Nature Communications
·
2026
·
IF 18.1
Peng Haibao,Zeng Youming,Huang Yang,Lin Chenyu,Lei Zeyu,Sun Peixin,Yang Jiahui,Sheng Shaoqi,Huang Yuxin,Li Xiaohui,Zhao Jiaxu,Zeng Rui,Li Cheng,Yang Wanqi,Di Xiangjie,He Sisi,Wang Yongsheng,Yang Hanting,Yang Wuli,Chi Yudan
The central nervous system is a critical reservoir for cancer metastasis, underscoring the urgent need for effective strategies for targeted drug delivery that minimize systemic side effects. Here, we present a zwitterionic polycarboxybetaine (PCB) designed to achieve selective accumulation within the tumor vasculature of brain metastases, thereby facilitating the rapid release of therapeutics without relying on external stimuli in preclinical models. PCB selectively targets the betaine-γ-aminobutyric acid transporter 1 (BGT1) at the blood-brain-tumor barrier (BBTB), enabling localized enrichment of nanoparticles within the tumor vasculature. The intrinsic mechanical flexibility of PCB activates the Piezo1 ion channel in endothelial cells, resulting in calcium ion influx and enhanced calpain activity, which together facilitate the degradation of VE-cadherin. The burst-release mechanism improves vascular permeability and compromises the integrity of the tumor vascular barrier, allowing for the swift release of encapsulated therapeutics and promoting extensive drug distribution within the tumor microenvironment. Notably, PCB encapsulating either osimertinib or cisplatin demonstrates therapeutic efficacy, intratumoral targeting, and favorable biological safety in disease models. These findings indicate that this zwitterion-functionalized platform effectively surmounts the challenges posed by the BBTB, supporting improved drug delivery and therapeutic efficacy in brain metastases.
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Nature Communications
·
2026
·Vol. 17
·期 1
·6517
·
IF 18.1
Wang Yinlong,Hou Qihang,Lv Xinying,Liu Jiongyan,Wang Huimei,Zhao Yan,Tong Haonan,Liu Yanli,Du Juan,Yang Xiaojun,Wu Shengru,He Shuixiang,Yang Xin
Although fecal microbiota transplantation (FMT) shows promise for ulcerative colitis (UC), its clinical success appears to be contingent upon the degree of donor microbiota engraftment. Using an LD50-based ecological model, our study reveals that inorganic nitrogen utilization capacity (IN-uc) critically determines gut microbial assembly in high oxidative stress environments, which significantly influences microbial engraftment outcomes. Building on this mechanistic insight, we engineer a probiotic-metabolite consortia designed to synergistically increase IN-uc in the gut ecosystem. We find that PM-mix 14 alleviates oxidative stress-mediated colonization barriers of donor microbiota by catalyzing the conversion of excess reactive nitrogen species through multi-step reactions, promotes L-glutamate biosynthesis and ATP production, thereby ensuring greater similarity in the structure and function of the recipient microbiota to those of the donor. In multiple male murine models of colitis, PM-mix 14 supplementation during FMT significantly improves microbial engraftment fidelity, which is correlated with increased anti-inflammatory responses and attenuated colonic pathology. Network meta-analysis of multiple clinical datasets further substantiates the prognostic value of donor gut microbial IN-uc in UC remission. Our findings establish the gut microbial IN-uc as an ecological driver of microbiota engraftment and present a rationally designed microbial therapy that optimizes FMT efficacy through targeted metabolic reprogramming.
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Nature Communications
·
2026
·
IF 18.1
Zhang Chunyu,Sun Haozhe,Liu Xiang,Kong Kejian,Zhou Tiancong,Wang Xi,Duan Haohong
Electrochemical C–S bond construction represents an attractive route to produce valuable organosulfur compounds, yet current approaches suffer from low reaction efficiency and rely on sulfites (SO 3 2− ) as the sulfur source. Here we report a paired electrolysis for hydroxymethanesulfonate synthesis from widespread industrial-waste sulfides (HS − ). Specifically, HS − is oxidized to SO 3 2− by in-situ generated H 2 O 2 at cathode, and methanol is oxidized to formaldehyde at anode, with following C–S coupling to form hydroxymethanesulfonate. By matching HS − concentration with current density and strengthening convective mass transfer between intermediates, we achieve efficient hydroxymethanesulfonate production with Faradaic efficiency of 102.8% and productivity of 282 μmol h −1 in a membrane-free H-cell under optimized conditions (50 mA cm −2 , 0.05 M HS − , stirring in anodic chamber). By constructing a flow reactor, this paired electrolysis enables conversion of HS − -contaminated wastewater (from <10 ppm to 3000 ppm) with Faradaic efficiencies exceeding 100%, while tolerating coexisting anions and heavy metals in real effluents. It also converts waste H 2 S gas with >87% conversion and >74% hydroxymethanesulfonate selectivity over 102 hours of stable operation, demonstrating more cost-effective economics to both industrial and previous electrochemical methods.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·Vol. 24
·期 1
·653
·
IF 15
Zhou Tao,Lin Yajing,Wang Ying,Lin Lin,Li Jingtong,Tang Ning,Mao Yingji,Zhou Pinghui
Immune dysregulation and scar tissue formation following traumatic spinal cord injury (SCI) result in the generation of a microenvironment that significantly inhibits nerve regeneration and functional recovery. Continuous drug delivery across the dura, with minimal damage, and modulation of this inhibitory microenvironment pose substantial challenges in SCI treatment. This study fabricated a pH-responsive immunomodulatory microneedle (MN) patch by incorporating zeolitic imidazolate framework-8 (Zif-8) nanoparticles loaded with chondroitinase ABC (ChABC) into a gelatin methacrylate (GelMA) hydrogel (Z@C-MN). As the patch progressively degraded, this system continuously released Zn 2+ and ChABC in a pH-responsive manner to facilitate in situ SCI repair. In vitro, Z@C-MN can down-regulate macrophage inflammatory responses, promote axon extension, and differentiate neural stem cells into neurons. In vivo, Z@C-MN reduced the inflammatory microenvironment in an injury model and promoted angiogenesis in a rat SCI model. In addition, it promoted axonal regeneration and neurogenesis by inhibiting nerve scar formation and regulating CD4 + T cell transformation. These effects contributed to the recovery of motor and neurological functions. Thus, this drug delivery system offers a highly efficient, transdural, and continuous-release multifunctional platform for patients with SCI. Graphical
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International Journal of Minerals Metallurgy and Materials
·
2026
·Vol. 33
·期 6
·1886-1899
·
IF 8.8
Zeng Yong,Che Xiyuan,Zhang Lei,Chen Peng,Song Shaoxian,Wang Deshou,Jia Feifei
Thiosulfate gold extraction technology has gained considerable interest owing to its environmental compatibility and broad applicability to diverse ore types. However, the lack of efficient methods to recover Au(S 2 O 3 )
3− 2
from leaching solutions has hindered its industrial implementation. To address this challenge, this study used a thiosulfate leaching solution from quartz-type gold ores to design an activated carbon-coated titanium electrode (Ti@AC) with a porous surface structure. This electrode facilitated the direct reduction of low-concentration Au(S 2 O 3 )
3− 2
to metallic gold (Au 0 ) in solution, achieving a gold recovery of 99.58%, surpassing other recovery methods from the leaching solution by 30%–80%. After ten consecutive 200 L pilot-scale tests, the Ti@AC electrode demonstrated remarkable stability, consistently maintaining a recovery >98% and yielding 20.23 g of gold. The porous architecture of the activated carbon (AC) promoted the adsorption of low-concentration Au(S 2 O 3 )
3− 2
, while its low charge transfer resistance facilitated the efficient conversion of Au(S 2 O 3 )
3− 2
to Au 0 . Moreover, the reduction reaction generated a concentration gradient near the cathode, promoting the diffusion of Au(S 2 O 3 )
3− 2
toward the electrode and ensuring an efficient recovery process. This study provides a feasible strategy for the direct reduction of low-concentration precious metal ions to monomers with high recovery and low costs, which is promising for industrial applications.
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Frontiers of Materials Science
·
2026
·Vol. 20
·期 3
·260775
·
IF 2.3
Chen Chen,Chang Jie,Wang Tao,Fatima Areeje,He Min,Huang Jiarui
It is of practical significance to develop gas sensors with high sensitivity and high selectivity. In this study, ZnO nanoflakes were synthesized by hydrothermal synthesis, and Au/ZnO, Pd/ZnO, and Pt/ZnO nanoflakes were fabricated by uniformly loading small-sized Au, Pd, and Pt nanoparticles using an ultraviolet-assisted reduction. Gas-sensing performance tests revealed that Au/ZnO nanoflakes exhibited a higher response to isopropanol compared to Pd/ZnO, Pt/ZnO, and ZnO nanoflake sensors. At the working temperature of 225 °C, it demonstrated response of 132.2 to 100 ppm isopropanol, with 8 s response time and 12 s recovery time, and showed high selectivity, repeatability, and stability. Hydrogen sensing performance of Au/ZnO nanoflakes was also evaluated at the optimal operating temperature, yielding a response of 13.5 to 100 ppm hydrogen, with response time and recovery time of 17 and 21 s, respectively, and exhibiting a high concentration-dependent response. The material’s enhanced gas sensing performance is due to a synergistic effect. This effect combines abundant active sites on nanoflakes with inherent catalytic properties of gold nanoparticles.
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JOURNAL OF SOILS AND SEDIMENTS
·
2026
·Vol. 26
·期 7
·252
·
IF 3.3
He Ye,Zhong Jiawen,Wei Xiaoli,Wang Jinjin,Xu Huijuan,Zhang Yulong,Li Wenyan
Purpose Polycyclic aromatic compounds (PACs) and heavy metals (HMs) frequently coexist in the soil of industrial areas, posing significant ecological risks. This study investigated the distribution and influencing factors of PACs and HMs in soil aggregates under co-contamination, as well as their interactive adsorption behavior and mechanisms with soil, with a focus on lead (Pb), phenanthrene (Phe), and 1-acenaphthenone (1-ACE). Methods Soil samples were collected from an industrial area and fractionated into four aggregate sizes. soil properties and the contents of PACs and HMs in different aggregates were determined. Single and co-adsorption behaviors of Pb, Phe, and 1-ACE were examined through batch adsorption experiments, with isotherms modeled using Freundlich, Langmuir, and Linear models. Adsorption mechanisms were further explored by X-ray photoelectron spectroscopy (XPS) analysis. Results Most PACs and HMs mainly accumulated in the < 0.002 mm aggregates, with HMs influenced by multiple soil properties and PACs primarily influenced by soil organic matter (SOM). The Freundlich parameters (K F and 1/n) indicated that Pb exhibited heterogeneous multilayer adsorption, while Phe and 1-ACE exhibited homogeneous adsorption. The presence of Phe inhibited Pb adsorption by 7.94–19.28%, whereas 1-ACE enhanced it by 3.28–12.65%. Conversely, Pb coexistence increased the adsorption of Phe (17.29–27.26%) and 1-ACE (40.10–60.03%). XPS revealed that Phe competed with Pb for C=O groups, weakening Pb’s complexation and ion exchange, while 1-ACE promoted Pb adsorption by increasing C=O proportions. Pb enhanced Phe adsorption via increased surface hydrophobicity and π-π interactions, while it promoted 1-ACE adsorption through strengthened complexation and iron oxides interactions. Conclusions The results demonstrated that the interaction between co-contaminants and soil can alter the adsorption behaviors of pollutants, thereby deepening our understanding of their environmental fates. These findings provide crucial insights for assessing environmental risks and developing remediation strategies for co-contaminated soils.
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Nature Communications
·
2026
·Vol. 17
·期 1
·4508
·
IF 18.1
Li Shuying,Wang Yonghong,Liu Yuan,Cao Qing,Chen Gaojie,Fan Xiaolong,Li Qinyi,Zhang Peng,Hu Renzhi,Tham Yee Jun,He Xu-Cheng,Chu Biwu,Ma Qingxin,Chen Jinsheng,He Hong
Chlorine atoms (·Cl) exhibit high reactivity and exert a substantial influence on the atmospheric oxidation capacity and chlorine cycle in the troposphere. The photolysis of molecular chlorine (Cl 2 ) is a crucial source of ·Cl. However, the daytime peaks of Cl 2 concentration cannot be entirely accounted for by the currently known pathways. Here we show that the photolytic oxidation of ammonium chloride (NH 4 Cl), a ubiquitous component of atmospheric aerosol, serves as an important daytime source of Cl 2 . Laboratory experiments demonstrate that oxygen, water vapour, and acidity are indispensable for Cl 2 generation and release, and that Cl 2 production is enhanced in the presence of black carbon aerosol. Field observation combined with model simulation demonstrates that the mechanism explains 12-55% of daytime Cl 2 concentration. These results reveal a photoactivation pathway for chlorine production that depends only on chlorine salts and solar radiation, with significant implications in regions with abundant chloride salts.
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Translational Psychiatry
·
2026
·
IF 7.5
Liu Chang,Zhang Ting,E Er-Deng,Xu Tian-Yang,Yang Fei-Ran,Li Jia-Wen,Shang Qing,Zhang Zhong-Yu,Shen Hao-Wei,Zhang Xiao-Qin
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder characterized by progressive cognitive decline, and increasing evidence indicates that systemic inflammation can accelerate disease progression. Maraviroc, a CCR5 antagonist approved for the treatment of human immunodeficiency virus (HIV) infection, has shown neuroprotective effects in several neurological contexts, but its role in AD-related pathology remains unclear. In this study, cognitive performance was assessed in 5 × FAD mice using the Y-maze, novel object recognition, novel location recognition, and social discrimination tests. Amyloid-related changes were evaluated by hippocampal APP/Aβ immunoblotting and plaque staining using 6E10 and Thioflavin S. Glial responses were examined by IBA1 and GFAP immunostaining, and inflammatory cytokines were quantified by ELISA. We found that 5 × FAD mice exhibited age-dependent cognitive impairments, with detectable deficits emerging at 3 months of age. Systemic administration of lipopolysaccharide (LPS) further exacerbated cognitive dysfunction, amyloid-related alterations, and neuroinflammatory responses in young 5 × FAD mice. Maraviroc treatment attenuated LPS-associated cognitive impairments, reduced amyloid-related measures, and dampened pro-inflammatory cytokine responses, with a trend toward reduced microglial cell density. Collectively, these findings demonstrate that systemic inflammation accelerates Alzheimer’s-like pathology and cognitive decline, and suggest that pharmacological modulation of neuroinflammatory signaling by maraviroc may mitigate inflammation-driven disease exacerbation at early stages. Schematic diagram illustrating the effects of maraviroc on LPS-induced cognitive deficits in 3-month-old 5 × FAD mice. In this model, maraviroc is associated with modulation of glial inflammatory responses, reduced pro-inflammatory cytokine levels, and alleviation of amyloid pathology in the hippocampus, which together coincide with improved cognitive performance. Figure created with BioRender.com.
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Nano-Micro Letters
·
2026
·Vol. 18
·期 1
·431
·
IF 38.5
Wang Dongdong,Dou Shuo,Huang Qiongying,Li Jiaying,Xu Mi,Li Jingshuai,Guo Zhendong,Qin Siqi,Wang Tieyan,Yu Haipeng,Dou Haozhen,Chen Zhongwei
A loose selective interface (LSI) is in situ constructed by self-assembly of porous organic cages for aqueous Zn metal batteries.
The porous LSI enables fast Zn 2+ transport, dynamic self-repairing capability and dendrite-free Zn deposition.
Ah-level aqueous Zn pouch cells deliver 1 Ah capacity with stable cycling performance.
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Advanced Composites and Hybrid Materials
·
2026
·Vol. 9
·期 4
·297
·
IF 15.5
Lv Ze,Fang Yu,Gao Yang,Li Hongwei,Yan Pengkun,Zhang Zheng,Wang Lei,Li Fengyu,Ma Yingjian,Zhao Rui,Guo Xinyu,Wu Xuemin,Xu Yong
Sustainable management of plant bacterial diseases calls for delivery systems that minimize reliance on conventional synthetic pesticides while improving deposition efficiency, on-demand release, and environmental compatibility. This study employs a coordination-driven hollowing strategy to construct interface-optimized hollow metal–phenolic nanocarrier (NaSA@PDA@ZIF-8), achieving synergistic loading of sodium salicylate and Zn 2+ . PDA-induced etching of ZIF-8 generates a well-defined hollow architecture while enhancing hydrophilicity and colloidal stability. The optimized nanocarrier, obtained via Box–Behnken response surface design, achieves a NaSA loading content of 23.90%. Regarding interfacial performance, the carrier exhibits significantly optimized wetting behavior with a contact angle reduced to 51.15°, enhanced dynamic spreading speed, and outstanding leaf adhesion and rain-wash resistance, ensuring effective retention and utilization in complex field environments. Under simulated bacterial wilt conditions in tobacco (acidic pH 5.0 and elevated temperature of 35 °C), the system exhibited enhanced release behavior. The cumulative release of NaSA reached 81.72% and 83.40%, while Zn 2+ release reached 23.19% and 18.72%, indicating good responsiveness to disease-relevant microenvironmental conditions. Its antibacterial activity (EC 50 = 17.80 mg·L -1 ) is likely associated with multiple contributing factors, including Zn 2+ release, potential ROS generation mediated by PDA, and NaSA-related activation of plant defense responses. This work demonstrates a hollow metal–phenolic nanoplatform that integrates interfacial adhesion, stimuli-responsive co-delivery, and biosafety, providing a multifunctional reference model for green plant protection. Graphical abstract
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CELLULAR & MOLECULAR BIOLOGY LETTERS
·
2026
·
IF 12.2
Zhou Daqian,Wang Liquan,Zhou Yang,Lv Jiale,Song Chao,Mei Yongliang,Liu Tao,Wu Taotao,Yu Fei,Liu Zongchao
Intervertebral disc degeneration (IVDD) is a common and challenging chronic condition in orthopedics, primarily characterized by the aging of nucleus pulposus cells (NPC). Current treatment strategies for IVDD, particularly those targeting NPC senescence, remain underdeveloped. Research has shown that NPC senescence is closely associated with mitochondrial damage, leading to the accumulation of cytoplasmic reactive oxygen species (ROS) and mitochondrial DNA (mtDNA). Mitochondrial autophagy, as a key mechanism of mitochondrial quality control, regulates ROS and mtDNA levels by eliminating dysfunctional and damaged mitochondria, thereby delaying cellular aging. Notably, mitophagy signaling associated with Sirtuin 6 (SIRT6) and PTEN-induced kinase 1 (PINK1)/Parkin has been implicated in this process. Traditional Chinese Medicine (TCM), with its holistic approach and unique theoretical system of syndrome differentiation and treatment, offers significant advantages in preventing and treating degenerative diseases such as IVDD. However, research into TCM formulations aimed at NPC senescence remains limited. In preliminary studies, we observed that Nodakenin, the primary active compound from the TCM formula Duhuo Jisheng decoction (DHJSD), exerts protective effects in a SIRT6-associated manner and appears to be associated with activation of PINK1/Parkin-related mitophagy signaling. In this study, we used single-cell analysis to construct human NPC senescence and rat IVDD models, assessing mitochondrial morphology, mitochondrial membrane potential, cell senescence, and autophagy-related gene expression. We further evaluated the effects of Nodakenin (Nod) on H 2 O 2 -induced NPC senescence and determined the optimal intervention concentration, followed by assessment of mitochondrial phenotypes and SIRT6- and PINK1/Parkin-associated markers. These findings provide new theoretical support for the clinical application of TCM in the treatment of IVDD.
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