity and poor mechanical performance limited its application in practice. In this study, zein-based composite nanofibers loaded with curcumin were prepared by electrospinning assisted with polyvinyl alcohol (PVA). The filtration efficiency of the modified nanofibers to the particles with diameters larger than 0.5 μm was all above 98%. The loaded curcumin interacted with protein molecular chains to form a network structure within tightly connected nanofibers, which exhibited excellent moisture resistance and good adhesion to cellulose paper towels used as air filter substrates. Meanwhile, its tensile strength had also been enhanced vastly to 0.72 MPa compared with the initial tensile strength of 0.21 MPa. This study provides a new electrospinning strategy for the preparation of zein-based composite nanofibers that can be widely utilized in air filtration with high moisture resistance.
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ACS Applied Bio Materials
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2022
·
IF 0
Ruofan Wang,Liming Ruan,Guohua Jiang,Pengfei Li,Uladzislau E. Aharodnikau,Khaydar E. Yunusov,Xiaofei Gao,Sergey O. Solomevich
Skin regeneration of full-thickness wounds remains a challenge, requiring a well-regulated interplay of cell–cell and cell–matrix signaling. Herein, the composite hydrogel films composed of silk fibroin (SF) and polyvinyl alcohol (PVA) as scaffolds loaded with curcumin nanoparticles (Cur NPs) were developed for skin wound healing. The structure and physicochemical properties of hydrogel films were first evaluated by scanning electron microscopy (SEM), water contact angle, and chemical and mechanical measurements. In addition, the as-fabricated composite hydrogel films have a unique 3D structure and excellent biocompatibility that facilitates the adhesion and growth of cells. Antimicrobial tests in vitro showed that they could inhibit the growth of bacteria due to the incorporation of Cur NPs into composite hydrogel films. The efficacy of the curcumin-loaded SF/PVA composite hydrogel films for skin wound healing was investigated on the skin defect model in vivo. Immunological analysis showed that the as-fabricated Cur NP-loaded SF/PVA composite hydrogel films inhibited inflammation at the wound sites, while promoting angiogenesis during the wound healing process.
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SENSORS AND ACTUATORS B-CHEMICAL
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2022
·
IF 9.221
Shaoyong Cai,Guangjie Song,Guofan Zhang,Lei Wang,Tianlan Jian,Jiatong Xu,Fengyu Su,Yanqing Tian
The colorimetric sensing label is a simple, cost-effective, and user-friendly tool for monitoring ammonia vapor (NH 3 ) concentrations in food packaging. Numerous natural dyes present excellent NH 3 -sensitivity, but their low solubility in water limits their food-related applications. Herein, a special cellulose-based ink system with an EtOH/water mixture as solvent was proposed to improve the dispersion of non-aqueous dyes (curcumin and its analogs (indexed as Bur and Bur-BF 2 )). Subsequently, three sensing labels containing different dyes were prepared by simple screen-printing after optimizing the inks' rheological properties. Benefiting from the different intramolecular charge-transfer (ICT) behaviors of dyes, each sensing label exhibited various characteristics in terms of the optical property , NH 3 -sensitivity, and fluorescent color-changing routes upon exposure to 0–50 ppm NH 3 . Importantly, all sensing labels showed excellent stability in environments with various relative humidity and temperature. Therefore, three sensing labels were used to construct a multicolor fluorescent sensor array, which aimed to visually monitor the freshness of shrimp for consumers.
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Polymers
·
2022
·Vol. 14
·期 11
·2133
·
IF 4.967
Ziwei Xia,Zhinan Fu,Li Li,Enguang Ma,Liang Sun,Qinyu Ma,Xuhong Guo
Metal coordination-driven nanocomplexes are known to be responsive to physiologically relevant stimuli such as pH, redox, temperature or light, making them well-suited for antitumor drug delivery. The ever-growing demand for such nanocomplexes necessitates the design of a scalable approach for their production. In this study, we demonstrate a novel coordination self-assembly strategy, termed flash nanocomplexation (FNC), which is rapid and efficient for the fabrication of drug-loaded nanoparticles (NPs) in a continuous manner. Based on this strategy, biocompatible chitosan (CS) and Cu2+can be regarded anchors to moor the antitumor drug (curcumin, Cur) through coordination, resulting in curcumin-loaded chitosan nanocomplex (Cur-loaded CS nanocomplex) with a narrow size distribution (PDI < 0.124) and high drug loading (up to 41.75%). Owing to the excellent stability of Cur-loaded CS nanocomplex at neutral conditions (>50 days), premature Cur leakage was limited to lower than 1.5%, and pH-responsive drug release behavior was realized in acidic tumor microenvironments. An upscaled manufacture of Cur-loaded CS nanocomplex is demonstrated with continuous FNC, which shows an unprecedented method toward practical applications of nanomedicine for tumor therapy. Furthermore, intracellular uptake study and cytotoxicity experiments toward H1299 cells demonstrates the satisfied anticancer efficacy of the Cur-loaded CS nanocomplex. These results confirm that coordination-driven FNC is an effective method that enables the rapid and scalable fabrication of antitumor drugs.Keywords:chitosan;flash nanocomplexation;coordination-driven;curcumin
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
·
IF 8.025
Xu Zhang,Yanfei Zhu,Lihong Fan,Junhong Ling,Li-Ye Yang,Nan Wang,Xiao-kun Ouyang
Mesoporous silica nanoparticles (MSN) are effective drug delivery carriers because of their adjustable large pore size and high porosity. In this study, complex nanoparticles containing disulfide bonds (SS) were designed and prepared as curcumin (Cur) carriers by using fucoidan (FUC) and MSN as the polymer matrix. The product was characterized using scanning electron microscopy, transmission electron microscopy, dynamic light scattering, Fourier-transform infrared spectroscopy, and an N 2 adsorption and desorption test. When the mass ratio of MSN to FUC was 2:1, the nanospheres particle size was the smallest (295.6 ± 0.98 nm, −35.2 ± 0.8 mV). Furthermore, the curcumin encapsulation rate by MSN-Cur-SS-FUC was over 90%, and the cumulative release rate in 24 h was over 80% due to the combined effect of weak acidity and high glutathione concentration in the tumor site microenvironment. When the Cur concentration was 50 μg/mL, the cell viability of free Cur was 63.8%, the cell viability of MSN-Cur-SS-FUC was 14.5%, and the cell viability of MSN-SS-FUC at the same concentration remained above 74.6%. MSN-SS-FUC composite nanoparticles showed a good delivery of Cur, a lipid-soluble active compound, and provides a new delivery route for other lipid-soluble and poorly bioavailable active compounds.
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Frontiers in Pharmacology
·
2022
·
IF 5.988
Xi Chen,Di Wang,Xuejun Guo,Xiaoming Li,Wenjing Ye,Yang Qi,Wen Gu
The present study was aim to prepare curcumin-loaded methoxypolyethylene-glycols-poly (lactic-co-glycolic acid) nanoparticles (Cur-mPEG-PLGA-NPs) and investigate curcumin's effect on reversing corticosteroid resistance induced by cigarette smoke extract (CSE) in rat tracheal epithelial (RTE) cells. The Cur-mPEG-PLGA-NPs were spherical, regular in shape with smooth surfaces, and well distributed and Cur-mPEG-PLGA-NP suspensions had good water solubility and presented prolonged release. Furthermore, we found that Cur-mPEG-PLGA-NPs were internalized more than curcumin into the cells and significantly alleviated apoptosis in RTE cells. In addition, 10% CSE reduced the maximal inhibition percentage and increased the half-inhibitory concentration of budesonide (BUD) on IL-8 secretion, and curcumin restored the efficacy of BUD inhibition. BUD in combination with Cur-mPEG-PLGA-NPs showed higher inhibitory rates for LPS- and CSE-induced IL-8 secretion than that in combination with curcumin. Moverover, the relative expression levels of HDAC2 was reduced after CSE exposure and curcumin could improve HDAC2 expression and reverse CSE-induced corticosteroid resistance. Curcumin in high concentration and Cur-mPEG-PLGA-NPs restored HDAC2 levels in RTE cells and thus Cur-mPEG-PCL-NPs have higher biological activity than curcumin.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Yi Li,Chunjing Guo,Qiang Chen,Yanguo Su,Huimin Guo,Ruoyang Liu,Changgang Sun,Shuqi Mi,Jinqiu Wang,Daquan Chen
Pneumonia can lead to high morbidity and mortality secondary to uncontrolled inflammation of the lung tissue. Blocking cytokine storm storms may be the key to saving the life of patients with severe pneumonia. According to the medicinal guide theory of Traditional Chinese Medicine (TCM) and the inherent affinity with macrophages for the site of inflammation, we constructed the drug delivery platform (MNPs) derived from macrophage-membrane encapsulated reaction oxygen species (ROS)-responsive Platycodon grandiflorum polysaccharides (PGP) nanoparticles (PNPs) to calm the cytokine storm and improve lung inflammation. By loading the anti-inflammatory agent Curcumin (Cur), we demonstrated that [email protected] significantly attenuated inflammation and cytokine storm syndrome in acute lung injury (ALI) mice by suppressing pro-inflammatory factor production and inflammatory cell infiltration. Interestingly, we observed that the PNPs also have potent pulmonary targeting ability compared to other polysaccharide carriers, which is in line with the medicinal guide theory of TCM. Our study revealed the rational design of drug delivery platforms to improve the treatment of lung injury, which inherits and develops the important theories of TCM through the perfect combination of guide theory and biomimetic nanotechnology and provides the experimental scientific basis for the clinical application of channel ushering drugs.
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Frontiers in Bioengineering and Biotechnology
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2022
·
IF 6.064
Li Wanyu,Chen Yanan,He Kun,Cao Tianshou,Song Daibo,Yang Huiling,Li Li,Lin Jiantao
The mitochondrion is one of the most important cellular organelles, and many drugs work by acting on mitochondria. Curcumin (Cur)-induced apoptosis of HepG2 in liver cancer cells is closely related to the function of inhibiting mitochondria. However, the mitochondrion-targeting curcumin delivery system was rarely been reported. It is important to develop a high-efficiency mitochondrion-targeting curcumin vector that can deliver curcumin into mitochondria directly. Here, a special mitochondrion-targeting delivery system based on triphenylphosphine bromide (TPP)-chitosan-g-poly-(N-3-carbobenzyloxy-l-lysine) (CZL) with TPP functional on the surface is designed to perform highly efficient mitochondria-targeting delivery for effective liver cancer cell killing in vitro. The TEM images showed that the nanomicelles were spherical; the results of fluorescence test showed that TPP-CZL nanomicelles could promote the cellular uptake of drugs and finally targeted to the mitochondria. The results of cell survival rate and Hoechst staining showed that curcumin/TPP-CZL nanomicelles could promote the apoptosis of liver cancer cells. Curcumin/TPP-CZL nanomicelles could significantly reduce the mitochondrial membrane potential, increase the expression of pro apoptotic protein Bcl-2, and reduce the expression of antiapoptotic Bax protein, and these results were significantly better than curcumin/CZL nanomicelles and curcumin. It is a potential drug delivery system with high efficiency to target mitochondria of liver cancer cells.
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JOURNAL OF CHEMICAL THERMODYNAMICS
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2021
·
IF 3.178
Rongguan Lv,Xuehua Zhang,Rong Xing,Weizhong Shi,Hongkun Zhao,Wanxin Li,Abolghasem Jouyban,William E. Acree
The intermolecular interactions and overall charge distribution of curcumin were respectively investigated by using Hirshfeld surface analysis and molecular electrostatic potential surface. The mole fraction solubility magnitudes of curcumin (I) in aprotic co-solvent blends of DMSO + water, acetone + water and acetonitrile + water ranging from 278.15 to 318.15 (333.15) K under 101.1 kPa was obtained by means of shake-flask method. Under the same conditions, e.g. identical temperature and mass fraction of DMSO (acetone or acetonitrile), the equilibrium solubility of curcumin was greater in DMSO + water blends than in acetone/acetonitrile + water blends. The lowest solubility magnitude was found in neat water at 278.15 K; and the highest one, in acetone/acetonitrile at temperature of T = 318.15 K (aqueous solutions of acetone or acetonitrile) or 333.15 K (aqueous solutions of DMSO). No crystal transition and solvate formation occurred in experimental processes as documented through X-ray power diffraction analysis. The acquired data were correlated by means of the Jouyban-Acree model, Apelblat model and modified van’t Hoff-Jouyban–Acree model. The preferential solvation at 298.15 K was investigated by the approach of inverse Kirkwood–Buff integrals. The parameters of preferential solvation for DMSO, acetone or acetonitrile were positive in the above three blends with middle and DMSO/acetone/acetonitrile-rich composition ranges, which specified that preferential solvation of curcumin was made by co-solvent. The extended Hildebrand solubility approach was further employed to describe the mole fraction solubility at 298.15 K in DMSO/acetone/acetonitrile + water blends studied in the current work and in ethanol/ n -propanol/isopropanol/PG + water blends reported previous by us, obtaining average relative deviations < 5.21%.
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INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
·
2021
·Vol. 57
·期 3
·1609-1620
·
IF 3.713
Hong Zhuang,Xinyu Jiang,Sijia Wu,Xueqian Li,Haiyang Yan
Curcumin has excellent antioxidant and antibacterial properties. The poor solubility and easy degradation limit its application. The present investigation was aimed to prepare curcumin nanoemulsions (Cur-Ne), employing homogeneous and ultrasonication for the encapsulation of curcumin to overcome these problems. Cur-Ne stabilised using whey protein isolate and rhamnose conjugate (Wpi-Rha) was prepared by Maillard reaction. Furthermore, the processing ( i.e . ionic strength, heat and freeze-thaw) and storage stability of Cur-Ne were evaluated. Moreover, the bactericidal capacity of Cur-Ne combined with photodynamic therapy (PDT) technology was estimated. Cur-Ne was prepared successfully with the droplet size of 185.97 ± 6.65 nm, polydispersity index (PDI) of 0.21 ± 0.01, zeta potential of −35.17 ± 0.15mV and entrapment efficiency of 97.0 ± 0.07%. Meanwhile, Cur-Ne was stable at different storage and processing conditions. In addition, the DPPH and ABTS radical scavenging rates of Cur-Ne were 84.86 ± 0.24% and 99.63 ± 0.48%, respectively. At the adding amount of 5 μL of Cur-Ne, the Cur-Ne could deactivate the Escherichia coli and Staphylococcus aureus with the antibacterial rate of 99.05 ± 0.13% and 99.11 ± 0.18%, respectively. Curcumin loaded in nanoemulsion and combined with PDT provide new ideas for food storage and sterilisation.
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JOURNAL OF MOLECULAR STRUCTURE
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2023
·
IF 3.8
Rui Shen,Jie Zhang,Xi Wang
The prime active ingredient of the herb curcuma longa , curcumin (CUR) has extensive pharmacological activities and high security. However, the low solubility severely restricts its investigation and application as a drug. In this paper, a new cocrystal, CUR–BPY, assembled by CUR and BPY (4,4′-bipyridine) has been synthesized and characterized by various analytical methods. Single-crystal X-ray diffraction reveals that CUR–BPY contains a pentameric BPY–CUR–BPY–CUR–BPY supramolecular architecture connected by O H⋯N hydrogen bonds and further extended to give a 1D loop-like chain through aromatic interactions. Powder dissolution experiment reveals that CUR–BPY exhibits obvious spring phenomenon and about 7 times higher apparent solubility than that of raw curcumin. The improved dissolution performance should be ascribed to the careful selection of BPY coformer and expected O H⋯N weak hydrogen bonding in CUR-BPY cocrystal.
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