Soft Matter
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2012
·Vol. 8
·期 14
·3756-3761
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IF 4.39
Xiuqin Cai,Kaiqiang Liu,Junlin Yan,Helan Zhang,Xiaoyu Hou,Zhang Liu,Yu Fang
A novel calix[4]arene-based dimeric-cholesteryl derivative was synthesized, and its gelation behaviour in thirty organic solvents was investigated. It has been shown that the compound cannot gel any of the pure solvents tested. However, it gels a mixture of solvents n-decane and acetonitrile efficiently, provided the volume ratio of the two solvents in a mixture is within 9 : 1 and 3 : 2. AFM and SEM measurements revealed that the molecules of the compound aggregate into micro-/nano-rods first, then fine fibers, and then thick fibers, and finally networked structures in the mixture solvents. Interestingly, the gel with a composition of 1 to 1 (Vn-Decane:VAcetonitrile) and 2.5% (w/v) of the compound exhibits super-smart and fully reversible thixotropic properties, a phenomenon never reported before. Furthermore, the mechanical strength of the gel could be easily adjusted by altering the concentration of the gelator and the composition of the mixture solvents. Further interrogation of the gel revealed that structurally the gel is a gel-emulsion with acetonitrile dispersed in n-decane, a rarely found O/O (oil in oil) gel-emulsion which may find uses in the templated preparation of low-density materials with complicated internal structures.
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APPLIED SURFACE SCIENCE
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2016
·
IF 3.15
Wenjuan Shen,Yi Mu,Bingning Wang,Zhihui Ai,Lizhi Zhang
In this study, we demonstrate that the bimetallic iron-nickel nanoparticles (nZVIN) possessed an enhanced performance in comparison with nanoscale zero-valent iron (nZVI) on aerobic degradation of 4-chlorophenol (4-CP). The 4-CP degradation rate constant in the aerobic nZVIN process (nZVIN/Air) was 5 times that in the classic nZVI counterpart system (nZVI/Air). Both reactive oxygen species measurement and inhibition experimental results suggested that hydroxyl radicals were the major active species contributed to aerobic 4-CP degradation with nZVI, on contrast, superoxide radicals predominated the 4-CP degradation in the nZVIN/Air process. High performance liquid chromatography and gas chromatography-mass spectrometer analysis indicated the intermediates of the nZVI/Air system were p -benzoquinone and hydroquinone, which were resulted from the bond cleavage between the chlorine and carbon atom in the benzene ring by hydroxyl radicals. However, the primary intermediates of 4-CP found in the nZVIN/Air system were phenol via the direct dechlorination by superoxide radicals, accompanying with the formation of chloride ions. On the base of experimental results, a superoxide radicals mediated enhancing mechanism was proposed for the aerobic degradation of 4-CP in the nZVIN/Air system. This study provides new insight into the role of bimetallic nickel on enhancing removal of organic pollutants with nZVI.
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SOLAR ENERGY MATERIALS AND SOLAR CELLS
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2014
·
IF 5.03
Wangen Zhao,Gang Wang,Qingwen Tian,Lijian Huang,Shang Gao,Daocheng Pan
Cu 2 CdSn(S,Se) 4 is an important candidate material for thin film solar cell absorber layers . In this work, low-cost Cu 2 CdSnS 4 nanocrytal thin film with a stannite structure has been successfully fabricated by a butyldithiocarbamate-based ethanol solution approach. The selenized Cu 2 CdSn(S,Se) 4 thin film shows large densely packed grains and has a suitable band gap value of 1.01 eV. The Cu 2 CdSn(S,Se) 4 thin film solar cell with a proof-of-concept power conversion efficiency of 3.1% was fabricated.
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PHYSICS LETTERS A
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2024
·
IF 2.3
Ting-ting Yan,Yi-fei Xu,Dong-yang Xi,Zhi-qing Yu,Ran Jiang,Dan-dan Zhang
The study investigates the structural stability of the hydrogen-bonded energetic material 4-nitropyrazole (4-NP, C 3 H 3 N 3 O 2 ) from ambient pressure to 10 GPa at room temperature using diamond anvil cell (DAC) and Raman spectroscopy. Based on the changes observed in the high-pressure Raman spectra, it is proposed that the hydrogen-bonded energetic material 4-NP undergoes a phase transition within the pressure range of 2.7–6.4 GPa. Upon complete pressure release from 10 GPa, the resulting spectrum is consistent with the Raman spectrum observed under ambient pressure, indicating that the phase transition is reversible. Ab initio calculations were used to explain the changes in molecular arrangements and hydrogen-bonded networks. Hirshfeld surfaces and fingerprint plots were used to directly compare the variations in packing patterns and intermolecular interactions. Based on the experimental and calculated results, it is proposed that the phase transition of 4-NP was likely caused by the rearrangements of the hydrogen-bonded networks.
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JOURNAL OF GENE MEDICINE
·
2024
·Vol. 26
·期 10
·e3742
·
IF 3.2
Fuyun Zhu,Dezeng Zou,Ping Shi,Lianhua Tang,Dan Wu,Xiaoxue Hu,Fei Yin,Jianhui Liu
Background With its rapidly increasing incidence and prevalence, ulcerative colitis (UC) has become a major global health challenge. Recent evidence suggests that ferroptosis plays a significant role in the development of UC. However, the relationship between ferroptosis and the progression of UC needs to be extensively studied. Methods The differentially expressed genes in UC patients were screened from the GEO database. The ferroptosis-related genes were obtained from FErrDB and GeneCards. The UC subtypes were identified with the R package “CancerSubtype” and evaluated with consensus clustering (CC) to identify gene expression patterns in patients with UC. The key genes were detected with qRT-PCR, Western blot, and immunohistochemistry in vitro and in vivo models. Ferroptosis was identified with western blotting on ferrotic-associated proteins and staining on Fe 2+ with commercial FerroOrange kits. Results Dipeptidyl peptidase 4 (DPP4), also known as CD26, is a potential biomarker for ferroptosis in UC patients. Transcriptome sequencing data showed a positive correlation between decreased DPP4 expression and proinflammatory cytokines such as TNF-α, IL-6, and IL-β, as well as immune cell infiltration in the colon tissues of UC patients. Furthermore, DPP4 was strongly associated with ferroptosis biomarkers, particularly in Subtype 2 of UC. Interestingly, our study also found that DPP4 expression was significantly reduced in RSL3-treated ferroptotic intestinal epithelial cells, more so than in LPS-treated cell models. Inhibition of DPP4 had a significant impact on the expression of ferroptotic biomarkers. Additionally, DPP4 expression was decreased in the colon tissues of DSS-treated mice, and the ferroptosis inhibitor Ferritin-1 effectively counteracted the effects of DSS on immune cell infiltration, colon length, and DPP4 expression. Conclusions DPP4 can serve as a biomarker for ferroptosis in the diagnosis and management of UC. Highlights DPP4-mediated ferroptosis is involved in ulcerative colitis DPP4 is a novel diagnostic biomarker of ulcerative colitis Ferroptosis involves intestinal epithelial cell death in ulcerative colitis
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PubMed
高影响因子
Journal of Cleaner Production
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2024
·
IF 9.7
Jiahui Zhang,Wenliang Zhang,Yue Wang,Shaoyi Jiang,Yan Wang,Zhezheng Ding,Xiaomin Liu
2,4-dichlorophenoxyacetic (2,4-D) acid and 4-chlorophenoxyacetic acid (4-CPA), as widely utilized organochlorine pesticides , are normally detected in wastewater and atmosphere. Their harmfulness to the ecosystem cannot be ignored. UV/H 2 O 2 is one of the most conventional advanced oxidation processes, which has remarkable advantages for the removal of refractory organic pollutants in wastewater. However, the reaction mechanisms and pathways of pollutants with reactive radicals are still unclear. In this study, the degradation efficacy and mechanisms during the photodegradation of 2,4-D and 4-CPA in UV/H 2 O 2 processes were investigated by experiments and density functional theory calculations. The results showed that 2,4-D was more likely to be degraded by UV/H 2 O 2 treatment than UV photolysis alone. In contrast, 4-CPA can be degraded effectively and rapidly under UV irradiation alone. By LC-MS analysis, the degradation products of 2,4-D and 4-CPA in the UV/H 2 O 2 processes were identified and they were produced by hydroxylation and photolysis. Therefore, we speculated a competition mechanism presented between direct photolysis and indirect photolysis in the UV/H 2 O 2 degradation of 2,4-D and 4-CPA. The OH-initiated reaction mechanisms of 2,4-D and 4-CPA in aqueous environments were investigated using quantum chemical methods SMD/M06–2X/6–311++G (3df, 2p)//SMD/M06–2X/6-311 + G (d,p). The pH dependence of the reaction mechanisms and rate constants in their degradation process induced by ·OH was also investigated. The calculation results showed that the ionic forms (2,4-D - and 4-CPA - ) were more prone to react with ·OH in comparison to the corresponding molecular forms (2,4-D and 4-CPA). The total rate constants of 2,4-D and 4-CPA with OH increased with the pH from 1 to 10, and decreased with continued pH increase. The toxicities of 2,4-D, 4-CPA and their products were assessed by the QSAR-based toxicity evaluation software. The results showed that several products were more toxic than their parent compounds, such as 2,4-dichlorophenol, 3,5-dichlorocatechol, 4-chlorophenol and hydroquinone . This work can contribute to clarifying the environmental risks of 2,4-D and 4-CPA and offer a complete understanding for the photodegradation behavior of 2,4-D and 4-CPA in aqueous ecosystems.
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ACS Omega
·
2025
·
IF 4.3
Qingquan Guo,Yudong Zhang,Chuanjin Tang,Qiuru Li,Fei Liu,Zhenming He,Chenyang Jiang,Jun Xu,Haishan Zhao
This study investigates the skin-whitening potential of 4-Hydroxyacetophenone (4-HAP), a compound commonly used as a preservative in cosmetics. Despite its widespread use, its whitening activity has not been extensively reported. Our preliminary research identified several commercial cosmetic formulations exhibiting whitening effects without known whitening agents. We hypothesized that 4-HAP might be a key ingredient. To test this, we employed a mushroom tyrosinase model, B16 mouse melanoma cells, and zebrafish to systematically evaluate the whitening activity of 4-HAP. Our findings demonstrate that 4-HAP is a potent tyrosinase inhibitor, significantly reducing melanin content in vitro and in vivo. Additionally, molecular docking and dynamics analyses revealed that the stable binding of 4-HAP to tyrosinase is crucial for its whitening effect. In formulations containing 2% 4-HAP, human skin models showed nearly complete recovery from UV-induced pigmentation after 4 weeks, while control groups exhibited persistent UV marks. These results confirm the efficacy of 4-HAP as a stable whitening agent in cosmetic formulations, highlighting its potential for further development in skin lightening products. This study has confirmed that 4-HAP holding the potential to become an effective whitening ingredient in the cosmetics field.
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PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Yuxin Wang,Zijian Tan,Hongli Wei,Nan Zhang,Lifei Wang,Yifan Yang,Weidong Liu,Leilei Zhu
D-Tagatose, a promising sugar substitute with various functional properties and commercial applications, can be enzymatically converted from D-fructose by tagatose 4-epimerase. The development of an efficient tagatose 4-epimerase that catalyzes the conversion of D-fructose into D-tagatose is essential to make the production technology of D-tagatose applicable. In this study, tagatose 4-epimerase from Thermotogae (TsT4Ease) was engineered through semi-rational design and directed evolution, resulting in a 2.8-fold improvement in catalytic activity compared to the wild type (WT). The production of D-tagatose reached 42 g/L in 2 h. Crystal structure analysis determined the structural features with a common (α/β)8-TIM barrel and a Zn2+-binding architecture at the active center. Subsequent molecular dynamics (MD) simulations revealed that the substitutions improved substrate binding energy and stabilized the active pocket. This study offers new insights into the structure–function relationship of TsT4Ease and provides a candidate tagatose 4-epimerase.
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PubMed
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JOURNAL OF LUMINESCENCE
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2024
·
IF 3.3
Weiguang Ran,Zicheng Zhang,Fukai Wang,Huixin Jiang,Yue Shao,Xiaoli Ma,Jiayi Geng,Tingjiang Yan
In this paper, the novel BaY 2 (MoO 4 ) 4 :xSm 3+ phosphors with strong red emission and high thermal stabilization were prepared by a conventional method of high temperature solid state reaction in air atmosphere. Morphology, phase purity, element distribution, UV–Vis–NIR diffuse reflectance spectroscopy (DRS), and luminescence properties were investigated in detail. The crystal structure of the BaY 2 (MoO 4 ) 4 host was refined with the aid of the Rietveld refinement method by the GSAS program. The electronic band structure and phonon dispersion were performed using plane-wave density functional theory (DFT). The prepared BaY 2 (MoO 4 ) 4 :Sm 3+ phosphor exhibits excellent red emission under near-ultraviolet excitation. Strong red emission intensity and high thermal stability suggest potential application in backlighting or phosphor-covered white light-emitting diodes (pc-LEDs).
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CHEMICAL PHYSICS LETTERS
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2025
·
IF 3.1
Tingting Yan,Han Li,Dongyang Xi,Lei Sun,Linan Liu,Dinghan Jin
This study investigated the behavior of energetic material 4-aminobenzamide (4-AMBZA; C 7 H 8 N 2 O) under high pressure utilizing Raman spectroscopy. Notable alterations were detected in the Raman spectra within 2.6–7.8 GPa, suggesting 4-AMBZA experiences a phase transition. Continued pressure caused the crystal to show a tendency towards amorphization. When the pressure is released, the amorphization phenomenon persists. Variations of N H bending vibration (amide II), C N stretching vibration (amide III), and C O stretching vibration (amide I) indicate that phase transition arises from the twisting and rearrangement of hydrogen-bonded networks. Hirshfeld surface energy were conducted to analyze intermolecular interactions within 4-AMBZA.
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BRAZILIAN JOURNAL OF CHEMICAL ENGINEERING
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2026
·
IF 1.7
Al-Khazaal Abdulaal Zuhayr,Khalid Rimsha,Raza Saqlain,Ghias Warda,Bhatti Nadia,Abid Amin,Tan Bien,Masood Hafiz Tariq,Iqbal Javed
Hypercrosslinked polymers (HCPs) show a scalable family of porous materials that are ideal for post-combustion CO 2 capture. This study reports two HCPs based on 4-bromoaniline (HCP-BA-A and HCP-BA-B), synthesized via FeCl₃-catalyzed Friedel–Crafts alkylation, which produce durable networks featuring hierarchical micro and mesoporosity. The material’s architecture and morphology are verified through FTIR, SEM, and TEM, while N 2 adsorption–desorption isotherms support the porous structure. These HCPs achieve BET surface areas (919.08 m 2 g⁻ 1 for HCP-BA-A; 753.42 m 2 g⁻ 1 for HCP-BA-B), good CO₂ uptakes (HCP-BA-A: 4.24 mmol g⁻ 1 at 273 K/1 bar, 2.82 mmol g⁻ 1 at 298 K/1 bar; HCP-BA-B: 3.06 mmol g⁻ 1 at 273 K/1 bar, 1.98 mmol g⁻ 1 at 298 K/1 bar), low isosteric heats of adsorption (28–32 kJ mol⁻ 1 ), and excellent cyclability (> 95% retention after multiple cycles). The kinetics follow a pseudo-1st order model, indicating rapid, surface-dominated uptake, and the adsorption isotherms most closely match the Langmuir–Freundlich model, reflecting heterogeneous surface energies. These HCPs outperform a variety of conventional porous sorbents because of inexpensive synthesis from accessible aromatic compound, straightforward scalability and enhanced hierarchical porosity. Graphical abstract
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MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Yang Liu,Xueping Dang,Hanyue Ding,Huaixia Chen
A molecularly imprinted polymer (MIP) monolith was in situ synthesized in pipette tip with 4,4′-methylenedianiline (4,4′-MDA) as template molecule and 4-vinylpyridine as functional monomer. The 4,4′-MDA-MIP monolith was used to extract three primary aromatic amines (PAAs), including 4,4′-MAD, 4-aminobiphenyl and 3,3′-dichlorobenzidine. The 4,4′-MDA-MIP monolith have specific recognition capacity and high adsorption capacity for the three PAAs. The imprinting factor for 4,4′-MAD was up to 4.26 and the adsorption capacity for 4-aminobiphenyl was up to 117.94 mg g −1 . The extraction parameters for the pipette tip solid-phase extraction (PTSPE) were optimized. A determination method for the three PAAs was established by coupling the PTSPE with high performance liquid chromatography-diode array detector. The detection linear range (LRs) was 0.70–500 µg kg −1 (R 2 > 0.998), and the limits of detection (LODs) was 0.23–1.00 µg kg −1 (S/N = 3). The method was used for the migration detection of the PAAs from four polypropylene spoons, which showed satisfactory recovery of 87.4–110.6 %, indicating that the 4,4′-MDA-MIP monolith had good enrichment ability for PAAs in a complex matrix.
研究领域:
分析化学
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食品安全
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