JOURNAL OF ALLOYS AND COMPOUNDS
·
2021
·
IF 5.316
Kaitong Liu,Jian Han,Fuming Li,Congcong Jin,Zhihua Yang,Miriding Mutailipu,Shilie Pan
A case of hydrous borate with the formula of Ba 2 B 13 O 19 (OH) 5 ·5H 2 O was synthesized by the traditional hydrothermal method . It crystallizes in the chiral P 1 space group and has a unique two-dimensional 2 [B 13 O 19 (OH) 5 ] ∞ layer that is constructed by the hydrogen involved [B 13 O 22 (OH) 5 ] fundamental building blocks (FBBs). The Ba atoms and H 2 O molecules are filled in the three-dimensional pore constructed by the 2 [B 13 O 19 (OH) 5 ] ∞ layer. Interestingly, Ba 2 B 13 O 19 (OH) 5 ·5H 2 O is the first case of hydrous borates that has the above rare [B 13 O 22 (OH) 5 ] FBB and 2 [B 13 O 19 (OH) 5 ] ∞ layer, which enriching the structural chemistry of borate system. The diffuse reflection spectrum result shows that the ultraviolet (UV) cutoff edge of Ba 2 B 13 O 19 (OH) 5 ·5H 2 O is below 200 nm. Its second harmonic generation (SHG) response is approximately 1.0 times that of potassium dihydrogen phosphate at the 1064 nm fundamental wavelength and it is also phase-matchable. Both results indicate that the title compound is a nonlinear optical crystal for UV spectral region. Theoretical simulation calculation shows that the occupied VE states are mainly contributed by the O-2p orbitals, and therefore [B 13 O 22 (OH) 5 ] groups are the main sources of SHG effects.
研究领域:
无机化学
·
材料科学
·
晶体工程
·
光学材料
·
固体化学
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DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2019
·
IF 3.621
Zhengang Ma,Rui Ma,Xue Wang,Jinlai Gao,Yufeng Zheng,Zhijie Sun
Colon-specific drug delivery systems are efficient for increasing the availability of drugs at colon region and are desirable for the treatment of local diseases such as ulcerative colitis and colonic cancer. We synthesized an acryloyl chloride modified olsalazine (olsalazine-AC) as an azo crosslinker which was copolymerized with hydroxyethyl methacrylate (HEMA) and methacrylic acid (MAA), and developed two types of azo hydrogels which contained single network hydrogel and interpenetrating network hydrogel as an enzyme responsive and pH responsive controlled release carrier for colon-specific drug delivery. The structure of the azo crosslinker was characterized by FT-IR and 1 H NMR spectra and the azo hydrogels were analyzed by using ultraviolet spectrophotometer and scanning electron microscopy. The in vitro release of the 5-flurouracil (5-FU) loaded azo hydrogels was carried out in PBS (pH 7.4), PBS (pH 2.0) and rat colonic fluid (RCF). The drug release profile revealed that 5-FU loaded in azo hydrogels released faster in rat colonic fluid. The results showed that these azo hydrogels could be potential drug carrier for colon-targeted delivery.
研究领域:
药剂学
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药物递送系统
·
高分子科学
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生物医学工程
·
结肠癌治疗
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FUEL PROCESSING TECHNOLOGY
·
2022
·
IF 8.129
Shiyun Mu,Kai Liu,Hong Li,Zhenyu Zhao,Xiaoqi Lyu,Yilai Jiao,Xingang Li,Xin Gao,Xiaolei Fan
This work presents an efficient method of supporting zirconia (ZrO 2 ) on COOH functionalized multi-walled carbon nanotubes (ZrO 2 /MWCNTs(C)) via a microwave (MW)-assisted method, which can be used as an efficient catalyst for converting fructose to 5-HMF. The developed composite by the MW-assisted route shows highly dispersed ZrO 2 with small sizes of 4–5 nm on the carbon support, which could not be achieved the conventional hydrothermal synthesis. Characterization shows a unique zirconia amorphous structure which was ascribed to the special interaction between the carbon support and MW irradiation. Specifically, MWCNTs were heated selectively due to their strong MW-absorbing ability, which led to the formation of microscopic “hot spots”, enabling rapid synthesis (8 min) of highly dispersed ZrO 2 with smaller sizes on the hot surface of MWCNTs. Conversely, under conventional heating, the nucleation rate of ZrO 2 was slow and prone to form agglomerated particles on the carbon support. The amorphous ZrO 2 contributed to the excellent activity of ZrO 2 /MWCNTs(C) in fructose conversion to 5-HMF. In detail, fructose conversion and 5-HMF yield were achieved at ~72.8% and ~62.9%, respectively, for the catalyst prepared by the MW method, whilst they are only about 24.7% and 15.7% over the catalyst prepared by the conventional hydrothermal synthesis.
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BIOPROCESS AND BIOSYSTEMS ENGINEERING
·
2019
·Vol. 43
·期 1
·67-73
·
IF 2.371
Xu Qianqian,Zheng Zhaojuan,Zou Lihua,Zhang Chen,Yang Fen,Zhou Kaijie,Ouyang Jia
Currently, biotransformation of 5-hydroxymethylfurfural (HMF) into a series of high-value bio-based platform chemicals is massively studied. In this study, selective biooxidation of HMF to 5-hydroxymethyl-2-furancarboxylic acid (HMFCA) by Pseudomonas putida KT2440 with superior titer, yield, and productivity was reported. The biocatalytic performances of P. putida KT2440 were optimized separately. Under optimal conditions, 100% yield of HMFCA was obtained when HMF concentration was less than 150 mM, while the maximum concentration of 155 mM was achieved from 160 mM HMF in 12 h. P. putida KT2440 was highly tolerate to HMF, up to 190 mM. Besides, it was capable of selective oxidation of other furan aldehydes to the corresponding carboxylic acids with good yield of 100%. This study further demonstrates the potential of P. putida KT2440 as a biocatalyst for biomass conversion, as this strain has been proved the capacity to convert and utilize many kinds of biomass-derived sugars and ligin-derived aromatic compounds.
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PubMed
高影响因子
ANALYST
·
2018
·Vol. 143
·期 9
·2051-2056
·
IF 3.864
Yin Yang,Guoqing Yang,Hongfei Chen,Hui Zhang,Jiu-Ju Feng,Chenxin Cai
The levels of 5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) in DNA (5-mC-DNA and 5-hmC-DNA) are strongly correlated with cancer occurrence and development. The ability to distinguish and quantitatively detect them is important for cancer research. We have developed a hybridization chain reaction (HCR)-based electrochemical assay for the signal-amplified detection of the relative contents of 5-mC-DNA and 5-hmC-DNA. The DNA duplexes (containing 5-mC-DNA and 5-hmC-DNA with different percentages) were modified on a gold electrode. Electroactive [Ru(NH3)6]3+ (RuHex) was used as the signal reporter, because it binds to DNA double strands. The duplexes can be cleaved by MspJI endonuclease without HCR, and result in a small peak current. However, the cleavage can be blocked after the 5-hmC-DNA duplex is converted to β-glucosyl-5-hydroxymethylcytosine (β-glu-5-hmC) by T4 β-glucosyltransferase (T4 β-GT), and with the addition of helper DNA, a long double-helix DNA was formed through HCR. A significantly amplified peak current can be achieved due to the adsorption of numerous RuHex. The electrochemical signal of RuHex is correlated to the content of 5-hmC-DNA. Upon fixing the total quantity of 5-mC-DNA and 5-hmC-DNA on the electrode, the signals increase with the increase in the percentage of 5-hmC-DNA for the HCR. With this assay, a detection limit of 0.05% for 5-hmC-DNA was achieved.
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高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2019
·
IF 14.229
Fu Yang,Jingjing Tang,Rui Ou,Zengjing Guo,Shuying Gao,Yinzhu Wang,Xuyu Wang,Lei Chen,Aihua Yuan
Biomass-derived resources exploited in depth toward the synthesis of high value-added chemicals is very promising, but still limited by the applicable catalyst. In this paper, we report regulated robust multilayer-like polyoxometalates(Niobium molybdate) specific to the catalytic synthesis of promising 5-Ethoxymethylfurfural (EMF). The present solid acid catalysts resulted from precisely-tuned compositions of Nb and Mo toward acquiring controlled Brønsted acid amounts and interlayer space coupling with specific Lewis acid sites are demonstrated to be the determining factors for tuning conversion and selectivity in the synthesis of EMF, respectively. The characterization results indicate that the increment in Nb moiety is beneficial to produce more accessible acid sites and the enlarged interlayer space in the catalyst, thereby promoting the acid-catalyzed conversion. As a result, the full conversion(Conv. 100%) of 5-hydroxymethylfurfural into the 5-Ethoxymethylfurfural (Select. >99%) by etherification with ethanol within only 60 min was realized as the record-high yield under the solvent-free condition, far outperforming several traditional catalysts. In addition, the rational 67% yield of EMF was received when using fructose as an initial reactant. Ulteriorly, the resultant catalyst inherits the superior catalytic activity in the substrate expansion experiments in the presence of different alcohols. More importantly, the resulted catalyst shows durable catalytic activity without any activity-loss during the eight recycling, which reveals the huge potential industrial application prospect.
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BIOSENSORS & BIOELECTRONICS
·
2024
·
IF 10.7
Mei Zhao,Jingyi Guo,Zilin Chen,Fang Wang
5-formylcytosine (5 fC) and 5-carboxylcytosine (5caC) serve as key intermediates in DNA demethylation process with significant implications for gene regulation and disease progression . In this study, we introduce a novel electrochemical sensing platform specifically designed for the sensitive and selective detection of 5 fC and 5caC in DNA . Protein A-modified magnetic beads (ProtA-MBs) coupled with specific antibodies facilitate the immunorecognition and enrichment of these modified bases. Signal amplification is achieved through several chemical reactions involving the interaction between N 3 -kethonaxl and guanine , copper-free click chemistry for the attachment of dibenzocyclooctyne (DBCO)-Biotin, and the subsequent recognition by streptavidin-conjugated horseradish peroxidase (SA-HRP). The assay's readout is performed on a disposable laser-induced graphene (LIG) electrode, modified with the bead-antibody-DNA complex in a magnetic field , and analyzed using differential pulse voltammetry in a system employing hydroquinone (HQ) as the redox mediator and H 2 O 2 as the substrate. This immunosensor displayed excellent sensitivity, with detection limits of 14.8 fM for 5 fC across a 0.1–1000 pM linear range and 87.4 fM for 5caC across a 0.5–5000 pM linear range, and maintained high selectivity even in the presence of interferences from other DNA modifications . Successful application in quantifying 5 fC and 5caC in genomic DNA from cell extracts, with recovery rates between 97.7% to 102.9%, underscores its potential for clinical diagnostics. N 3 -kethoxal was used for the first time in an electrochemical sensor. This work not only broadens the toolkit for detecting DNA modifications but also provides a fresh impetus for the development of point-of-care testing (POCT) technologies.
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高影响因子
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2018
·
IF 2.831
Ting-ting Du,Ting Cui,Hong-mei Qiu,Nian-ru Wang,Dan Huang,Xin-hui Jiang
A high-performance liquid chromatography method with a diode array and an electrochemical detection (HPLC-ECD/DAD) was developed to determine the levels of tryptophan (TRP), kynurenine (KYN), kynurenic acid (KYA), 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in rat plasma. The prepared samples were separated on a BDS column (4.6 mm × 250 mm, 5 mm) with column oven temperature of 25 °C. The mobile phase consisted of 5% acetonitrile and a buffer solution, which contained 25 mmol/L sodium acetate and 0.01 mmol/L EDTA, adjusting pH to 4.5 with acetic acid, and it was pumped at a flow-rate of 1.0 mL/min. KYN and KYA were measured by a variable wavelength detector at wavelengths 360 nm and 333 nm respectively, TRP and vanillic acid (as IS) both were measured at 280 nm. Determination of 5-HT and 5-HIAA was accomplished at the electrochemical working potential of 700 mV. Total run time was 14 min. Several parameters of the developed method were validated including linearity, accuracy precision, and stability. The results showed the established method had good LOD and separation for all of the five compounds and IS in the biological matrix. The method is simple, fast, economical and accurate. The analytical method and the results could provide a reference for the clinical and scientific research of depression.
研究领域:
分析化学
·
神经科学
·
药理学
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DOI
高影响因子
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
·
2011
·Vol. 2011
·期 29
·4585-4589
·
IF 2.91
Huaiqiu Wang,Weining Zhao,Yang Zhou,Zheng Duan,François Mathey
The reaction of tributylphosphane with a 7-(2′-formyl-2-biphenylyl)phosphanorbornadiene P-W(CO) 5 complex leads to the 5-phosphaphenanthrene P-W(CO) 5 complex via an intramolecular phospha-Wittig condensation. This complex is stable enough for detection by 31 P NMR spectroscopy but cannot be isolated due to its high reactivity. It is trapped by addition of MeOH or cycloaddition with 2,3-dimethylbutadiene or a nitrileimine. The adducts were characterized by X-ray crystal structure analysis. Graphical The reaction of 4 with tributylphosphane at room temperature gives phosphaphenanthrene complex 5 , which can be detected by 31 P NMR and trapped by addition, and [2+4] or [2+3] cycloaddition.
研究领域:
有机化学
·
有机磷化学
·
配位化学
·
合成方法学
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DOI
高影响因子
BRAZILIAN JOURNAL OF CHEMICAL ENGINEERING
·
2026
·
IF 1.7
Li Ying,Wang Zhijie,Ma Zhengsheng
In order to overcome the technical bottlenecks associated with the traditional synthesis of 5-nitrosalicylic acid, this study constructs a continuous nitration system using a microchannel reactor. Systematic process optimization of the nitration reaction of salicylic acid is conducted, focusing on the influence of reactor channel type, material ratio, residence time, and reaction temperature on product yield. The optimal process parameters identified are as follows: umbrella-shaped microchannel reactor is employed, using acetone as the solvent with a mass ratio of salicylic acid to acetone of 1:5.0. The molar ratio of salicylic acid to HNO 3 to H 2 SO 4 is controlled at 1:4:0.5. Under the conditions of 60 °C and a residence time of 4 min for continuous reaction, the product yield reaches 85.9% after recrystallization and purification with a 75% ethanol aqueous solution, achieving a purity of 97.2% as determined by liquid chromatography. Compared to traditional batch nitration processes, this method significantly reduces the consumption of concentrated sulfuric acid and substantially shortens reaction times, providing a technical reference for the safe and environmentally friendly industrial production of 5-nitrosalicylic acid.
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高影响因子
SENSORS
·
2021
·Vol. 21
·期 24
·8292
·
IF 3.576
Kaixuan Li,Ding Li,Yan Zhang
Applications of terahertz time-domain spectroscopy (THz-TDS) in the fields of chemistry and biomedicine have recently received increased attention. Specifically, THz-TDS is particularly effective for the identification of alkaloid molecules, because it can distinguish the vibration types of base molecules in the THz band and provide a direct characteristic spectrum for the configuration and conformation of biomolecules. However, when THz-TDS technology is used to identify alkaloid molecules, most of them are concentrated in the 0.1–3.0 THz band, limiting the amount of information that can be obtained. In this work, a wide-spectrum THz-TDS system was independently built to explore the absorption spectra of uracil and its 5-substituents in the range of 1.3–6.0 THz. We found that, in the THz band, uracil and its 5-substituents have similar absorption peaks near 4.9 and 3.3 THz, while the 5-substituents have an additional absorption peak in the range of 1.5–2.5 THz. This absorption peak is red-shifted as the relative atomic mass of the 5-substituted atoms increases. Gaussian software was adopted to calculate the absorption spectra of the samples. The simulation conclusions were in good agreement with the experimental results, revealing that the vibration of the base molecule at low frequencies can be attributed to the inter-molecular vibration. This work demonstrates that THz-TDS technology can be used to accurately identify biomolecules with similar molecular structures, reflecting the importance of molecular structure in biological activity.Keywords:terahertz time domain spectroscopy;absorption peaks;5-substituents of uracil;vibration;broad spectrum;molecular structures
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高影响因子
Analytical Methods
·
2024
·Vol. 16
·期 23
·3766-3773
·
IF 2.7
Xin He,Caiyun Jiang,Jie Yang,Shuangchao Sheng,Yuping Wang
5-Hydroxymethylfurfural (5-HMF) is a heterocyclic compound with six carbons commonly found in heat-treated carbohydrate-rich foods. 5-HMF exceeding the specified limit is cytotoxic to the human body, and will be converted into carcinogenic substances (5-sulfoxide methyl furfural) after long-term accumulation in the body. Therefore, it is highly necessary to develop a sensitive and accurate detection method for 5-HMF in the field of food safety. In this study, a photoelectric sensing method was developed for the highly sensitive detection of 5-HMF using hollow TiO2 nanospheres successfully synthesized by template, sol–gel and lye etching methods. The structure and composition of the materials were studied by XRD, XPS, SEM and TEM. The electrochemical and photoelectrochemical properties of an h-TiO2 electrode probe based on indium tin oxide (ITO) slides were investigated. The results indicated that the linear relationship of 5-HMF is good in the concentration range of 10−11–10−7 M, and the detection limit of 5-HMF is 0.001 nM. Moreover, the PEC sensor shows high accuracy in the detection of actual samples.
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