MOLECULES
·
2019
·Vol. 24
·期 16
·2972
·
IF 3.06
Jiang-Zhen Qiu,Long-Fei Wang,Jiuxing Jiang
Two-dimensional aluminophosphate is an important precursor of phosphate-based zeolites; a new Sun Yat-sen University No. 6 (SYSU-6) with |Hada|2[Al2(HPO4)(PO4)2] has been synthesized in the hydrothermal synthesis with organic structure-directing agent (OSDA) ofN,N,3,5-tetramethyladamantan-1-amine. In this paper, SYSU-6 is characterized by single-crystal/powder X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray analysis, transmission electron microscopy, infrared and UV Raman spectroscopy, solid-state27Al,31P and13C magic angle spinning (MAS) NMR spectra, and elemental analysis. The single-crystal X-ray diffraction structure indicates that SYSU-6 crystallized in the space groupP21/n, with a = 8.4119(3), b = 36.9876(12), c = 12.5674(3), α = 90°, β = 108.6770(10)°, γ = 90°, V = 3704.3(2) Å3, Z = 4, R = 5.12%, for 8515 observed data (I > 2σ(I)). The structure has a new 4,12-ring layer framework topology linked by alternating AlO4and PO4tetrahedra. The organic molecules reside between the layers and are hydrogen-bonded to the inorganic framework. The new type of layer provides a greater opportunity to construct zeolite with novel topology.Keywords:aluminophosphate;2-D zeolite;SYSU-6
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INTEGRATED FERROELECTRICS
·
2017
·
IF 0.457
Wei Hong,Jielin Wang,Qingshan Li,Heng Zhang,Guangzhong Xing
In this paper, the researcher first designed molecular structure of water-soluble polyurethane phase change material. Then, by taking HDI, PEG, chain extender (DMPA, BDO, EDA), catalyst (DBTDL) and neutralizing agent (TEA) as the main raw material, the author prepared waterborne polyurethane phase change material (WPUPC), which is available for wet spinning. The orthogonal design determined the optimal ratio of raw materials, namely, DMPA content is 7 wt%, R equals 6, emulsifying temperature is 30°C, the reaction temperature is 60°C and the reaction time is 180 min. What's more, WPUPCM was characterized utilizing FTIR, DSC-TG and TG-FTIR. A series of tests indicated that this experiment successfully prepared WPUPCM, which has the following advantages: reversible phase change process, high thermal stability, excellent thermal cycling stability, safety and environmental protection. It is foreseeable that this material has broad application prospects in the field of functional textiles.
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CANCER RESEARCH
·
2013
·Vol. 73
·期 4
·1362-1373
·
IF 8.65
Cao Jie,Cui Sisi,Li Siwen,Du Changli,Tian Junmei,Wan Shunan,Qian Zhiyu,Gu Yueqing,Chen Wei R.,Wang Guangji
Adriamycin (ADM) has been effective against many types of solid tumors in clinical applications. However, its use is limited because of systemic toxicities, primarily cardiotoxicity, and multidrug resistance. In this study, a new active receptor-mediated complex, ADM conjugated with 2-amino-2-deoxy- d -glucose and succinic acid (2DG–SUC–ADM), was designed to target tumor cells through glucose transporter 1 (GLUT1). MTT assay and confocal images showed that the complex had better inhibition rate to tumor cells and low toxicity to normal cells. Most importantly, the complex displayed a potential to reverse overcome multidrug resistance in cancer cells, with more complex transported into the nucleus of tumor cells. Our in vivo experiments also showed that this new complex could significantly decrease organ toxicity and enhance the antitumor efficacy compared with free ADM, indicating a promising drug of 2DG–SUC–ADM for targeted cancer therapy. Cancer Res; 73(4); 1362–73. ©2012 AACR .
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SOLID STATE SCIENCES
·
2015
·
IF 1.839
Xiao Zhao,Dajiang Mei,Jingli Xu,Yuandong Wu
The reactions of A 2 SO 4 ( A = K, Cs) and Sb 2 O 3 with H 2 SO 4 (98%) yielded single crystals of A Sb(SO 4 ) 2 ( A = K, Cs). The crystal structures were investigated by single crystal X-ray diffraction. KSb(SO 4 ) 2 crystallizes in the monoclinic space group P 2 1 / c (No. 14) with lattice parameters a = 10.6745(18), b = 7.1579(12), c = 8.7597(15) Å, β = 91.466(3) ° , V = 669.1(2) Å 3 , Z = 4. CsSb(SO 4 ) 2 crystallizes in the orthorhombic space group P 2 1 2 1 2 1 (No.19) with lattice parameters of a = 5.2429(8), b = 9.5942(16), c = 14.850(2) Å, V = 746.98(20) Å 3 , Z = 4. Both compounds show the Sb 3+ cations in same seesaw-type coordination of oxygen atoms from different SO 4 2 − anions, but exhibit complex two-dimensionally and one-dimensionally linked anionic structures. The alkali cations are located between the layers or chains. The compounds were characterized with FT-IR spectra and solid state UV–vis–NIR diffuse reflectance spectroscopy . The band gaps were estimated at 4.64 eV for KSb(SO 4 ) 2 and 4.68 eV for CsSb(SO 4 ) 2 .
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Molecular Medicine Reports
·
2017
·Vol. 16
·期 2
·1864-1870
·
IF 1.692
Chao Weng,Man Ding,Shanghua Fan,Qian Cao,Zuneng Lu
Transcription factor 7 like 2 (TCF7L2, also termed TCF4), is a Wnt effector induced transiently in the oligodendroglial lineage. The current well accepted hypothesis is that TCF7L2 inhibits oligodendrocyte differentiation and remyelination through canonical Wnt/β‑catenin signaling. However, recent studies indicated that TCF7L2 activity is required during oligodendrocyte differentiation and remyelination. In order to clarify this, in situ hybridization, immunofluorescence and western blot analysis using in vivo TCF7L2 conditional knockout mice, were performed and it was found that TCF7L2 promotes oligodendrocyte differentiation during myelin formation and remyelination. Furthermore, it was established that TCF7L2 does not affect oligodendrocyte precursor cells during remyelination. These data are of important clinical significance to develop novel therapeutic targets to overcome multiple sclerosis and other demyelinating diseases.
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MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING
·
2024
·
IF 4.2
Yi Chen,Zhu Ma,Tangjie Yu,Zhuowei Du,Wei You,Junbo Yang,Shanyue Hou,Yanlin Li,Qianyu Liu,Wenwen Li,Qian Zhang,Hao Du,Yixian Li,Fuchun Gou,Qiang Yang,Guoming Li,Yuelong Huang,Kuan Sun,Yaohua Mai,Wei Long
Interface defect is one of the main factors that lead to non-radiative recombination of carriers at the interface and the decomposition of perovskites . This ultimately results in low efficiency and poor stability of perovskite solar cells (PSCs). Here, a passivated molecule called 2-Aminopyridine (2-APy) was proposed to reduce the defects of the interface between the perovskite and the hole transport layer. The results showed that the amino group in 2-aminopyridine can interact with the vacancy and free iodide ions on the surface of perovskite, thus passivating the defects at the interface and enhancing the hole transport capacity. As a result, 2-APy-modified PSCs exhibited inhibited non-radiative recombination, and the efficiency of PSCs increased to 21.46 %. The increase in the efficiency of PSCs is primarily seen in the rise of the open circuit voltage (V OC , from 1.12 to 1.15 V) and short circuit current (J SC , from 22.86 to 23.77 mA/cm 2 ). This work demonstrates that pyridine is an effective group for passivating the defects between the perovskite layer and the hole transport layer.
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Materials Today Communications
·
2024
·
IF 3.7
Doudou Ma,Chuanhui Zhang,Yilong Wei,Li Ma,Xiaoliang Zhao,Weijie Zhang
Type 2 diabetes (T2D) is a chronic metabolic disorder characterised by hyperglycaemia, insulin resistance, and relative insulin deficiency. Insulin resistance results in patients requiring increased insulin injections and its limited bioavailability. The present subject matter aims to use Pueraria lobata polysaccharides, which can alleviate insulin resistance and have hypoglycaemic potency, as a medicinal excipient to prepare a hydrogel with excellent slow-release properties, which can be used to load insulin for injection or as a diabetic wound dressing material. Pueraria lobata polysaccharides (PLR) were extracted by hydroalcohol precipitation, and oxidised Pueraria lobata polysaccharides (O-PLR) were successfully prepared by sodium periodate oxidation and verified by structural characterisation. Subsequently, double crosslinked hydrogels were prepared using oxidised Pueraria lobata polysaccharides, chitosan and cellulose acetoacetate, and several of their properties were investigated in detail. The experimental results showed that the O-PLR double-crosslinked hydrogels possessed good rheological properties and injectability, as well as excellent self-healing and antimicrobial activities; moreover, the O-PLR hydrogels exhibited significant hypoglycemic activity, which is expected to be an important material for the treatment of Type 2 diabetes mellitus. Overall, this study provides a reliable theoretical and experimental basis for the development of hydrogels with hypoglycaemic, pro-healing and antibacterial functions.
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METABOLIC ENGINEERING
·
2025
·
IF 6.8
Dan He,Yan Chen,Junfeng Shen,Han Yu,Jay D. Keasling,Xiaozhou Luo
10-hydroxy-2-decenoic acid (10-HDA), a unique unsaturated fatty acid present in royal jelly, has attracted considerable interest due to its potential medical applications. However, its low concentration in royal jelly and complex conformational structure present challenges for large-scale production. In this study, we designed and constructed a de novo biosynthetic pathway for 10-HDA in Escherichia coli . Initially, we introduced the heterologous thioesterase UaFatB1 to hydrolyze trans-2-decenoyl ACP to produce trans-2-decenoic acid, a key precursor for 10-HDA. Subsequently, we employed the bacterial cytochrome P450 enzyme CYP153AMaq to catalyze the terminal hydroxylation of trans-2-decenoic acid. Furthermore, through redox partner engineering and directed evolution, we identified the optimal combination for 10-HDA production: CYP153AMaq Q129R/V141L mutant with redox partner FdR0978/Fdx0338. Finally, we optimized the fermentation conditions and achieved a 10-HDA titer of 18.8 mg/L using glucose as primary carbon source. Our work establishes a platform for producing α , β -unsaturated fatty acids and their derivatives, facilitating further studies on these compounds.
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COLLOID JOURNAL
·
2024
·Vol. 86
·期 4
·644-654
·
IF 1.4
Yan Y. T.,Liu L.,Lin X. F.,Wei Y. X.,Ren H. H.,Wang W.,He X. J.,Li X. M.,Liu E. G.
Abstract Ceramide 2 is the main lipid of stratum corneum and a popular component in skin healthcare products. But developing ceramide 2 based corneal protecting product is troublesome due to its insoluble feature in water. In this work, a novel type of inclusion nanoparticle was developed to solubilize and enhance the corneal repair effect of ceramide 2 by the anti-solvent method. It was revealed that the types of solvents and cyclodextrins influenced the precipitation rate as well as the stability of intermediate clusters of ceramide 2, where DMSO with moderate supersaturation promoted the formation of inclusion complex with β-cyclodextrins. The ceramide-cyclodextrin inclusion complex had an amphiphilic structure, which could self-assemble into nanoparticles in water, as evidenced by disappeared endothermic peaks of ceramide (78°C) and cyclodextrin (120°C), as well as appearance of two endothermic peaks corresponding to nanoparticle transition (45°C) and dissociation of cyclodextrin inclusion complex (102°C). Upon treating rat damaged skins with ceramide 2 inclusion nanoparticles, the cumulative permeation of indomethacin (IND, a model drug for skin permeability) were found to be 330.80 ± 54.86 μg/cm 2 , which was significantly lower than the control group (472.47 ± 154.83 μg/cm 2 ). In comparison, water suspensions of ceramide 2 showed no corneal repair effect.
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ACS Applied Bio Materials
·
2024
·
IF 4.6
Hao Chen,Xilin Xiong,Yuan Huang,Bo Huang,Xinxin Luo,Qi Ke,Pengyu Wu,Suxiao Wang
The global outbreak of the COVID-19 pandemic has indisputably wreaked havoc on societies worldwide, compelling the scientific community to seek urgently needed therapeutic agents with low-cost and low-side effect profiles. Numerous approaches have been investigated in the quest to prevent or treat COVID-19, but many of them exhibit unwelcome side effects, such as dysfunctional viral immune responses and inflammation. Herein, we present the preparation of solid natural human pulmonary alveolar epithelial cell (ATII) membrane-coated PLGA NPs (PLGA NPs@ATII-M), which demonstrate remarkable affinity and competitiveness to neutralize the SARS-CoV-2 S1 protein-coated NPs (SCMMA NPs–S1), which are employed as a surrogate for coronavirus particles. In addition, we first considered the antifouling properties of these types of NPs, and we found that this membrane-coated NP formulation boasts excellent antifouling capabilities, which serve to protect their neutralization properties out of shielding by protein coronas in blood circulation. Moreover, this formulation is easily prepared and stored with a low-cost profile and exhibits good specificity, high targeting efficiency, and potentially side effect avoiding, thus making it a highly promising candidate for COVID-19 treatment.
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GREEN CHEMISTRY
·
2016
·Vol. 19
·期 3
·722-728
·
IF 8.506
Miaomiao Han,Xiao Liu,Xiaosa Zhang,Yuanyuan Pang,Peng Xu,Jianwei Guo,Yadong Liu,Shuangyan Zhang,Shengxiang Ji
5-Hydroxymethylfurfural (HMF) is an important platform chemical derived from biomass. Tremendous efforts have been made to transform HMF into valuable chemicals for applications in biofuels, materials science, and pharmaceuticals. Here we report the conversion of HMF into 5-hydroxymethyl-2-vinylfuran (HMVF), a versatile adhesive. HMVF can bond to a variety of substrates, e.g. metal, glass, plastics and rubber, under heating or acid treatment at room temperature. Mechanistic studies show that the vinyl group undergoes free radical polymerization and the hydroxyl group dehydrates to form an ether linkage to crosslink HMVF under either heating or acid treatment. The bonding strength (τ) of HMVF cured by heating (h-HMVF) is close to that of Krazy Glue (Loctite 401, cyanoacrylate) and higher than that of white glue (Pattex No. 710, PVA) and Pattex PKME15C epoxy glue. The outstanding adhesive performance of HMVF is attributed both to the interaction of hydroxyl groups with substrates and crosslinking by etherification between hydroxyl groups. Similar to Krazy Glue, HMVF is also used in its monomer form, which eliminates the use of solvents. Cells show good adhesion on crosslinked HMVF, which makes HMVF a potential bio-adhesive.
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CHEMBIOCHEM
·
2026
·Vol. 27
·期 19
·e70567
·
IF 2.8
Binjie Li,Tianji Zhang,Mingjia Yu
Heparan sulfate (HS) is a key host-factor mediator of SARS-CoV-2 attachment and an attractive target for antiviral intervention, yet the synthesis of structurally defined HS oligosaccharides remains challenging. Here, we show that a defined HS hexasaccharide, heparin-dp6, efficiently inhibits RBD-ACE2 binding and exhibits superior antiviral activity compared with longer HS mimetics. Electronic-structure analyses suggest that the strong recognition capacity of HS arises from sulfate and carboxylate groups, which create highly negative electrostatic surfaces and serve as dominant hydrogen-bond acceptors, governing charge distribution and electronic properties along the glycan backbone to modulate binding specificity and affinity. Stepwise virtual screening of a comprehensive HS database further identified several high-affinity oligosaccharides, with top candidates displaying favorable RBD-binding properties. These findings indicate that HS activity is determined not only by chain length and sulfation pattern, but also by the spatial arrangement of charged functional groups, providing mechanistic insight into HS-RBD recognition and guiding the rational design of HS-based decoy inhibitors against SARS-CoV-2 entry. Graphical A systematic heparan sulfate oligosaccharide database reveals distinct structural features governing recognition of the SARS-CoV-2 receptor-binding domain. Molecular simulations uncover sequence-dependent binding patterns and highlight a hexasaccharide with particularly favorable RBD binding. Experimental studies further demonstrate that heparin oligosaccharides inhibit spike-ACE2 recognition and viral entry, supporting their potential as SARS-CoV-2 entry inhibitors.
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