INORGANIC CHEMISTRY COMMUNICATIONS
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2024
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IF 4.4
Han Song,Jiasheng Fan,Shengkai Liu,Boyu Chen,Jin Huang,Yujie Fu,Zhiguo Liu
In this study, we synthesized DOX-loaded H-ZIF-8@CaCO 3 -PEG nanocarrier, which combined with calcium overload and photothermal therapy (PTT) for synergistic therapy. The nanocarrier comprised a PEG modified calcium carbonate (CaCO 3 ) shell and a hollow imidazolate zeolite skeleton (H-ZIF-8) core, in which the chemotherapy drug doxorubicin hydrochloride (DOX) and photosensitizer indocyanine green (ICG) were simultaneously co-loaded. In vitro cellular experiments revealed that the lethality of DOX&ICG@H-ZIF-8@CaCO 3 -PEG against tumor cells was significantly higher than that of the single chemotherapy owing to the combination with chemotherapy and photothermal therapy as well as calcium overloading. This drug-loaded nanocarrier exhibits notable characteristics such as exceptional stability, elevated drug loading capacity and efficient release of the loaded drug, which provides a promising perspective for efficient synergistic therapy.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Wei Chen,Bing-Xin Gu,Yi-Jie Zhang,Hao Zheng,Yan-Li Ji,Quan-Fu An,Cong-Jie Gao
Rising global demand for antibiotics drives the development of nanofiltration (NF) membrane separation technology. However, traditional NF membranes face structural hurdles in practice, mainly the permeability-selectivity trade-off and poor separation precision for multi-component fermentation broths. We proposed a polyelectrolyte gel confined crystallization strategy to in-situ grow ZIF-8 crystals within a poly (acrylic acid)/polyethyleneimine (PAA/PEI) matrix, constructing a hybrid membrane (PAA/PEI@ZIF-8M) with high hydrophilicity, rigid interconnected pores, and good stability. By precisely controlling crystallization kinetics under nano-confinement, the membrane achieves synergistic integration of ZIF-8 molecular sieving and polyelectrolyte networks, and eliminates interfacial defects. The resultant PAA/PEI@ZIF-8M membrane exhibits a high water permeance of 35.3 L·m −2 ·h −1 ·bar −1 –12-fold improvement over the pristine PAA/PEI membrane, along with high selectivity for chlortetracycline hydrochloride (OTC)/sucrose (∼8.0) and OTC/NaCl (∼5.0). Simultaneously, ZIF-8 nanocrystals in PAA/PEI gel act as anti-deformation pillars, while covalent crosslinking and multiple coordination interactions form a stabilized network, resulting in a good and stable separation performance during long-term running process. Moreover, multistage purification tests confirm industrial feasibility, yielding OTC with 97 % purity and a 2-fold concentration increase, meeting pharmaceutical-grade standards. This strategy establishes a novel paradigm for designing stable and high-performance polyelectrolyte gel NF membranes, advancing sustainable antibiotic production.
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Nano-Micro Letters
·
2024
·Vol. 16
·期 1
·1-21
·
IF 31.6
Zhou Xi,Zhou Quan,He Zhaozhi,Xiao Yi,Liu Yan,Huang Zhuohang,Sun Yaoji,Wang Jiawei,Zhao Zhengdong,Liu Xiaozhou,Zhou Bin,Ren Lei,Sun Yu,Chen Zhiwei,Zhang Xingcai
The innovation of this work mainly lies in the auto-regulation of reactive oxygen species (ROS) balance effective by combination of ROS antibacterial and ROS scavenging anti-inflammatory functions with a core–shell nanoplatform (CeO 2 @ZIF-8/Au), which can not only achieve high antibacterial efficiency, but also promote wound healing, and provide a new idea for the nano-catalytic system in the field of wound healing of bacterial infection.
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高影响因子
Journal of Materials Chemistry B
·
2025
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IF 5.7
Mengnan Chai,Shengqian Wang,Jiangshan Liu,Yufan Li,Yulun Liu,Yubao Li,Jidong Li
Self-powered piezoelectric materials can generate continuous electrical stimulation in response to weak mechanical forces, holding great potential for accelerating wound healing. Herein, a multifunctional ZIF-8/PVDF piezoelectric fiber dressing was fabricated using the electrospinning method for generating electrical stimulation to enhance the endogenous electric field at the wound site. The incorporation of ZIF-8 nanoparticles and the stretching polarization effect of electrospinning on the fibers promote the formation of the piezoelectric β-phase in PVDF, leading to enhanced piezoelectricity. The improved piezoelectric and conductive properties collectively enhance the output electrical signals of the fiber. The short-circuit voltage and open-circuit current of the 5% ZIF-8/PVDF fiber were 2.97 V and 13.7 nA, respectively, showing significant improvement compared to the pure PVDF fiber. In vitro experiments demonstrate that the fiber can generate reactive oxygen species (ROS) and release Zn2+ under ultrasonic conditions, which together with electrical stimulation endows the dressing with effective antibacterial, anti-inflammatory, and angiogenic effects. In vivo studies of infected skin defect models demonstrated that the ZIF-8/PVDF fiber dressing can significantly inhibit bacterial infection, regulate inflammatory responses, enhance angiogenesis, and ultimately accelerate the infected wound healing process. This developed multifunctional piezoelectric fiber dressing provides an effective strategy for infected wound repair.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
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IF 13.3
Keming Zhang,Xianye Luo,Sihui Li,Xiaohe Tian,Qingnan Wang,Chenlu Liu,Yanting Tang,Xiaoting Feng,Rui Zhang,Shuangfeng Yin,Shaofei Wang
Developing high-performance H 2 /CH 4 separation membranes is of great potential for H 2 production in the petroleum industry. Incorporating nanofillers into a polymer matrix to form mixed matrix membranes (MMMs) can elevate selectivity and permeability, but poor polymer-filler interfacial compatibility and filler aggregation are formidable problems. Targeting this, we propose a novel approach by incorporating a metal–organic framework (MOF) gel, ZIF-8 gel, as the versatile filler to a high free volume polymer PIM-1 and investigate the H 2 /CH 4 separation capabilities of the MMMs. Benefiting from the gel network morphology of ZIF-8, they were dispersed evenly in the PIM-1 matrix. The interconnected gel network structure of ZIF-8 gel helped to construct continuous gas transport pathways in the polymer. As a result, the H 2 /CH 4 separation performance was notably improved, demonstrating a substantial increase in H 2 permeability by 78.9% (exceeding 6800 Barrer) and a 38.0% enhancement in H 2 /CH 4 selectivity at a ZIF-8 gel loading of 31.0 wt%. These improvements surpassed the upper bound established in 2008. The Maxwell and Lewis-Nielsen models were developed to clarify gas transport mechanisms across membranes, and the experimental data of ZIF-8 gel/PIM-1 was well-matched with the calculated results of the Lewis-Nielsen models. Adopting MOF gel as fillers may pave a new approach to design high-performance MMMs with interconnected transport pathways.
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ACS Applied Materials & Interfaces
·
2024
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IF 8.3
Yaxin Li,Chenci Xu,Jing Mao,Lixia Mao,Weiqi Li,Ziyang Liu,Airi Shin,Jiaqing Wu,Lingli Hou,Dejian Li,Kaili Lin,Jiaqiang Liu
Periodontitis, an inflammatory bone resorption disease associated with dental plaque, poses significant challenges for effective treatment. In this study, we developed Mino@ZIF-8 nanoparticles inspired by the periodontal microenvironment and the unique properties of zeolitic imidazolate framework 8, aiming to address the complex pathogenesis of periodontitis. Transcriptome analysis revealed the active engagement of Mino@ZIF-8 nanoparticles in innate and adaptive inflammatory host defense and cellular metabolic remodeling. Through sustained release of the anti-inflammatory and antibacterial agent minocycline hydrochloride (Mino) and the generation of Zn2+ with pro-antioxidant effects during degradation, Mino@ZIF-8 nanoparticles synergistically alleviate inflammation and oxidative damage. Notably, our study focuses on the pivotal role of zinc ions in mitochondrial oxidation protection. Under lipopolysaccharide (LPS) stimulation, periodontal ligament cells undergo a metabolic shift from oxidative phosphorylation (OXPHOS) to glycolysis, leading to reduced ATP production and increased reactive oxygen species levels. However, Zn2+ effectively rebalances the glycolysis-OXPHOS imbalance, restoring cellular bioenergetics, mitigating oxidative damage, rescuing impaired mitochondria, and suppressing inflammatory cytokine production through modulation of the AKT/GSK3β/NRF2 pathway. This research not only presents a promising approach for periodontitis treatment but also offers novel therapeutic opportunities for zinc-containing materials, providing valuable insights into the design of biomaterials targeting cellular energy metabolism regulation.
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Acta Metallurgica Sinica-English Letters
·
2024
·
IF 2.9
Zeng Yanwei,Xu Peng,Liu Guoqiang,Wang Tianguan,Lei Bing,Feng Zhiyuan,Zhang Ping,Meng Guozhe
Chloride-induced corrosion of steel reinforcement is the key factor leading to the degradation of reinforced concrete building durability. Improving the corrosion resistance of oxide scale of rebar has always been a research hotspot in the field of civil engineering materials. A ZIF-8 modified Ce–Sol–gel (ZCS) film was prepared on oxide scale of plain steel rebars by sol–gel method. It is observed that the | Z | 0.01 Hz value of the ZCS film reached 320 kΩ cm 2 , which is about 29 times higher than that of blank rebar in simulated concrete pore (SCP) solution with 0.1 M NaCl. Then, they were inserted into mortar block and curing them in a curing box at T = 20 ± 2 °C and RH = 95 ± 2% for 28 days. Subsequently, these samples were subject to electrochemical impedance spectroscopy in 3.5 wt% NaCl. The | Z | 0.01 Hz value of the rebar with the ZCS film was six times higher than that of the blank rebar after immersing for 20 days, resulting in an overall increase in corrosion resistance for rebar. The results indicated that the modification by ZIF-8 could reduce the porosity of Ce–sol–gel (CS) film and improved the “labyrinth effect” of the film. Additionally, the negative charge on the surface of ZIF-8 in alkaline condition increased the repulsion effect with Cl − , significantly reducing the sensitivity of rebar to Cl − .
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APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Tianyi Zhang,Da Teng,Jiaojiao Zhang,Zihui Meng,Lili Qiu
The unique periodic structure of photonic crystals demonstrates an effective slow photon effect that enhances the interaction between light and matter. This study designed and prepared MOF photonic crystal beads, and significantly improved the photocatalytic efficiency by utilizing the slow light effect. Utilizing microfluidic technology, ZIF-8 was self-assembled to form photonic crystal beads (PCB-Z) to enhance adsorption properties and light absorption. The surface of PCB-Z is modified with CdS to form a heterostructure (PCB-ZC), which widens the absorption spectrum, reduces the carrier recombination rate, and increases the specific surface area, while the photocurrent intensity of PCB-ZC is about 1.8 and 29 times that of CdS and PCB-Z. Under the combined effect of photonic crystal structure, ZIF-8/CdS heterojunction and slow photon effect, the degradation rate of Rhodamine B by PCB-ZC was 15.22 times higher than the disordered ZIF-8 powder, and the photocatalytic performance was significantly improved. The dominant role of holes in Rhodamine B degradation was confirmed by free radical trapping experiments and EPR tests. This research confirms that MOF-based photonic crystals can be assembled into periodic structures to enhance adsorption properties and light absorption, which provides a new paradigm for the development of MOF-based photocatalysts.
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MICROCHEMICAL JOURNAL
·
2025
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IF 5.1
Wenwen Wang,Xin Jiang,Junyi Huang,Yuchan Ma,Jiaxin Xian,Zhifeng Fu,Yuting Zhao,Hui Ouyang
Although pyrene-based fluorophores possess some merits including outstanding fluorescent (FL) emission and long-lived excited intermediates, their practicability have been dramatically limited by an obvious aggregation-caused quenching (ACQ) impact. Due to the isolation effect of metal-organic frameworks (MOFs), pyrene-based fluorophores are utilized as the FL dopant rather than organic ligands to anchor onto the porous supports for inferior ACQ effect along with enhanced FL emission. Herein, a one-step alkaline coprecipitation method was proposed to efficiently load 4,4′,4″,4″‘-(1,9-dihydropyrene-1,3,6,8-tetrayl)tetrabenzoic acid onto ZIF-8 MOFs (Py@ZIF-8). Since ZIF-8 effectively rigidified the location of the FL emitter, the decreased ACQ effect of Py@ZIF-8 was realized along with an intriguing FL quantum yield of 77.3 %. Furthermore, the protective activity of the rigid framework endowed Py@ZIF-8 with an attractive long-term FL stability. Note that, green FL microspheres could remarkably quench the luminescent signal of Py@ZIF-8 based on the marked Förster resonance energy transfer (FRET) effect. The FRET donor-acceptor pair of Py@ZIF-8 and green FL microspheres was employed to establish a sandwich ratiometric FL protocol for cardiac troponin I. Superior to a traditional single-signal mode, the dual-signal ratiometric mode displayed an enhanced sensitivity, wherein a low detection limit of 0.5 pg/mL (3σ) was achieved. Moreover, the quantitation results of cardiac troponin I in serum samples by the proposed FL method showed a good agreement with those by a commercial Abbott chemiluminometer. The reliable ratiometric platform exhibited improved precision and preferable feasibility of pyrene-doped MOFs in sensitive diagnosis and trace testing.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Huanhuan Dong,Xudong Wu,Lei Li,Ruixiang Wang,Qingqing Liu,Yihao Wang,Xun Yang,Mao Hu,Tao Chen
Advances in nuclear energy have led to steady accumulation of radioactive uranium wastewater, requiring the worldwide implementation of safe and efficient disposal methods. Adsorption has become a viable solution for purifying uranium-contaminated wastewater and recovering uranium resources due to its efficiency, environmental compatibility, and simplicity. This study utilized konjac glucomannan’s (KGM) gel properties to create a ZIF-8@KGM aerogel. Liquid nitrogen-induced rapid directional freezing combined with KGM’s exceptional plasticity yielded an aerogel with a uniform layered structure and directional channels. ZIF-8 (2-Methylimidazolezincsalt) particles are dispersed uniformly within the aerogel pores, significantly improving adsorption site accessibility. Compared with ZIF-8, the [email protected] aerogel achieved improved kinetics and adsorption capacity for uranium separation. After 90 min in a 200 mg/L acidic U(VI) solution, it achieved 96.4 % removal efficiency and a maximum capacity of 687.8 mg/g. Mechanistic studies revealed synergistic adsorption: KGM’s oxygen-containing functional groups coordinated with uranyl ions, together with the nitrogen-containing groups and hydroxyl Zn(Ⅱ) sites on ZIF-8 particles. Overall, this approach provides a promising strategy for uranium wastewater remediation that exhibits broader applicability in water treatment.
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PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
·
2024
·
IF 4.2
Zhe-Ran Wu,Yi-Wen Pei,Xiao-Qing Zhang,Min Lu,Xiao-Long Liu
Chemical sensing systems are vital in the growth and development of insects. Orius sauteri (Poppius) (Hemiptera: Anthocoridae) is an important natural enemy of many pests. The molecular mechanism of odorant binding proteins (OBPs) binding with common insecticides is still unknow in O. sauteri . In this study, we expressed in vitro OsauOBP8 and conducted fluorescence competition binding assay to investigate the function of OsauOBP8 to insecticides. The results showed that OsauOBP8 could bind with four common insecticides (phoxim, fenitrothion, chlorpyrifos, deltamethrin). Subsequently, we used molecular docking to predict and obtained candidate six amino acid residues (K4, K6, K13, R31, K49, K55) and then mutated. The result showed that three key residues (K4, K6, R31) play important role in OsauOBP8 bound to insecticides. Our study identified the key binding sites of OsauOBP8 to insecticides and help to better understand the molecular mechanism of OBPs to insecticides in O. sauteri .
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PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2020
·Vol. 30
·期 13
·1909389
·
IF 16.836
Xiaoxue Yao,Guoshuai Zhu,Pingan Zhu,Jing Ma,Wenwen Chen,Zhou Liu,Tiantian Kong
Bacterial adhesion and colonization can result in chronic non-healing wounds. Current hydrophilic wound dressings can release antibacterial agents into the wound exudate, but may result in overhydrated wounds, bacterial overgrowth, and even tissue maceration. Hydrophobic dressings are anti-fouling, though ineffective to encapsulate and release bactericidal agents. Combining the advantages of hydrophilic and hydrophobic dressings seems difficult, until the development of superwettability surfaces offers an opportunity for omniphobic dressings from intrinsic hydrophilic polymers. Herein, omniphobic porous hydrogel wound dressings loaded with a zinc imidazolate framework 8 (ZIF-8) are fabricated by a microfluidic-emulsion-templating method. The fabricated porous hydrogel membrane with its reentrant architecture is repellent to blood and body fluids, though intrinsically hydrophilic. This unique combination not only reduces the adhesion of harmful microbes, but also enables the encapsulation and release of antibacterial ingredients to wounded sites from hydrophilic polymer networks. As such, the omniphobic metal-organic frameworks (MOFs)@hydrogel porous wound dressing can inhibit bacteria invasion and enable the controlled release of the bactericidal, anti-inflammatory, and nontoxic zinc ions. Furthermore, in vivo study of infected full-thickness skin defect models demonstrates that the dressing also accelerates wound closure by promoting angiogenesis and collagen deposition. Therefore, the omniphobic MOFs@hydrogel porous wound dressings are potentially useful for clinical application.
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