查找使用阿拉丁产品的科研文献

Formulation of water-in-oil-in-water (W/O/W) emulsions containing trans-resveratrol

Jun Wang,Aimin Shi,Dominic Agyei,Qiang Wang

Resveratrol is a high-value bioactive polyphenolic compound with vast applications in functional foods; as such, effective and scalable delivery strategies for this compound are worthy of study. In this research, W/O/W emulsions were successfully prepared using polyglycerol polyricinoleate (PGPR) as a lipophilic emulsifier and Tween 80 as a hydrophilic emulsifier with the goal of developing biocompatible carriers to improve the bioavailability of resveratrol. The effects of the type of emulsifier, the concentration of emulsifier, the ratio of the oil phase to the internal water phase, and homogeneous pressure on the physical properties of the W/O/W emulsions (such as microstructure, droplet size, distribution, zeta potential, viscosity and encapsulation efficiency) were investigated. The optimum processing conditions for preparing W/O/W emulsions are as follows: the ratio of the oil phase to the internal water phase is 80 : 20, the concentrations of lipophilic and hydrophilic emulsifiers are 10 wt% and 5 wt%, and the homogeneous pressures in the first and second steps are 30 MPa and 10 MPa. The optimal preparation process of the W/O/W emulsions was used to encapsulate resveratrol. The results showed that at up to 0.040 wt% in the internal water phase (ethanol), resveratrol could be successfully encapsulated in W/O/W emulsions with an encapsulation efficiency of 99.97 ± 0.001%. Moreover, resveratrol was successfully encapsulated in the internal water phase and oil phase together; thus, it was not necessary to increase the amount of carrier materials. This study provides a novel encapsulation formulation to increase the delivery efficacy of resveratrol.

Low-Voltage Operating Field-Effect Transistors and Inverters Based on In₂O₃ Nanofiber Networks

Yufeng Xia,Gang He,Wenhao Wang,Qian Gao,Yanmei Liu

Ultrasensitive and selective fluorescence recognition of selenite by o-phenylenediamine functionalized carbon quantum dots

Wenxian Wang,Yufei Zhou,Dan Yang,Xianfen Zhang,Lijiao Guan,Yuding Zhang,Saipeng Huang

Selenite (SeO32−), as the most toxic form of selenium in water, is a great threat to water quality and human health, which also has been closely associated with various physiological and pathological processes. The sensitive detection and quantification of SeO32− are imperative for the early diagnosis and prevention of selenite-associated disease. Herein, we constructed novel o-phenylenediamine functionalized carbon quantum dots (OPD-CQDs) by a one-step hydrothermal method. The OPD-CQDs exhibited good water solubility, high quantum yield, strong photostability, excellent biocompatibility and cell imaging capabilities, and also displayed high selectivity and sensitivity to SeO32− with an excellent linear relationship and a low limit of detection (86 nM). Moreover, the OPD-CQDs were successfully employed for the quantitative determination of SeO32− in tap water and human serum with high accuracy and recovery rate. In particular, the designed OPD-CQDs were successfully applied for intracellular SeO32− detection with excellent biocompatibility and cellular imaging capability. The present research demonstrated that OPD-CQDs provided a novel approach for imaging and detecting SeO32− in live cells and in vivo. Based on these excellent properties and comprehensive applications, OPD-CQDs illustrated great potential to offer a scientific and effective method for SeO32− detection in complex environments and clinical early diagnosis of SeO32− related diseases.

Illiciumlignans G–O from the leaves of Illicium dunnianum and their anti-inflammatory activities

Sen-Ju Ma,Hai-Bo Li,Ting Li,Zhen-Zhen Su,Zhen-Zhong Wang,Xin-Sheng Yao,Wei Xiao,Yang Yu

Phytochemical investigations on the dry leaves of Illicium dunnianum have led to the isolation of 24 lignans. Illiciumlignans G–K (1–5) were five undescribed benzofuran lignans, illiciumlignan L (6) was one undescribed ditetrahydrofuran lignan, illiciumlignans M–O (7–9) were three new sesquilignans, and compounds 10, 12, 13, 15, and 18–21 were firstly isolated from the genus Illicium. Their structures were elucidated by detailed spectroscopic analyses (UV, IR, HR-ESI-MS, and NMR) and CD experiments. All isolates were evaluated by measuring their inhibitory effects on PGE2, and NO production in LPS-stimulated RAW 264.7 macrophages.

Ginsenoside-Rb1 Improved Diabetic Cardiomyopathy through Regulating Calcium Signaling by Alleviating Protein O-GlcNAcylation

Linhui Qin,Jianping Wang,RongRong Zhao,Xiao Zhang,Yingwu Mei

Ginsenoside-Rb1 (Rb1), a major active component of ginseng, has many benefits for cardiovascular disease and diabetes mellitus (DM), but the effect and mechanism on diabetic cardiomyopathy are not clear. In the present study, we found that Rb1-feeding significantly improved cardiac dysfunction and abnormal cardiomyocytes calcium signaling caused by diabetes. This improved calcium signaling was because Rb1 reduced Ca2+ leakage caused by overactivated ryanodine receptor 2 (RyR2) and increased Ca2+ uptake by sarcoplasmic reticulum Ca2+-ATPase 2a (SERCA 2a). Furthermore, we found that Rb1 not only enhanced energy metabolism like metformin and eliminated O-GlcNAcylation of calcium handling proteins to regulate calcium signaling but also directly inhibited RyR2 activity to regulate calcium signaling. The present study indicated that as a health supplement or drug, Rb1 was a relatively effective auxiliary therapeutic substance for diabetic cardiomyopathy.

O-bridged NiSe2/CQDs composite synergistically triggers interfacial electrons transfer to promote H2O2 electrosynthesis

Qianqian Xu,Haihong Zhong,Chunli Li,Rong Jiang,Yongjun Feng,Luis Alberto Estudillo-Wong

Modulating the electronic structure of electrocatalysts represents a widely employed strategy to enhance the oxygen reduction reaction (ORR) activity and H 2 O 2 selectivity, yet achieving precise control over this process remains challenging. In this work, we introduce oxygen-doped carbon quantum dots (O-CQDs) into NiSe 2 nanoparticles/nanosheets to regulate the electronic structure of Ni active sites. This optimization promotes favorable O 2 adsorption and reduces the energy barrier for • OOH formation, thereby significantly boosting the electrocatalytic production of H 2 O 2 via the two-electron (2e – ) ORR pathway. Combined spectroscopic analysis and density functional theory calculations reveal that the O-bridged interface facilitates electron transfer to surface Ni sites, strengthening O 2 adsorption in an “end-on” configuration and favoring the 2e – ORR mechanism. The resulting O-bridged NiSe 2 /CQDs catalyst exhibits outstanding 2e – ORR performance under alkaline conditions, achieving a high H 2 O 2 production rate of 7458.24 mmol g cat –1 h –1 at 31.25 mA cm –2 and a Faradaic efficiency of 92.88% at 0.5 V. The efficient degradation of the Rhodamine B and Methylene Blue is achieved by utilizing the electrolyte obtained after the H 2 O 2 electrosynthesis process as a Fenton reagent. This study demonstrates that rational tailoring of interfacial charge distribution in hybrid catalysts provides an effective strategy for enhancing catalytic performance, offering a promising design principle for advanced electrocatalysts.

Iron-catalyzed pyrolysis converts o-xylene pollutants into graphitic carbon and COx-free hydrogen

Xinru Wang,Zhuocheng Li,Jinjin Qian,Dandan Zhao,Xiaoxu Zhang,Xiaolong Ma

Removing volatile organic compounds (VOCs) from emissions is critical, yet current approaches often cause CO 2 emissions or merely transfer VOCs between phases. We present an iron-catalyzed pyrolysis technique that converts o -xylene into solid carbon and COx-free hydrogen, offering the potential to produce COx-free hydrogen from VOCs. Using a high-temperature fixed-bed reactor (800–1000 °C), we found that the reduced Fe catalyst activity increases with temperature and reaction time. Optimal conditions gave a removal capacity of 376.1 mg g −1 , hydrogen production of 394.6 mL g −1 , and carbon production of 268.8 mg g −1 . The decomposition process involves carbon infiltration and the transformation of intermediate Fe 3 C, leading to catalyst fragmentation and enhanced activity. The resulting iron-carbon hybrid features a carbon-encapsulated iron structure comprising crystalline α-Fe and graphite. This structure exhibits superior catalytic performance in degrading methylene blue via H 2 O 2 , offering a promising foundation for developing environmentally friendly VOC treatment technologies.

Boosting Photocatalytic Hydrogen Peroxide Production via Multiscale Engineering O-Doped g-C3N4/CuO Nanosheets

Mingzhi Xu,Mengru Ji,Tianqiao He,Fei Ke,Yuqing Pang,Jie Mao,Xin Dong,Yulu Feng,Jiale Liang,Na Xu,Chunyan Zhang

Graphitic carbon nitride (g-C 3 N 4 ) is a promising semiconductor for solar-to-chemical conversion, yet its practical application in hydrogen peroxide (H 2 O 2 ) photosynthesis is severely limited by inefficient charge separation and rapid electron–hole recombination. Herein, we report a synergistic multiscale engineering strategy to construct O-doped g-C 3 N 4 /CuO (CuO/O─C 3 N 4 ) heterostructures designed for highly efficient photocatalytic H 2 O 2 production. By integrating atomic-level oxygen doping with interface-level CuO coupling, this strategy simultaneously regulates the intrinsic electronic structure of g-C 3 N 4 and establishes an efficient interfacial charge-transfer pathway. The optimized CuO/O─C 3 N 4 -2 composite achieves a high H 2 O 2 concentration of 3978 μmol L −1 under visible-light irradiation in an acidic medium with HCOOH as a sacrificial agent, significantly outperforming pristine g-C 3 N 4 . Comprehensive characterizations and theoretical insights reveal that the dual-functionalization of oxygen-induced electronic modulation and CuO-mediated interfacial charge transfer synergistically promote carrier separation and facilitate the two-electron oxygen reduction reaction. This work provides a sophisticated paradigm for the rational design of g-C 3 N 4 -based systems toward sustainable solar-fuel production. Graphical A facile synergistic multiscale engineering strategy is presented for the preparation of O-doped g-C 3 N 4 /CuO heterostructures with abundant nitrogen vacancies. The optimal CuO/O─C 3 N 4 -2 shows enhanced visible-light harvesting and charge separation, achieving superior photocatalytic activity for hydrogen peroxide production under visible-light irradiation.

Redesigning chondroitin 6-O-sulfotransferase for efficient whole-cell biosynthesis of chondroitin sulfate C

Weiwei Meng,Mengjian Gao,Lulu Li,Liming Liu,Xiaomin Li,Wanqing Wei,Jing Wu

Osteoarthritis remains a global health problem and chondroitin sulfate C (CSC) is effective to treat arthritis. The biosynthesis of CSC offers a sustainable and promising alternative to conventional extraction from animal tissues. However, the scarcity of chondroitin-6-O-sulfotransferases and their low catalytic performance have severely hindered the large-scale biosynthesis of CSC. To overcome these limitations, a novel chondroitin-6-O-sulfotransferase from Rattus norvegicus ( Rn CHST3) was identified via gene fishing, which demonstrates regioselectivity in transferring a sulfate group from 3′-phosphoadenosine-5′-phosphosulfate (PAPS) to the 6-position of chondroitin. Subsequent optimization of expression conditions and truncation of the N -terminal region enhanced the sulfation rate from 4.6% to 11.5%. For the first time, the regioselective mechanism of Rn CHST3 was elucidated through molecular dynamics (MD) simulations and site-directed mutagenesis. A mechanism-guided rational design led to the development of mutant M5, which increased the sulfation rate to 46.2%. Furthermore, a novel “physical sieve”-guided PROSS design was developed to improve kinetic thermostability, resulting in mutant M7. This variant exhibited an extended half-life from 9.4 h to 12.3 h and achieved a sulfation rate to 74.5%. Finally, a whole-cell catalytic system was constructed for CSC production, reaching a sulfation rate of 86.4% and a titer of 12.9 g·L −1 -the highest level reported to date. This study lays a solid foundation for the industrial biosynthesis of CSC.

Synthesis of carbon quantum dot-decorated V₂O₅ nanobelts for non-enzymatic glucose sensing

Wenfang Liu,Sarenqiqige Bao,haiyan yu,Xiaohui Liu,Na Wang,Jun Wang

Carbon quantum dots (CQDs) were prepared via a hydrothermal method using glucose and citric acid as precursors. The synthesized CQDs and V2O5 nanomaterials were characterized using TEM, SEM and XPS, while their optical properties were analyzed by UV-Vis and fluorescence spectroscopy. The fluorescence of CQDs in aqueous solution was significantly quenched in the presence of V2O5 nanomaterials. At pH 8.2, the addition of glucose to the CQDs + V2O5 nanocomposite solution induced the reduction of V5+ to V4+ in V2O5, resulting in the fluorescence recovery of CQDs. Glucose could be quantitatively detected using CQDs + V2O5 nanocomposite, exhibiting a wide linear range (0.1 - 1000 μmol/L) and a low detection limit (0.539 μmol/L). Furthermore, the selectivity and anti-interference capability of the CQDs + V2O5 nanocomposite for glucose detection were investigated. Additionally, cytotoxicity assays and cellular imaging of CQDs were conducted. Overall, the integration of CQDs + V2O5 nanocomposite demonstrates potential as a novel diagnostic platform for non-enzymatic glucose detection in clinical applications

Bioinspired Asymmetric W-O-Ni Active Centers for Selective Electrochemical Upcycling of Polyethylene Terephthalate

Rui Zhang,Xu Liu,Huimin Mao,Zhenyu Xiao,Jingqi Chi,Xiaobin Liu,Lei Wang

Electrochemical upcycling of waste PET into value-added formate • Soybean root-inspired design of symbiotic active sites • Oxygen-bridge-induced 3d-5d orbital hybridization The efficient transformation of waste poly(ethylene terephthalate) (PET) into high-value chemicals represents a pivotal strategy toward a circular plastics economy. Drawing inspiration from the cooperative nitrogen-fixation relationship between rhizobia and leguminous plants, we report a tungsten-modified nickel phosphide (W-Ni 2 P) catalyst for the selective electrooxidation of PET-derived ethylene glycol (EG) into formic acid (FA). Upon electrochemical activation, robust asymmetric W-O-Ni oxygen-bridged configurations are formed in situ, establishing cooperative catalytic centers in which W operates as an electronic modulator while Ni serves as the dominant active site. The tungsten centers display strong adsorption toward *EG and *OH intermediates, functioning as dynamic buffering sites that regulate the interfacial microenvironment and concurrently facilitate the reconstruction of Ni into highly active oxyhydroxide species. This synergistic interplay, governed by W-O-Ni-mediated 3d-5d orbital interactions, effectively reduces the kinetic barriers associated with C-H dehydrogenation and C-C bond cleavage. Consequently, the optimized W-Ni 2 P catalyst achieves a current density of 500   mA   cm -2 at 1.45   V versus RHE, delivering a Faradaic efficiency of 98.9% for FA production. Moreover, an anion-exchange-membrane electrolyzer sustains stable operation for over 200   hours in authentic PET hydrolysate, highlighting the system’s practical durability, scalability, and economic potential for plastic waste upcycling. Download: Download high-res image (212KB) Download: Download full-size image Inspired by rhizobium-legume symbiosis, W was incorporated into Ni 2 P to form cooperative W-O-Ni active sites, which facilitate Ni reconstruction, optimize intermediate adsorption, lower EGOR energy barriers, and promote highly efficient formic acid production from PET waste.

Accelerated Deprotonation Triggered by the Se–Ru–O Asymmetric Configuration Enables Acidic Oxygen Evolution

Feng Xinlian,Zhu Ting,Wu YuChi,Ji Shumin,Ji Yadong,Yu Zhongwei,Zhang Nan,Yin Shuhu,Xu Jun

Developing efficient and durable electrocatalysts toward the acidic oxygen evolution reaction is crucial for the advancement of renewable hydrogen energy technologies. Ruthenium dioxide stands out as one of the most promising acidic OER catalysts. However, the unsatisfactory stability of RuO 2 and the sluggish proton-coupled electron transfer kinetics of OER hinder its practical application. Herein, we introduce Se doping to form a Se–Ru–O asymmetric configuration into RuO 2 to tailor electron redistribution and achieve both high activity and stability. The obtained Se-RuO 2 shows superior electrocatalytic activity with a small overpotential of 212 mV at 10 mA cm –2 and a long durability of 230 h. Electrochemical tests and density functional theory calculations demonstrate that Se-RuO 2 exhibits enhanced deprotonation kinetics and optimized adsorption energy of reaction intermediates, thereby boosting OER activity. Morever, the electronic interactions mediated by the asymmetric Se–Ru–O bond diminish the covalency of Ru–O bonds and thus boost the stability of RuO 2 . This work offers a facile strategy for the development of high-performance catalysts incorporated with nonmetallic elements.