JOURNAL OF APPLIED POLYMER SCIENCE
·
2021
·Vol. 138
·期 34
·50854
·
IF 3.125
Xiangfei Sun,Ping Yang,Shaohua Wang,Honglong Xing
Because of the good fluorescence of zinc phthalocyanine-phenolic resin (ZnPc-PFR) photosensitizer and large specific surface area of mesoporous silica nanoparticles (MSNs), a highly efficient nano-drug carrier system, denoted as ZnPc-PFR@MSN, was constructed for photothermal therapy (PTT) and pH-sensitive drug delivery. The facile hydrothermal reaction was used to synthesize ZnPc-PFR nanoparticles in one-step. After loading the as-synthesized ZnPc-PFR nanoparticles into MSNs, and a good high drug-loading rate (143.7 mg g −1 ) to the anticancer drug of Adriamycin (DOX) could be obtained. Thus, a novel nanosphere with the merits of good fluorescence, high drug-loading rate (143.7 mg g −1 ), better sustained-release properties, and photothermal properties (reached 43.23°C within 260 s) was prepared. The as-synthesized multifunctional composites make it a good candidate in fluorescence imaging, PTT, and drug delivery.
研究领域:
生物医学工程
·
纳米医学
·
肿瘤学
✓ 已验证
DOI
高影响因子
LANGMUIR
·
2025
·
IF 3.9
Jiaqi Zhang,Hua Yuan,Manting Wang,QingJian Yu,Caixia Li,Jie-Xin Wang,Yuan Le
Diabetic chronic wounds are plagued by persistent bacterial infections and dysregulated pH, leading to high amputation risks. Promoting multifunctional and smart dressing systems has been identified as a potential solution to enhance the healing process. In this work, a multifunctional fiber film (PCSNP) was built, integrating a pH-responsive drug release for on-demand antibacterial action. PCSNP comprised three layers of electrospun fibers: a fast-acting germicidal inner layer, a pH-responsive coaxial inter layer, and a self-powered outer layer. Electrical performance tests revealed that PCSNP generated 1.6 V of electrical stimulation, which was helpful to enhance cell growth. PCSNP could change color to indicate wound status and facilitate rapid drug release when the diabetic wound came into contact. The antibacterial activity against Staphylococcus aureus, E. coli, P. aeruginosa, and MRSA was 98.71%, 99.01%, 98.25%, and 87.3%, respectively. Meanwhile, PCSNP possessed excellent capabilities in proliferation, migration, anti-inflammation, and angiogenesis promotion. The stability studies showed that PCSNP maintained ideal safety and functional characteristics after long-term storage. The design of the smart response fiber is expected to effectively address multiple potential problems in diabetic wounds, thereby improving the overall efficacy of healing.
研究领域:
生物医学工程
·
创伤修复
·
纳米医学
·
感染控制
·
再生医学
·
药物递送
·
材料科学
✓ 已验证
DOI
高影响因子
Sustainable Energy & Fuels
·
2025
·
IF 4.1
Liyun Cao,Wenchao Li,Jianfeng Huang,Dewei Chu,Yijun Liu,Faliang Luo,Xuemeng Huo,Dongping Wang,Yongqiang Feng
To enhance the efficiency of electrochemical water splitting for hydrogen production, it is essential to employ hydrogen evolution reaction (HER) electrocatalysts that lower the energy barrier and accelerate the HER kinetics. In this study, a ruthenium (Ru) nanoparticle anchored on zirconium dioxide (ZrO2) matrix derived from Zr-based metal-organic framework (MOF), denoted as Rux@UiO-bpy-900 (bpy refers to bipyridine), was synthesized via a liquid-phase impregnation and subsequent calcination method at 900 ℃. The incorporation of Ru, which exhibits platinum-like hydrogen binding energy, modulates the hybrid structure of UiO-bpy-derived carbon materials, enhances electron transport, and leverages the synergistic effect of Ru/Zr bimetallic sites to alter the electronic structure of the material, thereby improving the hydrogen evolution efficiency. The catalyst requires an overpotential of only 28 mV to achieve a current density of 10 mA cm-2 in 1 M KOH, outperforming the reference Pt/C catalyst. It also demonstrates superior HER activity across the entire pH range compared to UiO-bpy-900. This work provides a foundation for the development of MOF-based electrocatalysts suitable for energy conversion and storage applications.
✓ 已验证
产品关联
DOI
高影响因子
Pharmaceuticals
·
2022
·Vol. 15
·期 4
·480
·
IF 5.215
Yang Qu,Zhiqi Wang,Miao Sun,Tian Zhao,Xuanlei Zhu,Xiaoli Deng,Man Zhang,Ying Xu,Hongfei Liu
Although polymeric platinum(IV) (Pt(IV)) prodrugs can reduce the side effects of cisplatin, the efficacy of the prodrug is still limited by its non-targeted distribution, poor penetration in deep tumor tissue, and low cytotoxicity in tumor cells. To improve the clinical potential of polymeric prodrug micelle, we synthesized amphiphilic polymeric Pt(IV) with high Pt content (22.5%), then developed a theranostic nanocomplex by integrating polymeric Pt(IV) with superparamagnetic Mn0.6Zn0.4Fe2O4via simple self-assembly. Due to the high content of Mn0.6Zn0.4Fe2O4(41.7%w/w), the theranostic nanocomplex showed high saturation magnetization (103.1 emu g−1) and excellent magnetocaloric effect (404 W g−1), both of them indicating its advantages in efficient magnetic targeting (MT), magnetic hyperthermia (MH), and magnetic resonance imaging (MRI). In vitro, in combination with MH, the theranostic nanocomplex showed as high cytotoxicity as cisplatin because of a significant increase in platinum of cellular uptake. In vivo, the accumulation of theranostic nanocomplex in tumors was increased by MT and confirmed by MRI. Furthermore, MH improved penetration of theranostic nanocomplex in tumors as expanding blackened area in tumors was observed by MRI. Based on these properties, the theranostic nanocomplex, under the assistance of MT and MH, showed the highest tumor growth inhibition rate (88.38%) after different treatments, while the body weight of mice increased slightly, indicating low side effects compared to those of cisplatin. The study provided an advanced theranostic nanocomplex with low toxicity and high efficacy, indicating a great clinical potential of polymeric Pt(IV).Keywords:polymeric prodrug;theranostic nanocomplex;pH-triggering releasing;magnetic targeting;magnetic hyperthermia;magnetic resonance imaging
研究领域:
肿瘤学
·
药剂学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2018
·
IF 5.123
Zhihui Xu,Ling Cai,Huijun Jiang,Yujie Wen,Luming Peng,Yuan Wu,Jin Chen
During the past decade, accumulating studies have been conducted on the mesoporous silica materials as the matrix of controlled drug-delivery, in which the complicated post-synthesis procedures are often involved with the molecular design to achieve the efficacy. In this study, a simplified drug delivery system of anti-cancer drug of doxorubicin (DOX) based on mesoporous SBA-15 functionalized with ferrocenecarboxylic acid (FCA) was constructed. Through a combination of physicochemical characterizations, the presence of FCA that was anchored inside the pore wall of amine groups grafted SBA-15 exhibits electron-accessible behavior without affecting the intactness of composite material. The pH-responsive release of drug molecules was achieved through the conjugation of DOX with FCA in the interior channels of mesoporous composites, which also favors the more coverage of DOX. Furthermore, the real-time cell analysis was performed to monitor the release of DOX from the mesopores and resulting cytotoxicity of cancer cell of A549 was evaluated, which results in a calculated IC 50 of 43.8 μg/ml (24 h). The constructed mesoporous FCA-SBA-15 composite material provides an integrated nanoplatform to exert controlled-delivery of anti-cancer drug molecules.
研究领域:
药物递送系统
·
生物材料
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
POLYMER BULLETIN
·
2012
·Vol. 69
·期 5
·597-620
·
IF 1.532
Luo Yan-Ling,Yu Wei,Xu Feng
pH-sensitive hydrophilic poly(methacrylic acid)- b -poly(ethylene glycol)- b -poly(methacrylic acid) (PMAA- b -PEG- b -PMAA) triblock copolymers were synthesized through atom transfer radical polymerization, and were characterized by FT-IR, 1 H NMR, and GPC. The as-synthesized polymers can self-assemble into stable and almost spherical nanomicelles in aqueous solution with an average size range from 18 to 89 nm, depending on the micellar concentrations, while they assumed well-defined spherical morphologies in PBS solutions. The micellization behavior in different media was investigated by a fluorescence spectroscopy technique, UV–Vis transmittance, and dynamic light scattering measurements. The critical micelle concentration and size of the micelles decrease with the increasing the length or molecular weights of PEG and PMAA chains. A pH-dependent phase transition behavior produces at a pH value of about 5.2, and the stable pH micellization behavior varied within a narrow pH range from ca. 4.8 to 7.4. These triblock copolymers are generally low cytotoxicity at a micellar concentration below 400 mg L −1 , as revealed by the MTT assay. The prednisone release and release kinetics studies disclosed that these pH-sensitive polymeric micelles are good carriers for the drug delivery.
研究领域:
材料科学
·
药学
·
生物医学工程
✓ 已验证
DOI
高影响因子
Journal of Integrative Agriculture
·
2022
·
IF 4.384
Muhammad Irfan WARIS,Aneela YOUNAS,Rana Muhammad Kaleem ULLAH,Fatima RASOOL,Muhammad Muzammal ADEEL,Man-qun WANG
Chemosensory proteins (CSPs) are important molecular components of the insect olfactory system, which are involved in capturing, binding, and transporting hydrophobic odour molecules across the sensillum in sensillar lymph in regulating insect behavior. This protein family (CSPs) is also involved in many other systems that are not linked to olfactory receptors in olfactory sensilla. The brown planthopper (BPH) is a monophagous pest of rice that causes damage by sucking phloem sap and transmitting a number of diseases caused by viruses. In this study, fluorescence competitive binding assay and fluorescence quenching assay at acidic pH were performed as well as homology modelling to describe the binding affinity of NlugCSP10. Fluorescence competitive binding assay (FCBA) demonstrated that NlugCSP10 bound strongly to nonadecane, farnesene, and 2-tridecanone at acidic pH. The results of FCBA indicated that NlugCSP10 bound different ligands at the physiological pH (5.0) of the bulk sensillum lymph. Fluorescence quenching assay demonstrated that NlugCSP10 generated a stable complex with 2-tridecanone, while two ligands nonadecane and farnesene collided due to molecular collisions. The interaction of selected ligands with the modelled structure of NlugCSP10 was also analyzed, which found the key amino acids (Gln23, Gln24, Gln25, Asn27, Met33, Ser34, Ile35, Tyr36, Asn42, Met43, Val45, Asn46, Asn93, Arg96, Ala97, Lys99, and Ala100) in NlugCSP10 that were involved in binding of volatile compounds. The present study contributes to the binding profile of NlugCSP10 that promotes the development of behaviorally active ligands based on BPH olfactory system.
研究领域:
昆虫学
·
分子生物学
·
生物化学
✓ 已验证
DOI
高影响因子
Journal of Biomedical Nanotechnology
·
2016
·Vol. 12
·期 8
·1688-1698
·
IF 3.929
Zhang Xueqiong,Zhang Hong,Yin Liangquan,Hu Rui,Qiu Tong,Yin Yihua,Xiong Xiong,Zheng Hua,Wang Qun
Nanoparticles, such as polymeric micelles, are currently regarded as effective drug delivery vehicles. In this study, a series of carboxymethyl chitosan/daunorubicin (CMCS/DNR) conjugates with macromolecular carriers of different molecular weights (MWs) were prepared and structurally
characterized by Fourier transform infrared spectroscopy (FT-IR) and 1H-NMR spectroscopy. The results indicated that the MWs of the carriers greatly influenced the drug loading capacity. DNR was conjugated to the polymer via an acid-sensitive hydrazone linkage susceptible to hydrolysis
at pH 5–6, thereby enabling intracellular DNR release. In aqueous media, the conjugates spontaneously formed nano-sized particles with core–shell structures (CMCS and DNR as the shell and core, respectively). Dynamic light scattering (DLS) and trans-mission electron microscopy
(TEM) indicated that the prepared nanoparticles were spherical in shape with diameters of 100–200 nm and had a slight negative surface charge. In addition, in vitro drug release studies demonstrated that the micelles were highly sensitive to mild acidic conditions (pH 5.0) but
remained reasonably stable at pH 6.5 and pH 7.4. Importantly, cell counting kit-8 (CCK-8) assays demonstrated that DNR-conjugated nanoparticles exerted a cytotoxic effect on HeLa cells, with the IC50 being approximately 2 times higher than that of free-DNR. Furthermore, confocal
laser scanning microscopy (CLSM) revealed that the CMCS-hyd-DNR nanosystem could efficiently deliver and release DNR in the nuclei of cancer cells. Taken together, the developed CMCS based pH-sensitive nanosystem may be a potential drug delivery vehicle for cancer therapy.
研究领域:
药学
·
纳米技术
·
癌症研究
·
药物递送系统
✓ 已验证
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 37
·7347-7354
·
IF 4.726
Chao Qi,Ying-Jie Zhu,Yong-Gang Zhang,Ying-Ying Jiang,Jin Wu,Feng Chen
A rapid and simple strategy is reported for the synthesis of amorphous calcium phosphate (ACP) vesicle-like nanospheres using the adenosine 5′-triphosphate (ATP) disodium salt as a biocompatible phosphorus source and stabilizer by the sonochemical method in mixed solvents of water and ethylene glycol (EG). The ACP vesicle-like nanospheres are characterized by X-ray powder diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, UV/Vis absorption spectroscopy, thermogravimetric (TG) analysis, scanning electron microscopy (SEM) and transmission electron microscopy (TEM), dynamic light scattering (DLS) and Brunauer–Emmett–Teller (BET) nitrogen adsorption. The ACP vesicle-like nanospheres exhibit essentially inappreciable toxicity to the cells in vitro. Furthermore, the as-prepared ACP vesicle-like nanospheres can be used as anticancer drug nanocarriers and show a pH-responsive drug release behaviour using doxorubicin (Dox) as a model drug. The ACP vesicle-like nanosphere drug delivery system exhibits a high ability to damage cancer cells, thus, it is promising for application in pH-responsive drug delivery.
研究领域:
材料科学
·
生物医学工程
·
药学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
·
2020
·
IF 1.624
Licong Peng,Xianwu Zeng,Qianqian Qi,Hailiang Zhang,Jinping Fu,Miao Zhou,Jianchao Yuan
The emergence of multiple drug delivery systems can solve the disadvantages of single-drug therapy, such as high dose and easy generation of drug resistance. Here, we designed a sialic acid–targeted dextran-mercaptopurine prodrug linked by carbonyl vinyl sulfide for coordinate ZnO quantum dots to achieve multiple drug delivery (doxorubicin, 5-fluorouracil, 6-mercaptopurine), which can be released under the trigger of pH and glutathione. To enhance the antitumor effect, we used inorganic photosensitizer CdSe quantum dots to achieve photodynamic therapy, which can produce cytotoxic reactive oxygen species (hydroxyl radicals) under light conditions. Notably, we found that glutathione is consumed by the delivery of 6-mercaptopurine. It is able to efficiently amplify intracellular oxidative stress via increasing •OH generation. After chelating 99mTc4+ radioisotopes by diethylenetriamine pentaacetic acid, the drug delivery system could be tracked under in vivo single-photon emission computed tomography imaging. The results showed that the phenylboronic acid targeting substance can specifically recognize sialic acid, so that the drug system has a good accumulation in the tumor site, which can better increase the therapeutic effect. Compared to free doxorubicin, the drug system can reduce the IC50 value of cells 4.4-fold under light conditions and significantly inhibit tumor growth in vivo. These data indicate that the sialic acid–targeted nanomedicine system has achieved ideal antitumor effects and apparent photodynamic therapy effects and has broad application prospects.
研究领域:
肿瘤学
·
药物递送
·
纳米医学
·
生物材料
✓ 已验证
DOI
高影响因子
KOREAN JOURNAL OF CHEMICAL ENGINEERING
·
2020
·Vol. 37
·期 4
·614-622
·
IF 2.69
Haleem Abdul,Syaal Sidra Bibi,Ajmal Muhammad,Ambreen Jaweria,Rauf Sajid,Ali Nasir,Muhammad Saz,Shah Afzal,Zia Muhammad Abid,Siddiq Muhammad
Here in, we demonstrate facile fabrication of silver and palladium nanoparticles in dual responsive poly(N-isopropylacrylamide- co -2-Acrylamido-2-methylpropane sulfonic acid) microgel with temperature- and pH-dependent catalytic potential. Palladium-based catalyst showed better catalytic efficiency as compared to silver-based catalyst for degradation of Rhodamine-B and P-Nitrophenol in aqueous medium under the same set of reaction conditions. The responsive nature of the microgel was found to be useful to tune the catalytic activity of the as-prepared catalysts, and reduction rate was enhanced with the pH and temperature elevation of the reaction medium; however, the increasing trend was slowed in the volume phase transition region of the microgel. Under a specific set of reaction conditions, the reduction of Rhodamine-B was as fast as 0.968 and 0.571 min −1 when catalyzed with palladium and silver based catalysts, respectively. The hydrodynamic radius of the particles of microgel support was found to be in the range of 65-180 nm when pH and temperature of the medium were varied in the range of 2-12 and 25-45, respectively. The estimated diameter of silver and palladium nanoparticles fabricated in the microgel support under the same set of reaction conditions was 9-15 and 7-11 nm, respectively.
研究领域:
材料科学
·
化学工程
·
纳米技术
✓ 已验证
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2019
·
IF 5.256
Yingying Zhang,Fanqiang Bu,Yanliang Zhao,Bing Zhao,Liyan Wang,Bo Song
Intracellular pH (pHi) plays an essential role in organelles . Fluorescent probe combined with fluorescence imaging analytical approach has been used for detection pH fluctuation due to high sensitivity and good photostability. Herein, a benzoindole-based colorimetric and naked-eye hemicyanine fluorescent probe 2,3-trimethy-3-[2,4-(dihyoxyl-4-yl)vinyl]-3 H -benzo[e]indole ( BiDD ) was developed in one step. Upon the decreasing of pH, BiDD exhibited strong a pH-dependent characteristic with p K a 4.98 and responded linearly within the pH range of 4.4–6.2. BiDD also showed high sensitivity and selectivity , colorimetric and fluorometric dual-modal response, high photostability, low cytotoxicity as well as good cell membrane permeability. More importantly, the probe was applied to sense and visualize the pH fluctuations in HeLa cells successfully by the fluorescence confocal microscope .
研究领域:
生物化学
·
细胞生物学
·
分析化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）