FOOD CHEMISTRY
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2026
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IF 10.4
Jiawei Zheng,Xuan Hu,Jiufang Chen,Fengxia Lan,Li Xu,Zeping Lu,Binbin Nian,Nanjing Zhong
CALB@GA-NH 2 -UiO-66 exhibited 97.31% oleic acid conversion and 77.60% DAG content. • CALB@GA-NH 2 -UiO-66 retained full initial activity after 11 reuse cycles. • The immobilized CALB exhibited a single conformational basin. • Covalent enzyme–carrier conjugates were formed via Schiff base linkages. • The immobilization moderately restrained the flexibility of α-helix 5 of CALB. This study aimed to develop a robust biocatalyst for diacylglycerol (DAG) synthesis. Candida antarctica lipase B (CALB) was immobilized on NH₂-UiO-66 via glutaraldehyde (GA) cross-linking. The cross-linked CALB exhibited significantly better performance than the adsorbed counterpart. Oleic acid conversion reached 97.31% with DAG content up to 77.60%. Moreover, the immobilized CALB retained its full initial activity after 11 reuse cycles. The temperature dependence of oleic acid conversion followed the equation ln V₀ = 8.86–4.67 × 10 3 / T , with an activation energy of 38.83 kJ·Mol −1 . Molecular dynamics simulations revealed that the flexibility of α-helix 5 in CALB@GA-NH₂-UiO-66 is moderately restrained, and the immobilized CALB exhibits a single conformational basin. Additionally, immobilization induces slight contraction of the CALB active site pocket, and reduced length and increased bottleneck radius of the tunnel. This study provides molecular insights into the structure–stability relationship of immobilized enzymes, guiding the rational design of robust biocomposites We develop a robust biocatalyst via glutaraldehyde cross-linking of CALB onto NH₂-UiO-66 for DAG production by esterification. Download: Download high-res image (210KB) Download: Download full-size image
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BIOMACROMOLECULES
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2026
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IF 5.9
Zehui Wei,Shuxian Ge,Yukai He,Lina Mu,Shuangxian Yan,Yu Cheng,Tiantian Gao,Kefan Xie,Miaomiao Zhang,Suhong Wang,Mei Tian
Carbohydrate antigen 15-3 (CA15-3) is an important biomarker for early breast cancer diagnosis and therapeutic monitoring. This work presents an ultrasensitive fluorescent probe based on a dual-ligand peptides/UiO-66-NH2@AYG composite for CA15-3 detection. Dual-ligand peptides (GTTFSNYW and MHYLEYPF) target distinct CA15-3 epitopes, enhancing the binding affinity and specificity. The peptides are immobilized on UiO-66-NH2, whose high surface area supports efficient loading of the fluorescent reporter Acridine Yellow G (AYG). This probe demonstrates exceptional performance with a linear detection range of 0.05–1.5 pg/mL (R2 = 0.9981) and an ultralow detection limit of 0.004147 pg/mL. Practical validation in spiked mouse serum shows recovery rates of 91.57–103.7%, while clinical testing with serum samples from 10 cancer patients reveals a strong correlation with ELISA results (r = 0.9944, P < 0.001). This robust platform offers significant potential for cost-effective, early cancer screening in primary healthcare settings.
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BIOSENSORS & BIOELECTRONICS
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2026
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IF 11.8
Jixiang Li,Genyun Zhou,Fei Wu,Jinping Yuan,Linan Hu,Qiang Zhang,Wenge Yang,Yonghong Hu
Tetracycline (TC) is a persistent broad-spectrum antibiotic that poses significant threats to human health and the environment. Herein, we developed an ultrasensitive photoelectrochemical (PEC) biosensor for rapid TC detection. The sensor utilizes a flexible Si-doped carbon fiber membrane derived from polyacrylonitrile and dimethyldiethoxysilane as a conductive substrate. After coating with poly (3,4-ethylenedioxythiophene) and polystyrene sulfonate (PEDOT: PSS), a ternary UiO-66-NH 2 /Ag/g-C 3 N 4 Z-scheme heterojunction is assembled as the photoactive core, followed by electrostatic immobilization of laccase to achieve specific TC recognition. Electrochemical characterization confirmed that laccase improved both the biocatalytic activity and electron-transfer efficiency of the electrode. Combined with transient photocurrent measurements and molecular dynamics simulations, the sensing mechanism was shown to be dominated by steric hindrance arising from TC occupation of the laccase active site, followed by oxygen consumption, yielding a detection limit of 0.012 μM over 0-30 μM TC (R 2 = 0.993). UV diffuse reflectance spectra (UV-DRs), Mott–Schottky analysis (M-S), and electron paramagnetic resonance (EPR) measurements further verified that the Ag-mediated Z-scheme pathway significantly enhanced carrier separation. With excellent stability and anti-interference performance in real river water and complex matrices, this work provides an effective strategy for antibiotic detection by integrating flexible carbon-based substrates with advanced Z-scheme photocatalytic systems.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2026
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IF 6.7
Mingming Dong,Zewen Huang,Shuyong Yang,Peng Zhou,Shenghui Tu
The growing prevalence of antibiotic residues in aquatic environments, particularly recalcitrant antibiotics like tetracycline (TC), poses significant ecological risks. In this study, a novel Bi 2 WO 6 /Mo-doped BiVO 4 /NH 2 -UiO-66 (BBU) ternary heterojunction photocatalyst was successfully synthesized via a solvothermal method to enhance visible-light-driven TC degradation through component synergy. Systematic characterization revealed that Mo doping induced lattice distortion in BiVO 4 , while the incorporation of NH 2 -UiO-66 drastically increased the specific surface area from 23.647 to 398.804 m 2 ·g −1 , providing abundant active sites. Photoluminescence (PL) and Electrochemical Impedance Spectroscopy (EIS) analyses demonstrated that the optimized BBU-3 sample exhibited the lowest charge carrier recombination rate. Under visible light irradiation for 80 min, BBU-3 achieved 95.2% degradation of TC, with reaction kinetics 8.61, 15.76, and 5.01 times higher than those of pristine Bi 2 WO 6 , BiVO 4 , and binary heterojunctions, respectively. Degradation-trapping experiments and electron paramagnetic resonance (EPR) measurements indicate that h + , 1 O 2 and ·O 2 - are the primary reactive species, suggesting that this system is a synergistic radical-non-radical degradation system. Additionally, possible degradation pathways and intermediate toxicity were evaluated. This work offers a promising strategy for designing efficient bismuth-based MOF heterojunctions for antibiotic remediation in water.
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LANGMUIR
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2026
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IF 4.4
Yunyun Li,Xiaohui Zeng,Ge Wang,Dingyi Zhang
The widespread misuse of nonsteroidal anti-inflammatory drugs (NSAIDs) has become a growing concern due to their severe threats to aquatic ecosystems and human health. Current adsorption technologies face limitations including low capacity, poor efficiency for trace-level contaminants, and unclear removal mechanisms. These limitations stem from poorly optimized pore architectures and surface chemistries in existing materials, necessitating the development of multifunctional adsorbents with tailored active sites. Herein, a series of MnO2/UiO-66-x composites were rationally designed via a solvothermal approach and comprehensively characterized using powder X-ray diffraction (PXRD), Fourier transform infrared (FTIR) spectroscopy, N2 physisorption, scanning electron microscopy (SEM), and zeta potential analysis. Systematic optimization demonstrated that MnO2/UiO-66-1 (5 mg) achieved exceptional adsorption capacity (qmax = 659.49 mg·g–1) for diclofenac sodium (DCF, 20 mg·L–1, 30 mL), with >90% removal within 10 min (k2 = 0.0081 g·mg–1·min–1). Mechanistic studies revealed that this performance was attributed to hierarchical porosity (micro-/mesopores), which enables size-selective uptake, synergistic binding, and pH-dependent electrostatic enhancement. Structure–activity relationships indicated that NSAIDs adsorption efficiency (naproxen ≈ ibuprofen ≈ ketoprofen > indomethacin > paracetamol) was governed by molecular structure, size, and pKa values. Thermodynamic and kinetic studies confirmed a spontaneous (ΔG0 < 0), endothermic (ΔH0 > 0), and entropy-driven (ΔS0 > 0) process dominated by chemisorption through synergistic interactions (including coordination bonding, hydrogen bonding, Lewis acid–base effects, electrostatic attraction, and π–π stacking). This study establishes a new paradigm for metal–organic-framework-based adsorbent design through precise control of metal–organic interfaces and defect engineering. With 87% capacity retention after 5 regeneration cycles, MnO2/UiO-66-x shows strong potential for practical water remediation applications.
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DESALINATION
·
2026
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IF 9.9
Haifeng Zhang,Mengyu Tang,Yilei Fang,Xin Yu,Ranwen Ou
Boron is both an essential trace element and an important industrial raw material, rendering its efficient extraction from brines highly valuable. This study synthesized UiO-66-p-PhOH (phenolic hydroxyl) and UiO-66-p-AlOH (aliphatic hydroxyl) by grafting ortho-hydroxyl functional groups onto UiO-66-p, achieving adsorption capacities of 2.28 and 3.65 mmol/g in 4000 mg/L B solution, respectively. Both adsorbents reached adsorption equilibrium within 20 mins, enabling efficient boron extraction. UiO-66-p-OHs maintained structural stability in complex brines and exhibited higher selectivity coefficients ( K B were between 1.5 and 18.1) compared to that in binary solutions ( K B were between 0.09 and 5.2). Moreover, boric acid bound by each phenolic hydroxyl was 2.5–4.3 times of aliphatic hydroxyls. DFT calculations revealed that phenolic hydroxyls exhibited stronger affinity, with an adsorption energy of −29.01 compared to −27.24 kJ/mol for aliphatic hydroxyls. UiO-66-p-PhOH and UiO-66-p-AlOH could be regenerated through a simple water-washing and mild-acid soaking process, achieving regeneration rates of 77.5% and 95.4%, respectively. This work demonstrated the boron extraction efficiency of phenolic hydroxyl and aliphatic hydroxyl groups in saline water, providing important reference for designing boron adsorbents under high salinity conditions.
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ChemCatChem
·
2026
·Vol. 18
·期 7
·e70718
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IF 4.1
Somboon Chaemchuen,Xingxing Chen,Deshuang Lu,Panchan Sricharoon,Suwin Apichartpattanasiri,Nikom Klomkliang,Francis Verpoort
Highly dispersed palladium nanoparticles (Pd NPs) embedded within a hierarchical UiO-66 structure, referred to as Pd@U-12, have been successfully synthesized via a green, straightforward of solid-solid thermal (SST) method. This innovative SST technique enables uniform dispersion of Pd NPs, allowing their encapsulation within the hierarchical framework of UiO-66. The unsaturated sites in the host UiO-66 facilitate the coordination of Pd, which are subsequently reduced to nanoparticles during the SST process, forming Pd@U-12. The Pd NPs are highly dispersed on the hierarchical support (U-12) and serve effectively as catalytic sites for hydrogenation reactions. The optimally synthesized 20%Pd@U-12 demonstrated exceptional performance as a heterogeneous catalyst for the hydrogenation of cyclohexene, achieving 99% conversion with stable activity over five consecutive cycles. Notably, the SST method for encapsulating Pd NPs (Pd@U-12) offers several advantages, including rapid incorporation of metal nanoparticles within a short time, a green, solvent-free synthesis process, high dispersion and stability of the metal content within the host material. These features could significantly enhance the effectiveness of Pd@U-12 as a robust heterogeneous catalyst in various catalysis applications. Graphical
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SEPARATION AND PURIFICATION TECHNOLOGY
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2025
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IF 9
Ruihua Chen,Hao Deng,Junpeng Jiang,Daoyang Han,Gang Shao,Hailong Wang,Rui Zhang,Chao Ma
To overcome the problem of insufficient molybdenum adsorption capacity of commercially utilized alumina in 99 Mo/ 99m Tc generator, UiO-66(Ce)@MXene composites as potential molybdenum adsorbents were successfully prepared via in-situ growth method in this work. The adsorption performance and adsorption mechanism were investigated. The results indicate that the UM3 possesses superlative adsorption behavior compared to the other two samples. The adsorption kinetics are well described by the quasi-second-order model and the adsorption reaches equilibrium within 30 min. The adsorption isotherm can be well fitted with the Langmuir model, displaying the maximum molybdenum adsorption capacity of 833 mg/g at pH 3, superior to other reported adsorbents. The adsorption capacity manifests that polymolybdates are captured by the hydroxyl groups on MXene through hydrogen bonds. The monomolybdates can diffuse into micropores and are adsorbed on adsorption sites, e.g. missing-linker defects and Ce-OH groups. Consequently, the constructed hierarchical frameworks promote molybdenum adsorption and increase adsorption capacity significantly. The unrivalled adsorption performance of UiO-66(Ce)@MXene composites as molybdenum adsorbents have promising potential for the application in 99 Mo/ 99m Tc generator.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Bin Zhao,Yue Li,Min Sun,Zhaohui Zhang,Liang Wang,Jiaxue Yao
The growing concern over pharmaceutical and personal care products (PPCPs) in drinking water sources underscores a serious public health risk. Although polyamide (PA) nanofiltration (NF) membranes are highly effective at removing PPCPs, their performance for neutral and hydrophobic PPCPs requires improvement. To overcome this challenge, we fabricated a hydrophilic NF membrane containing a calcium alginate (CaAlg) hydrogel interlayer and UiO-66-NH 2 nanofillers (PA/UiO-66-NH 2 /CaAlg) to reduce membrane affinity for hydrophobic PPCPs. A fishnet-like structure was created on the membrane surface, which enhanced the effective area for filtration. Consequently, the water permeance of the PA/UiO-66-NH 2 /CaAlg membrane reached 22.7 L·m −2 ·h −1 ·bar −1 , representing an 83 % increase over the control thin-film composite (TFC) membrane. The hydrophilic CaAlg interlayer also restricted the diffusion of piperazine (PIP), thereby slowing its interfacial polymerization with trimesoyl chloride (TMC). This resulted in a highly hydrophilic PA film, evidenced by a water contact angle below 10°. The reduced adsorption of hydrophobic PPCPs on this hydrophilic surface diminished the driving force for their penetration. Furthermore, the inherent hydrophilicity of the CaAlg hydrogel interlayer suppressed the diffusion of hydrophobic PPCPs across the membrane. As a result, the removals for hydrophobic methylparaben (MP), propylparaben (PP), bisphenol A (BPA), and benzylparaben (BP) were significantly enhanced. The selectivity ( A/B ) for BPA increased by more than four times compared to that of the TFC membrane. This study demonstrates that integrating a hydrogel interlayer with MOF nanofillers offers a promising approach for developing high performance NF membranes that exhibit both improved water permeance and superior PPCP removal.
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TRANSACTIONS OF TIANJIN UNIVERSITY
·
2025
·
IF 8.5
Song Yanyan,Sun Zhichao,Sun Jiamin,Liu Ying-Ya,Wang Anjie,Peng Chong
The development of efficient photocatalysts for selective organic transformations under visible light remains a major challenge in sustainable chemistry. In this study, we present a straightforward solvothermal strategy for fabricating a defect-engineered ZrO 2 /UiO-66-NH 2 hybrid material with abundant oxygen vacancies, enabling the visible-light-driven oxidation of benzyl alcohol to benzaldehyde. By optimizing the solvothermal treatment duration, the composite (UiO-66-NH 2 -2 h) achieves a 74.1% conversion of benzyl alcohol with > 99% selectivity toward benzaldehyde under mild conditions, substantially outperforming pristine UiO-66-NH 2 . Structural and mechanistic studies reveal that the solvothermal process induces the in situ formation of ultrasmall, uniformly dispersed ZrO 2 nanoparticles (~ 2.3 nm) within the MOF matrix, while simultaneously generating abundant oxygen vacancies, as confirmed by XPS, EPR, and HRTEM analyses. The defect-mediated electronic structure of the ZrO 2 /UiO-66-NH 2 hybrid enhances visible-light absorption, facilitates charge carrier separation, and promotes efficient activation of O 2 into superoxide radicals (·O 2 − ), the primary reactive species. Transient photocurrent measurements and electrochemical impedance spectroscopy further verify the improved charge separation efficiency. The synergistic interplay between oxygen vacancies and the intimate ZrO 2 /UiO-66-NH 2 interface provides a unique defect-mediated charge transfer pathway, distinguishing this system from conventional heterojunctions. This study demonstrates a facile, one-step approach to integrate defect engineering with interfacial hybridization in MOF-based photocatalysts, offering a scalable route for solar-driven organic synthesis. Graphical
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Chunlin Chen,Xinyu Bai,Guoqing Xiao,Fei Zhong,Beibei Ren,Guirong Zhao,Chunyan Chen,Chuanlin Mou
This study in situ encapsulated hexachlorotriphosphonyl cyanide (HCCP) within the pore structure of UiO-66 to prepare zirconium-based metal-organic framework material (UHP) with high nitrogen and phosphorus content. Subsequently, using gradient assembly technology, a transition metal-based borate flame retardant layer (Co-Ni/B) and a polyethyleneimine (PEI) layer were sequentially constructed on the UHP surface. Afterwards, the UHP/Co/Ni-B composite was combined with MXene via electrostatic interactions, ultimately yielding a novel multilevel flame retardant material (MX@UHPB/PEI). Experimental results demonstrated that the MX@UHPB/PEI-containing sample exhibited the lowest backside temperature (163.4 ℃) and highest expansion characteristics (27.2 mm, 20.76), confirming its effective ability to block heat propagation. Furthermore, the MX@UHPB/PEI/EP sample exhibited the highest residual char content (31.1%) and the most intact, dense char layer. This is attributed to transition metals such as titanium, zirconium, cobalt, and nickel within the material catalyzing the conversion of more pyrolyzed small molecules into stable char under high-temperature conditions. Notably, the formation of this catalytic char layer suppressed further decomposition of intermediates during combustion, enabling the MX@UHPB/PEI/EP sample to achieve the lowest smoke density rating (36.4%). The development of this multifunctional composite flame retardant offers a novel approach to enhancing the protective performance of water-based epoxy intumescent fireproof coatings.
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CHEMICAL ENGINEERING JOURNAL
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2022
·
IF 16.744
Nini Luo,Yue Shu,Chuanlong Zhu,Xiaoxue Cheng,Lixue Chen,Jiang Wang,Rui Liu,Huangxian Ju,Wei Cheng,Qianfeng Xia
The abnormal protein phosphorylation is closely related to a series of diseases including cancers, neurodegeneration, and other immune/inflammatory disorders. However, a simple, accurate, and pragmatic methodology for the direct detection of phosphorylation levels of target proteins is largely unavailable. Herein, a surface plasma resonance (SPR) biosensor was developed to detect phosphorylated protein based on significant SPR enhancement using UiO-66 and its high affinity for phosphate residues. Furthermore, the pH of the incubation buffer and the NaOH concentration in the washing solution to eliminate nonspecific adsorption of nanoparticles on the chip surface were optimized to adjust the surface charges of UiO-66. This improved the specificity and sensitivity of the proposed method. The designed biosensor could distinguish 1% phosphorylated peptides from non-phosphorylated peptides background. Moreover, the method could directly analyze the phosphorylation level of target protein in complex samples such as cell or tissue extracts without requiring a purification step in a single workflow. This simple and robust biosensor is a sensitive, accurate, and pragmatic toolbox to detect phosphorylated proteins without destroying the protein structure and can significantly facilitate phosphoproteomics and clinical diagnosis research.
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