ACS Sustainable Chemistry & Engineering
·
2023
·
IF 8.4
Liyue Zhang,Qiucheng Xu,Yanjie Hu,Ling Chen,Hao Jiang
Anion exchange membrane water electrolysis (AEMWE) is one of the most promising technologies for producing green hydrogen; however, they still suffer from durability issues. One task is to find suitable electrolyte conditions for anode catalysts that endow them with both high activity and stability. Herein, we benchmark the pH–stability relationship of four typical metal oxides as anode catalysts in the AEMWE. Their electrochemical performance and structural stability were in-depth analyzed through impedance, dissolved composition in the electrolyte, and correlated Pourbaix diagram. NiFe2O4 with the best activity and stability in the strong alkaline (pH = 14) shows terrible stability in pure water, which is then verified due to the severe Fe leaching, and it cannot be alleviated by alkaline pre-activation. Notably, Co3O4 shows comparable activity and stability to IrO2 in pure water and weak alkaline conditions. At pH = 12, it entails only ∼2.18 V to reach 1.0 A cm–2 and stabilizes for 40 h, being superior to others. This work screens out suitable transition metal oxides as a substitute for noble metals and their optimal application scenarios for AEMWE.
研究领域:
电化学
·
材料科学
·
可再生能源
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DOI
高影响因子
BIORESOURCE TECHNOLOGY
·
2025
·
IF 9
Yuntong Xu,Guiyuan Yu,Zhitong Wang,Wen Cao,Min Feng,Wenwen Wei,Liejin Guo
Microalgae offer high lipid content and significant carbon–neutral potential, yet inefficient bioprocess and carbon source management fundamentally hinder their scalability. Addressing these challenges, this study developed an innovative integrated two-stage continuous cultivation system for Synechococcus sp., combining pH-triggered CO 2 delivery with wastewater nutrient recycling. Elucidating the relationships among growth, pH, and inorganic carbon, the precise CO 2 -based pH strategy eliminated salt stress, enhancing biomass productivity by 25 % over conventional chemical methods. The optimized nitrogen-deficiency two-stage mode achieved a 2.3-fold increase in lipid productivity and enabled high-efficiency nutrient removal (NH 4 + >70 %, PO 4 3− near-complete). A comprehensive techno-economic analysis confirmed superior cost-effectiveness, demonstrating a ∼45 % reduction in minimum biodiesel production cost compared to single-stage operations. These findings establish a highly feasible, scalable, and sustainable wastewater-to-bioenergy solution.
研究领域:
环境生物技术
·
可再生能源
·
微生物生理学
·
废水处理
·
生物能源工程
·
碳循环管理
·
工业生物技术
·
系统生物工程
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DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Shumin Chen,Xiaoguo Ji,Mengyao Zhao,Jiayang Jin,Haiping Zhang,Liming Zhao
AZD9291 can prolong the survival of patients with non-small cell lung cancer. Unfortunately, resistance to AZD9291 is inevitable and hinders effectiveness. Studies showed the combination of Cyclosporin A (CsA) and AZD9291 could increase the efficacy of AZD9291, but the delivery efficiency of free drugs was limited. A chitooligosaccharide (COS) -based nanoparticle with enhanced delivery efficiency and endocytosis was constructed in this study. The results showed that this pH/redox cascade responsive nanoparticles improved therapeutic effect. The system is small and the surface charge changed from negative to positive according to the weakly acidic tumor microenvironment. After endocytosis, the nanoparticles decomposed and released AZD9291 and CsA in redox-rich cytoplasm. Experiments in vitro and in vivo proved that the nanoparticles overcame the biological barrier and significantly enhanced the anti-tumor effect of AZD9291. The novel multifunctional nanoparticle provides a way to overcome the drug resistance and the possibility of clinical application.
研究领域:
药学
·
纳米技术
·
肿瘤学
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DOI
PubMed
高影响因子
CRYSTENGCOMM
·
2012
·Vol. 15
·期 1
·206-212
·
IF 3.842
Xin-Yu Zhao,Ying-Jie Zhu,Feng Chen,Bing-Qiang Lu,Jin Wu
In this paper, a surfactant-free rapid microwave-assisted hydrothermal synthesis of hydroxyapatite nanosheet-assembled flower-like hierarchical nanostructures (NFHNs) is reported. The effects of the experimental conditions on the morphology and crystal phase of the product are investigated. A possible formation mechanism of hydroxyapatite NFHNs is proposed. The morphology of the product can vary from flower-like to polyhedra by adjusting the microwave heating temperature. The protein and DNA adsorption properties of the as-prepared hydroxyapatite NFHNs are studied. The loading capacities of the as-prepared hydroxyapatite NFHNs for bovine serum albumin (BSA), hemoglobin (Hb) and fish sperm DNA are determined to be 165, 164 and 112 mg g−1, respectively. The protein release process is conducted at different pH values (pH 7.2, 5.5 and 4.8) in phosphate buffer saline (PBS), and the pH-controlled protein release behavior has been found. Thus, the as-prepared hydroxyapatite NFHNs are promising for protein drug delivery applications.
研究领域:
材料科学
·
生物医学工程
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DOI
高影响因子
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
·
2017
·Vol. 2017
·期 15
·2236-2246
·
IF 2.444
Ying Yang,Yunlong Wang,Wanghua Xu,Xiuzhen Zhang,Yong Shang,Anjian Xie,Yuhua Shen
Graphical A multifunctional nanocomposite, reduced graphene oxide@mesoporous silica–doxorubicin/hydroxyapatite (rGO@mSiO 2 -DOX/HA), is fabricated by a simple method for synergistic chemotherapy and photothermal therapy. The introduction of biocompatible HA nanoparticles as a biodegradable pore-capping agent results in the controlled release of DOX under pH and near-infrared (NIR) dual stimulation. A new nanocomposite, reduced graphene oxide@mesoporous silica–doxorubicin/hydroxyapatite (rGO@mSiO 2 -DOX/HA), was prepared by a simple method under mild conditions. Owing to the relatively high loading capacity of the anticancer drug DOX, the biomimetic capping of nontoxic and pH-dependent biodegradable HA on the surface of rGO@mSiO 2 -DOX, and the efficient photothermal conversion effect of rGO under near-infrared (NIR) irradiation, the rGO@mSiO 2 -DOX/HA nanocomposite provides a lasting and pH–light dual-triggered drug release. Therefore, the excellent biocompatibility and drug-permeation ability of the nanocomposite are realized, and synergistic chemo-photothermal therapy is also achieved. The in vitro experimental results indicate that the chemotherapy of DOX and hyperthermia of rGO under NIR light irradiation killed HeLa cells effectively. Therefore, the new nanocomposite has promising prospects as a nano-drug-delivery system and in other biomedical applications because of the pH–light dual-factor sensitivity and chemo-photothermal synergistic therapy.
研究领域:
纳米医学
·
生物材料
·
肿瘤治疗
✓ 已验证
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2025
·
IF 7.3
Chuanying Wei,Xianhui Zhang,Yajun Deng,Bo Wu,Jianhua Wu
In response to complex marine fouling issues, this study developed pH-responsive amphiphilic antifouling coatings (PDHM) synthesized via condensation reactions between protonated zwitterionic-tertiary amine polymers and polydimethylsiloxane (PDMS). These amphiphilic coatings demonstrate pH-responsive surface charge transitions governed by protonation equilibria. Under seawater conditions (pH ∼ 8.3), the PDHM surface exhibits negative charge enrichment, synergizing with a hydrated interfacial layer to impede biofouling adhesion. Subsequent surface acidification induced by colonizing organisms triggers protonation of tertiary amines, converting the surface charge to positive. This transition disrupts fouling organism viability and promotes release under hydrodynamic shear forces. Relative to PDMS, PDHM coatings achieved 99.54 % and 99.59 % reduction in bacterial adhesion ( B. subtilis and P. ruthenica , respectively), alongside a 98.23 % reduction in algal adhesion ( P. ruthenica ). Marine field evaluations in the East China Sea confirmed sustained antifouling efficacy for 180 days. Furthermore, 16S rDNA analysis revealed significantly attenuated biofilm formation and reduced abundance of mobile genetic elements (MGEs) on PDHM surfaces versus PDMS, corroborating its superior antifouling performance. This work establishes a novel methodology for designing smart-responsive marine antifouling coatings.
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2015
·
IF 6.723
Qing-Lan Li,Shi-Han Xu,Hang Zhou,Xin Wang,Biao Dong,Hui Gao,Jun Tang,Ying-Wei Yang
A dynamic cross-linked supramolecular network of poly(glycidyl methacrylate)s derivative chains was constructed on mesoporous silica nanoparticles via disulfide bond and ion–dipole interactions between cucurbit[7]urils and protonated diamines in the polymer chains. This kind of multifunctional organic–inorganic hybrid material with pH- and glutathione- (GSH-) stimuli responsiveness can be applied to anticancer drug delivery and controlled release. Good release performance toward doxorubicin hydrochloride (DOX) was achieved under the simulative tumor intracellular environment (pH = 5.0, CGSH = 2–10 mM). Significantly, the release amount of DOX increased upon lowering the solution pH value and increasing the concentration of GSH, as demonstrated by a series of controlled release experiments. Furthermore, the DOX-loaded hybrid nanomaterials displayed apparent cell-growth inhibition effects to cancer cell lines, as evidenced by MTT assay and confocal laser scanning microscopy.
研究领域:
材料科学
·
药学
·
肿瘤学
✓ 已验证
DOI
高影响因子
JOURNAL OF CATALYSIS
·
2025
·
IF 6.5
Xuyao Duo,Zhonghui Hu,Hengkang Pan,Bingxu Chen,Fengchen Zhou,Panpan Liu,Yifan Zhang,Wen Luo,Zailai Xie,Runhai Ouyang,Xing Huang,Jia Yu,Yuanqing Wang
The pH effects play a critical role in electro-catalysis, yet their influence on the structural evolution of electrocatalysts during the oxygen evolution reaction (OER) remains underexplored. In this study, we combined in-situ Raman and UV–Vis spectroscopy with density functional theory (DFT) calculations to track the structural evolution of electrodeposited amorphous cobalt (oxy)hydroxide under different pH conditions. Our findings reveal distinct responses of the synthesized catalyst to varying electrolyte pH levels. The formation of relatively ordered β-CoOOH structure from amorphous cobalt (oxy)hydroxide under alkaline conditions may serve as the active phase, while the less active amorphous cobalt (oxy)hydroxide remained stable under neutral conditions. This study emphasizes the pivotal role of electrolyte pH in driving surface reconstruction of metal oxides, even in the absence of applied electrode potential.
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS AND CORROSION-WERKSTOFFE UND KORROSION
·
2018
·Vol. 69
·期 6
·736-748
·
IF 1.259
Xiaojie Liu,Weihua Li,Wei Wang,Liying Song,Weijie Fan,Xiang Gao,Chuansheng Xiong
Mesoporous micro- or nanocontainers have been indicated to be potential carriers of corrosion inhibitors to modify water-based coatings for self-healing properties and excellent anti-corrosion performance. In this work, the eco-friendly mesoporous chitosan microspheres loaded with green corrosion inhibitor sodium phytate were incorporated in self-healing water-based polyacrylate coating. The microspheres with mesoporous surface, uniform size, and promising pH responsiveness were prepared via the water-in-oil (W/O) emulsion chemical cross-linking method. On this basis, chitosan microspheres loaded with 25.79 wt% sodium phytate were obtained by negative pressure impregnation method and the pH-responsive was demonstrated by the electrochemical impedance spectroscopy (EIS). The results of EIS and seawater immersion tests revealed that artificial defected water-based polyacrylate coating containing 5 wt% chitosan microspheres showed high anti-corrosion performance and exhibited self-healing capabilities due to the release of corrosion inhibitor sodium phytate.
研究领域:
材料科学
·
腐蚀工程
·
高分子化学
·
环境科学
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2016
·
IF 3.902
Jing Li,Xiaotong Du,Nan Zheng,Lu Xu,Jinghua Xu,Sanming Li
In this study, dual functionalized mesoporous silica nanoparticle (Dual-MSN) with functions of carboxyl modification and chirality was successfully developed and its special contribution in delivering doxorubicin hydrochloride (DOX) in vitro was mainly studied. Characteristics of Dual-MSN and its application as DOX carrier were intensively explored by comparing with naked non-functionalized MSN (Naked MSN). The results indicated that both Naked MSN and Dual-MSN significantly controlled DOX release due to the release hindrance caused by mesopores. As expected, Dual-MSN exhibited obvious enhanced pH-response because of its negative charges of carboxyl groups. DOX loaded Naked MSN and DOX loaded Dual-MSN presented better cytotoxicity than DOX due to carrier-mediated endocytosis and the favorable intercalation of DOX into DNA in the nuclei. The cytotoxicity of DOX loaded Dual-MSN was better than DOX loaded Naked MSN owing to its enhanced cellular uptake induced by chirality of Dual-MSN, demonstrating that double functions of Dual-MSN had unique advantages in improving antitumor effect of DOX towards MCF-7 cells and thus confirming its special contribution in DOX delivery.
研究领域:
药剂学
·
肿瘤学
·
纳米医学
✓ 已验证
DOI
PubMed
高影响因子
ENVIRONMENTAL RESEARCH
·
2025
·
IF 7.7
Shengnan Zhang,Xiaoyan Qian,Jie Ma,Xiao Liu,Juanxiang Zhang,Chong Liu,Xinqiang Liang,Xuefei Hu,Fayong Li
Tetracycline (TC) and copper (Cu) are among the most widely used additives in livestock and poultry production. When introduced into soils via organic fertilizers, they can co-occur and interact, creating complex contamination scenarios that may threaten environmental quality and human health. Biochar effectively inhibits the co-transport of TC and Cu in saline-alkali soils. However, the underlying quantum and molecular mechanisms remain unclear. In this study, column experiments, transport modeling, quantum chemical calculations, and molecular dynamics simulations demonstrated that biochar increases the microdomain pH (> 10), thereby facilitating the synergistic immobilization of TC and Cu within saturated porous media. Soil alkalinization promoted TC deprotonation, and di-deprotonation significantly enhanced the covalent complexation between TC and Cu. The binding energy for the di-deprotonated TC complexed with dual Cu reached –50.38 kcal·mol -1 . Cu binding at distinct TC sites formed molecular clusters with heterogeneous surface potentials, facilitating their aggregation and deposition, preferentially onto biochar and illite surfaces. This synergistic retention intensified with an increase in biochar dosage. Pig manure biochar (PMBC) exhibited a significantly higher retention capacity for TC-Cu complexes than that of cotton straw biochar, which was attributed to the substantially high hydroxyl and carboxyl functional groups and ash content of PMBC. The application of PMBC within a closed-loop cotton-pig farming system reduces environmental risks from combined antibiotic and heavy metal pollution while enhancing soil carbon sequestration. This provides a sustainable remediation strategy and its basis in environmental structural chemistry.
✓ 已验证
DOI
PubMed
高影响因子
Sustainability
·
2022
·Vol. 14
·期 21
·14097
·
IF 3.889
Jiangyi Yan,Lihong Nie,Guiliang Li,Wenxin Wu,Ming Gao,Yuanlu Zhu,Weixing Wu,Beifu Wang
In this paper, we report for the first time the successful formation of a covalent cross-linking structure between polyacrylic acid and polyamide 66 in an electrospun nanofiber membrane by the facilitated amidation reaction using N-Hydroxy-succinimide (NHS) and N-(3-Dimethylaminopropyl)-N’-ethyl-carbodiimide hydrochloride (EDC). The structure and properties of the fiber membrane are characterized using scanning electron microscopy, wide field X-ray diffraction and differential scanning calorimetry. The results show that the presence of the cross-linked structure not only affects the construction of the nanofiber network framework but also influences the pore size distribution and size of the fiber membrane surface, which in turn affects its retention of contaminants and water absorption performance. After modification, the cross-linked membranes exhibited a significant retention performance of up to 77% for methyl tert-butyl ether (MTBE) with a reduced pure water flux. Furthermore, after crosslinking, the fiber membrane has been strongly enhanced with more stable pH response behavior.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）