ACS Applied Materials & Interfaces
·
2016
·
IF 7.145
Ruimin Li,Yuting Zhang,Jing Tan,Jiaxun Wan,Jia Guo,Changchun Wang
Utilizing fluorescence reporters and SERS probes as the security labels, a series of dual-mode encoded magnetic composite microspheres with micrometer size was designed and prepared for anticounterfeiting applications. At first, the micro-meter-sized melamine formaldehyde microspheres with different fluorescence molecules (FMF) were prepared by precipitation polymerization, and then the magnetite composite microspheres (FMF/MNPs) were fabricated by direct immobilization of magnetic nanoparticles (MNPs) onto the surface of FMF microspheres. After deposition of Ag nanoparticles (Ag-NPs) onto FMF/MNPs microspheres, the SERS probes were absorbed onto the surface of Ag-NPs, and then a protection layer of silica was coated on the composite microspheres by Stöber method. The combination of different fluorescence reporters and SERS probes greatly increased the encoding complexity and volume for high-level anticounterfeiting. The structure of the dual-encoded FMF/MNPs/Ag-NPs/SiO2 composite microspheres was characterized by FESEM, TEM, FLS(fluorescence spectrometer), XRD, VSM, UV–vis and EDS. The embedded magnetic nanoparticles enable the composite microspheres to be quickly isolated from the marked latex paint by magnet at the concentration of as low as 1 ppm, and the covert tag information can be read out even from one composite microsphere. In addition, the covert security information in the marked coating film can be also read out in situ and the existence of the composite microspheres does not influence the visible appearance of the coating film. All the above outstanding properties will make these dual-mode encoded composite microspheres as advanced security tags for next-generation anticounterfeiting applications.
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DOI
PubMed
高影响因子
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2025
·
IF 4.6
Guangli Li,Nayu Chen,Yafeng Zhang,Tianyu Wang,Rui Zhu,Yuan Jin,Nanke Ma
Rhodamine B (RhB) is highly carcinogenic and is therefore prohibited as a food colorant. Hence, it is necessary to establish a simple but effective technique for the sensitive determination of RhB in foodstuff. Herein, an efficient voltammetric platform was established for the detection of RhB in chili oil based on flower-like β-Bi 2 O 3 microsphere/multiwalled carbon nanotube composites (β-Bi 2 O 3 /MWCNTs). Various microscopic and spectroscopic techniques confirmed the successful formation of β-Bi 2 O 3 /MWCNTs. Owing to the synergistic effect from β-Bi 2 O 3 microspheres and MWCNTs, the β-Bi 2 O 3 /MWCNTs demonstrated superior electrocatalytic activity for the oxidation of RhB as compared to the individual components. Electrochemical kinetics tests confirmed that the RhB electrooxidation was governed by an irreversible and adsorption-controlled process, and involved two electrons one proton transfer pathway. The oxidation peak currents of RhB were linearly correlated with RhB concentrations ranging from 0.05 to 100 μM with a low limit of detection (0.002 μM). The β-Bi 2 O 3 /MWCNT demonstrated strong anti-interfering ability against other azo colorants, and retained robust voltammetric responses for at least 14 days. Moreover, the concentrations of RhB in chili oil were accurately detected by the β-Bi 2 O 3 /MWCNT via second-order derivative linear scan voltammetry with satisfactory recovery. Overall, the β-Bi 2 O 3 /MWCNT/GCE shows great potential for in-situ analysis of trace amounts of RhB in various food matrices.
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高影响因子
Small
·
2025
·
IF 12.1
Chenyang Wang,Tiantian Guo,Ruizhi Tang,Shujuan Ma,Yinmao Wei,Yangyang Bian,Junjie Ou
The development of monodisperse hybrid silica microspheres with highly regular pore structure and uniform distribution of functional groups have significant value in the biomolecular separation field. In this work, the short range ordered pore channels are precisely constructed onto the non-porous silica microsphere surface by a bi-phase assembly method, and the cylindrical silica channel introduced a plethora of vinyl groups by “one-pot” co-condensation to form vinyl hybrid silica shell. As hydrophilic interaction chromatography (HILIC) stationary phase, the vinyl hybrid core–shell silica microsphere is simply modified with zwitterion glutathione (SiO 2 @SiO 2 -GSH), in which the HILIC enrichment process is significantly shortened due to its specific porous characteristics. Most importantly, SiO 2 @SiO 2 -GSH microsphere can enrich 2186 N-glycopeptides from the rat liver protein digest within 2 min, which mapped to 806 glycoproteins. Compared with HILIC enrichment result within 1 h, the glycoproteins and glycopeptides overlap are 88.3% and 79.1%, performing excellent reproducibility. The short range ordered channels onto the silica microsphere surface exhibit excellent mass transfer efficiency, so the developed bi-phase assembly method is expected to design more advanced hybrid silica materials for other urgently fields.
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高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2025
·
IF 3.8
Yansong Liu,Yongsheng Liu,Yejie Cao,Xiang Zheng,Xiaokun Sun,Yang Xu
Dual porous yttria-stabilized zirconia (YSZ) ceramics were fabricated via digital light processing (DLP) additive manufacturing using polymethyl methacrylate (PMMA) microspheres as pore-forming agent for the first time. The results showed that the introduction of PMMA microspheres effectively reduced the viscosity of the photosensitive YSZ ceramic slurry used in DLP printing, improved the cured depth of the slurry, and did not exert a strong influence on stability. After sintering at 1400°C, pores with dual scales were generated in the ceramics, while exhibiting the optimal physical and mechanical properties. With the increase of PMMA content from 0 to 40 vol%, the open porosity increased from 1.96% to 34.06% and the density decreased from 5.92 to 3.82 g/cm 3 , respectively. The compressive strength and thermal conductivity of porous ceramics decreased from 350.54 to 99.85 MPa and from 2.80 to 1.46 W/(m⋅K), respectively. This investigation opens up new prospects for the fabrication of porous YSZ ceramics with low thermal conductivity and high mechanical properties.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Li Li,Yupeng Wu,Zexian Xu,Yaoxiang Xu,Xiaohan Gao,Yaru Diao,Yanshan Liu,Liqiang Chen,Jian Sun
Magnesium ions (Mg 2+ ) play an essential role in the metabolism and regeneration of bone tissue. Appropriate amounts of Mg 2+ have been shown to promote osteogenic differentiation of bone-derived cells and angiogenesis of endothelial cells. However, the initial burst release of Mg 2+ may compromise the osteogenic effect, so the controlled release of Mg 2+ is the critical consideration of the magnesium-containing tissue-engineered bone materials. This study proposes a microsphere-hydrogel complex to enhance the sustained-release effect and prolong the release cycle of Mg 2+ . For the initial release of Mg 2+ , polylactic acid (PLA) microspheres containing MgO and MgCO 3 were fabricated with uniform morphology. Further microspheres were incorporated into the chitosan-based hydrogel to form microsphere- hydrogel complex for extended release. The complex demonstrated effective sustained release of Mg 2+ over a period exceeding 28 days. In vitro cell experiments, CS/PLA@MgO-MgCO 3 significantly enhanced migration and osteogenic differentiation of MC3T3-E1. Meanwhile, it can facilitate the generation of blood vessels in HUVECs. In conclusion, the magnesium-loaded microsphere-hydrogel complex achieves excellent dual sustained-release properties with an extended-release cycle while enhancing vascularized osteogenic activity in vitro , showing promising prospects for clinical application in bone defect treatment.
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PubMed
高影响因子
Theranostics
·
2025
·Vol. 15
·期 9
·3750
·
IF 13.3
Ziliang Xiu,Yujing Zhu,Xiaofeng Li,Xiaoxi Jiang,Yunru Feng,Li He,Chunhui Li,Rui Cai,Gang Tao
Background: Pathogenic bacteria and activated immune cells in periodontal tissues continuously generate reactive oxygen species (ROS) and inflammatory mediators, creating an oxidative stress microenvironment that causes damage to cells and tissues. Antimicrobial strategies and ROS scavenging are crucial for treating periodontitis. Methods: This study encapsulated iron-curcumin nanoparticles (Fe-Cur NPs) within GelMA microspheres using microfluidic technology. The microsphere surface was then modified with a polydopamine (PDA) layer, and minocycline hydrochloride (MH) was attached to it to form multifunctional composite microspheres (GM@Fe-Cur/PDA/MH). Results: The GM@Fe-Cur/PDA/MH microspheres exhibited excellent adhesion, allowing them to remain in periodontal pockets for prolonged periods to maintain their functionality. Benefiting from the photothermal properties of PDA combined with MH, these microspheres effectively kill bacteria and mitigate excessive immune responses. Additionally, they regulate the M1/M2 polarization of macrophages, suppress the expression of inflammatory factors, and promote osteogenic protein expression under oxidative stress conditions in vitro . In a rat model of periodontitis, GM@Fe-Cur/PDA/MH effectively controlled inflammation progression and reduced alveolar bone loss. Further studies indicated that GM@Fe-Cur/PDA/MH may promote ROS scavenging by modulating the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway while inhibiting the activation of the nod-like receptor protein-3 (NLRP3) inflammasome. Conclusions: In summary, GM@Fe-Cur/PDA/MH represents an effective therapeutic approach that integrates antibacterial, antioxidant, anti-inflammatory, and bone loss mitigation properties, demonstrating significant potential for application in the treatment of periodontitis.
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高影响因子
ACS Applied Polymer Materials
·
2024
·
IF 4.4
Liangyong He,Bin Yang,Sen Wang,Yuqing Yang,Yingying Wang,Haiyang Hu,Zhengzhi Zheng,Jiashuo Liu,Jiasheng Qian,Jibin Miao,Weiguo Zhang,Yuchao Ke
The increasing demand for improving the performance of optical devices and the development of nanotechnology have driven research on diffusion films. The preparation of diffusion films with well-defined microstructures can achieve uniform diffusion and scattering of light, thereby improving the efficiency and performance of optical devices. In this study, diffusion films with high transmittance and haze were prepared using PMMA@TiO2@SiO2 (P@T@S) composite microspheres, and the PMMA microspheres and nanoparticles were combined through electrostatic attraction. As compared with PMMA microspheres, the P@T@S composite microspheres displayed better heat resistance as well as swelling resistance. Optical performance data showed that the P@T@S diffusion film had the perfect optical performance with a transmittance up to 90.5% and a haze of 88.3%. The excellent light diffusion effect of the P@T@S diffusion film was experimentally demonstrated, with the light through the film not only displaying the largest area but also maintaining a relatively high brightness. Our findings can provide reference and guidance for further development of light diffusion films, which are of potential application in optoelectronic devices.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Tao Dong,Guangze Sun,Zhonghuang Yang,Yiming Jiao,Jinze Li,Ziting Lin,Xin Zhang,Zihan Bian,Aihua Liu
Respiratory infectious diseases pose a serious threat to human health worldwide. Timely diagnosis is crucial for effective clinical management and infection control. Herein, we developed a dual-channel lateral flow immunoassay (DC-LFIA) for simultaneous sensitive detection of influenza A virus (IAV) and respiratory syncytial virus (RSV) nucleoprotein (NP) antigens. The high brightness latex microspheres (HB-LMs) exhibiting typical absorption peak at 540 nm with uniform size and excellent optical stability, were prepared by a simple surfactant-free emulsion polymerization by mixing Sudan red, which overcame the complexity and color instability met for traditional synthesis methods. After affinity evaluation, two antibody pairs have good affinity for IAV NP and RSV NP were separately identified. Then, combining antibody pairs as probes and HB-LMs as based signal tag, a DC-LFIA was constructed, by which the visual limit of detection is 25 pg/mL, 100 pg/mL for IAV NP and RSV NP, respectively, 10-fold more sensitive than gold nanoparticles based LFIA. The calculated limit of detection (S/N=3) of IAV NP and RSV NP was improved 22.8- and19.5-fold, respectively, in comparison with gold nanoparticles based LFIA. Additionally, the developed sensor shows excellent specificity and reproducibility. Furthermore, the as-proposed method was validated through the analysis of clinical samples, in good agreement with commercial colloidal gold kits. Thus, the developed DC-LFIA has great potential for clinical application in the multiplex detection of respiratory viral antigens.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Xing Dong,Junjie Chi,Changmin Shao,Lanjie Lei,Lei Yang,Chao Zhao,Hong Liu
Tumor microenvironment (TME) is a pivotal factor in tumor progression. Here we report an injectable multifunctional hydrogel microsphere with responsive photonic structure for in vivo monitoring of TME pH. The pH determination is based on measurement of the characteristic reflection peak of the hydrogel microsphere in near-infrared (NIR) region that is sensitive to pH, and decreasing pH leads to a blue shift of the peak. With deep tissue penetration ability of the NIR light, the pH of normal and tumor tissues of mice are continuously monitored in vivo using the microspheres injected subcutaneously. The biocompatibility and the cytotoxicity of the material is investigated based on MTT assays to evaluate its potential for long-term continuous in vivo monitoring of TME pH. A drug for cancer treatment is also preloaded into the hydrogel microsphere for simultaneous drug release in TME and monitoring of the treatment effectiveness of drug by the TME pH tests.
研究领域:
生物医学工程
·
肿瘤学
·
材料科学
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高影响因子
Materials
·
2022
·Vol. 15
·期 14
·4959
·
IF 3.748
Chen Zhang,Yuhong Qi,Zhanping Zhang
To understand the microstructure evolution of hydrogels swollen in seawater, freeze-drying technology was used to fix and preserve the swollen three-dimensional microstructure. By this method, we revealed the swelling behavior of hydrogels in seawater, and elucidated the mechanism of the swelling process. Meanwhile, we also used Fourier-transform infrared spectroscopy; laser confocal microscopy; field emission scanning electron microscopy, and swelling performance tests to research the structure and properties of PS-PEG hydrogels, before and after seawater swelling, and analyzed the structure and properties of PEG-based hydrogels with different contents of polystyrene microspheres. Results showed that PS-PEG hydrogels went through three stages during the swelling process, namely ‘wetting-rapid swelling-swelling equilibrium’. Due to the capillary effect and hydration effect, the surface area would initially grow tiny pores, and enter the interior in a free penetration manner. Finally, it formed a stable structure, and this process varied with different content of polystyrene microspheres. In addition, with the increase of polystyrene microsphere content, the roughness of the hydrogel before swelling would increase, but decrease after swelling. Appropriate acquisition of polystyrene microspheres could enhance the three-dimensional network structure of PEG-based hydrogels, with a lower swelling degree than hydrogels without polystyrene microspheres.
研究领域:
材料科学
·
高分子化学
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高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2022
·Vol. 30
·期 4
·9416-9427
·
IF 5.19
Zhu Dandan,Shi Linan,Li Haoming,Zhang Jinyi,Zhang Jiupeng,Wei Cundi
In this study, TiO 2 /MSGM composite material with adsorption-photocatalytic properties was prepared by extracting mesoporous silica glass microsphere (MSGM) from coal gasification fine slag (CGFS) as a novel TiO 2 carrier. The results of characterization and properties of the composite showed that MSGM could improve the adsorption capacity and photocatalytic activity of the composite by improving the pore structure of the composite, hindering the growth of TiO 2 particles, increasing the phase transition temperature of TiO 2 , enhancing the dispersion of TiO 2 particles. The sample 1:3-TiO 2 /MSGM-2–500 prepared under the optimized conditions possesses satisfactory morphology characteristics, high adsorption capacity, and photocatalytic activity to rhodamine B (RhB). The synergistic effects of adsorption and photocatalytic significantly increase the total removal rate of RhB. This study not only provides a new direction for high-value-added resource utilization of CGFS but also gives a new kind of low-cost carrier material with adsorption property for TiO 2 loading to remove organic dye pollutants.
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高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2023
·Vol. 34
·期 6
·1918-1932
·
IF 3.4
Yuqian Du,Xueya Wang,Ziwen Zhou,Feng Zhao,Song Li,Zhihua Liu,Zhengyu Wu,Shuai Zhao,Lin Li
Nowadays, although highly conductive polymer composites filled with two-dimensional graphene-based nano-fillers have been explored extensively, constructing nanocomposites with high performance, industrial feasibility, and more efficient conductive networks at lower nano-filler contents remains a challenge. To achieve the above objectives, industrial wastes microsilica powder (N98) with amorphous spherical structure and large particle size is employed in this work. And the hybrids (TGN) are obtained between N98 and graphene (GE) by the effective bridging and interface coupling of tannic acid, which can achieve the purpose of obtaining conductive composites with low-filler contents by traditional polymer processing technologies. The volume exclusion effect of N98 and its own assisted dispersion effect can prevent and attenuate graphene agglomeration, enabling the formation of a dense, complete and uniform conductive network in natural rubber (NR) matrix based on a small amount of graphene addition (parts per thousand). Thus, it give the nanocomposite highly functional, especially electric property. The results show that when the ratio of GE to N98 hybridization is 1:20, N98 and graphene are more uniformly hybridized together, and the volume exclusion effect is best matched with the rubber composites, and the comprehensive performance is optimal. Moreover, the electrical conductivity of NR/TG 1 N 20 nanocomposite can reach the balanced value of 10 −3 S·cm −1 with the GE loading of 0.48 phr, which shows the effectiveness of the prepared hybrids.
研究领域:
高分子科学
·
纳米复合材料
·
功能高分子
·
材料化学
·
导电聚合物
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高影响因子
危险品化学品经营许可证（带存储）