Catalysts
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2025
·Vol. 15
·期 6
·584
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IF 4
Benlong Yu,Tao Wang,Chao Xiao
This study describes a monolithic silicalite-1 catalyst support designed for tritium oxidation reactions under humid conditions. Monolithic molecular sieves (sil-s) were fabricated by converting silica binders to silicalite-1 through secondary crystallization (175 °C, 24 h). In addition to the binder conversion to silicalite-1, some recrystallization of starting silicalite-1 (sil) results in higher crystallinity, lower concentration of silanol defects, and higher hydrophobicity. With the addition of 2% platinum, Pt/sil-s exhibited better stability under humid conditions, showing only 0.01%/min conversion decay over 800 min. This work has demonstrated a moisture-resistant Pt catalyst for tritium oxidation in fusion energy systems.
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APPLIED CATALYSIS A-GENERAL
·
2025
·
IF 4.8
Jin Guo,Xueying Bai,Xianquan Li,Jifeng Pang,Lele Feng,Yujia Zhao,Yang Su,Shimin Liu,Chaoqian Liu,Mingyuan Zheng
Copper(Cu)-based catalysts are highly promising candidates for ethanol dehydrogenation owing to their exceptional activity in cleaving O-H and C-H bonds. Nevertheless, their widespread application is hindered by challenges such as rapid deactivation and complex preparation procedures. Herein, inspired by the deactivation mechanism of Cu/MFI (silicalite-1) catalysts, two strategies, i.e., using mixed solvents for impregnation and enriching silanol nests of MFI to anchor Cu particles, were used to synthesize Cu/MFI-R catalysts with high stability and activity. The mixed solvent approach reduces the surface tension of solvents, enhancing the uniform dispersion of Cu over the hydrophobic surface of MFI. Subsequently, a MFI-R support with abundant silanol nests was synthesized via optimizing hydrothermal conditions, as confirmed by reaction results and characterizations of FT-IR, UV-Vis and solid NMR. By combining these strategies, Cu/MFI-R catalysts were synthesized for ethanol dehydrogenation, achieving > 90 % ethanol conversion and 95 % acetaldehyde selectivity over the 600 h time on stream test. This work provides a very promising scalable approach for the design of stable Cu-based catalysts in hydrogen-related reactions.
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NEW JOURNAL OF CHEMISTRY
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2026
·
IF 2.6
Yining Chen,Fangna Shangguan,Weilong Chun,Lijia Li,Xin Yang,Jiale Qi,Yujing Xun,Huiyong Chen
TS-1 zeolite demonstrates notable activity and selectivity in cycloolefin epoxidation when employing H₂O₂ as the oxidant.However, the practical application of conventional TS-1 is significantly limited by factors including surface hydrophilic structures and mass transfer constraints. To address these challenges, a carbon-encapsulated hierarchical TS-1 (3DC_TS-1) has been synthesized through the confined growth approach, in which 3DOm carbon is used as a confined space provider for TS-1 crystallization and further acts as a hydrophobic wrapper to modulate the surface microenvironment of TS-1 crystals. In the epoxidation of cyclopentene and cyclohexene with using H₂O₂ as the oxidant, the hydrophobic 3DC_TS-1 catalyst exhibits a superior selectivity to epoxide products by suppressing epoxide hydrolysis and allyl oxidation side reactions, comparing with the 3D_TS-1 catalyst without carbon wrapper and the conventionally microporous TS-1 catalyst.It is expected that this study will provide an effective strategy for designing zeolite catalysts applying to selective oxidation reactions.
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APPLIED SURFACE SCIENCE
·
2021
·
IF 6.707
Jiahao Yao,Haiyang Liu,Qingming He,Kai Chen,Yaping Wu,Xu Li,Chunmiao Zhang,Zhiming Wu,Junyong Kang
Two-dimensional (2D) 2H-1 T′ heterojunctions based on transition-metal dichalcogenides have attracted great attention due to their special interface structures and novel properties. Understanding the growth mechanism and the interface structures is essential for their controllable growth. In this work, we successfully synthesize lateral and vertical MoS 2 /ReS 2 heterojunctions by using a two-step chemical vapor deposition (CVD) method, and deeply explore the evolution of the structure. It is found that the growth mode of heterojunction undergoes a transition from lateral epitaxy to vertical stacking under a high Re/S ratio during the growth. Furthermore, the interface structure is greatly determined by the edge shape of MoS 2 core. Two kinds of structures, with the b-axis of 1 T′ ReS 2 shell parallel to the (1 0 0) and (0 1 0) plane of MoS 2 core respectively, are observed. Meanwhile, by comparing with MoS 2 monolayer, MoS 2 /ReS 2 heterostructures possess a reduced emission intensity due to the carrier transfer. This work provides a robust and controllable strategy for the synthesis of heterostructures with different phase structures.
研究领域:
材料科学
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纳米技术
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凝聚态物理
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半导体器件
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Regenerative Therapy
·
2026
·
IF 4
Yi Zhang,Qi Fang,Xiao Yang
Introduction 3D-printing implants have attracted increasing attention for enhancing the regeneration of various wound types. The rigidity of traditional 3D printing materials limits their applicability in skin wound repair. In addition, improving the bioactivity of polymeric materials remains an urgent challenge to be addressed. Insulin-like growth factor-1 (IGF-1) is widely recognized for its efficacy in skin wound repair. However, the potency of IGF-1 in wound regeneration is limited by its unstable binding to the implants. Methods In this study, A phase inversion-based deposition modeling 3D printing technique was employed to construct flexible poly(lactic-co-glycolic acid) (PLGA) scaffold. Additionally, a novel 3D-printing flexible skin implantation functionalized with bioorthogonal IGF-1 (DA-IGF-1) was fabricated. The adhesion, proliferation and relative mRNA expression of cells on PLGA scaffold were assessed. Meanwhile, a full-thickness skin defect regeneration model was established on the rat back to evaluate the wound repair efficacy of the implanted scaffolds. Results The DA-IGF-1 exhibited outstanding binding ability on the scaffold. The resulting PLGA flexible scaffold modified with DA-IGF-1 showed significantly enhanced hydrophilicity and biocompatibility compared with the control group materials ( p < 0.05). The expression of wound regeneration related genes was also upregulated significantly in the DA-IGF-1 group ( p < 0.05). In vivo study indicated that bioactive implants effectively promoted healing and neovascularization of full-thickness skin defects in rats. Conclusion These results demonstrated that the 3D-printing flexible PLGA scaffold modified with bioorthogonal IGF-1 holds great potential for application as a novel therapeutic strategy for wound regeneration.
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MICROPOROUS AND MESOPOROUS MATERIALS
·
2023
·
IF 5.2
Lei Wu,Mengmeng Zhao,Qiuyan Ye,Xian Xin,Kun Zhang,Yongnan Chen,Ziwei Wang
Electrochemical synthesis of polymer/MOF composite membranes holds great potential for practical applications, yet the preparation of flexible and dense MOF layers remains a challenge, which is crucial for achieving practicality. Herein, a novel ultra-flexible polyethersulfone (PES)/Cu-based metal–organic framework (HKUST-1) composite membrane has been fabricated via an electrochemical synthesis method. Various reaction conditions, including voltage, stirring speed, and reaction time, were systematically investigated to elucidate their influence on crystal growth and the resulting membrane uniformity. The characterization results showed that high voltage and moderate stirring as well as are conducive to obtaining uniform fine crystals. Additionally, a relatively extended reaction time is advantageous for achieving a more continuous and denser MOFs membrane with outstanding flexibility. The optimized membrane possesses an excellent separation flux (2.81 × 10 3 ±32 L m −2 h −1 ·bar −1 ) and efficiency (99.7 ± 0.3%) for n -hexane/water mixtures, as well as excellent photodegradation efficiency (>99%) for methylene blue (MB). Remarkably, the optimized membrane exhibits remarkable scalability and stability, maintaining superior separation performance even after being rolled up 10 times with a curvature of 200 m −1 . This suggests that it has great potential for practical applications in complex environments.
研究领域:
材料科学
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环境工程
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膜技术
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电化学
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纳米材料
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Cell Host & Microbe
·
2026
·Vol. 34
·期 6
·1000-1017
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IF 23.2
Liang Bian,Yang Cai,Yuan Zhang,Ling Shen,Huijuan Wang,Feng Gao,Ningbo Cai,Wenbo Chen,Conghui You,Yurui Yang,Fang Wang,Yonggui Yuan,Bing Han,Honghong Yao
Despite widespread clinical use of glucagon-like peptide-1 receptor (GLP-1R) agonists for metabolic disease, their neuropsychiatric effects remain poorly understood and controversial. Here, we demonstrate that liraglutide alleviates depression through a gut-brain pathway that operates independently of GLP-1R. Using both pharmacological and genetic approaches, we demonstrated that liraglutide retained antidepressant efficacy in GLP-1R antagonist-Exn9-treated mice or in Glp1r −/− mice, whereas gut microbiota depletion abolished its effects. Multi-omics analyses revealed that liraglutide increased the abundance of Lactobacillus delbrueckii , which in turn restored the levels of the endocannabinoid 2-arachidonoylglycerol (2-AG). The elevation of 2-AG mediated the antidepressant effects by normalizing excessive neuronal activity in emotional processing brain regions. Importantly, fecal microbiota transplantation from liraglutide-treated mice or Lactobacillus delbrueckii colonization replicated the antidepressant effects. These findings uncover a non-canonical mechanism of action for GLP-1 analogs, highlighting a specific microbiota-endocannabinoid metabolic pathway as a potential therapeutic target for depression.
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DOI
PubMed
高影响因子
Food Chemistry-X
·
2023
·
IF 6.1
Zhuoting Liu,Yunfang Ping,Lumei Zhang,Jingran Zhang,Ann Van Schepdael,Xu Wang
In this study, a ligand fishing method was developed to screen potential indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors from coffee extracts by immobilization of IDO1 enzyme on amino-modified magnetic nanoparticles combined with UHPLC-Q-TOF-MS/MS analysis. Parameters including enzyme concentration, immobilization time, the pH of glutaraldehyde and the amount of magnetic nanoparticles were optimized. The results indicated that immobilized IDO1 could be reused 5 times and was stable during storage for 7 days. Several IDO1 ligands were captured by incubating immobilized IDO1 with coffee extract, of which 10 showed an obvious difference comparing to non-conjugated bare nanoparticles. In vitro inhibitory activity was further performed by CE analysis, in which ferulic acid and chlorogenic acid had better IDO1 inhibitory activity, with IC 50 value of 113.7 μM and 307.5 μM. These results demonstrate that this method provides an effective platform for identifying and screening IDO1 inhibitors from natural products.
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PubMed
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2022
·
IF 5.062
Dongzhi Xu,Haihao Wu,Chunguang Zhou
Osteoporosis is a common severe orthopedic disease that can lead to bone fractures and significantly reduce a patient's quality of life. Teriparatide (parathyroid hormone, PTH (1–34)) has been approved for the treatment of osteoporosis. However, PTH (1–34) needs to be injected once daily due to its short half-life of 1 h. To improve the pharmacokinetic and pharmacodynamic profiles of PTH (1–34), a G148-ABD3 (GA3) domain, which can bind to albumin non-covalently, was employed to modify PTH (1–34). The resultant PTH 34 -GA3-GS1 and PTH 34 -GA3-GS3 fusion proteins were constructed by fusing PTH (1–34) to the N-terminus of GA3 via (G 4 S) 1 and (G 4 S) 3 linkers, respectively. The fusion proteins were highly expressed in Escherichia coli . In vitro results showed that both PTH 34 -GA3-GS1 and PTH 34 -GA3-GS3 could bind to human serum albumin (HSA) with high affinity. The fusion proteins significantly increased the proliferation and differentiation of osteoblastic MC3T3-E1 cells, thereby promoting osteogenesis. PTH 34 -GA3-GS3 increased intracellular and serum calcium levels more than PTH 34 -GA3-GS1 did. The half-lives of PTH 34 -GA3-GS1 and PTH 34 -GA3-GS3 were 8.4 h and 9.1 h, respectively, which are significantly longer than that of PTH (1–34). Injection of PTH 34 -GA3-GS3 every three days increased bone mineral density and improved trabecular structure in ovariectomized mice, indicating that PTH 34 -GA3-GS3 has the potential to alleviate osteoporosis in humans. In conclusion, the fusion proteins maintained the biological activity of native PTH (1–34) and were not affected by the GA3 moiety, which extended the half-life of PTH (1–34). Long-acting GA3-fusion PTH (1–34) proteins have therapeutic effects on osteoporosis by improving osteogenesis and by enhancing the proliferation and differentiation of osteoblasts.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2023
·
IF 6.1
Ming-Shan Chen,Jia-Xin Wang,Hao Zhang,Jia-Gen Cui,Yi Zhao,Jin-Long Li
Phthalates are widely used to improve the flexibility of poly(vinyl chloride) (PVC) polymer agriculture products. Di(2-ethylhexyl) phthalate (DEHP) is a type of addition to plastic and can lead to many health problems. Hemeoxygenase-1 (HO-1) is an extremely important molecule that releases enzymatic products to promote ferroptosis. This research aimed to explore the function of HO-1 in DEHP-induced renal proximal tubule cell ferroptosis. In the experiment, ICR male mice are exposed to (0, 50, 200, and 500 mg/kg BW/day) DEHP for 28 days. Here, we observed that DEHP induced glomeruli atrophy and the tubules swell. Furthermore, DEHP exposure could increase ferrous iron content and decrease antioxidant activity. We also found that DEHP exposure increased the expression of nuclear factor-erythroid 2 p45-related factor 2 (NFE2L2) in the nucleus. In particular, the expression of (HO-1) is significantly increased both in protein and mRNA levels. Glutathione peroxidase 4 (GPX4) as an endogenous control of ferroptosis was downregulated, which proved the occurrence of ferroptosis. In the study, exposure to DEHP activated the NFE2L2/HO-1 signaling pathway and resulted in ferroptosis of the proximal tubule. This research connects ferroptosis with HO-1, providing new insights into the potential roles of phthalates in nephrotoxicity.
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CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
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2022
·
IF 1.193
Xin Yang,Xin-Yi Yu,Qing Wang,Jie Zou,Gui-Ping Liao,Meng-Tian Li,Xin-Li Liu,Hui Xia,Fu-Jian Xu
Herein, a label-free, sensitive, and selective fluorescence probe for the detection of trace nitrite in water sample by metal–organic cages (ZrT-1-NH 2 ) was reported. The fluorescence emission of as-prepared ZrT-1-NH 2 was 450 nm upon the excitation of 373 nm with a quantum yield of about 8.6%, which can be quenched by the addition of nitrite. The proposed sensor owned the advantages of high sensitivity (limit of detection = 0.5 µM), quick response (100 s), and excellent selectivity in the presence of various ions. The fluorescence quenching was due to the diazotization and reduction reaction of –NH 2 with the preliminary studying. Under the optimized condition, the sensor was successfully exemplified by real water samples and comparative performance was achieved.
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NEUROCHEMICAL RESEARCH
·
2022
·Vol. 48
·期 2
·570-578
·
IF 4.414
Guo Shenglong,Lei Qi,Guo Hena,Yang Qian,Xue Yanli,Chen Ruili
Ferroptosis and neuroinflammation play a crucial role in the pathogenesis of Alzheimer’s disease (AD), and Edaravone (EDA) has been demonstrated to have anti-inflammatory, antioxidant and neuroprotective effects in neurodegenerative diseases. However, the relationship between EDA and ferroptosis in AD is unidentified. This research aimed to elucidate the mechanism of EDA in AD with Aβ 1-42-induced HT22 cells as in vitro cell model. The results showed that EDA could significantly reduce Aβ 1-42 -induced apoptosis of HT22 cells and formation of pro-inflammatory factors TNF-α, IL-1β and IL-6, prevent the activation of TLR4/NF-κB /NLRP3 signaling pathway, and inhibit ferroptosis and lipid peroxidation. Taken together, EDA contributes to inhibiting neuroinflammatory injury and ferroptosis in Aβ 1-42-induced HT22 cells, and thus may be a potential candidate for the treatment of AD.
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