JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2014
·
IF 2.045
Yu Sun,Yu-Feng Hu,Chao Miao,Zhen-Yu Yang,Chen-Chen Jiang,Xiao-Ming Peng,Yu-Fei Chen
The densities of the binary aqueous solutions of 1-carboxymethyl-3-methylimidazolium chloride ([HOOCMMIm]Cl), 1-carboxymethyl-3-propylimidazolium chloride ([HOOCMPIm]Cl), 1-(2-hydroxylethyl)-3-propylimidazolium chloride ([HOEtPIm]Cl), and the ternary solutions [HOOCMMIm]Cl + [HOOCMPIm]Cl + H2O, [HOEtPIm]Cl + [HOOCMPIm]Cl + H2O, and [HOEtPIm]Cl + [HOOCMMIm]Cl + H2O have been measured at (293.15, 298.15, and 303.15) K, respectively. The densities of the examined ternary solutions have been predicted by the equation of Patwardhan and Kumar established for the density of aqueous electrolyte solutions. The predictions were not very satisfactory probably due to the presence of the functional group −COOH. The coupling of the Patwardhan and Kumar’s equation and the rule of Young and Smith considerably improves the predictions, and the predicted results show excellent agreements with the experimental results.
研究领域:
物理化学
·
化学工程
·
热力学
·
离子液体
·
溶液化学
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高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2017
·
IF 2.323
Tiantian Ye,Haibin Qu,Xingchu Gong
The liquid–liquid equilibrium (LLE) data of ternary systems of water + d-fructose + 1-butanol, water + d-glucose + 1-butanol, and water + d-galactose + 1-butanol were determined at three temperatures (288.2, 303.2, and 318.2 K) and atmospheric condition. The distribution coefficients of the monosaccharides were lower than 0.05. For all the three saccharides, their content in the organic-rich phase increased as their content in the aqueous phase increased. The experimental tie-line data were fitted using the Othmer–Tobias equation. The saccharide universal quasichemical functional-group activity coefficient (S-UNIFAC) model was used to predict the LLE data with all the average absolute deviations (AAD) values higher than 0.013. The modified universal quasichemical model was then used to correlate the LLE data. The correlation results agreed better with experimental data than the prediction results obtained with S-UNIFAC. In the production of traditional Chinese medicines, 1-butanol is a promising extractant used to separate active compounds and saccharides in aqueous herbal extracts.
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Bioengineered
·
2021
·
IF 3.269
Yunxin Zhang,Jianlong Liu,Wei Jia,Xuan Tian,Peng Jiang,Zhiyuan Cheng,Jinyong Li
This study is aimed at identifying the roles of AGE/RAGE and ET-1 in deep vein thrombosis (DVT). Advanced glycation end products (AGEs) in glycated human serum albumin (M-HSA) were detected by ELISA. The viability of HUVECs was examined by CCK-8 assay. Flow cytometry was performed to detect cell apoptosis, followed by ELISA for the detection of inflammatory cytokine level and oxidative stress level in HUVECs. Immunofluorescence was performed to detect ET-1 and eNOS expression. The expression of specific proteins was assayed by western blot. As a result, decreased HUVEC viability was observed after stimulation with M-HSA, whereas RAGE inhibitor improved it. Cell apoptosis showed the opposite trend. Additionally, M-HSA-induced inflammatory cytokine release and oxidative stress of HUVECs were both alleviated by RAGE inhibitor. RAGE inhibitor also increased the levels of NO and eNOS while decreasing the level of ET-1 in M-HSA-stimulated HUVECs. Furthermore, decreased protein expression of Bax, cleaved-caspase3, RAGE, p65, ET-1 and iNOS was observed after treatment with RAGE inhibitor, in addition to increased protein expression of Bcl-2 and eNOS. In conclusion, blocking AGE/RAGE pathway downregulates ET-1, thereby mitigating HUVEC damage in DVT.
研究领域:
心血管疾病
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分子生物学
·
细胞生物学
·
血栓形成
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PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2021
·
IF 5.875
Hongji Liu,Jinju Nie,H.C. Stephen Chan,Hailu Zhang,Liang Li,Hongqing Lin,Henry H.Y. Tong,Ande Ma,Zhengzheng Zhou
Herein, we reported a new bergenin : 4-aminobenzamide ( BGN-4AM ) cocrystal with significantly enhanced solubility and low hygroscopicity probed from two aspects such as phase solubility diagrams and theoretical calculations. Compared with anhydrous BGN , BGN-4AM solubilities in water and different buffer solutions (pH = 1.2, 4.5, 6.8) increase significantly. It is noted that BGN-4AM solubility in pH = 6.8 buffer solution presents 32.7 times higher than anhydrous BGN . Interestingly, BGN-4AM (0.31 ± 0.07%) showcases lower hygroscopicity than anhydrous BGN (9.31 ± 0.16%). The predicted and experimental solubilities agree with each other when considering solubility product ( K sp ) and solution binding constant ( K 11 ) in phase solubility diagrams, indicating the solution complexes formation occurs. Further crystal surface-water interactions and Bravais, Friedel, Donnay-Harker (BFDH) analyses based on Density Functional Theory with dispersion correction (DFT- d ) methods support the enhanced solubility. The water probe demonstrates an average interaction energy of −6.48 kcal/mol on the 002 plane of BGN-4AM , and only −5.47 kcal/mol on the 011 plane of BGN monohydrate. The lower lattice energy of BGN-4AM guarantees its lower hygroscopicity than BGN monohydrate. BGN-4AM with enhanced solubility and low hygroscopicity can be a potential candidate for further formulation development.
研究领域:
药剂学
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理论化学
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DOI
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2018
·
IF 2.631
Ying Zhang,Taotao Zhan,Junshuai Chen,Maogang He
The mutual diffusion coefficients of binary mixtures, 3–methyl–1–butanol + n–heptane and 2–methyl–1–butanol + n–heptane, were measured over the mass fraction from 0.05 to 0.95 at temperatures T = 288.15 K, 298.15 K, 308.15 K and 318.15 K under atmospheric pressure. A digital holographic interferometry system was employed for the measurements and its expanded relative uncertainty of mutual diffusion coefficients was estimated to be less than 2.4%. The influences of temperature and composition on the mutual diffusion coefficients were investigated. Furthermore, the correlations of the mutual diffusion coefficients were fitted to the experimental data as functions of the mass fraction and temperature. The correlations represent the data with the absolute average of relative deviations (AARDs) of 0.88% for 3–methyl–1–butanol + n–heptane and 0.89% for 2–methyl–1–butanol + n–heptane, respectively.
研究领域:
物理化学
·
热力学
·
化学工程
·
传递性质
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DOI
高影响因子
JOURNAL OF FOOD PROCESSING AND PRESERVATION
·
2020
·Vol. 44
·期 12
·e14925
·
IF 1.405
Hui-Yun Chen,Ling-Feng Jiang,Ji-Hao Zeng,Yan-Rong Huo,Yong-Xin Li
Nanoemulsion has been shown to extend the postharvest life of horticultural produce. In this study, “Fuji” apple were treated with the combination of nanoemulsion coating-1 (NC-1) and 1-methylcyclopropene (1-MCP). Biochemical and nutritional values were assessed every 35 days during 280 days storage at 4°C and 90% RH. Results show that apples treated with the combination of NC-1 and 1-MCP has significantly reduced mass loss and decay, suppressed malondialdehyde (MDA) content. The combination treatment of NC-1 and 1-MCP also retained significantly higher ascorbic acid (ASC), titratable acid (TA), and total soluble solid (TSS) content. NC-1 and 1-MCP treatments alone or in combination produced higher peroxidase (POD) and catalase (CAT) activities but lower phenylalanine ammonia-lyase (PAL) and polyphenol oxidase (PPO) activities than control. Therefore, the combination of NC-1 and 1-MCP preserved better “Fuji” apple quality, which could be used to extend the postharvest life of “Fuji” apple during long-term storage. Practical applications This research work shows that the combined treatment of NC-1 and 1-MCP on “Fuji” apple reduced mass loss, decay and MDA level, retained higher ASC, TA, and TSS content, promoted POD and CAT activities but suppressed PAL and PPO activities, by which preserved better “Fuji” apple qualities during long-term storage. Moreover, the combination of NC-1 and 1-MCP could provide a potential alternative to extend the storage life, which helps in reducing postharvest losses in the supply chain.
研究领域:
采后生理学
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园艺科学
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食品保鲜
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植物生物化学
·
农业纳米技术
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DOI
高影响因子
Frontiers of Chemical Science and Engineering
·
2025
·Vol. 19
·期 8
·1-11
·
IF 4.5
Zhang Yingqi,Chen Chao,Xie Enxue,Hu Mengping,Fu Guoying,Wang Yan,Li Liang,Yan Xianzai,Zhang Zedong,Wu Guoqiang
Microporous and mesoporous silicalite-1 (S-1) and titanium silicalite-1 (TS-1) zeolite supported molybdenum (Mo) catalysts were synthesized and applied in the transesterification of Jatropha seed oil (JO) to produce biodiesel. Various analytical results have revealed that the MoO 3 species are highly dispersed on their surface without destroying the zeolite framework and pore structure. Compared with the mesoporous 7Mo/mesoporous S-1 and 7Mo/mesoporous TS-1 catalysts, the microporous 7Mo/S-1 and 7Mo/TS-1 catalysts exhibit high Mo species contents and surface acidity, indicating that Mo species can enter the inner surface of mesoporous zeolites. However, the Mo species on the outer surface of catalysts are only activity centers owing to the accessibility between the Mo species and JO. Therefore, compared with the low activity of the S-1 and TS-1 catalysts, the 7Mo/S-1 catalyst exhibited the highest catalytic performance, with a JO conversion of 95.7% and a biodiesel selectivity of 99.9%. Finally, 7Mo/S-1 demonstrated good catalytic stability, regeneration performance and broad substrate versatility, and the fuel properties of the as-synthesized biodiesel conformed to the current international standard. The influence of the pore structure and Mo species on the catalytic activity has been clarified, providing a theoretical and practical foundation for developing efficient heterogeneous catalysts for biodiesel production.
研究领域:
化学工程
·
催化科学
·
可再生能源
·
材料科学
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Guangxu Liu,Di Wang,Min Li,Yang Wang,Qiubai Jiang,Hui Deng
Interfacial solar evaporation is widely used in desalination, but its application in wastewater treatment is limited by secondary contamination of the condensate by volatile organic compounds (VOCs). In this study, a BiOBr@C composite material was prepared by calcining cotton stalk pyrolysis carbon (C) with BiOBr, and a two-dimensional interfacial evaporator (BCF) was fabricated by coating the composite onto filter paper. Under 1 kW m −2 illumination, the evaporator achieved an evaporation rate of 1.94 kg·m −2 ·h −1 for a 20 mg/L phenol solution, while the phenol removal efficiency in the condensate reached 95%, demonstrating the successful coupling of interfacial evaporation and photocatalysis. Mechanistic analysis showed that C enhanced the solar absorption of BiOBr@C and facilitated charge-carrier separation through efficient electron transport. As a result, the catalytic activity of BiOBr@C in the phenol adsorption–degradation process was improved, and the reaction rate was approximately 1.5 times that of pure BiOBr. In addition, compared with the bulk photocatalytic mode, the BCF interfacial catalytic mode exhibited higher stability and stronger resistance to deactivation during cycling and under different environmental conditions. This study provides a new strategy for synergizing interfacial solar evaporation with photocatalysis and offers a promising solution to the secondary contamination of condensate.
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高影响因子
LANGMUIR
·
2013
·
IF 4.187
Xiu-Juan Shi,Gao-Jian Chen,Yan-Wei Wang,Lin Yuan,Qiang Zhang,David M. Haddleton,Hong Chen
Surface-initiated SET-LRP was used to synthesize polymer brush containing N-isopropylacrylamide and adamantyl acrylate using Cu(I)Cl/Me6-TREN as precursor catalyst and isopropanol/H2O as solvent. Different reaction conditions were explored to investigate the influence of different parameters (reaction time, catalyst concentration, monomer concentration) on the polymerization. Copolymers with variable 1-adamantan-1-ylmethyl acrylate (Ada) content and comparable thickness were synthesized onto silicon surfaces. Furthermore, the hydrophilic and bioactive molecule β-cyclodextrin-(mannose)7 (CDm) was synthesized and complexed with adamantane via host–guest interaction. The effect of adamantane alone and the effect of CDm together with adamantane on the wettability and thermoresponsive property of surface were investigated in detail. Experimental and molecular structure analysis showed that Ada at certain content together with CDm has the greatest impact on surface wettability. When Ada content was high (20%), copolymer–CDm surfaces showed almost no CDm complexed with Ada as the result of steric hindrance.
研究领域:
材料科学
·
生物医学工程
·
高分子化学
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PubMed
高影响因子
Current Pharmaceutical Analysis
·
2021
·Vol. 17
·期 9
·1197-1205
·
IF 0.89
Wang Jie,Lu Ping,Zhang Shengting,Li Wanwan,Ji Xiuling,Li Jing,Zhang Hui,Wei Yunlin,Liang Chenggang
Background: Current methods for assaying bioactivity of GLP-1 analogues are costly and time consuming, mainly dependent on AlphaScreen luminous beads, based on fluorescent resonance energy transfer technology, and cAMP-GloTM Max assay kit, and on ATP to generate a negative- association
curve. Objective: To establish a sensitive, stable, and low-cost method for the determination of biological activity of therapeutic glucagon-like peptide-1(GLP-1) and their analogous drugs in vitro in quality control. Methods: An applicable fluorescent high-content system (fHCS)
method was developed in U2OS cell, which was stably transfected with green fluorescent protein (GFP) labeled at the C-terminal of glucagon-like peptide-1 receptor (GLP-1R). HCS was firstly used to measure per unit area of fluorescent intensity changes as a result of drug-stimulated receptor
endocytosis. Results: The detection sensitivity improved at least 30 folds than the other reported methods. This method showed a wide detection range with a good linear regression of R2>0.98. In five scgs from 50~150% SCG, the accuracy achieved the standard of the 41st United States
Pharmacopoeia with all biases being less than 7.5%. The precision attained the 9.0th European Pharmacopoeia standard with all relative standard deviations (RSDs) below 10%. This assay result can be kept stable over 100 h at room temperature. Furthermore, the U2OS/GLP-1R cells showed a sharp
specificity towards GLP-1 analogues during detecting activities in a mixture of different ligands. Conclusion: These results suggested that the GLP-1R/fHCS method can be employed broadly in the bioactivity determination of GLP-1 analogous drugs and as a platform for screening GLP-1 similar
active ingredients in natural products.
研究领域:
药理学
·
药物开发
·
生物技术
·
细胞生物学
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DOI
高影响因子
Brazilian Journal of Pharmaceutical Sciences
·
2023
·
IF 1.3
Mei Xuejiao,Lu Dingqiang,Yan Xiangping
L-Malic acid is the Active Pharmaceutical Ingredient of the latest generation of compound electrolyte injection (STEROFUNDIN ISO, Germany) and plays a very important role in the rescue of critically ill patients. The optical purity of L-malic acid is a Critical Quality Attributes. A new reversed-phase high performance liquid chromatography (RP-HPLC) method for pre-column derivatization of D-malic acid enantiomer impurity in L-malic acid bulk drug was established. The derivatization reaction was carried out using (R)-1-(1-naphthyl)ethylamine ((R)-NEA) as a chiral derivatization reagent. The Kromasil C18 column was used with a detection wavelength of 225 nm, a flow rate of 1.0 mL·min-1, and a column temperature of 30 °C. The mobile phase was acetonitrile-0.01 mol·L-1 potassium dihydrogen phosphate solution (containing 20 mmol·L-1 sodium heptanesulfonate, adjusted to pH 2.80 with phosphoric acid) (at a ratio of 45:55) and the resolution of D-malic acid and L-malic acid derivatization products reached 1.7. The proposed method possesses the advantages of simple operation, mild conditions, stable derivatization products and low cost. Also it gave better separation and was more accurate than previous methods.
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高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2022
·
IF 3.841
Qian Liu,Jia Wang,Yao Chong,Jinyan Liu
The corrosion inhibition efficiency of Betaine , 3-(N, N-dimethyldodecylammonio) propanesulfonate (SB3–12) and 2-(DodecyldiMethylaMMonio) acetate (BS-12) on Q235 steel in 1 mol⋅L −1 hydrochloric acid (HCl) solution were studied at various inhibitor concentration and temperature by means of the weight loss method (WLM), electrochemical impedance spectroscopy (EIS), potential polarization curve, atomic force microscope (AFM), X-ray photoelectron spectroscopy (XPS), Raman spectra , scanning electron microscopy (SEM) and electronic energy spectrum analyzer (EDS). The weight loss results showed that the increase of inhibition efficiency mainly attributed to its high concentration. While Betaine had almost no protective effect for metals, SB3–12 and BS-12 were powerful inhibitors with the inhibition efficiency of 89.06% and 95.98%, respectively at 1 × 10 −1 mol⋅L −1 at 30 °C. The blocking effect of BS-12 for metal corrosion that induced by HCl was stronger than SB3–12. The potential polarization curve potential demonstrated that SB3–12 and BS-12 were both mixed type corrosion inhibitors . The surface analysis results revealed that SB3–12 or BS-12 could be well adsorbed on the Q235 surface to form a compact membrane that is responsible for the protection of Q235 steel from corrosion. The theoretical calculations including quantum chemical calculations and molecular dynamics simulations , which based on density functional theory provided strong evidence for the close relationship between the molecular structure of inhibitor and its inhibition efficiency. Our study of corrosion inhibition efficiency of green betaine type surfactants laid a theoretical foundation for the application of betaine derivatives in metal anti-corrosion.
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危险品化学品经营许可证（带存储）