JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2023
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IF 2.6
Chenyang Yao,Ji Mi,Pengfei Jiang,Cui Ye,Yitong Dai,Yongsheng Guo,Wenjun Fang
Active cooling by endothermic hydrocarbon fuels (EHFs) is considered as a practical approach to deal with the thermal management problem of hypersonic aircrafts. As a typical component of EHFs, decalin is usually thermally stable while it is apt to coke and has poor combustion performance. n-Hexadecane, a normal alkane with a relatively high H/C ratio, can effectively improve the combustion performance of EHFs, and 1-butanol has remarkable anti-coking properties. As a fundamental work for fuel design, decalin, n-hexadecane, and 1-butanol were selected as model compounds to construct a surrogate fuel system, which was used to investigate the effects of composition and condition on its thermophysical properties. Densities (ρ) and viscosities (η) of the ternary system of decalin (1) + n-hexadecane (2) + 1-butanol (3) and corresponding binary systems were measured at temperatures T = (293.15 to 333.15) K and pressure p = 0.1 MPa. The excess molar volumes (VmE) and the viscosity deviations (Δη) of the mixtures were calculated and fitted to several semi-empirical equations. The tendencies of VmE and Δη with composition and temperature were discussed from intermolecular force and molecular size, respectively.
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JOURNAL OF MOLECULAR LIQUIDS
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2014
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IF 2.083
Yajie Jiang,Tao Geng,Qiuxiao Li,Guojin Li,Hongbin Ju
The 1:1 salt-free catanionic surfactant dodecyltrimethylammonium decanoate (DTAD) was synthesized directly by a novel method, and the product was recrystallized to come up to purity received. Surface activity and self-assembly of 1:1 salt-free catanionic surfactant DTAD and the influences of temperature, pH and salinity on which have been studied in the present work. The critical micelle concentration (CMC), surface tension reduction (γ CMC ), surface excess (Γ max ), and mean molecular surface area ( A min ) were determined from plots of surface tension (γ) versus logarithm of surfactant concentration. The results showed that the salt-free catanionic surfactant had much lower CMC, γ CMC and A min values than their corresponding single cationic and anionic surfactants . The Gibbs energy of mixing (△ G E ) was negative, indicating the strong interaction of cationic and anionic parts. The tested temperature and salinity had no significant effect on the surface properties of DTAD. The surface activity enhanced in acidic pH and decreased slightly in alkaline pH . The aggregate structure almost had no change with temperature, but transformed into spheres with addition of inorganic salts. The pH effect was complex, the ability of vesicles formation was improved in strong alkaline condition; vesicles transformed into large disks or large cubes in acidic condition.
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STEROIDS
·
2024
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IF 2.1
Jinwen Chen,Wei Chen,Xiaoyu Li,Yiping Ye,Wenkang Huang,Lijuan Gao,Meng Zhang
Colorectal cancer (CRC) is one of the most common gastrointestinal cancers that results in death in worldwide. The Hedgehog (HH) signalling pathway regulates the initiation and progression of CRC. Inhibiting the HH pathway has been presented as a potential treatment strategy in recent years. Cynanbungeigenin C (CBC) is a new type of C 21 steroid that has been previously reported for the treatment of medulloblastoma. However, its further investigation was limited by its poor water solubility. In this study, six new CBC derivatives were synthesized through the structural modification of CBC, and four of them showed better water solubility than CBC. Moreover, their antiproliferative activities on CRC were evaluated. It was found that CBC-1 presented the best inhibitory effect on three types of CRC cell lines, and this effect was superior to that of CBC. Mechanistically, CBC-1 inhibited the proliferation of CRC cells through regulation of mRNA and proteins of the HH pathway according to qRT–PCR and Western blotting analysis. Furthermore, Cellular Thermal Shift Assay results indicated that CBC-1 regulated this signalling pathway by targeting glioma‑associated oncogene (GLI 1).In addition, cell apoptosis was induced increasingly by transfection with GLI 1 siRNA or treatment with CBC-1 to downregulate GLI 1. Last, the in vivo results demonstrated that CBC-1 significantly reduced tumour size and downregulated GLI 1 in CRC. Therefore, this study suggests that CBC-1, a new GLI 1 inhibitor derived from natural products, may be developed as a potential antitumour candidate for CRC treatment.
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JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
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2024
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IF 3.7
Pei Haibing,Lin Zhiyin,Yao Kexin,Luo Yeqing,Tong Ping,Chen Hongbing,Wu Yong,Wu Zhihua,Gao Jinyan
Ovalbumin (OVA) is a major allergen in eggs and could induce severe allergic reactions in sensitive individuals, where the innate immune system works as a regulator. The mechanism of how innate immunity adjusts to food allergy is relatively well-studied, however, the effects of allergen uptake on the innate immune system remain unclear. Therefore, the Caenorhabditis elegans ( C. elegans ) model was utilized to assess the effects of OVA on its innate immune system. OVA enhanced the immune response of C. elegans with higher survival rates under Pseudomonas aeruginosa infection. Moreover, sustaining OVA treatment improved the health states that were reflected in the prolonged lifespan, alleviated oxidative stress, accelerated growth, and promoted motility. RNA-sequencing analysis and the slow-killing assays in the mutants of insulin/IGF-1 signaling (IIS)-related genes confirmed that IIS was necessary for OVA to regulate innate immunity. Besides, OVA activated SKN-1 temporarily and facilitated the nuclear localization of DAF-16 for improving immunity and health status in C. elegans . Together, OVA could enhance the innate immune responses via DAF-16 and SKN-1 pathways in the IIS of C. elegans , and this work will provide novel insights into the regulation of innate immunity by OVA in higher organisms.
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JOURNAL OF SOLID STATE CHEMISTRY
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2025
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IF 3.5
Yuan Li,Shengkai Sun,Hanfang Liu,Wenna Wang,Dehong Chen,Yu Yang,Feng Liu,Bin Yu,Jia Liu,Binjie Li,Lei Wang,Bin Li
Epoxidation of olefin catalyzed by titanium silicalite-1 (TS-1) can obtain important intermediate epoxides of industrial production in a green and pollution-free manner. However, due the problem of macromolecules transport path restraint, which cause the catalyst to fail in lifetime and activity. Strategically, to increase the transport channel of macromolecules and shorten the transport path, it is necessary to introduce mesoporous structures into zeolite. Here, we report a solid-state synthesis of hierarchical TS-1 zeolite by optimizing carbon black sequence. The texture property of hierarchical TS-1 can be optimized by carbon black. Most importantly, the addition sequence of carbon black can impact the porosity of hierarchical TS-1. The hierarchical zeolite is synthesized by incorporating 0.2 g carbon black into the seeds. When carbon black is firstly combined with seeds, the enhanced interaction facilitates the subsequent growth process, leading to large surface area from mesopores (121 m 2 /g) and abundant pores size (8–40 nm) and enhanced exposure of Ti active sites. The optimized hierarchical TS-1 possesses excellent catalytic performance with high conversion rate (24.4 %) and similar selectivity (93.8 %), which are 1.6 times higher than that of traditional TS-1 zeolites.
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Catalysts
·
2024
·Vol. 14
·期 12
·939
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IF 3.8
Yuting Sun,Xinyu Chang,Junling Zhan,Chongyao Bi,Zhehan Dong,Shuaishuai Sun,Mingjun Jia
To synthesize high-quality TS-1 zeolites with enhanced catalytic performance for 1-hexene epoxidation is highly attractive for meeting the increased need for sustainable chemistry. Herein, we report that a series of framework Ti-enriched TS-1 zeolites with high crystallinity can be effectively synthesized by the hydrothermal crystallization of a composite precursor composed of diol-based polymer (containing titanium and silicon) and tetrapropylammonium bromide (TPABr). The pre-addition of a certain amount of TPABr into the polymer-based precursor plays a very positive role in maintaining the high crystallinity and framework Ti incorporation rate of TS-1 zeolites under the premise that a relatively low concentration of tetrapropylammonium hydroxide (TPAOH) template is adopted in the following hydrothermal crystallization process. The condition-optimized TS-1 zeolite with a smaller particle size (300–500 nm) shows excellent catalytic activity, selectivity, and recyclability for the epoxidation of 1-hexene with H2O2as an oxidant, which can achieve a 75.4% conversion of 1-hexene and a 99% selectivity of epoxide at a reaction temperature of 60 °C, which is much better than the TS-1 zeolites reported in the previous literature. The relatively small particle size of the resultant TS-1 crystals may enhance the accessibility of the catalytically active framework Ti species to reagents, and the absence of non-framework Ti species, like anatase TiO2, and low polymerized six-coordinated Ti species could effectively inhibit the ineffective decomposition of H2O2and the occurrence of side reactions, leading to an improvement in the catalytic efficiency for the epoxidation of 1-hexente with H2O2.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2025
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IF 9
Shaohui Xiong,Xingyi Ou,Qingquan Liu,Yiwen Li,Juntao Tang,Guipeng Yu,Chunyue Pan,Shibo Guo,Sitong Li,Menghan Yong
Polymers of intrinsic microporosity (PIM) have attracted considerable attention in the development of mixed matrix membranes (MMMs) for CO 2 separation. A prominent challenge lies in engineering the spacing of the polymer matrix chains while eliminating non-selective interfacial defects. In this study, a CO 2 -philic triazine-based porous polymer, featuring robust hydrogen bond donating groups, was employed to fabricate a series of interfacial defect-free PIM-1 based MMMs (denoted as PIM-1/CSU-1). The interfacial adhesion and compatibility have been greatly improved due to the strengthened hydrogen bond interaction, which was systematically validated through variable-temperature infrared spectroscopy. Additionally, the formation of hydrogen bonds allowed for the regulation of the polymer matrix chain spacing, making the chain distance loose. Remarkably, the resulting membrane exhibited a CO 2 permeability of 13,429 Barrer and CO 2 /N 2 selectivity of 33.1—246.6% and 70.2% higher than pristine PIM-1, respectively, surpassing the latest Jansen/McKeown upper bound established in 2019, but also significantly exceed the performance of previously reported MMMs for CO 2 separation. The strategy of mitigating interfacial defects through the formation of hydrogen bonds between fillers and the polymer matrix emerges as a viable and effective method for fabricating gas separation membranes with exceptional separation capabilities.
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MOLECULAR CARCINOGENESIS
·
2024
·
IF 3
Beibei Wang,Xin Fan,Lingang Wang,Xiaosong Wei
Sorbin and SH3 domain-containing 2 (SORBS2) is an RNA-binding protein and has been implicated in the development of some cancers. However, its role in bladder cancer (BC) is yet to be established. The expression of SORBS2 in BC tissues was determined from the Gene Expression Omnibus and Gene Expression Profiling Interactive Analysis databases and collected paired tumor/normal samples. The effects of SORBS2 on BC cells were detected by CCK-8, colony formation, Transwell, dual-luciferase, RNA immunoprecipitation, chromatin immunoprecipitation, and DNA pull-down assays. In vivo, BC cell growth and metastasis were studied by a xenograft subcutaneous model and a tail-vein metastasis model. The results showed that SORBS2 expression was significantly decreased in BC tissues and cells. SORBS2 overexpression inhibited cell proliferation, migration, invasion, and epithelial–mesenchymal transition in vitro and tumor growth and metastasis in vivo, while silencing SORBS2 produced the opposite effect. Mechanistically, we found that SORBS2 enhanced the stability of tissue factor pathway inhibitor (TFPI) mRNA via direct binding to its 3′ UTR. Restoration of TFPI expression reversed SORBS2 knockdown-induced malignant phenotypes of BC cells. In addition, SORBS2 expression was negatively regulated by the transcription factor specificity protein 1 (SP1). Conversely, SORBS2 can be transcriptionally regulated by SP1 and inhibit BC cell growth and metastasis via stabilization of TFPI mRNA, indicating SORBS2 may be a promising therapeutic target for BC.
研究领域:
肿瘤学
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分子生物学
·
癌症研究
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2014
·
IF 2.045
Yu Sun,Yu-Feng Hu,Chao Miao,Zhen-Yu Yang,Chen-Chen Jiang,Xiao-Ming Peng,Yu-Fei Chen
The densities of the binary aqueous solutions of 1-carboxymethyl-3-methylimidazolium chloride ([HOOCMMIm]Cl), 1-carboxymethyl-3-propylimidazolium chloride ([HOOCMPIm]Cl), 1-(2-hydroxylethyl)-3-propylimidazolium chloride ([HOEtPIm]Cl), and the ternary solutions [HOOCMMIm]Cl + [HOOCMPIm]Cl + H2O, [HOEtPIm]Cl + [HOOCMPIm]Cl + H2O, and [HOEtPIm]Cl + [HOOCMMIm]Cl + H2O have been measured at (293.15, 298.15, and 303.15) K, respectively. The densities of the examined ternary solutions have been predicted by the equation of Patwardhan and Kumar established for the density of aqueous electrolyte solutions. The predictions were not very satisfactory probably due to the presence of the functional group −COOH. The coupling of the Patwardhan and Kumar’s equation and the rule of Young and Smith considerably improves the predictions, and the predicted results show excellent agreements with the experimental results.
研究领域:
物理化学
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化学工程
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热力学
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离子液体
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溶液化学
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2017
·
IF 2.323
Tiantian Ye,Haibin Qu,Xingchu Gong
The liquid–liquid equilibrium (LLE) data of ternary systems of water + d-fructose + 1-butanol, water + d-glucose + 1-butanol, and water + d-galactose + 1-butanol were determined at three temperatures (288.2, 303.2, and 318.2 K) and atmospheric condition. The distribution coefficients of the monosaccharides were lower than 0.05. For all the three saccharides, their content in the organic-rich phase increased as their content in the aqueous phase increased. The experimental tie-line data were fitted using the Othmer–Tobias equation. The saccharide universal quasichemical functional-group activity coefficient (S-UNIFAC) model was used to predict the LLE data with all the average absolute deviations (AAD) values higher than 0.013. The modified universal quasichemical model was then used to correlate the LLE data. The correlation results agreed better with experimental data than the prediction results obtained with S-UNIFAC. In the production of traditional Chinese medicines, 1-butanol is a promising extractant used to separate active compounds and saccharides in aqueous herbal extracts.
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Bioengineered
·
2021
·
IF 3.269
Yunxin Zhang,Jianlong Liu,Wei Jia,Xuan Tian,Peng Jiang,Zhiyuan Cheng,Jinyong Li
This study is aimed at identifying the roles of AGE/RAGE and ET-1 in deep vein thrombosis (DVT). Advanced glycation end products (AGEs) in glycated human serum albumin (M-HSA) were detected by ELISA. The viability of HUVECs was examined by CCK-8 assay. Flow cytometry was performed to detect cell apoptosis, followed by ELISA for the detection of inflammatory cytokine level and oxidative stress level in HUVECs. Immunofluorescence was performed to detect ET-1 and eNOS expression. The expression of specific proteins was assayed by western blot. As a result, decreased HUVEC viability was observed after stimulation with M-HSA, whereas RAGE inhibitor improved it. Cell apoptosis showed the opposite trend. Additionally, M-HSA-induced inflammatory cytokine release and oxidative stress of HUVECs were both alleviated by RAGE inhibitor. RAGE inhibitor also increased the levels of NO and eNOS while decreasing the level of ET-1 in M-HSA-stimulated HUVECs. Furthermore, decreased protein expression of Bax, cleaved-caspase3, RAGE, p65, ET-1 and iNOS was observed after treatment with RAGE inhibitor, in addition to increased protein expression of Bcl-2 and eNOS. In conclusion, blocking AGE/RAGE pathway downregulates ET-1, thereby mitigating HUVEC damage in DVT.
研究领域:
心血管疾病
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分子生物学
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细胞生物学
·
血栓形成
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2021
·
IF 5.875
Hongji Liu,Jinju Nie,H.C. Stephen Chan,Hailu Zhang,Liang Li,Hongqing Lin,Henry H.Y. Tong,Ande Ma,Zhengzheng Zhou
Herein, we reported a new bergenin : 4-aminobenzamide ( BGN-4AM ) cocrystal with significantly enhanced solubility and low hygroscopicity probed from two aspects such as phase solubility diagrams and theoretical calculations. Compared with anhydrous BGN , BGN-4AM solubilities in water and different buffer solutions (pH = 1.2, 4.5, 6.8) increase significantly. It is noted that BGN-4AM solubility in pH = 6.8 buffer solution presents 32.7 times higher than anhydrous BGN . Interestingly, BGN-4AM (0.31 ± 0.07%) showcases lower hygroscopicity than anhydrous BGN (9.31 ± 0.16%). The predicted and experimental solubilities agree with each other when considering solubility product ( K sp ) and solution binding constant ( K 11 ) in phase solubility diagrams, indicating the solution complexes formation occurs. Further crystal surface-water interactions and Bravais, Friedel, Donnay-Harker (BFDH) analyses based on Density Functional Theory with dispersion correction (DFT- d ) methods support the enhanced solubility. The water probe demonstrates an average interaction energy of −6.48 kcal/mol on the 002 plane of BGN-4AM , and only −5.47 kcal/mol on the 011 plane of BGN monohydrate. The lower lattice energy of BGN-4AM guarantees its lower hygroscopicity than BGN monohydrate. BGN-4AM with enhanced solubility and low hygroscopicity can be a potential candidate for further formulation development.
研究领域:
药剂学
·
理论化学
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