JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2026
·
IF 3.4
Rong He,Yanjie Zhu,Weiping Zhou,Muhammad Azhar Hayat Nawaz,Yunhui Li,Jianwei Zhu,Huimin Feng,Anna Maria Nowicka,Wenzhao Han,Cong Yu
The detection of important inflammatory biomarkers possesses substantial advantages in guiding clinical decision-making. In particular, simultaneous detection of interleukin-6 (IL-6) and procalcitonin (PCT) significantly improves the differentiation between bacterial and viral infections, a critical challenge in early-stage diagnostics. To address this need, a reliable lateral flow immunoassay (LFIA) incorporating aggregation-induced luminescent nanoparticles (BTA@PS) was successfully developed. A novel aggregation-induced emission (AIE) probe was designed and encapsulated within polystyrene microspheres, thereby overcoming the limitations of aggregation-caused quenching (ACQ) in conventional fluorescent materials. The resulting BTA@PS nanoparticles, conjugated with specific antibodies against IL-6 and PCT, served as stable and effective immunofluorescent probes for the LFIA platform. Under optimized experimental conditions, the developed BTA@PS-LFIA enabled simultaneous quantification of IL-6 and PCT, demonstrating excellent linearity over the range of 2–8000 pg/mL and 0.04–30 ng/mL, respectively, with coefficient of variation (CV) values of below 5%. Furthermore, this method demonstrated superior detection capability for PCT and IL-6 in serum, confirming its high potential for rapid clinical diagnostics.
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PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2026
·
IF 6
Jia Liu,Lu Liu,Haofeng Zheng,Caiye Chen,Baixian Zhou,Changfei Liu,Weiqiang Zeng,Yantong Lu,Kaixia Fu,Sha Lai,Fenglan Song,Saizhu He,Wei Yang,Fan Yang
6-Mercaptopurine (6-MP), a first-line drug for the maintenance treatment of acute lymphoblastic leukemia (ALL) in pediatric patients, has an extremely narrow therapeutic window and exhibits considerable dosage variability. This study employed semi-solid extrusion (SSE) 3D printing to fabricate precisely dosed subdivided 6-MP tablets of 1, 3, 5, 15, and 20 mg using two formulations (low-dose and high-dose). Printability-guided optimization was conducted to identify the optimal formulations. The low-dose formulation comprised commercial 6-MP powder, 10% hydroxypropyl methylcellulose (HPMC) hydroalcoholic gel, and a 6:7 (w/w) mixture of cornstarch and microcrystalline cellulose, whereas the high-dose formulation consisted of commercial 6-MP powder, 10% HPMC hydroalcoholic gel, 2% magnesium stearate, and 3% sodium carboxymethyl starch. All five dosage specifications met pharmacopoeial standards for mass uniformity, drug content, content uniformity, and dissolution. High-performance liquid chromatography, powder X-ray diffraction, Fourier transform infrared spectroscopy, and Raman spectroscopy were employed to analyze the physicochemical characterization of 6-MP before and after 3D printing, confirming that the drug content, crystal form, and chemical structure of 6-MP remained unchanged during SSE 3D printing and 7-day storage. Pediatric patients with ALL were treated with either 3D-printed or pharmacist-splitting group subdivided 6-MP doses. Paired t-tests within each group revealed significant differences in white blood cell counts pre-treatment and post-treatment (pharmacist-splitting group: P < 0.01; 3D-printed group: P < 0.001), indicating that both groups exhibited pharmacological activity, with the 3D-printed group achieving improved control of hematological indices. Overall, SSE 3D printing technology enables accurate and safe individualized drug dosing.
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CHEMICAL ENGINEERING & TECHNOLOGY
·
2017
·Vol. 41
·期 2
·353-366
·
IF 2.051
Shumin Wang,Qingping Guo,Shujun Liang,Peng Li,Xin Li,Jujie Luo
For the evaluation of CH 4 /N 2 separation, mixed-matrix membranes (MMMs) were fabricated by adding [Ni 3 (HCOO) 6 ] as a filler into the poly(styrene- b -butadiene- b -styrene) (SBS) polymer. The structures and morphologies of [Ni 3 (HCOO) 6 ] and [Ni 3 (HCOO) 6 ]/SBS MMMs were characterized by different techniques, proving the crystalline structure of [Ni 3 (HCOO) 6 ] in SBS polymer matrices. The structural integrity of the MMMs and good compatibility between [Ni 3 (HCOO) 6 ] and SBS polymer were examined by scanning electron microscopy. Gas permeation measurements revealed that membranes containing various [Ni 3 (HCOO) 6 ] loadings exhibited different separation performances. The operational temperature exerted a significantly positive effect on the separation of CH 4 and N 2 .
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RSC Advances
·
2017
·Vol. 7
·期 47
·29779-29785
·
IF 3.108
Fengmei Ren,Ran Zhou,Fang Sun,Haihong Ma,Zhengfa Zhou,Weibing Xu
The surface of alumina (Al2O3) particles was modified by a blocked isocyanate silane coupling agent, which was synthesized by using methylethyl ketoxime (MEKO) to block isocyanate-propyltriethoxy silane via nucleophilic reactions. For comparison, the surface of Al2O3 particles was also modified by propyltrimethoxy silane (KH-331). The thermally conductive and electrical insulating Al2O3/polyamide 6 composites were prepared by dispersing modified Al2O3 in polyamide 6 (PA6) using a twin-screw extruder. The X-ray photoelectron spectroscopy (XPS) results revealed that blocked isocyanate-propyltriethoxy silane and KH-331 were successfully attached to the surface of Al2O3 particles with chemical bonds. The blocked isocyanate silane modified Al2O3 were well dispersed in PA6 as revealed by scanning electron microscopy (SEM). When the Al2O3 content was 70 wt%, the tensile strength (85.2 MPa) and flexural strength (136.4 MPa) of blocked isocyanate silane modified Al2O3/PA6 composites were higher than those of KH-331 modified Al2O3/PA6 composites (52.5 MPa, 77.8 MPa), respectively. The thermal conductivity and impact strength of blocked isocyanate silane modified Al2O3/PA6 composites were also higher than that of KH-331 modified Al2O3/PA6 composites at the same content of Al2O3. The volume electrical resistivity of modified Al2O3/PA6 composites decreased with increasing Al2O3 content, but they still were good electrical insulating materials.
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Inorganic Chemistry Frontiers
·
2018
·Vol. 5
·期 3
·619-625
·
IF 5.106
Ying Liu,Maxim S. Molokeev,Quanlin Liu,Zhiguo Xia
Crystal structure evolution and temperature-dependent phase transition of solid solutions are much desired for the understanding of the optimization of functional properties. Herein, the NASICON-type NaZr2(PO4)3–SrZr4(PO4)6 solid solutions with the formula Na(2−2x)Srx[ ]xZr4(PO4)6 (0 ≤ x ≤ 1), where [ ] represents the vacancy, were prepared by the sol–gel method, and their crystal structures, phase transitions and thermal expansion properties were investigated in detail. In the range of x = 0.3–0.35, there is a reversible structural phase transition Rc ↔ R and the different structural models of the R phase and Rc phase were built to better understand the phase transition mechanism. We determined the phase transition boundary between the Rc and R structures and predicted the phase transition temperature of Na(2−2x)Srx[ ]xZr4(PO4)6 with any x for further investigation of controlled physical properties. The results indicated that Na0.5Sr0.75[ ]0.75Zr4(PO4)6 showed a near zero thermal expansion in the temperature range of 450–600 K, which can find potential applications.
研究领域:
材料科学
·
无机化学
·
功能材料
·
结构表征
·
热物理性能
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高影响因子
DALTON TRANSACTIONS
·
2019
·Vol. 49
·期 2
·504-510
·
IF 4.052
Hongmei Su,Qi Wang,Ning Wang,Yanzhao Yang
The first gemini-type benzimidazole ionic liquid ([C4-6-C4BIm]Br2) with two sites of action was synthesized and applied for gold extraction. The effects of [C4-6-C4BIm]Br2 concentration, initial gold(III) concentration, acidity, and the loading capacity of [C4-6-C4BIm]Br2 were examined in detail. It was found that [C4-6-C4BIm]Br2 has excellent extraction ability for obtaining high purity gold. The anion exchange mechanism between [C4-6-C4BIm]Br2 and Au(III) was proved by Job's method and 1H NMR and FTIR spectroscopy. Quantum chemical calculations were carried out to prove the mechanism theoretically. The extraction equilibrium process was modeled using Langmuir and Freundlich isotherms. Thermodynamic parameters ΔH, ΔG and ΔS indicated that the extraction process was exothermic and spontaneous. The pseudo-second-order kinetic model well fitted the experimental data (R = 0.99). In addition, [C4-6-C4BIm]Br2 has high selectivity for Au(III) compared to other base metals. In summary, [C4-6-C4BIm]Br2 has great application prospects in industry due to its excellent characteristics such as low cost, easy availability, and high extraction capacity.
研究领域:
化学工程
·
材料科学
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高影响因子
Journal of Physical Chemistry C
·
2026
·
IF 3.4
Jiaying Liu,Shiwei Wang,Dong Wang,Zhihao Yu,Lin Zhu,Chunzheng Wu,Hongbo Yu
Modifying noble metal catalysts with transition metal oxides (MOx) is an effective strategy to enhance both catalytic activity and selectivity through interfacial synergy. However, achieving precise spatial colocalization of the metal and oxide phases remains a challenge. Herein, Pd1-(CuOx)1 hybrid nanostructures confined within KIT-6 mesoporous silica were rationally synthesized via in situ oxidative transformation of PdCu bimetallic nanoparticles (NPs) under controlled thermal treatment. The resulting Pd1-(CuOx)1/KIT-6 catalysts exhibited markedly enhanced activity and chemoselectivity for the hydrogenation of acetophenone to 1-phenylethanol compared with monometallic Pd/KIT-6 and PdCu/KIT-6. The optimal catalyst with a Pd/Cu molar ratio of 1:1 achieved 93.1% acetophenone conversion and 98.2% selectivity toward 1-phenylethanol, and demonstrated broad applicability across a range of ketone substrates. Comprehensive structural characterization revealed that the Pd-CuOx interfacial sites are central to the observed performance enhancement: metallic Pd facilitates H2 dissociation, while adjacent CuOx species are proposed to facilitate carbonyl adsorption, contributing to the overall synergistic enhancement. This interface-driven synergistic mechanism provides a general, efficient, and cost-effective strategy for the selective hydrogenation of multifunctional molecules.
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高影响因子
Hepatology Communications
·
2026
·Vol. 10
·期 5
·e0916
·
IF 6
Xiao-Wen Wang,Wen-Jie Zheng,Hao-Qi Chen,Tao Huang,Yuan Zhang,Xi-Jing Yan,Wen-Chao Li,Long Zou,Jie-Zhong Wu,Wen-Feng Zhu,Qi-Wei Yang,Gen-Shu Wang,Kun-Peng Hu
Background: Hepatic ischemia–reperfusion injury (IRI) is an important factor affecting the prognosis of liver transplantation patients. The role of Arrb2 in liver injury is unclear. Our study aimed to determine the role of Arrb2 in hepatic IRI and to identify its underlying mechanisms. Methods: An analysis of clinical samples was conducted to assess the association between Arrb2 expression and the prognosis of liver transplantation. A 70% hepatic ischemia/reperfusion model in mice was established to verify the mechanism of Arrb2 in hepatocytes promoting M2 macrophage polarization in attenuating hepatic IRI by regulating 6-ketoLCA. A model of hypoxia/reoxygenation in vitro was established to investigate the molecular mechanism of 6-ketoLCA in promoting M2 macrophage polarization and pharmacological screening. Results: Arrb2 in hepatocytes has been shown to provide significant liver protection against hepatic IRI, primarily through promoting the polarization of liver macrophages to M2. Arrb2 remodels bile acids and upregulates 6-ketoLCA through Cyp7a1 in hepatocytes, promoting M2 polarization of macrophages, thereby alleviating hepatic IRI. Mechanistically, TGR5 plays a crucial role in promoting the induction of M2 polarization in macrophages by 6-ketoLCA. Pharmacological screening indicates that dutasteride enhances the activity of the Arrb2 promoter and upregulates Arrb2 expression in hepatocytes, thereby mitigating hepatic IRI. Conclusions: Arrb2 in hepatocytes attenuates hepatic IRI by promoting macrophages toward the M2 phenotype through bile acid. Moreover, dutasteride, a selective agonist of Arrb2, emerges as a promising targeted therapeutic agent for the clinical management of liver injury.
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PubMed
高影响因子
Frontiers in Microbiology
·
2026
·
IF 5.8
Nesreen Aljahdali
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic amine (HCA) that is formed during high-temperature meat cooking, especially grilling, and is classified as a carcinogenic food-borne compound that can impact multiple physiological systems. The aim of this study was to evaluate how exposure to PhIP affects the composition of the cecal microbiota in mice. A total of 32 mice were randomly divided into four groups: A negative control group, a positive control group, and two groups treated orally with either 10 or 20 mg/kg PhIP for 2 months. The V3-V4 regions of the bacterial 16S rRNA gene were sequenced to characterize the cecal microbial communities. Microbial richness and diversity decreased in the PhIP-treated mice compared to the negative control group. At the phylum level, the relative abundance of Bacillota and Actinomycetota decreased significantly after PhIP exposure, while the abundance of Campylobacterota and Bacteroidota increased. At the genus level, the abundance of Roseburia, Lactobacillus, and Bifidobacterium decreased, while the abundance of Blautia, Lachnospiraceae-NK4A136 group, Bacteroides, Alistipes, Helicobacter, and Escherichia–Shigella increased. The results highlight that bacterial community composition and its relative abundance in the cecum change with PhIP exposure and offer further evidence of microbiota dysbiosis that occurs with PhIP exposure.
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高影响因子
ACS Applied Polymer Materials
·
2026
·
IF 5.2
Shiyang Zhu,Zongsheng Liu,Baoli Huang,Kaiming Du,Meng Ma,Si Chen,Yanqin Shi,Huiwen He,Yulu Zhu,Xu Wang
Although polyamide 6 (PA6) is a widely used engineering plastic, its high flammability with severe melt dripping poses significant fire risks, and common additive flame retardants often deteriorate its mechanical properties. Herein, an intrinsic flame-retardant PA6 copolymer was successfully synthesized by incorporating a phosphorus-containing monomer (PD) derived from DOPO and a Schiff base intermediate, and the copolymer was named PA6-co-PDx and was prepared by melt polycondensation. The incorporation of PD significantly enhanced the flame retardancy of PA6, with PA6-co-PD40 passing a UL-94 V-0 rating and a limiting oxygen index of 26.1%. Cone calorimetry revealed remarkable reductions in the peak heat release rate (53.6%) and total heat release (27.6%), indicating suppressed combustion intensity. The flame-retardant mechanism was attributed to the synergistic effect of high-temperature self-cross-linking and catalytic char formation in the condensed phase, along with gas-phase radical quenching by phosphorus-containing species. Although the introduction of PD slightly reduced the crystallinity and mechanical properties, the copolymer retained acceptable processability, demonstrating great potential for applications requiring high flame retardancy.
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Hai Yang,Song Ma,Shanshan Li,Yi Liu,Fuchao Wang,Zhuowei Li,Ge Zhu
Broadband near-infrared phosphor-converted LEDs (NIR pc-LEDs) are highly desirable for emerging spectroscopic applications. However, the simultaneous realization of long-wavelength emission and broad spectral coverage remains challenging. Herein, we report a novel Cr 3+ -activated phosphate phosphor SrHf 4 (PO 4 ) 6 : Cr 3+ that exhibits broadband NIR emission centered at 890 nm with a full width at half maximum of 162 nm under blue-light excitation. The red-shifted and broadened emission is enabled by a weak crystal-field environment and the dual-site occupation of Cr 3+ in the SrHf 4 (PO 4 ) 6 lattice. Structural analysis and electron paramagnetic resonance measurements indicate that Cr 3+ ions occupy both Sr 2+ and Hf 4+ sites, which is further supported by the emission-band deconvolution, wavelength-dependent lifetime analysis and formation-energy calculations. The thermal-quenching behavior is also investigated to clarify the non-radiative relaxation mechanism associated with electron-phonon coupling. Moreover, a prototype NIR pc-LED fabricated with the optimized phosphor delivers an output power of 57.4 mW and a photoelectric conversion efficiency of 5.1% at 350 mA, demonstrating its potential applications in non-destructive testing, information encryption and night-vision imaging. This work provides a structurally interpretable dual-site strategy for extending and broadening Cr 3+ NIR emission in phosphate hosts, offering guidance for the development of advanced broadband NIR light sources.
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ENVIRONMENTAL RESEARCH
·
2026
·
IF 8.2
Minming Chen,Yongjie Liu,Wenwen Qu,Qianlong Zhang,Fei Li,Yi Wang,Xuan Zhai
Per- and polyfluoroalkyl substances (PFASs) are persistent environmental contaminants closely linked to metabolic liver disease; however, the transgenerational hepatotoxicity and underlying mechanisms of emerging PFAS substitutes remain poorly understood. Herein, we focused on 6:2 polyfluoroalkyl phosphate diester (6:2 diPAP), a prominent PFAS substitute, to evaluate its developmental hepatotoxicity. By integrating zebrafish phenotyping, transcriptomic feature selection, virtual gene knockout, and experimental validation, we characterized the candidate molecular events through which 6:2 diPAP triggers non-alcoholic fatty liver disease (NAFLD)-like injury in offspring. Early-life exposure to environmentally relevant concentrations of 6:2 diPAP from 0 to 5 dpf, particularly 500 ng/L, induced persistent hepatic lipid accumulation, hepatic vacuolation, and metabolic disturbances in zebrafish at 28 dpf. Integrated network and transcriptomic analyses identified sequestosome 1 (SQSTM1) as a key stress-responsive hub associated with pathological hepatocyte remodeling. Quantitative real-time polymerase chain reaction (RT-qPCR) and immunofluorescence analyses further demonstrated exposure-responsive increases in sqstm1 expression and SQSTM1/p62 protein fluorescence intensity, with the strongest changes observed in the 500 ng/L group. Human single-nucleus RNA-seq and pseudotime analyses revealed that SQSTM1-high hepatocytes were enriched in injury-associated and senescence-associated states during NAFLD progression, suggesting a link between SQSTM1 activation and hepatocyte-state deterioration. Furthermore, virtual SQSTM1 knockout in NASH hepatocytes predicted oxidative stress, xenobiotic metabolic, and inflammatory rewiring. Molecular docking predicted a feasible 6:2 diPAP-SQSTM1 interaction with a binding affinity of −6.0 kcal/mol, and 200 ns molecular dynamics simulation supported the structural plausibility of the ligand-protein complex. Collectively, this study proposes a 6:2 diPAP-SQSTM1-hepatocyte remodeling axis and provides a comprehensive framework linking early-life PFAS exposure with hepatocyte-state transition and NAFLD-like metabolic dysfunction.
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