SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Ji-Ying Song,Lei Pan,Fu-Hao Zhang,Xin-Yun Song,Qi Wu
The residues of tetracycline antibiotics (TCs) in aquatic environments have led to pressing environmental issues, necessitating the development of efficient removal technologies. In this study, we constructed an adsorption-degradation synergistic system based on Fe₃O₄ nanoparticles/graphene oxide/layered double hydroxides (Fe₃O₄/GO/LDHs) for the removal of TCs from water. This Fe₃O₄/GO/LDHs composite ingeniously combines the adsorption advantages of both GO and LDHs: GO serves as a growth substrate for LDHs, effectively preventing the LDHs from agglomerating into bulk masses, while LDHs also inhibit the interlayer stacking of GO. This leads to enhanced specific surface area of up to 581.7 m 2 /g, establishing a robust structural foundation for efficient adsorption. The incorporation of Fe₃O₄ nanoparticles not only endows the material with excellent magnetism for convenient magnetic separation and recovery but also utilizes its peroxidase-like activity to achieve catalytic degradation. The equilibrium adsorption capacities of Fe₃O₄/GO/LDHs for tetracycline, oxytetracycline, and chlortetracycline reached 676.5 mg/g, 814.1 mg/g, and 808.1 mg/g, respectively, primarily driven by electrostatic, π-π and complexation interactions. In the presence of H₂O₂, Fe₃O₄/GO/LDHs activating H₂O₂ to generate reactive oxygen species, achieving over 90% degradation rate within 1 h, demonstrating strong catalytic capability. Integrating adsorption with in-situ degradation, Fe₃O₄/GO/LDHs functions as a network of micro-reactor factories, rapidly concentrating pollutants at catalytic active sites and creating a high-local-concentration microenvironment that dramatically accelerates catalytic reactions, thereby enhancing overall degradation efficiency. This study advances the development of adsorption-degradation bifunctional nanozymes for water purification.
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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
·
2025
·Vol. 29
·期 23
·e70940
·
IF 4.2
Hao Tan,Cao Fang,Yiyun Tan,Zhi Wang,Yun Zhou,Xing Li
Astragalus polysaccharides (APS) are a crucial bioactive component known for their various pharmacological properties. Abnormal O‐linked β‐N‐acetylglucosamine modification (O‐GlcNAcylation) is noted in cases of intervertebral disc degeneration (IVDD). Nonetheless, it remains uncertain whether APS regulates the process of O‐GlcNAcylation associated with IVDD. We employed molecular docking, cycloheximide chase assay, immunohistochemistry, and immunoprecipitation to investigate APS‐mediated OGT/O‐GlcNAcylation regulation of Nrf2. The effects of APS and its role in promoting the O‐GlcNAcylation of Nrf2 in IVDD through both in vivo and in vitro studies are discussed. In vitro investigations demonstrated an increase in the levels of OGT and O‐GlcNAcylation in nucleus pulposus cells (NPCs) following exposure to tert‐butyl hydroperoxide (TBHP). APS further facilitated improvements in OGT expression and O‐GlcNAcylation processes, restoring the viability of NPCs inhibited by TBHP and promoting the synthesis of collagen II and aggrecan, while reducing apoptosis. Mechanistically, APS promotes the expression of OGT by targeting it. Furthermore, O‐GlcNAcylation mediated by OGT stabilizes the expression of Nrf2 via the ubiquitin‐proteasome pathway. Rescue experiments indicated that the disruption of either OGT or Nrf2 expression negated the protective role of APS on NPCs. Ultimately, both in vitro and in vivo studies indicated that APS significantly enhanced OGT expression and O‐GlcNAcylation, which subsequently improved Nrf2 expression and contributed to the alleviation of IVDD in rats. APS promotes O‐GlcNAcylation through OGT, thereby stabilizing the expression of Nrf2, which in turn contributes to the improvement of IVDD.
研究领域:
药理学
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分子生物学
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骨科学
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细胞生物学
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天然产物研究
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高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Zhe Li,Zeyang Li,Hao Lu,Boyu Song,Xiya Zhao,Hanyang Zhou,Lei Wang,Qingli Zou,Yusen Yang,Min Wei
Tin oxide is widely recognized as a promising candidate for the electrochemical synthesis of formate from CO2. However, challenges such as suboptimal performance and a limited understanding of the reaction mechanisms persist. In this study, we developed an integrated electrode by optimizing a hierarchical metal–metal oxide nanoarray via a combination of hydrothermal synthesis and electrodeposition. This design enables direct growth of the catalyst on the current collector, eliminating the need for polymer binders. The constructed metal–loading structure effectively regulates the electronic structure of Sn and facilitates the formation of Snδ+ species, which thereby enhances the adsorption strength of *OCHO intermediate, significantly enhancing formate production. The resulting electrocatalyst, Bi–Sn(In)O, demonstrates a Faradaic efficiency (FE) of 83.66% for the reduction of CO2 to formate, with a maximum production rate of 768.12 μmol·h–1·cm–2 and a current density of 54.45 mA·cm–2. In situ infrared characterization and theoretical calculations reveal that local charge redistribution and the presence of high-valence Snδ+ improve the adsorption and stabilization of the crucial *OCHO intermediate, thereby lowering the energy barrier for HCOOH formation. Additionally, the integrated electrode design enables the exposure of more active sites, substantially increasing the electrochemical surface area and catalytic activity. This study offers valuable insights into the catalyst design for high-valence Snδ+ in CO2 reduction.
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ACS Synthetic Biology
·
2025
·
IF 3.9
Zhen Zong,Lianghua Xie,Jiaqi Fu,Zhongyang Liu,Wen-Wen Zhou,Wei Chen
Cyanidin-3-O-galactoside (C3Ga), a natural pigment, has various beneficial biological activities and is widely used as a food colorant. However, traditional plant extraction methods are time-consuming and unsustainable. Rapid and sustainable synthesis of C3Ga by engineered microorganisms offers a promising alternative to traditional plant-based methods and deserves to be explored. In this study, the bioproduction of C3Ga by Escherichia coli was achieved for the first time. The biosynthetic pathway of C3Ga from (+)-catechin was constructed by introducing anthocyanidin synthase (ANS) and UDP-galactose:cyanidin galactosyltransferase. Some strategies, including enhancement of the UDP-galactose biosynthesis pathway, identification of efficient ANS, overexpression of the C3Ga transporter, and modulation of multigene expression, were subsequently used to drive the metabolic flux toward C3Ga production. Next, the two-stage process for C3Ga production was optimized to mitigate limitations for further metabolic engineering. Combined with the knockout of β-phosphoglucomutase (ycjU), a newly identified competitive pathway for UDP-galactose, the production of C3Ga finally reached 217.9 mg/L. The strategies used in this study could be applied to the biosynthesis of other anthocyanins and galactosylated natural products.
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MICROCHEMICAL JOURNAL
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2025
·
IF 5.1
Jianwei Xin,Irfan Muhammad,Zihui Meng,Yuqi Zhang
O-Phthalaldehyde (OPA) is a novel chemical disinfectant that has seen widespread use in healthcare environments. To ensure the efficacy of OPA-based disinfection in clinical practice, precise and reliable determination of its operational concentration is essential. Current methods, such as indicator strips, offer only semi-quantitative results, with their accuracy being influenced by multiple factors. Thus, there is an urgent need for the development of novel, efficient, and straightforward quantitative detection methods for OPA. DVD-R discs can be regarded as one-dimensional photonic crystals, which inspired the design of one-dimensional photonic crystal hydrogel (1DPCH) using DVD-R discs as templates. A sensor responsive to OPA was constructed by functionalizing the 1DPCH with ethylenediamine, thereby introducing amino groups into the hydrogel. These amino groups interact with OPA, and as the OPA concentration increases, the hydrogel undergoes enhanced crosslinking, leading to volume shrinkage. This shrinkage results in a reduction in the groove spacing of the embedded photonic crystal, which in increase the first-order diffraction spacing. By measuring the variation of the first-order diffraction spacing, the change in groove spacing can be quantified through a mathematical relationship. The experimental results exhibited a strong linear correlation with the change in groove spacing over the concentration logarithm range of 10 1 –10 6 nmol/L. the limit of detection was 1.26 nmol/L. additionally, the sensor exhibited high recovery rates (96.09–103.35 %) and low relative standard deviation (1.68–3.95 %) when detecting OPA in diluted disinfectant solutions. These findings suggest that the developed 1DPCH sensor is highly effective for the detection of OPA in clinical applications
研究领域:
分析化学
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生物医学工程
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传感器与生物传感器
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光子材料
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临床诊断
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Journal of Environmental Chemical Engineering
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2025
·
IF 7.2
Qiming Li,Hongli Wang,Boran Yang,Yunwei Zhang,Yan Liu,Jinhan Xie,Chengxu Wang,Lixin Chen,Gaofeng Han
With the growing emphasis on sustainable energy and carbon-neutral strategies, the efficient utilization of alcohol has attracted increasing attention. Direct ethanol fuel cells (DEFCs), which convert ethanol into electricity, offer a nontoxic, environmentally friendly, and efficient pathway for green alcohol valorization. The commercialization of DEFCs critically depends on the development of highly active and durable electrocatalysts for the ethanol oxidation reaction (EOR). In this work, we report a green and facile self-reduction method to synthesize surface-clean AuPd alloy nanoparticles (NPs) uniformly anchored on nitrogen and oxygen co-doped porous carbon sheets (AuPd/NOPCS), without the use of external reductants, surfactants, or organic solvents. The high porosity and low reduction potential of NOPCS facilitate the formation of well-dispersed NPs on NOPCS. The resulting AuPd/NOPCS exhibits a significantly enhanced EOR mass activity of 12.68 A mg Pd −1 , surpassing that of commercial Pd/C (1.96 A mg Pd −1 ), AuPd/OPCS (1.81 A mg Pd −1 , OPCS defined as oxygen doped porous carbon sheets), and Pd/NOPCS (4.16 A mg Pd −1 ). Density functional theory (DFT) calculations further reveal that the superior EOR performance of AuPd/NOPCS due to optimized electronic interactions and reduced intermediate adsorption. This work not only advances the rational design of efficient EOR electrocatalysts but also contributes to the broader goal of clean energy production from alcohols.
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CORROSION SCIENCE
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2019
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IF 6.355
Mingjun Cui,Siming Ren,Jibin Pu,Yonggang Wang,Haichao Zhao,Liping Wang
In this research, soluble poly(o-phenylenediamine) nanoparticles were synthesized to noncovalently functionalize the graphene nanosheets via π-π interactions, and the corresponding protective performance of epoxy composite coatings was also investigated. Results showed that the impedance modulus of the composite coatings incorporated with 0.5–1.0% G-Popd was about 10 10 Ω cm 2 after 60 days of immersion. Furthermore, the corrosion of substrate was still retarded even if there is an artificial scratch to the composite coatings. The superior protective performance of the composite coating derived from the synergistic action in the barrier property of graphene nanosheets and metal surface passivation by Popd nanoparticles.
研究领域:
材料科学
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腐蚀与防护
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纳米技术
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高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2026
·
IF 5.9
Xuan Shang,Mingyue He,Huiying Jiang,Fangying Jiang,Deping Wang,Jimin Cao,Yan Tan,Jigen Li,Yanlin Feng,Xin Zhou
Cancer remains a global health challenge, calling for integrated strategies that combine precise diagnosis with synergistic treatment. Although glucose oxidase (GOx)-mediated starvation therapy disrupts tumor metabolism by converting glucose into cytotoxic hydrogen peroxide (H 2 O 2 ), its clinical translation is hindered by inefficient delivery and insufficient monotherapy efficacy. To address these issues, we developed a multifunctional nanoplatform by encapsulating GOx within hollow porous superparamagnetic Fe 3 O 4 nanoparticles (Fe 3 O 4 -GOx NPs) to preserve its catalytic activity and enable high loading capacity. This system simultaneously enables magnetic resonance imaging (MRI), photothermal therapy, and enzyme-mediated catalytic intervention. In vitro studies demonstrated strong T 2 -weighted MRI contrast for precise tumor localization, together with near-infrared laser-triggered hyperthermia that enhance the efficacy of GOx-mediated starvation therapy, elevating oxidative stress and promoting apoptosis in 4T1 cells. In 4T1 tumor-bearing mice, a single administration of Fe 3 O 4 -GOx NPs combined with laser irradiation elicited potent tumor suppression through the synergistic effects of intratumoral ROS generation, glucose depletion, and localized photothermal ablation, outperforming either modality alone. Histopathological assessment revealed negligible systemic toxicity and preserved organ integrity. This work presents an integrated theranostic nanoplatform that unites tumor-targeted imaging, enzyme- driven metabolism intervention, and photothermal therapy into a single system, offering a promising strategy for precision cancer management.
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ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19
Xuefeng Sha,Shiru Wu,Peng Gao,Zixing Wang,Fan Zeng,Wang Zhou,Xueli Wu,Minghao Yu,Jiaxu Yan,Xianyin Song,Jilei Liu,Changzhong Jiang
The self-discharge phenomenon remains a fundamental challenge that limits the practical deployment of advanced supercapacitors, particularly in MXene-based systems where the interfacial ion-electron coupling dominates charge redistribution dynamics. Here, a surface terminal engineering strategy was proposed by utilizing 1,2-bis(triethoxysilyl)ethane (BTSE) to construct a surface passivation layer through hydrogen-bond-mediated assembly. Benefiting from the generated tension effect between BTSE and MXene, it directly results the weakened hybridization effect between Ti atoms and surface terminal atoms, together with an upward shift of the d -band center and reduce of reaction energy barriers. Collectively, the passivation of surface Ti–O terminals promotes the electron transfer kinetics (Ti–O + e − + H + → Ti-OH) and inhibits the dissociation of Ti-OH terminal from the perspective of electron transfer coupling. As a result, the optimized MXene@BTSE electrode has effectively reduced the Ti–OH dissociation rates by 2.23-fold and demonstrates a remarkable self-discharge suppression, achieving 55.16% decrease of self-discharge rate in 1 m H 2 SO 4 electrolyte, compared to the pristine MXene. Moreover, the modified MXene electrode shows around 92.43 % capacitance retention over 80 000 cycles, demonstrating excellent stability. This work establishes an electron-structure-property paradigm for interfacial design in electrochemical energy storage systems.
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Physica Status Solidi-Rapid Research Letters
·
2018
·Vol. 12
·期 5
·1800034
·
IF 3.721
Anran Song,Kashif Javaid,Yu Liang,Weihua Wu,Jingjing Yu,Lingyan Liang,Hongliang Zhang,Linfeng Lan,Ting-Chang Chang,Hongtao Cao
Concerning the revolutionary future of electronic devices, high-performance solution-processable semiconductors have earned increasing academic and industrial research interests. In this paper, we synthesize In-Ga-Cd-O semiconductor thin films via a solution method. Transparent amorphous/nanocrystalline oxide thin films with small surface roughness have been grown by controlling the relative ratio of Cd-content. The present thin-film transistor with an optimized Cd-ratio exhibits a saturation field-effect mobility up to 10 cm 2 V −1 s −1 , an on/off current ratio of ≈1.3 × 10 9 , and a threshold voltage shift of ≈2.6 V under −5 V gate bias of 10 000 s, which are superior or comparable to those reported values of solution-processed conventional In-Ga-Zn-O counterparts. Our results indicate that the proposed In-Ga-Cd-O semiconductor would endow a promising transparent amorphous/nanocrystalline active material for electronic devices.
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CATALYSIS TODAY
·
2019
·
IF 4.888
Huixian Zhong,Jiaming Wang,Kang An,Jie Yang,Zhi Ma,Hong Wang,Yuan Liu
A new catalyst for direct ethanol synthesis (DES) from syngas composed of Rh nanoparticles (NPs) highly dispersed on La-Ce-O modified LaFeO 3 which was loaded on SiO 2 support was studied in this work. Over the best catalyst 40.6 % of the reacted CO could be directly converted into ethanol with CO conversion of 14.2 % at 250 °C, 3 MPa and GHSV of 3900 mL (g cat h) −1 . The results indicated that adding cerium into LaFe 0.5 Rh 0.5 O 3 /SiO 2 resulted in La 1-x Ce x Fe 0.5 Rh 0.5 O 3 /SiO 2 , the incorporation of Ce effectively regulated the interface electronic states of Rh NPs . The well matched catalyzing process by the active sites of Rh 0 , Rh + (or Rh δ+ ) and the oxygen vacancies on the surface of LaFeO 3 , of those, Rh 0 dissociatively adsorbed CO and the latter two associatively adsorbed CO could effectively improve the activity and selectivity for DES. Moreover, the interaction of La-Ce-O and LaFeO 3 strengthened the CO adsorption on the oxygen vacancies on LaFeO 3 , which improved the capacity of assistance in activating CO associatively, thus further increasing the selectivity to ethanol. The catalyst exhibited excellent resistance to carbon deposition and sintering, attributing to the small size of Rh NPs and the carbon eliminating effect of La 2 O 3 and oxygen vacancies on the surface of LaFeO 3 .
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ELECTROCHIMICA ACTA
·
2012
·
IF 3.832
Shaohua Zheng,Ying Huang,Guonan Chen
In this paper, a sensitive graphite/poly(methyl methacrylate) (PMMA) composite electrode was firstly applied to the determination of o-sec -butylphenol ( os BP). This polymer carbon paste electrode (CPE) effectively improved the soft surface of traditional CPE, and enhanced the sensitivity and reproducibility. Factors influencing detection processes were optimized and kinetic parameters were calculated. Under the optimal conditions, the amperometric current density was linear with the concentration of os BP in the range from 2.50 × 10 −7 to 3.55 × 10 −5 mol L −1 and the detection limit was 3.48 × 10 −8 mol L −1 . The proposed method was successfully used to determine os BP in greengrocery samples and satisfactory results were obtained.
研究领域:
电化学
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分析化学
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环境监测
·
材料科学
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