Environmental Science-Nano
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2026
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IF 5.1
Fengyang Jing,Shimeng Chang,Xingyu Zhang,Chen-Liang Zhou,Yao Weng,Xuewei Li,Hongmei Ye,Yuting Sun,Jiuyang Lin,Wenyuan Ye,Wenjing Yuan
In this study, double S-scheme heterojunctions were constructed by a simple hydrothermal and calcination method, accompanied by the special layered structure of BiOIO3 employed for its I- modification. This resulted in the formation of CeO2/[Bi6O6(OH)3](NO3)3·1.5H2O (BHN)/I--BiOIO3, which possesses double S-scheme heterojunctions. The improvement of photocatalytic degradation efficiency is derived from the result of the synergistic effect of double S-scheme heterojunctions and I- modification. In photocatalytic degradation experiment with norfloxacin as the target pollutant, the degradation efficiency of typical sample (CeO2/BHN/I--BiOIO3-2) reaches 97.50%, which is 9 times and 1.6 times than that of pure CeO2 and BHN/BiOIO3, respectively. Obviously, the CeO2/BHN/I--BiOIO3 double S-scheme heterojunctions significantly enhances its photocatalytic degradation ability of antibiotics in comparison to single-substance photocatalysts and simple two-phase composite. It is noteworthy that the CeO2/BHN/I--BiOIO3 double S-scheme heterojunctions are also capable of achieving a degradation rate of up to 70% for norfloxacin in river water. Furthermore, this double S-scheme heterojunctions demonstrate the degradation efficiencies of approximately 90% for quinolone antibiotics, including ofloxacin, enrofloxacin, ciprofloxacin, and norfloxacin. This research offers a novel approach to enhance the photocatalytic degradation of organic pollutants through double S-scheme heterojunctions and elemental modification.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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2026
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IF 6.7
Ya-Kun Zhang,Jian-Bo Tong,Hong-Yan Zhang,Zhi-Peng Qin,Cheng-Jian Tan
A bioactivity repurposing strategy expanded the potential pharmacological applications of sophoridine derivatives. • Sophoridine derivatives modulated the Topo I–DNA catalytic system and exhibited preliminary antitumor activity. • Molecular simulations characterized potential interactions and dynamic behaviors within the Topo I–DNA complex. Sophoridine is a quinolizidine-type natural alkaloid with favorable structural modifiability and diverse biological activities. However, the pharmacological potential of sophoridine derivatives originally optimized for insecticidal activity remains largely unexplored. Here, a bioactivity repurposing strategy was applied to investigate the antitumor potential of these derivatives. Screening across multiple cancer cell models identified A549 cells as a sensitive model, and compounds 5 and 9 were selected as active candidates with IC 50 values of 0.124 μM and 1.396 μM, respectively. Topo I-mediated DNA relaxation assays showed that both compounds interfered with the activity of the Topo I–DNA catalytic system in a concentration-dependent manner. Molecular docking, molecular dynamics simulations, and PMF analyses characterized their potential interactions within the Topo I–DNA complex. Preliminary in vivo evaluation suggested inhibitory effects on tumor growth accompanied by tumor tissue necrotic changes following treatment with compounds 5 and 9 . Collectively, these findings highlight the antitumor potential of sophoridine derivatives and suggest that modulation of the Topo I–DNA system may represent one potential mechanism contributing to their biological effects, providing preliminary insights for the further development of sophoridine-based anticancer candidates. A series of sophoridine-based derivatives were systematically evaluated for their antitumor potential. In vitro antiproliferative assays identified compounds 5 and 9 as active candidates against A549 cells, with IC 50 values of 0.124 μM and 1.396 μM, respectively. Topo I-mediated DNA relaxation assays showed that both compounds interfered with the Topo I–DNA catalytic system in a concentration-dependent manner. Molecular docking, molecular dynamics simulations, and PMF analyses further characterized their potential interactions and dynamic behaviors within the Topo I–DNA complex. Preliminary in vivo evaluation suggested that compounds 5 and 9 exhibited inhibitory effects on tumor growth, accompanied by increased tumor necrotic changes. Collectively, these findings indicate that sophoridine derivatives possess promising antitumor potential, while modulation of the Topo I–DNA system may represent one potential mechanism contributing to their biological effects, providing a basis for further optimization and development of sophoridine-based antitumor candidates. Download: Download high-res image (333KB) Download: Download full-size image
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Cell Reports
·
2026
·Vol. 45
·期 7
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IF 7.7
Liwei Zheng,Minghui Li,Weilin Gu,Jing Zhao,Bei Jiang,Qianqian Jiang,Kun Liu,Yu Guo,Ran Xu,Xin Liu,Ting Zhang,Danli Yang,Sidi Yang,Lihong Liu,Qingquan Liu,Lin Wang,Sujun Zheng,Fengmin Lu,Xiangmei Chen
SARS-CoV-2 infection remains a global health threat, yet its pathogenic mechanisms are incompletely understood. Here, we show that viral nucleocapsid protein (NP) is detectable in the serum of patients with SARS-CoV-2 infection independently of viral RNA. Using virus-like particle (VLP) systems and in vitro infection models, we demonstrate that NP is secreted in a vesicle-free form via type I unconventional protein secretion (UPS) pathway. This process is regulated by NP phosphorylation and oligomerization, coordinated by viral structural proteins, and dependent on membrane components including heparan sulfate proteoglycans (HSPGs) and phosphatidylinositol 4,5-bisphosphate (PI (4,5) P 2 ). Secreted NP is preferentially taken up by granulocytes and induces the release of inflammatory cytokines, including IL-6 and TNF-α. Our findings shed a light on the secretion mechanism of this pro-inflammatory NP, highlighting it as a potential therapeutic target for COVID-related systemic inflammation.
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JOURNAL OF LUMINESCENCE
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2026
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IF 3.8
Hongwei Xu,Yang Chen,Leilei Kuai,Chengjun Liu,Jianjun Zhao,Quan Liu,Bo Wei,Junpeng Xue,Zutao Fan
Metal halide perovskite nanocrystals (PNCs), particularly all-inorganic CsPbX 3 (X = Cl, Br, I), exhibit exceptional optoelectronic properties, positioning them as revolutionary materials for LEDs, displays, and photodetectors. However, their commercialization is impeded by environmental instability under moisture, heat, and light. To address this, we introduce a solvent-induced surface rheological engineering (SISRE) strategy to fabricate super-hydrophobic CsPbX 3 -PS composite membranes inspired by the lotus leaf effect. Key innovation lies in controlled spraying of a THF/ethanol mixture (3:1 v/v) onto the membrane surface. THF selectively dissolves surface PS to induce micro/nano hierarchical roughness, while ethanol triggers rapid polymer re-solidification. By modulating spray passes (5–15 cycles), we achieved tunable hydrophobicity with contact angles increasing from 70° to >140° (Cassie-Baxter state), while maintaining PLQY∼72% for CsPbBr 3 PNCs membrane. The optimized super-hydrophobic membrane (12 spray cycles) nearly exhibited a 2.7-fold enhancement in water stability (PLQY decay rate: 1.65%/day vs. 4.46%/day for untreated films). In addition, when applied as a down-conversion layer on blue LEDs (λ peak = 452 nm), the device achieved 111% NTSC color gamut coverage (98% Rec.2020) with CIE coordinates (0.328, 0.288) and CCT = 5722 K. This work provides a scalable, appliable route to concurrently enhance environmental stability and optoelectronic performance of PNCs.
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JOURNAL OF MOLECULAR STRUCTURE
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2026
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IF 4.9
Qiang Zhao,Zhi Shen,Lin-Xi Qin,Meng-Ting Fan,Pei-Xuan Zhang,Xin-Yue Zhang
Complex 1 and 2 exhibit excellent red and green fluorescence, respectively. • Complexes 1 and 2 exhibit excellent selectivity towards Fe 3+ . • Complex 1 and 2 have good recognition of I - and F - in anions, respectively. • Complex 2 can achieve naked eye recognition of F - . To further advance research on rare earth complexes as Luminescent probes, this work investigates the cation and anion recognition capabilities of europium and terbium carboxylate complexes, Eu(ocpia) ( 1 ) and Tb(ocpia) ( 2 ), in dispersed systems. Cation recognition experiments were performed using DMF as the dispersion medium, with the complex concentration fixed at 0.2 mg/mL. Results demonstrate that both complexes 1 and 2 exhibit excellent selectivity for Fe³⁺, with detection limits as low as 0.076 μM and 0.069 μM, respectively. These findings indicate that complexes 1 and 2 hold great potential as fluorescent probes for Fe³⁺ detection. Anion recognition experiments were conducted in acetonitrile dispersion (0.2 mg/mL complex concentration). Complex 1 shows high selectivity for I⁻, achieving a detection limit of 0.052 μM. In contrast, complex 2 displays strong affinity for F⁻, with a detection limit of 0.087 μM. Notably, F⁻ can coordinate with complex 2 to form a soluble adduct, enabling visual, naked-eye recognition of F⁻. Collectively, these results highlight the promising application of complexes 1 and 2 as selective fluorescent probes for I⁻ and F⁻, respectively. Eu and Tb complexes exhibit excellent red and green fluorescence, respectively, and both have excellent recognition for Fe 3+ . Tb complex can experimentally recognize F - with naked eyes Download: Download high-res image (228KB) Download: Download full-size image
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ANALYTICA CHIMICA ACTA
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2026
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IF 6.1
Hai Li,Ping Guo,Min Li,Ming Ma,Wei Luo,Bo Chen
Background Thallium, a highly toxic heavy metal, is widely distributed in the environment. The substance poses a grave threat to human health through contamination of the food chain, drinking water, and environmental exposure. Consequently, the monitoring of thallium levels, particularly in water, is of critical importance. In this study, a novel analytical method was developed for the direct quantification of thallium ions (Tl + ) in aqueous samples. This method is based on the specific supramolecular interaction between cryptand[2.2.2] and Tl + , and it utilizes electrospray ionization tandem mass spectrometry (ESI-MS/MS). Results The method demonstrated remarkable analytical performance, exhibiting a linear range of 2.5 to 100 μg/L (R 2 > 0.999), a limit of quantification (LOQ) of 2.5 μg/L, and a limit of detection (LOD) of 0.8 μg/L. The recovery rates exhibited a range from 88.65% to 118.09%, with relative standard deviations (RSD) falling below 10%, thereby affirming the attainment of satisfactory accuracy and precision. It is noteworthy that this method necessitated only 5 μL of sample and did not require any preliminary separation steps. Despite the inhibitory effects exhibited by complex sample matrices, these effects were effectively mitigated through a straightforward dilution strategy. The method was successfully applied to the analysis of 66 real-world environmental water samples. Significance This work presents a novel tool that enables rapid and reliable detection of Tl + in water samples. Compared with traditional ESI methods for heavy metals, the application of cryptand[2.2.2] makes the developed method more selective and sensitive, since it has strong binding ability and selective to Tl + ion. The study introduces a novel design concept and practical application for the development of supramolecular recognition-based ESI-MS methods for metal ion analysis. These methods hold significant potential for environmental monitoring and related fields.
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ANALYTICAL SCIENCES
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2026
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IF 2
Zheng Diantao,Li Qiuyan,Hu Ran,Zhang Baoliang
Serum C-terminal telopeptide of type I collagen (CTX-I) is a key bone turnover biomarker in osteoporosis, and its elevated levels are indicative of increased bone resorption. Current techniques for CTX-I measurement suffer from high operational requirements, complex procedures, and high costs. This study focuses on a novel strategy for detecting serum CTX-I concentration to predict the occurrence and severity of osteoporosis. Using silver-capped Fe 3 O 4 (Fe 3 O 4 @Ag) as the substrate material, an artificial antibody for CTX-I was prepared via magnetic core-shell molecularly imprinted polymers (MIPs), and surface-enhanced Raman scattering (SERS) was used as a signal output device. With crystal violet (CV) at 10 −4 M as the reporter molecule, the proposed biosensor exhibited a good linear response over the range of 10 pg/mL to 2 ng/mL (R 2 = 0.986, LOQ = 4.79 pg/mL), covering the normal reference range required for identifying bone turnover. Moreover, the biosensing platform demonstrated resistance to matrix interference in real serum and urine samples. After six reuse cycles, the SERS intensity of CV decreased by only 10.5%, and after 15 days of storage at 4 °C, it decreased by 15.7%. The Fe 3 O 4 @Ag-MIPs were used to detect CTX-I with excellent uniformity (RSD = 4.1%) and repeatability (RSD = 2.7%), and the overall analysis time was 30 min. The proposed biosensing platform was applied to analyze known real serum samples obtained from human. The proposed biosensor was validated using enzyme-linked immunosorbent assay (ELISA), and the developed biosensor showed good correlation with ELISA. The experimental results indicate that the proposed novel biosensing platform is a fast, low-cost, and reliable tool for the rapid detection of the bone biomarker CTX-I in serum or urine. Graphical abstract
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2026
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IF 9.2
Shijie Cao,Quanquan Li,Hui Yun,Boyu Zhang,Zhixue Wang,Xiaowen Wang,Jing Bai,Xiaodong Wang,Yunhua Xu
Magnesium Hydride (MgH 2 ) is a promising hydrogen storage material but suffers from a high dehydrogenation temperature and sluggish sorption kinetics, which hinder its practical application. Accordingly, we report the use of a Cu-based metal-organic framework (HKUST-1) derived carbon material as a catalyst for optimizing the MgH 2 hydrogen storage performance. The MgH 2 containing 10 wt% HKUST-1 (denoted as MgH 2 -HKUST-1) exhibits a maximum dehydrogenation temperature of 50 °C, much lower than pure MgH 2 . Additionally, it demonstrates enhanced hydrogenation dynamics: it adsorbs 6.4 wt% H 2 within 240 s when heated to 350 °C, and even at 200 °C, it still captures 5.7 wt% H 2 in 60 min. Moreover, the dehydrogenation activation energy is 85.01 kJ per mole of H 2 , showing a marked reduction compared to pure MgH 2 . Furthermore, the excellent H 2 storage performance perhaps stems from the synergistic interaction of Cu 2+ /Cu + redox reactions, mechanochemical size effects, and in situ carbon scaffolding.
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Journal of Translational Medicine
·
2026
·Vol. 24
·期 1
·1029
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IF 9.7
Cheng Kai-wen,Zhou Shao-jun,Zeng Jie,Zhang Yang-rui,Jin Bing-qian,Wang Ping,He Ling-yan,Qi Xu-chen,Liu Xu-dong,Yu Lu-shan,Zhang Yan-xing
Background Among tumors affecting the central nervous system (CNS), glioblastoma multiforme (GBM) is the most aggressive and lethal form. Given the complex mechanisms of the CNS and the blood-brain barrier (BBB), effective therapies for GBM remain limited. To identify potential therapeutic candidates for glioma, we developed a small-molecule library to screen for compounds with potent anti-proliferative effects and BBB permeability. The mechanisms underlying their anti-glioma activity were further elucidated to provide insights into new treatment strategies. Methods A library of small molecules was screened to identify agents that significantly inhibit glioma cells activity. The effects of the lead compound (Dihydrotanshinone I, DHT) on glioma progression were evaluated through a series of experimental approaches, including cell counting kit-8 assays, cell cycle analysis, apoptosis detection, wound healing, transwell migration, reactive oxygen measurement, subcutaneous xenograft mouse models, and intracranial orthotopic tumor models. To elucidate the underlying mechanisms, network pharmacology and transcriptomic analyses were employed. The mechanism of DHT in glioma pathogenesis was further validated using bioinformatics analyses and clinical glioma tissue samples. Results Based on pharmacokinetic evaluation, DHT was found to traverse the BBB, indicating its capacity to reach the cerebral parench. In vitro and in vivo experiments demonstrated that DHT significantly suppresses glioma growth and progression. Mechanistic analyses using network pharmacology and RNA sequencing revealed that DHT induces glioma cell apoptosis by inhibiting the Janus kinase-signal transducer and activator of transcription 3 (STAT3) signaling pathway, increasing intracellular reactive oxygen species levels and triggering intrinsic apoptotic cascades. Furthermore, bioinformatic analyses of clinical cohorts coupled with validation in patient-derived glioma specimens confirmed that elevated STAT3 expression was correlated with unfavorable prognosis and was significantly increased in patients with high-grade glioma. Conclusions This study demonstrates that, in addition to its role as a key contributor to glioma malignancy and a prognostic marker, STAT3 is also a target of DHT, highlighting its potential as a promising therapeutic candidate for treating GBM. Graphical
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ADVANCED FUNCTIONAL MATERIALS
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2026
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IF 19.9
Xuefei He,Kai Han,Lihan Chen,Liang Li,Yongsheng Sun,Maxim Molokeev,Binbin Su,Zhiguo Xia
Metal halide scintillators have attracted continuously increasing interest for low-dose and high-resolution X-ray imaging, yet typical luminescent silver halides suffer from severe hygroscopicity and exciton quenching caused by Ag–Ag cluster aggregation. To address these challenges, we design and report mononuclear five-coordinate silver(I) halide complexes (dppb) 2 AgX·DMSO (X = I, Br, Cl) with 1,2-Bis(diphenylphosphino)benzene (dppb) ligand. Halogen substitution enables tunable broadband emission, while the chloride analogue achieves efficient thermally activated delayed fluorescence (TADF) and a high PLQY of 76%. The chloride analogue possesses more rigid AgClP 4 coordination environment compared with its bromide and iodide counterparts, enabling restricts excited-state relaxation, suppresses non-radiative decay, and preserves favorable singlet-triplet energetics and spin-orbit coupling. Meanwhile, the chloride analogue shows superior scintillation with a high light yield of 26631 photons/MeV, and a detection limit of 304.67 nGy air s −1 . Furthermore, a high spatial resolution of 20.2 lp mm −1 for X-ray imaging is achieved based on the transparent Ag-Cl composite gel scintillator screen. This work not only provides a promising design principle for achieving high scintillation in TADF-type Ag(I) halide complexes by halogen regulation, but also provide a new platform for Ag(I) halide complexes in X-ray imaging.
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OPTICAL MATERIALS
·
2025
·
IF 4.2
Qi Chen,Fang Lei,Ying Shi
Perovskite light-emitting diodes (PeLEDs) employing CsPbX 3 nanocrystals (NCs) face persistent challenges in balancing emission efficiency and spectral stability due to surface halide vacancies, which trigger nonradiative recombination, halide phase segregation, and self-doping effects. In this work, we address these limitations by introducing 3,5-dicarboxyphenylboronic acid (3,5-DA) as a multifunctional bidentate ligand additive. The unique coordination architecture of 3,5-DA, featuring multiple chelating groups, enables strong binding affinity to perovskite NC surfaces. This interaction effectively passivates halide vacancies while suppressing ion migration and defect formation. The optimized CsPb(Br/I) 3 NCs exhibit enhanced stability and suppressed nonradiative losses, enabling high-performance white LEDs (WLEDs). At a driving current of 10 mA, the fabricated WLEDs demonstrate a luminous efficiency of 10.32 lm·W −1 , a CIE coordinate of (0.3379, 0.3391), a correlated color temperature (CCT) of 5260 K, and an external quantum efficiency (EQE) of 6.48 %. This work provides a ligand engineering strategy to concurrently resolve efficiency-stability trade-offs in PeLEDs.
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CHEMICAL PHYSICS
·
2020
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IF 1.771
Yuejun Li,Tieping Cao,Zemin Mei,Xiaoping Li,Dawei Sun
Among tremendous efforts for enhanced photocatalysis, construction of heterojunction has been deemed as an effective means. In comparison with type II heterojunction, type I heterojunction receives less attention due to accumulation and increased recombination of charge carriers in one side of heterojunction. Herein, we take NaBi(MoO 4 ) 2 /Bi 2 MoO 6 as an example of type I heterojunction and explore means to improve the photocatalytic performance of NaBi(MoO 4 ) 2 /Bi 2 MoO 6 heterojunction. We employ TiO 2 electrospun nanofibers as substrates and separately grow NaBi(MoO 4 ) 2 and Bi 2 MoO 6 nanostructures on the skeleton of TiO 2 . The characterization results show that TiO 2 changes type I heterojunction into multiheterojunction integrating two type II heterojunctions. Photocatalytic tests demonstrate that as-constructed multi-heterojunction is of higher activity than that of single type I or II heterojunction, respectively, where photogenerated electrons are accumulated on the surface of TiO 2 and photogenerated holes are accumulated on NaBi(MoO 4 ) 2 and Bi 2 MoO 6 , respectively. This study highlights the potential application of TiO 2 electrospun nanofibers in the construction of multiheterojunction for enhanced visible light photocatalysis.
研究领域:
材料科学
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环境科学
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