JOURNAL OF APPLIED POLYMER SCIENCE
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2026
·
IF 3.1
Shijie Tang,Sen Wen,Haiyang Feng,Kesan Yang,Haichuan Li,Shenwen Fang
The highly efficient air flotation hydrocyclone separation technology has been gradually promoted and applied. However, the performance of flocculant reported in the literature needs improvement. In this study, a novel flocculant was synthesized using poly[N-(3-dimethylaminopropyl)methacry] (PDPM) and polyether monoamine (PMA) as the main raw materials. The synthesis conditions of the flocculant were optimized based on the oil removal rate. It was found that when PMA M-2095 was used, the resulting product, Cl-0.4-P-0.2-2095, exhibited the best flotation-flocculation oil removal performance. At a dosage of 20 mg/L and a treatment time of 7 min, the oil removal rate of Cl-0.4-P-0.2-2095 reached 90.63%, which was 31.7% higher than that of the reported flocculant. Mechanistic investigations, including measurements of surface tension, interfacial tension, zeta potential, and interfacial elastic modulus, as well as oil-coated bubble experiments, revealed that Cl-0.4-P-0.2-2095 adsorbs onto the surfaces of bubbles and oil droplets. This adsorption enhances the collision and adhesion efficiency between bubbles and oil droplets, thereby improving the flotation-flocculation oil removal performance. This study provides a novel treatment agent for the efficient treatment of produced water from offshore oilfields.
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INORGANIC CHEMISTRY
·
2026
·
IF 4.7
Hangwei Jia,Yaqi Jin,Junwei Feng,Bailin Chen,Feng Yu,Xueling Hou
Guanidine units have garnered significant attention in the study of ultraviolet (UV) nonlinear optical (NLO) materials due to their excellent microscopic optical properties, making them ideal systems for developing novel optical devices. A novel guanidinium-templated UV NLO crystal, [C(NH2)3]SbCl4 (GSC), was successfully synthesized via an aqueous solution method. GSC crystallizes in the orthorhombic chiral space group P212121, featuring a seesaw shaped [SbCl4]− anion. Remarkably, GSC exhibits a moderate second harmonic generation (SHG) response of 1.1 × KDP at 1064 nm and a large refractive index difference of 0.2 at 546 nm. This NLO effect originates from the synergistic interaction between the [C(NH2)3]+ unit and the stereochemically active [SbCl4]− unit. This work provides a candidate for the guanidine family of NLO materials.
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Cell Reports Medicine
·
2026
·
IF 14
Xiaoliang Dong,Mengwen Wang,Bingxin Wang,Hongli Li,Zeyun Cao,Binbin Li,Xun Zou,Xuan Kong,Huanxin Yang,Yufeng Zhou,Le Zhang,Li-Long Pan,Jia Sun
Neonatal necrotizing enterocolitis (NEC) is a severe inflammatory disease primarily affecting premature infants, characterized by high mortality and morbidity, with limited therapeutic options available. While emerging evidence links microbiota to NEC pathogenesis, the role of commensal metabolites in NEC and safe metabolite-based therapies remain unexplored. Metabolomic profiling reveals a significant reduction in 3-indoleacrylic acid (IA), a tryptophan-derived metabolite, in NEC infants and animal models. IA supplementation alleviates intestinal inflammation and tissue damage. Single-cell RNA sequencing analysis reveals the activation of STAT1 signaling as a necroptosis driver in intestinal epithelial cells, which is suppressed by IA. Protection is abolished by aryl hydrocarbon receptor (AhR) inhibitor CH-223191 or in intestinal epithelium-specific AhR knockout mice. Oral administration of Bifidobacterium longum subsp. infantis containing the IA-producing fldI gene prevents NEC in mice. Our study uncovers IA as a microbiota-derived therapeutic inhibiting STAT1-driven necroptosis via the AhR-SOCS5 axis, offering a targeted strategy for NEC management.
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Advanced Healthcare Materials
·
2026
·
IF 11
Xingxiu Jiang,Haoliang Shi,Binbin Chu,Yulan Gu,Yicheng Zhang,Li Wang,Yao He,Xiaofeng Zhang
Among working-age adults in the contemporary era, more than 30% of individuals with diabetes are at risk of developing diabetic retinopathy (DR), a progressive ocular disorder that is the leading cause of visual impairment and blindness. Despite its high prevalence, treatment options remain limited. Current therapeutic strategies only focus on the inhibition of neovascularization or prevention of vascular leakage. Additionally, the majority of conventional eye drop formulations fail to deliver drugs efficiently to the retina, further limiting clinical applicability. To address these issues, we herein designed and developed an eye drop formulation based on the chitosan-modified liposomes encapsulating epigallocatechin-3-gallate (EGCG), capable of transporting EGCG from the ocular surface to the retina. Mechanistic studies revealed that efficient retinal delivery of EGCG could protect Müller cells against high glucose (HG)-induced injury via SIRT1-BNIP3-mediated mitophagy. In vivo, the developed EGCG@CS-LIP showed enhanced fundus delivery and therapeutic efficacy compared with conventional liposomes or free EGCG systems, attributed to the transient modulation of corneal tight junctions. More importantly, the EGCG@CS-LIP eye drops could effectively increase the expression level of SIRT1 protein and inhibit the apoptosis and damage in retina, thus exerting significant in vivo therapeutic effects for the effective treatments of DR. Lastly, the constructed EGCG@CS-LIP indicated the excellent ocular biocompatibility, highlighting its promise for future clinical translation in DR therapy.
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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2026
·Vol. 46
·期 15
·118583
·
IF 6.3
Qinghu Guo,Ting Wang,Jinglong Fan,Yimang Zhao,Xiangyu Meng,Xiaoyi Gao,Zhonghua Yao,Weiping Gong,Hanxing Liu,Hua Hao,Shujun Zhang
Electrostrictive ceramics are crucial for high-precision actuators due to their low hysteresis, fast response, and low heat dissipation. In this work, Nd 3+ was strategically employed to optimize the electrostrictive properties of x Nd-doped Pb(Ni 1/3 Nb 2/3 )O 3 -PbZrO 3 -PbTiO 3 (PNN-PZ-PT) ceramics. A phase transition from the morphotropic phase boundary to a cubic structure, accompanied by enhanced dielectric relaxor behavior was observed with increasing Nd content, which can be attributed to the disruption of long-range ordered ferroelectric domains caused by aliovalent Nd doping-induced local structural heterogeneities—thereby reducing strain hysteresis and enabling improved electrostrictive response. Notably, outstanding electrostrictive strain of 0.105% and high electrostrictive coefficient M 33 = 10.5 × 10 −16 m 2 /V 2 were obtained under a 10 kV/cm for the 3%Nd-doped PNN-PZ-PT ceramic, superior to other relaxor ferroelectric ceramics. Additionally, this composition exhibits outstanding cycling reliability with only 5% strain degradation over 10 6 electrical cycles, positioning it as a promising candidate for precision micro-actuators applications requiring ultra-stable, high-efficiency electromechanical responses.
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Advanced Science
·
2026
·
IF 14.1
Dan Zhao,Lingling Zhang,Yue Wen,Lianghui Cheng,Sidan Tian,Fanling Meng,Liang Luo
Pyroptosis holds great promise for evoking robust anti‐tumor immunity, but many pyroptosis induction strategies rely on caspase‐3 (Casp‐3) activation and face challenges of the immunosuppressive nature of apoptosis and the frequent silencing of gasdermin E (GSDME), a substrate of Casp‐3, in tumors. Here, we report a strategy to rewire the pyroptotic pathway by bypassing Casp‐3 to directly activate gasdermin D (GSDMD). We identify a small‐molecule agonist, (E)‐2,3‐diiodobut‐2‐ene‐1,4‐diol (DIBDO), which undergoes deiodination to release iodide ions upon activation by the tumor‐abundant nucleophile glutathione, thereby catalytically generating singlet oxygen and molecular iodine. This cascade induces oxidative damage that downregulates key mediators of caspase‐9 and caspase‐8 pathways, thereby down‐regulating Casp‐3 activation. This mechanism selectively triggers GSDMD‐mediated pyroptosis, provoking robust immunogenic cell death and inflammatory cytokine release to reconfigure the tumor immune microenvironment. In murine tumor models, DIBDO enhances tumor infiltration of cytotoxic T cells and synergizes with checkpoint blockade therapy to suppress both primary and distal tumors. It can also serve as an in situ or exogenous vaccine to elicit potent and durable antitumor immunity. This work presents a paradigm‐shifting approach to cancer immunotherapy by decoupling pyroptosis from Casp‐3 dependence, offering a promising avenue to expand the scope of immunogenic cell death‐based treatments. This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death. This reconfigures the tumor microenvironment, transforms the tumor cells into in situ or exogenous vaccine, offering a novel paradigm for cancer immunotherapy.
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NEUROCHEMICAL RESEARCH
·
2026
·Vol. 51
·期 4
·226
·
IF 4.5
Qin Dani,Lei Yong,Le Meini,Cheng Mengke,Zhao Yingmin,Xia Lingyun,Li Xinyuan,Dong Xiaohua
Hypoxic-ischemic encephalopathy (HIE) is a severe perinatal brain injury that often leads to neurological impairments in survivors. Currently, effective therapeutic strategies for HIE remain limited and require further exploration. Emerging evidence indicates that microglia-mediated neuroinflammation plays a pivotal role in the pathophysiology of HIE. Nevertheless, clinically effective anti-inflammatory agents specifically targeting HIE are still lacking. Glycerol-3-phosphate (G3P) is a biologically significant metabolite involved in various cellular metabolic pathways. In this study, we investigated the neuroprotective effects of G3P against hypoxic-ischemic (HI)-induced brain injury by modulating microglial activation. In LPS-treated microglia, G3P suppressed the release of pro-inflammatory cytokines IL-6, IL-1β, and TNF-α, reduced reactive oxygen species (ROS) levels, restored mitochondrial membrane potential (MMP), and promoted a shift toward an anti-inflammatory microglial phenotype. In addition, G3P treatment in zebrafish showed no toxicity and significantly mitigated HI-induced oxidative stress, while suppressing both the recruitment and pro-inflammatory activation of mpeg1⁺ macrophages and lyzc⁺ neutrophils. Moreover, administration of G3P dramatically reduced infarct volume and alleviated neuronal loss in rats with hypoxic-ischemic brain damage (HIBD). Y-maze and Morris water maze tests demonstrated that G3P treatment significantly enhanced spatial learning and memory in HIBD rats. Furthermore, G3P markedly reduced the hyperactivation of microglia and astrocytes in both cortical and hippocampal regions. Mechanistically, Immunofluorescence and Western blot analyses revealed that G3P exerted anti-inflammatory effects by inhibiting cyclic GMP-AMP synthase -stimulator of interferon genes (cGAS-STING) signalling pathway and its downstream TBK1/the nuclear factor kappa B (NF-κB) signaling pathway. These findings highlight G3P as a promising therapeutic candidate for HIE.
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ACS Synthetic Biology
·
2025
·
IF 3.9
Zhen Zong,Lianghua Xie,Jiaqi Fu,Zhongyang Liu,Wen-Wen Zhou,Wei Chen
Cyanidin-3-O-galactoside (C3Ga), a natural pigment, has various beneficial biological activities and is widely used as a food colorant. However, traditional plant extraction methods are time-consuming and unsustainable. Rapid and sustainable synthesis of C3Ga by engineered microorganisms offers a promising alternative to traditional plant-based methods and deserves to be explored. In this study, the bioproduction of C3Ga by Escherichia coli was achieved for the first time. The biosynthetic pathway of C3Ga from (+)-catechin was constructed by introducing anthocyanidin synthase (ANS) and UDP-galactose:cyanidin galactosyltransferase. Some strategies, including enhancement of the UDP-galactose biosynthesis pathway, identification of efficient ANS, overexpression of the C3Ga transporter, and modulation of multigene expression, were subsequently used to drive the metabolic flux toward C3Ga production. Next, the two-stage process for C3Ga production was optimized to mitigate limitations for further metabolic engineering. Combined with the knockout of β-phosphoglucomutase (ycjU), a newly identified competitive pathway for UDP-galactose, the production of C3Ga finally reached 217.9 mg/L. The strategies used in this study could be applied to the biosynthesis of other anthocyanins and galactosylated natural products.
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Analytical Methods
·
2026
·
IF 2.6
Bingyu Fu,Yanru Shao,Zhixiong Zheng,Shengxin Wen,Yingli Guo,Qi Xu,Hualin Yang
In this study, a simple and sensitive dual-mode biosensor was designed based on the color of 2,6-dichloroindiphenol (DCIP) and the fluorescence of calcein. The target alkaline phosphatase (ALP) can catalyze the dephosphorylation of L-ascorbic acid-2-phosphate (AAP) to form ascorbic acid (AA) and phosphate ions. The reducing properties of AA can reduce the DCIP from blue to colorless. Meanwhile, phosphate ions can chelate with europium ions (Eu 3+ ) to restore the fluorescence of Eu 3+ -Calcein. In colorimetric mode, the linear detection range for ALP was 1.56-50 U/L with a limit of detection (LOD) of 0.27 U/L. In fluorescence mode, the linear detection range was 0.78-25 U/L and LOD was 0.23 U/L. Besides, the selectivity of this dual-mode for ALP was very excellent and the recovery rates in serum samples were also satisfactory.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Zhiping Zhang,Xinmiao Xi,Yongjie Wang,Hongfei Liu
At room temperature , monoclinic In 2 W 3 O 12 ceramics exhibits positive thermal expansion. However, it transforms into an orthorhombic phase above 253 ℃, and then stably exhibits negative thermal expansion (NTE). In this work, to improve the NTE performance and extend the NTE temperature range of In 2 W 3 O 12 , the K x Mn x In 2-x W 3 O 12 (0≤x≤0.5) ceramics were synthesized via the solid-state reaction method. The effects of (KMn) 3+ double cation co-doping on the composition , microstructure, and thermal expansion behaviors of In 2 W 3 O 12 ceramics were studied using XRD , Raman, XPS, SEM, and TMA. The results show that (KMn) 3+ cations can replace In 3+ in In 2 W 3 O 12 ceramics. As the (KMn) 3+ doping amount increases, monoclinic In 2 W 3 O 12 gradually changed into monoclinic K x Mn x In 2-x W 3 O 12 . Meanwhile, the grains grow up and the density of K x Mn x In 2-x W 3 O 12 ceramics was increased. Pure monoclinic K x Mn x In 2-x W 3 O 12 ceramics were prepared when x rises to 0.25 and 0.4. Among them, the thermal expansion coefficient of K 0.4 Mn 0.4 In 1.6 W 3 O 12 ceramics in 100–700 ℃ is as high as -17.83×10 -6 ℃ -1 , which was significantly improved compared to In 2 W 3 O 12 ceramics. In addition, the structural phase transition of In 2 W 3 O 12 ceramics around 253 ℃ was gradually eliminated and the NTE temperature range was widened. Double cation (KMn) 3+ co-doping effectively improves the NTE performance of In 2 W 3 O 12 .
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DALTON TRANSACTIONS
·
2013
·Vol. 42
·期 19
·7051-7058
·
IF 3.806
Chao Huang,Chun-Li Hu,Xiang Xu,Bing-Ping Yang,Jiang-Gao Mao
The synthesis, crystal and band structures and optical characterizations of a new polar thallium(I) vanadyl iodate, namely Tl(VO)2O2(IO3)3, are reported. Tl(VO)2O2(IO3)3 crystallizes in the orthorhombic polar space group Ima2 (No. 46) with a = 14.1143(17), b = 10.2116(12), c = 8.0319(9) Å, V = 1157.6(2) Å3 and Z = 4. The structure of Tl(VO)2O2(IO3)3 exhibits a 1D [(VO)2O2(IO3)3]− chain in which neighboring distorted VO6 octahedra are interconnected by both bridging oxo and iodate anions. The SHG measurements on Tl(VO)2O2(IO3)3, using a 2050 nm laser radiation, showed a moderate strong SHG response of 1.2 × KTP(KTiOPO4). Furthermore, the material is phase-matchable. Theoretical calculations based on DFT methods were performed by using the total-energy code CASTEP.
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JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
·
2013
·Vol. 66
·期 1
·133-138
·
IF 1.66
Peng Shusen,Zhao Wenjie,Zeng Zhixiang,Li He,Xue Qunji,Wu Xuedong
In this report, hybrid silica sol–gel coating was prepared using Ce(NO 3 ) 3 (Sol-Ce) as catalyst. Structure, surface morphology and anticorrosion ability of Sol-Ce solution/coating were studied by infrared spectroscopy (IR), scanning electron microscopy, energy dispersive spectrometer (EDS), potentiodynamic scan (PDS) and electrochemical impedance spectroscopy (EIS). IR results showed that Ce(NO 3 ) 3 had a stronger influence on reactivity of alkoxysilane. EDS results revealed that the fraction of Fe in Sol-Ce coating was significantly lower than regular acid-catalyzed hybrid silica sol–gel coating (Sol-Ac) and Sol-Ac with Ce(NO 3 ) 3 -doped coating (Sol-Ac/Ce). The results of PDS and EIS demonstrated that Sol-Ce coating had better anticorrosion ability than Sol-Ac and Sol-Ac/Ce on carbon steel. The enhanced anticorrosion performance of the Sol-Ce coating might result from the following two reasons: (a) Ce(NO 3 ) 3 as a catalyst could alleviate the negative effects of low pH with using acid catalyst (dissolution of carbon steel) and (b) Ce(NO 3 ) 3 could impede corrosion of carbon steel as corrosion inhibitor.
研究领域:
材料科学
·
表面工程
·
腐蚀与防护
·
无机化学
·
电化学
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