INORGANICA CHIMICA ACTA
·
2024
·
IF 2.7
Qiang Zhao,Su-Juan Jin,Zhi Shen,Guo Zang,Wen-Jun Lv
In order to further enrich the research on the synthesis of complexes with polycarboxylic acid ligands and rare earth metal ion. In this study, four rare earth complexes, namely, [Gd(cpia)] n ( 1 ), [Er(cpia)] n ( 2 ), [Pr(cpna) 2 ·2H 2 O] n ( 3 ) and [Gd(Hcpna)(cpna)•3H 2 O] n ( 4 ) have been synthesized by solvothermal method based on 5-(2-carboxyphenoxy)isophthalic acid (H 3 cpia) and 5-(4-carboxyphenoxy)nicotinic acid ligand (H 2 cpna) with rare earth metal ions Pr 3+ , Gd 3+ and Er 3+ . Single crystal X-ray diffraction analyses reveal that complexes 1 , 2 and 3 are two-dimensional network structure, 4 is one-dimensional chain structures. The fluorescence test results show that the fluorescence intensity of complexes 1 and 2 were lower than that of the H 3 cpia ligand, the fluorescence intensity of complexes 3 and 4 were lower than that of the H 2 cpna ligand. Magnetic results indicate complex 1 has ferromagentic behavior and weak antiferromagentic behavior in the complexes 2, 3 and 4 .
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高影响因子
MOLECULAR AND CELLULAR ENDOCRINOLOGY
·
2016
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IF 3.859
Aiyun Li,Shuihong Zhang,Jia Li,Kang Liu,Fang Huang,Baolin Liu
Objective This study was designed to investigate the hypothesis that metformin and resveratrol exhibited the same effect on inhibition of NLRP3 inflammasome activation with regulation of AMPK in adipose tissue exposed to high glucose. Methods To induce adipose tissue dysfunction, we treated epididymal adipose tissue of mice or differentiated 3T3-L1 adipocytes with high glucose (33 mM) for 24 h. Meanwhile, mice were injected with streptozotocin STZ to induce diabetes and followed by oral administration of metformin (200 mg/kg), resveratrol (50 mg/kg) or ER stress inhibitor TUDCA (50 mg/kg) for 7 days. The effects of metformin and resveratrol on ROS production, mitochondrial fission , ER stress, TXNIP/NLRP3 inflammasome activation, inflammation and apoptosis were observed. Results Metformin and resveratrol inhibited ROS-associated mitochondrial fission by upregulating Drp1 phosphorylation (Ser 637) in an AMPK-dependent manner, and then suppressed ER stress indicated by dephosphorylation of IRE1α and eIF2α in the adipose tissue. As a result from suppressing TXNIP/NLRP3 inflammasome activation, metformin and resveratrol inhibited inflammation and reduced cell apoptosis in adipose tissue or adipocytes exposed to high glucose. Conclusion Metformin and resveratrol protected mitochondrial integrity by inhibiting Drp1 activity and prevented NLRP3 inflammasome activation by suppressing ER stress, and thereby protected adipose function from high glucose insult.
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PubMed
高影响因子
OPTICS AND LASER TECHNOLOGY
·
2026
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IF 5.2
Wei Gao,Jiaxi Li,Junlin Qi,Qingyan Han,Chengyun Zhang,Xuewen Yan,Jun Dong
Balancing red-emission intensity and the red-to-green (R/G) emission ratio remains an important challenge in Er 3+ -based upconversion nanoparticles. Herein, a multilayer core–shell architecture was developed to achieve differential regulation of red-emission intensity and the red-to-green (R/G) emission ratio in Er 3+ -based upconversion nanoparticles. After screening NaYbF 4 : x %Er 3+ @NaYF 4 core–shell nanoparticles, the sample containing 2% Er 3+ exhibited a favorable balance between overall emission intensity and the R/G ratio and was therefore selected as the precursor for constructing NaYbF 4 :2%Er 3+ @NaYF 4 @NaErF 4 :y%M 3+ @NaYF 4 (M = Yb or Tm) multilayer nanoparticles. In this architecture, the Yb-rich core, intermediate NaYF 4 layer, compositionally tunable Er-rich shell, and outer NaYF 4 shell were designed to provide spatially differentiated excitation harvesting, interfacial modulation, spectral regulation, and surface passivation, respectively. Under identical 980 nm excitation and collection conditions, incorporation of 15%Yb 3+ into the Er-rich shell increased the integrated red-emission intensity to 2.40 times that of the undoped multilayer counterpart, whereas incorporation of 0.5%Tm 3+ produced the highest R/G ratio of 17.1 while retaining comparatively strong emission. Power-dependent and time-resolved luminescence measurements, together with the proposed energy-transfer model, indicate that Yb 3+ incorporation is predominantly associated with enhanced local excitation sensitization and energy utilization within the Er-rich region, whereas trace Tm 3+ incorporation is more closely associated with excited-state population redistribution toward the red-emitting pathway. These results demonstrate that red-emission intensity and the R/G ratio can be differentially regulated within the same multilayer platform through Yb 3+ or Tm 3+ incorporation into the Er-rich shell. This work provides a spatially organized and compositionally tunable strategy for tailoring red upconversion emission in Er 3+ -based multilayer nanoparticles.
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高影响因子
TALANTA
·
2026
·
IF 6.7
Yasheng Dai,Jie Yao,Shiyuan Wang,Changgan Lai,Jie Gong,Chenjie Gu,Tao Jiang,Kerong Wu
Exosomes are regarded as cancer-associated biomarkers for early diagnosis and prognosis in clinical bioassays. Nevertheless, it remains a challenge to develop an approach that can achieve ultra-sensitive and quantitative detection of exosomes. Herein, an innovative dual-mode immunoassay dependent on surface-enhanced Raman scattering (SERS) and upconversion luminescence (UCL) was developed to detect prostate cancer-derived exosomes. A novel SERS-active immunosubstrate was constructed by combining black phosphorus (BP) with Ag nanoparticles, which exhibited an enhancement factor (EF) of about 3.69 × 10 9 , due to the synergistic electromagnetic and chemical effects. Meanwhile, an immunoprobe with stable and visually distinguishable UCL was developed based on Yb/Er co-doped NaGdF 4 nanoparticles with an intrinsic two-photon process. The specific capture of exosomes was achieved through antigen-antibody binding within the sandwich immunostructure, achieving limits of detection (LOD) as low as 93 and 172 particles/mL based on the dual-modal detection, respectively. Furthermore, the recognition of different derived exosomes was simply realized by visually observing the green fluorescence with different intensities, which paves the way for efficient preliminary identification of prostate cancer. Finally, the validation with clinical serum samples proved that the proposed approach holds significant promise for rapid cancer screening and diagnosis.
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高影响因子
NANOTECHNOLOGY
·
2021
·Vol. 32
·期 39
·395703
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IF 3.874
Zhihua Li,Xin Ding,Bing Yu,Yu Min,Bin He,Youqing Shen,Hailin Cong
Near-infrared (NIR) emission materials can be widely applied in various fields, such as food detection, imaging, treatment, electronic products. With the trend of miniaturization of equipment, smaller materials are needed. In this work, we successfully synthesized a series of M2Ga2GeO7:N3+ (M = Ca, Ba, Sr; N = Cr, Nd, Er) samples and then focused on the study of Nd3+ doped Sr2Ga2GeO7 (SGGO). A series of SGGO:xNd3+ sub-micron phosphors were prepared via a microwave-assisted sol–gel process combined with subsequent calcination at 750 ℃, and the structural information and luminescent properties were systematically studied. SGGO is a representative tetragonal crystal and belonging to the space group of P4¯21m (113). The Nd3+ ions occupy eight-coordinated Sr2+ sites in the crystal lattice. From SEM analysis, the average particle size distribution is 219.7 ± 41.4 nm. The sub-micron phosphors have rich excitation spectra ranging from 350 nm to 850 nm and can produce multiband NIR emissions of 1331, 1056, and 905 nm when excited by ultraviolet and NIR light. The maximum emission intensity was obtained by optimizing the doping ratio of Nd3+ ions. A commercial chip was then utilized to fabricate light-emitting diodes (LEDs) to verify its application potential in NIR-II mini-LEDs. Compared with blue light LEDs, the as-prepared LEDs had good imaging penetration depth and could be clearly observed under 10 mm of chicken breast coverage. The maximum imaging penetration depth can be 33 mm.
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高影响因子
CERAMICS INTERNATIONAL
·
2023
·
IF 5.2
Hang Liu,Ziyi Zhang,Jian Liu,Kailin Wang,Yuhong Zhang
In this paper, the upconversion(UC) and downshifting(DS) luminescence and thermal sensing performances of the CaIn 2 O 4: RE 3+ /Tm 3+ /Yb 3+ (RE=Er, Ho) phosphors are investigated in detail. The bright UC emission bands from 450 to 900 nm and the DS luminescence bands from 1000 to 1700 nm are obtained under 980 nm excitation. The typical near infrared(NIR) emisson band(∼1550 nm) of Er 3+ ions and the NIR emission band(∼1200 nm) of Ho 3+ ions are gained. The temperature sensing features of CaIn 2 O 4: RE 3+ /Tm 3+ /Yb 3+ (RE=Er, Ho) phosphors are investigated with the luminescence intensity ratio (LIR) technique. The results indicate that the maximum relative sensitivity (S Rmax ) of CaIn 2 O 4: Er 3+ /Tm 3+ /Yb 3+ sample reaches 1.576% K -1 at 313 K, and the S Rmax of CaIn 2 O 4: Ho 3+ /Tm 3+ /Yb 3+ sample reaches 0.797% K -1 at 353 K in UC range. In addition, the higher temperature measuring sensitivities have been obtained in NIR-II region with the DS luminescence of CaIn 2 O 4: RE 3+ /Tm 3+ /Yb 3+ phosphors. The above results indicate that the CaIn 2 O 4: RE 3+ /Tm 3+ /Yb 3+ phosphors show bright emission bands in visible and NIR-II, and higher sensitivity for temperature measurement. The CaIn 2 O 4: RE 3+ /Tm 3+ /Yb 3+ phosphors present great application in optical temperature measurement.
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高影响因子
TALANTA
·
2019
·
IF 4.916
Leilei Sun,Tao Wang,Yuzhen Sun,Zexin Li,Haining Song,Bin Zhang,Guangjun Zhou,Haifeng Zhou,Jifan Hu
Dual-functional nanosensors based on small molecule regulation can be widely used due to their simplicity, high sensitivity and selectivity. Herein, glutathione (GSH) calibrated dual-functional system for GSH and cadmium ions (Cd 2+ ) detection based on fluorescence resonance energy transfer (FRET) between NH 2 –NaYF 4 :Yb,Er/NaYF 4 @SiO 2 upconversion nanoparticles (UCNPs) and gold nanoparticles (AuNPs) is designed. Unmodified AuNPs are easy to aggregate in high-salt solution and thereby quenching the red emission of UCNPs. The presence of GSH prevents the aggregation of AuNPs, so GSH can be detected by the changes in the color of solution and the recovery of red emission of UCNPs. However, Cd 2+ can interact with GSH, which makes AuNPs easy to aggregate, resulting in a gradual decrease in red emission of UCNPs. The fluorescence response of the system is linear with the concentrations of GSH and Cd 2+ in a wide range of concentrations, with low detection limits of 0.016 μM and 0.059 μM, respectively. Furthermore, the nanosensor demonstrates high selectivity for GSH and Cd 2+ detection and can be applied for the detection of GSH in human plasma and Cd 2+ in drinking water .
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高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Jun-Min Zhang,Xiao-Wu Chen,Xiao You,Qing-Gang Li,Meng-Meng Wang,Xiang-Yu Zhang,Yan-Mei Kan,Yu-Dong Xue,Shao-Ming Dong
The effect of RE 2 O 3 (RE = La, Y, Er, Lu) on the oxidation behavior of RMI-SiC ceramics in air and wet oxygen atmospheres at 1400 °C were studied. The outward migration of RE 3+ cations reduces the oxidation resistance of SiC-RE ceramics in air, but improves the wet-oxidation resistance of SiC-RE ceramics due to the formation of denser RE 2 Si 2 O 7 layer. The outward migration rates of RE 3+ cations may be influenced jointly by the RE 3+ cation radius and the formation rate of RE 2 Si 2 O 7 . The higher mobility of Er 3+ and Y 3+ cations makes Y 2 O 3 and Er 2 O 3 promising modifier for enhancing the wet-oxidation resistance of RMI-SiC f /SiC composites, although the modified components need to be optimized and further analyzed in a more realistic service environment.
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高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2019
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IF 2.813
Bixia Huang,Xuewen Hu,Jiancheng Wang,Ping Li,Jun Chen
Hyperuricemia strongly correlates with an increased risk of the development of gout, and cardiovascular and kidney diseases, etc. Er Miao Wan (EMW) is a classical traditional Chinese medicine (TCM) formula extensively used for the treatment of hyperuricemia and gout. However, the global components and action mechanism of the formula are still unknown. Here, the chemical constituents of EMW extract were identified by ultra-high performance liquid chromatography quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF/MS) and gas chromatography–mass spectrometry (GC–MS). A total of 24 alkaloids, 15 organic acids, 4 terpenoids , 3 lactones , 3 glycosides , 46 volatile constituents and 3 other compounds were tentatively identified from the EMW extract. Additionally, based on the hyperuricemic rat model induced by long-term high-fructose feed, a GC–MS based metabolomics approach was conducted to holistically assess the mechanism of EMW. Principal component analysis (PCA) and orthogonal partial least squares-discriminant analysis (OPLS-DA) were applied for screening differential metabolites. A total of 21 metabolites that markedly changed in hyperuricemic rats were identified. Further univariate analysis showed that 9 differential metabolites among them were profoundly reversed by EMW intervention. Metabolic pathway analysis revealed that the variations of these metabolites were mainly associated with glycerolipid metabolism, amino acid metabolism, primary bile acid metabolism, taurine and hypotaurine metabolism and purine metabolism. It was inferred that EMW possibly induced its anti-hyperuricemic effect through restoring multiple disturbed pathways to the normal state. This study could assist with elucidating the potential mechanisms of EMW.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Xiaoping Jiang,Yue Guo,Lixi Wang,Qitu Zhang
Multi-mode dynamic anti-counterfeiting materials can provide complex anti-counterfeiting performance and ensure the anti-counterfeiting strategy becomes more secure. Herein, a new type of multi-mode anti-counterfeiting encryption material of CaAl 12 O 19 :Eu, Er with different Er doping concentration was developed by sol–gel method. Interestingly, the CaAl 12 O 19 :Eu, Er phosphor and its composite have multi-mode anti-counterfeiting characteristics of multi-color down-conversion luminescence, up-conversion luminescence, dynamic luminescence, and photochromism. Effect of different Er doping concentration on the down-conversion luminescence, up-conversion luminescence, dynamic luminescence, and photochromism of CaAl 12 O 19 :Eu, Er was systematically investigated, and the relevant mechanisms were discussed. These anti-counterfeiting features can be simultaneously applied in both bright and dark fields, which can achieve high-level anti-counterfeiting in both spatial and temporal dimensions. The CaAl 12 O 19 :Eu, Er phosphors cannot be easily replaced by other materials with the same anti-counterfeiting properties. They display good application foreground in the field of anti-counterfeiting encryption.
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高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2025
·
IF 5.9
Yan-Yun Liu,Zheng-Ao Li,Yu-Zheng Zhou,Sen-Lin Wang,Zong-Peng Chen,Si-Xu Liu,Peng Zhan,Ying-Jun Zhou,Zan-Xian Xia,Xu Deng
The global COVID-19 pandemic caused by SARS-CoV-2 has underscored the urgent need for the development of new broad-spectrum antivirals to combat its high mutation rate and the emerging variants. Host ER α-glucosidases I/II are promising host-targeted therapeutic targets for the development of broad-spectrum antivirals against viral strains that depend on ERQC for infectivity. Herein, we designed and synthesized a series of TCM theory-inspired DNJ-flavonoid conjugates as novel α-glucosidase inhibitors, which were screened against their in vitro antiviral activities in non-replicative SARS-CoV-2 pseudovirus (PsV) assay. Remarkably, DNJ-20 not only demonstrated remarkable inhibition activity against α-glucosidase and viral entry process, but also exerted potent and broad-spectrum anti-coronaviral activity against SARS-CoV-2 pseudovirus (PsV), several SARS-CoV-2 variants, as well as HCoV-229E and HCoV-OC43, with EC 50 values up to 1.49 μM, which is more potent than the benchmark α-glucosidase inhibitor UV-4 ( DNJ-3 ). Besides, it had no observable cytotoxicity in HeLa-ACE2, HEK-293T and Beas-2B cells. Therefore, TCM theory-inspired DNJ-flavonoid conjugates can be served as promising drug leads for pan-coronavirus therapeutic development to combat current and future coronavirus pandemics.
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高影响因子
ACS Applied Nano Materials
·
2025
·
IF 5.5
Hanqing Liu,Yifei Zhou,Jing Xu,Le Ding,Chuan Liao,Tao Wang,Haifeng Zhou,Guangjun Zhou
High-efficiency detection of cadmium ions (Cd2+) and mercury ions (Hg2+) is crucial due to their harmful effects on the environment and human health. Here, we developed a ratiometric upconversion fluorescence (UCF)-based nanosensor by incorporating lanthanide-doped upconversion nanoparticles (UCNPs) and gold nanoparticles modified with trithiocyanuric acid (TMT-AuNPs) as specific recognition elements for the highly sensitive and selective real-time detection of Cd2+ and Hg2+. The developed nanosensor exhibited selective absorbance enhancement and UCF quenching behavior with the addition of Cd2+ and Hg2+ based on the inner filter effect (IFE). The sensitivity of the nanosensor was significantly enhanced by converting the change in absorbance into an exponential variation in UCF intensity. Therefore, the quantitative detection of Cd2+ and Hg2+ was achieved by measuring the UCF ratio I654/I540. In order to distinguish between Cd2+ and Hg2+, two biomolecules, glutathione (GSH) and ascorbic acid (AA), were used based on their different interactions with Cd2+ and Hg2+. GSH formed a specific tetrahedral complex (GSH)4Cd with Cd2+, thereby preventing Cd2+ from inducing changes in UCF intensity. In contrast, AA specifically reduced Hg2+, thereby preventing Hg2+-induced UCF changes. Thus, GSH and AA could also be detected. The limits of detection (LODs) of Cd2+, Hg2+, GSH, and AA were 2.8, 5.2, 5.1, and 7.2 nM, respectively. The designed detection platform provides a sensitive and straightforward sensing strategy for the multiplex detection of heavy metal ions and biological small molecules.
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高影响因子
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