Heliyon
·
2023
·
IF 4
Shi-Jun Yin,Hua Chen,Shengpeng Wang,Yitao Wang,Feng-Qing Yang
A core-shell structure UiO-66-(OH) 2 @UiO-66-NH 2 (MOF@MOF) nanoparticle was synthesized through a simple hydrothermal method and employed as an adsorbent and laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) matrix for the quantitative analysis of rhubarb anthraquinones (RAs). The properties of the materials were characterized by field emission scanning electron microscopy, transmission electron microscopy, energy-dispersive X-ray spectroscopy, X-ray powder diffraction, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, thermogravimetric analysis, and Brunauer-Emmett-Teller. The results indicate that MOF@MOF is regular octahedral structure with a size distribution of about 100 nm, having large BET specific surface area (920 m 2 /g). Using the MOF@MOF as a matrix shows lower background interference, higher sensitivity, and better storage stability than that of traditional matrices. The MOF@MOF matrix exhibits excellent salt tolerance even under a NaCl concentration of 150 mM. Then, the enrichment conditions were optimized, and the adsorption time of 10 min, adsorption temperature of 40 °C and adsorbent amount of 100 μg were selected. In addition, the possible mechanism of MOF@MOF as an adsorbent and matrix was discussed. Finally, the MOF@MOF nanoparticle was employed as a matrix for the sensitive MALDI-TOF-MS analysis of RAs in spiked rabbit plasma, and the recoveries are in the range of 88.3-101.5% with RSD ≤9.9%. In short, the novel MOF@MOF matrix has demonstrated its potential in the analysis of small-molecule compounds in biological samples.
研究领域:
分析化学
·
材料科学
·
质谱技术
·
药物分析
·
纳米技术
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DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Xuedong Wei,Na Li,Xianming Zhang
It remains a huge challenge to develop non precious electrocatalysts with high activity to substitute commercial Pt catalysts for hydrogen evolution reactions (HER). Here, the C-Cu-DI and C-Cu materials with the copper based nanoporous carbon structures were synthesized by carbonizing MOF199 and DI-MOF199. The composite structure and HER electrocatalytic properties of the C-Cu-DI and C-Cu materials are studied. The results show that C-Cu-DI and C-Cu samples exhibit good catalytic activity. And C-Cu-DI sample through the addition of Dimethyl imidazole(DI) in the DI-MOF199 precursor has higher electrocatalytic activity than the C-Cu sample. The superior catalytic activity is attributed to the special composite structure of nanoscale deposition particles on the framework with plenty of nano pores and nano copper and few copper oxidation particles distributed or wrapped into the amorphous porous carbon phase. The nano copper and few copper oxidation particles in the C-Cu and C-Cu-DI catalysts maybe provide the more effective catalytic activity sites. The C-Cu-DI composite with large size spherical hollow deposition particles has higher conductivity, better BET surface area and reasonable micro-meso-macro porous distribution, so the overpotentials at the current density of 1 mA cm −2 and 10 mA cm −2 are respectively 270 mV and 390 mV vs. RHE. Although the HER activity has a big gap with commercial platinum catalyst, this study can provide an important experimental exploration for the design of copper based non noble metal/nano porous carbon composite HER electrocatalyst.
研究领域:
材料化学
·
电化学
·
纳米材料科学
·
能源催化
·
功能材料
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2020
·
IF 7.183
Rong Rong,Yanwei Sun,Taotao Ji,Yi Liu
Zirconium-based MOF (Zr-MOF) membranes have attracted widespread attention due to their highly tailorable pore aperture and adsorption behavior achieved by functional group decoration and ligand/cluster-missing defect regulation as well as extraordinary chemical/thermal stability. Nevertheless, it has remained a great challenge to further improve the separation performance of Zr-MOF membranes due to very limited available zirconium sources and heating modes. In this study, we prepared polycrystalline UiO-66 membranes exhibiting unprecedented CO 2 /N 2 selectivity (31.3). The use of layered ZrS 2 , a representative of transition-metal dichalcogenides (TMDCs), as zirconium source during tertiary solvothermal growth was found to be indispensable for improving the separation performance of UiO-66 membranes. As far as we know, the CO 2 /N 2 selectivity reported in this study was the highest among all pristine polycrystalline MOF membranes measured under ambient conditions. More importantly, our study highlighted the importance of concurrent metal source and fabrication process innovation in performance enhancement of polycrystalline MOF membranes.
研究领域:
材料科学
·
化学工程
·
膜技术
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Bo Liu,Shuhan Liu,Youjing Shi,Yali Cheng,Xiuling Zhang,Feng Tian,Kun Yang,Fan Li
Highly sensitive point-of-care testing (POCT) with an extended dynamic range is critical for accurate serum procalcitonin (PCT) quantification in grading diagnosis. However, conventional single-fluorescence POCT assays face inherent limitations in balancing trace-level sensitivity with broad detection spans. Herein, we demonstrate a dual-strategy POCT system based on the synergistic integration of homogeneous immunoassay and lateral flow immunoassay. Via rational design of blue/near-infrared carbon dots@metal-organic framework (CDs@MOF) functional probes (Tris-CDs@ZIF-8/NIR-CDs@ZIF-8), ultrasensitive detection of PCT with an ultra-wide dynamic range spanning from pg to ng levels was achieved, facilitating stratified diagnosis. Under the confinement effect of MOF, both Tris-CDs and NIR-CDs exhibited enhanced fluorescence intensity and stability. In the homogeneous immunoassay, leveraging fluorescence resonance energy transfer and signal amplification, Tris-CDs@ZIF-8 (donor) and NIR-CDs@ZIF-8 (acceptor) enabled direct detection of PCT in raw serum ranging from 0 to 100 ng/mL with a limit of detection (LOD) of 0.2 ng/mL, which is well-suited for rapid screening at ≥10 ng/mL. In the lateral flow immunoassay, a portable UV analyzer equipped with highly fluorescent Tris-CDs@ZIF-8 probes achieved semi-quantitative visualization (threshold: 0.01 ng/mL) and quantitative detection (LOD: 0.001 ng/mL) of PCT, enabling precise stratification at ≤10 ng/mL concentrations. The dual-strategy synergistic system significantly overcomes the performance limitations of conventional single-fluorescence POCT assays, providing a novel approach for the immediate graded detection of disease markers.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2026
·
IF 8.8
Yijing Zhang,Si Sun,Ming Wang,Yaling Han,Xuan Luo,Shenzhen Cong,Tao He,Huan Pang
Membranes featuring structural stability and precise ion selectivity are indispensable for efficient lithium recovery from magnesium-rich brines. Despite the promising potential of metal-organic framework (MOF) membranes in ion separation, the flexibility of aromatic linkers in conventional MOF structures often induces pore size fluctuations, which compromises size-based discrimination efficiency. Herein, defect-free Zr-Frustrated Trigonal-symmetry Rotor (Zr-FTR) membranes were fabricated on polyethylene terephthalate (PET) substrates via a counter-diffusion interfacial growth method. The Zr-FTR framework is constructed with bicyclopentane linkers, whose rigid geometric configuration and substantial torsional energy barriers ensure the retention of a fixed pore aperture (∼4.3 Å). This rigid confinement effect significantly suppresses transient pore expansion, enabling effective ion size sieving while retaining exceptional structural stability. The optimized Zr-FTR-24 membrane exhibits a high Li + permeability of 0.09 mol m −2 h −1 and a Li + /Mg 2+ selectivity of 235, with sustained performance stability over a 7-day continuous operation in mixed-ion solutions. This work establishes a novel design paradigm for suppressing linker dynamics in MOF membranes through rigid linker engineering, ultimately achieving structurally stable and size-exclusive ion transport.
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Duo Sun,Shihui Yang,Shuwei Qiao,Zhuoran Wang,Xiao Han,Sihan Ma,Heyi Gong,Jinghui Zhao,Fei Yan
3D-printed polyetheretherketone (PEEK) scaffolds hold great promise for personalized bone repair owing to their excellent mechanical properties and highly tunable porous architectures. However, their intrinsic bioinertness severely limits osseointegration and long-term clinical efficacy. We have developed an innovative bioactive scaffold (SIM@MPSP) by engineering a multifunctional biointerface onto 3D-printed porous PEEK. The biointerface consists of a polydopamine-anchored bimetallic (MgCu) metal-organic framework (MOF) coating that enables efficient loading and sustained release of simvastatin (SIM), Mg 2+ , and Cu 2+ . The coordinated release of these agents creates a therapeutically conducive microenvironment that promotes osteogenesis and angiogenesis, while reprogramming macrophages from a pro-inflammatory M1 phenotype to a pro-regenerative M2 state through modulation of both canonical and non-canonical NF-κB pathways. This immune-regulatory process effectively mitigates inflammation and rescues inflammatory suppression of osteogenesis, thereby establishing a favorable osteoimmunomodulatory niche. SIM@MPSP demonstrated excellent biocompatibility, significantly attenuated foreign-body responses, and enabled robust bone regeneration in in vivo models. Mechanistically, the scaffold facilitates deep bone growth throughout its porous network and forms an interlocked interface with native bone, thereby achieving robust osseointegration. This study presents a powerful biointerface engineering strategy for converting bioinert PEEK into a bioinstructive platform capable of orchestrating coordinated osteogenic, angiogenic, and immunomodulatory responses, thus offering new opportunities for personalized treatment of complex bone defects.
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DOI
高影响因子
Biomaterials Science
·
2026
·
IF 5.7
Yu Cao,Cheng Cao,Yingao Jiao,Huifang Hao,Dengyao Gao,Yan Gao,Kunhou Yao,Ruiyi Wu,Yanlei Liu
Prostate cancer remains one of the most common malignant tumors among men worldwide, and treatment options are limited in the advanced stage. To address this challenge, we have developed a pH-responsive copper porphyrin metal–organic framework (CuTCPP-MOF), which integrates photodynamic therapy (PDT) and chemodynamic therapy (CDT). It enables efficient electron transfer and ROS generation. Under 488 nm laser irradiation, MOF acts as a self-sensitizing photosensitizer to generate single-state oxygen (1O2), which gradually releases Cu2+ in an acidic environment. Subsequently, it is reduced to Cu+ by intracellular glutathione (GSH), achieving continuous consumption of GSH and enhancing the Fenton-like reaction to promote the continuous formation of hydroxyl radicals (˙OH). This amplifies the oxidative stress within tumor cells. In vitro experiments have shown that ROS accumulation and mitochondrial membrane depolarization lead to apoptosis of RM-1 prostate cancer cells. In vivo, CuTCPP-MOF combined with laser irradiation can significantly inhibit tumor growth without causing systemic toxicity and hemolysis. Histological analysis confirmed that after treatment, the apoptosis of tumor cells was enhanced and their proliferation ability was reduced. In conclusion, CuTCPP-MOF is a promising nano-therapeutic agent that can work in synergy with PDT and CDT to achieve effective and safe treatment of prostate cancer.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2022
·
IF 10.53
Shuqing Song,Mingang Zhao,Zheyuan Guo,Yanxiong Ren,Jianyu Wang,Xu Liang,Yunchuan Pu,Shaoyu Wang,Hanze Ma,Xuerui Wang,Guangwei He,Zhongyi Jiang
Mixed matrix composite membranes (MMCMs) hold great potential to realize efficient CO 2 removal from natural gas. However, the reduction of separation performance arising from the interfacial defects, significant plasticization and aging effect in the thin films severely limit their application. Herein, we fabricated a series of polyimide MMCMs with MOF-protruding structure wherein amino-functionalized ZIF-8 nanocrystals nearly penetrate the thin selective layer. Through engineering the interfacial interactions, e.g., covalent or hydrogen bondings , we successfully fabricated defect-free MMCMs with the thickness ranging from 140 to 280 nm. The stronger interfacial interactions eliminate the interfacial defects and restrict the mobility of polymer chains under high pressure. Accordingly, the MMCM displays a high CO 2 permeance of 778 GPU and a CO 2 /CH 4 selectivity of 34 with significantly improved resistance to plasticization and aging. Considering the superior performance, we anticipate our work could provide guidelines on designing advanced MMMs to tackle critical separations.
研究领域:
材料科学
·
膜分离技术
·
高分子化学
·
气体分离
·
能源化工
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DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2022
·Vol. 169
·期 12
·127509
·
IF 4.386
Rui Kuang,Ning Deng,Fuying Dong,Yongling Ding,Xuan Kuang
Electrochemical enantiorecognition of Tryptophan (Trp) isomers using Cys@In2S3/GCE prepared by two steps of sulfidation and chiralization from MIL-68(In) is reported. The Cys@In2S3/GCE electrode shows highly selective, sensitive and quantitative analysis towards Trp enantiomers. This proposed chiral sensors could be considered for practical applications in the field of Trp related medical recognition.
研究领域:
生物化学
·
分析化学
·
材料科学
✓ 已验证
DOI
高影响因子
ANALYST
·
2026
·
IF 3.3
Yijie Zhang,Yongxin Tao,Shan Li,Yong Qin,Jinmin Wang
Baicalin (Bn), a bioactive compound derived from natural plants, has significant pharmaceutical value and is used in the treatment of diseases such as influenza. However, excessive baicalin administration may lead to increased drug toxicity, immune system disturbances, reduced therapeutic efficacy, and allergic reactions. The synergistic combination of bimetallic MOF and carbon nanotubes (CNT) yields a pronounced enhancement in electrochemical signal toward the analyte. In this study, a simple and low-cost one-pot method was proposed to fabricate ZnNi-MOF@MWCNT nanocomposites, which were used to develop an electrochemical sensor for the detection of Bn. Under optimized conditions, the sensor demonstrated a wide linear detection range of 5 × 10⁻⁹ to 6 × 10⁻⁷ M for Bn, with a limit of detection (LOD) of 1.12 × 10⁻⁹ M and a sensitivity of 130 A•M⁻¹. The sensor exhibited excellent stability, reproducibility, and resistance to interference from various substances. Additionally, the sensor showed satisfactory stability and recovery rates when applied to real sample goat serum. The proposed sensor material can be synthesized at room temperature, offering a new approach for the green synthesis of MOF-derived materials in pharmaceutical analysis.
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产品关联
DOI
PubMed
高影响因子
BMC Chemistry
·
2026
·Vol. 20
·期 1
·139
·
IF 5.1
Zhang Qiuyun,He Shijian,Hu Siyu,Zou Huixin,He Maozhen,Zhang Tingting,Deng Taoli,Cheng Jingsong,Zhang Yutao
Photocatalysts have offered a successful strategy for degrading organic pollutants, such as various dyes and antibiotics, in wastewater. In this study, the flower-like Bi 2 MoO 6 balls were impregnated on the zirconium-based MOFs (MOF-801) to construct the Bi 2 MoO 6 /MOF-801 heterojunction composite photocatalytic materials through a simple one-pot hydrothermal method. The systematically characterization of the as-synthesized composite materials was performed using various analytical techniques, including XRD, FTIR, SEM-EDS, N 2 adsorption⁃desorption testing, TG, XPS, UV-Vis DRS, PL, transient photocurrent, and EIS techniques, thereby confirming the successful impregnation of Bi 2 MoO 6 into MOF-801. The degradation effect of the Bi 2 MoO 6 /MOF-801 composites on rhodamine B (RhB) dye was investigated, along with the photocatalytic degradation mechanism. Results showed that 0.1-Bi 2 MoO 6 /MOF-801 has better degradation efficiency for RhB dye than that of pure Bi 2 MoO 6 and MOF-801 under visible light conditions, with a complete degradation efficiency of 98.1% achieved within 40 min. The boosted photocatalytic performance of the 0.1-Bi 2 MoO 6 /MOF-801 composite is attributed to their high specific surface area (529.2 m 2 /g) and mesoscale pore size (6.9 nm), wide visible spectral absorption, well-optimized band gap (2.81 eV), and the close contact of Bi 2 MoO 6 and MOF-801 ensuring efficient charge separation and suppressing the recombination of photogenerated electron-hole pairs. Visible-light driven photocatalysis of 0.1-Bi 2 MoO 6 /MOF-801 composite further confirmed superior degradation of MB, AO, CR, MO, and ARS dyes, reaching degradation efficiencies up to 99.7%. Moreover, the results of the free radical capture experiments confirmed that the holes ( h + ) and superoxide radicals (•O 2 − ), and electrons ( e − ) were the primary active substances during the degradation process, supporting the Z-scheme heterojunction charge transfer mechanism. This research study will point the direction for designing potential and affordable MOF-based heterojunction materials for the treatment of dye-contaminated wastewater. Graphical
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2026
·
IF 8.8
Rongbo Li,Zemin Li,Yuqi Zhu,Yichang Pan,Rujing Hou
The separation of benzene/cyclohexane (BZ/CHX) represents a critical yet challenging task in the chemical industry, as their nearly identical boiling points and kinetic diameters render conventional distillation highly energy-intensive. Pervaporation, driven by a transmembrane pressure difference, offers an energy-efficient alternative by breaking the azeotropic equilibrium of BZ/CHX mixtures. Metal–organic framework (MOF) membranes have emerged as promising candidates for such separations owing to their exceptional structural tunability. However, their application in this context remains largely unexplored. Herein, we report a dual-ligand engineering strategy to fabricate UiO-66-CDC MOF membranes, wherein a cubic alkane ligand is incorporated into a planar parent ligand to create a dual-ligand-modified framework. This approach enables precise regulation of the pore microenvironment and enhances preferential adsorption and recognition of aromatic benzene over aliphatic cyclohexane through multiple interactions (C···C, H···C, C–H···π, C–H···O, and π···π). Consequently, under a single-stage operation with an equimolar (50:50) BZ/CHX feed, the optimized membrane delivered a permeation flux of 478 g m −2 h −1 and a separation factor of 5.8, corresponding to a 40% increase in flux and an 81% increase in separation factor, respectively, over the control membrane, and yielding a 110% higher PSI. When further applied to a two-stage membrane separation process, the total flux and separation factor reached 1747 g m −2 h −1 and 40.7, respectively, demonstrating the potential of process intensification. This dual-ligand design offers fundamental guidance for the development of advanced separation membranes targeting diverse aromatic/alkane mixtures.
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DOI
高影响因子
危险品化学品经营许可证（带存储）