JOURNAL OF APPLIED POLYMER SCIENCE
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2025
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IF 2.8
Gang Chen,Hai Lan
To address the issues of collapse-type degradation and poor toughness observed in PLGA-based bone repair scaffolds during degradation, this study blends PLGA with poly (trimethylene carbonate) (PTMC) and fabricates microsphere scaffolds through the emulsion method followed by sintering to form solid microsphere scaffolds. Additionally, to enhance the osteogenic potential of the scaffold, β-tricalcium phosphate (β-TCP) and varying amounts of titanium dioxide (TiO 2 ) are incorporated into the polymer. Performance analysis of the composite microsphere scaffolds reveals that the scaffold exhibits a continuous pore structure with a compressive modulus comparable to that of cancellous bone. After the incorporation of inorganic particles, the compressive modulus exceeded 70 MPa. In vitro degradation experiments confirm that the composite microsphere scaffold prepared by blending PTMC exhibited a degradation rate of 9.1% at week 12 while maintaining stable macroscopic morphology. Moreover, the pH at the final stage of degradation effectively mitigated the issue of acidic degradation associated with PLGA (pH = 6.32). In vitro cell experiments demonstrate that the prepared microsphere scaffolds possess good biocompatibility, and the incorporation of β-TCP and TiO 2 enhances the composite scaffold's osteogenic potential and antibacterial properties. This scaffold holds promise as a novel approach for the treatment of bone defects.
研究领域:
生物材料
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组织工程
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生物医学工程
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高分子科学
·
骨科
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2022
·Vol. 30
·期 4
·9416-9427
·
IF 5.19
Zhu Dandan,Shi Linan,Li Haoming,Zhang Jinyi,Zhang Jiupeng,Wei Cundi
In this study, TiO 2 /MSGM composite material with adsorption-photocatalytic properties was prepared by extracting mesoporous silica glass microsphere (MSGM) from coal gasification fine slag (CGFS) as a novel TiO 2 carrier. The results of characterization and properties of the composite showed that MSGM could improve the adsorption capacity and photocatalytic activity of the composite by improving the pore structure of the composite, hindering the growth of TiO 2 particles, increasing the phase transition temperature of TiO 2 , enhancing the dispersion of TiO 2 particles. The sample 1:3-TiO 2 /MSGM-2–500 prepared under the optimized conditions possesses satisfactory morphology characteristics, high adsorption capacity, and photocatalytic activity to rhodamine B (RhB). The synergistic effects of adsorption and photocatalytic significantly increase the total removal rate of RhB. This study not only provides a new direction for high-value-added resource utilization of CGFS but also gives a new kind of low-cost carrier material with adsorption property for TiO 2 loading to remove organic dye pollutants.
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POLYMERS FOR ADVANCED TECHNOLOGIES
·
2023
·Vol. 34
·期 6
·1918-1932
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IF 3.4
Yuqian Du,Xueya Wang,Ziwen Zhou,Feng Zhao,Song Li,Zhihua Liu,Zhengyu Wu,Shuai Zhao,Lin Li
Nowadays, although highly conductive polymer composites filled with two-dimensional graphene-based nano-fillers have been explored extensively, constructing nanocomposites with high performance, industrial feasibility, and more efficient conductive networks at lower nano-filler contents remains a challenge. To achieve the above objectives, industrial wastes microsilica powder (N98) with amorphous spherical structure and large particle size is employed in this work. And the hybrids (TGN) are obtained between N98 and graphene (GE) by the effective bridging and interface coupling of tannic acid, which can achieve the purpose of obtaining conductive composites with low-filler contents by traditional polymer processing technologies. The volume exclusion effect of N98 and its own assisted dispersion effect can prevent and attenuate graphene agglomeration, enabling the formation of a dense, complete and uniform conductive network in natural rubber (NR) matrix based on a small amount of graphene addition (parts per thousand). Thus, it give the nanocomposite highly functional, especially electric property. The results show that when the ratio of GE to N98 hybridization is 1:20, N98 and graphene are more uniformly hybridized together, and the volume exclusion effect is best matched with the rubber composites, and the comprehensive performance is optimal. Moreover, the electrical conductivity of NR/TG 1 N 20 nanocomposite can reach the balanced value of 10 −3 S·cm −1 with the GE loading of 0.48 phr, which shows the effectiveness of the prepared hybrids.
研究领域:
高分子科学
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纳米复合材料
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功能高分子
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材料化学
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导电聚合物
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VETERINARY JOURNAL
·
2026
·
IF 2.7
Yitong Lu,Yajing Guo,Wanjin Ma,Yifan Li,Shun Wang,Zhiyong Wu
Anorexia is a clinically significant condition in companion animals, particularly cats, that disrupts metabolic homeostasis and impedes recovery from underlying diseases. Mirtazapine (MRZ), a commonly prescribed appetite stimulant in veterinary medicine, has limited clinical utility due to its intense bitterness and suboptimal bioavailability in conventional dosage forms. To address these limitations, we developed a novel drug delivery system integrating microencapsulation technology with an orally disintegrating tablet (ODT) formulation. Using an optimized emulsification-solvent diffusion method, we produced ethyl cellulose-based microspheres exhibiting high encapsulation efficiency (93.19 ± 0.71%), uniform particle size distribution (106.12 ± 1.49 μm), and pH-responsive drug release characteristics. Comprehensive physicochemical characterization confirmed the structural integrity of the microspheres and the absence of detrimental drug-polymer interactions. Furthermore, the ODT formulation exhibited excellent pharmaceutical properties, including rapid disintegration and complete drug release under gastric conditions, and effective masking of MRZ's bitter taste in the oral cavity. In vivo evaluations revealed significantly improved palatability (p < 0.05) and preliminary evidence of appetite stimulation (p < 0.05) compared with conventional formulations, supporting further clinical development. Stability studies indicated robustness under standard storage conditions. This advanced delivery system successfully overcomes the major limitations of current MRZ therapies, offering a promising solution for enhancing treatment compliance and therapeutic outcomes in veterinary practice. Moreover, the developed technology platform provides valuable insights for formulating other challenging active pharmaceutical ingredients requiring taste masking and controlled release.
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PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2021
·
IF 7.963
Jiahao Li,Rong Cheng,Jiaao Chen,Jirong Lan,Shiyao Li,Min Zhou,Tianyu Zeng,Haobo Hou
A series of nitrogen-doped carbon aerogels (NCAs) were obtained through phase reaction polymerization and different carbonization temperatures to enhance adsorption efficacy of hexavalent chromium (Cr[VI]) from wastewater significantly. Factors that influence adsorption properties of carbon aerogel microspheres toward Cr(VI), such as pH, adsorbent content, initial Cr(VI) concentrations, and coexisting anion, were investigated. Three isotherm (Langmuir, Freundlich, and Sips) and three kinetic (pseudofirst-order, pseudosecond-order, and Elovich) models were used to interpret the adsorption process. The adsorption capacity of Cr(VI) reached 180.62 mg·g −1 , which was superior to that of most aerogel adsorbents. In addition to the adsorption effect, the XPS results also showed that N-containing groups on the NCA surface reduce the adsorbed Cr(VI) to the less toxic Cr(III). The prepared sorbent demonstrates a negligible loss in adsorption capacity after 6 cycles. NCAs show acceptable application prospects in selective removal of Cr(VI) ions.
研究领域:
环境科学
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材料科学
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高影响因子
Materials
·
2022
·Vol. 15
·期 14
·4959
·
IF 3.748
Chen Zhang,Yuhong Qi,Zhanping Zhang
To understand the microstructure evolution of hydrogels swollen in seawater, freeze-drying technology was used to fix and preserve the swollen three-dimensional microstructure. By this method, we revealed the swelling behavior of hydrogels in seawater, and elucidated the mechanism of the swelling process. Meanwhile, we also used Fourier-transform infrared spectroscopy; laser confocal microscopy; field emission scanning electron microscopy, and swelling performance tests to research the structure and properties of PS-PEG hydrogels, before and after seawater swelling, and analyzed the structure and properties of PEG-based hydrogels with different contents of polystyrene microspheres. Results showed that PS-PEG hydrogels went through three stages during the swelling process, namely ‘wetting-rapid swelling-swelling equilibrium’. Due to the capillary effect and hydration effect, the surface area would initially grow tiny pores, and enter the interior in a free penetration manner. Finally, it formed a stable structure, and this process varied with different content of polystyrene microspheres. In addition, with the increase of polystyrene microsphere content, the roughness of the hydrogel before swelling would increase, but decrease after swelling. Appropriate acquisition of polystyrene microspheres could enhance the three-dimensional network structure of PEG-based hydrogels, with a lower swelling degree than hydrogels without polystyrene microspheres.
研究领域:
材料科学
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高分子化学
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高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Wan Qiu Xia,Su Han Wang,Yin Liang Wu,Jian Ping Wang
In this study, pentachlorobenzene was used as dummy template to synthesize a type of magnetic molecularly imprinted microsphere for pentachlorophenol. At the same time, pentachloroaniline was coupled to streptavidinated horseradish peroxidase to synthesize an enzyme labeled tracer. The two reagents were used to develop a semi-homogeneous method on conventional microplate for detection of pentachlorophenol in fish samples. Due to the use of biotinylated horseradish peroxidase as signal amplification agent, the method sensitivity was improved for 375 folds in comparison with the use of conventional horseradish peroxidase labeled tracer with a limit of detection of 0.8 fg/g. After comparison, it was found that this method showed better performances than the previous immunoassays and molecularly imprinted polymer based methods for detection of pentachlorophenol. This study for the first time reported a magnetic molecularly imprinted microsphere based semi-homogeneous method for detection of small molecule, and this method could be used for routine determination of pentachlorophenol residue in fish samples.
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PROGRESS IN ORGANIC COATINGS
·
2023
·
IF 6.6
Jialiang Kang,Xueting Wang,Xiaoxiang He,Cun Lv,Caixia He,Zhanxiong Li
In this study, the perfluoropolyether carboxylic acid (PFPE-COOH) was used to react with polycaprolactone (PCL) to synthesise the hydrophobic block copolymer PCL- b -PFPE. The esterification reaction was performed successfully with the terminated hydroxyl group in the PCL-OH after activation of PFPE-COOH with N, N′ -dicyclohexyl carbon diimide. The PCL- b -PFPE was dissolved in various solvents to prepare microspheres using electrostatic spraying technology, and the flow rate, voltage, temperature and humidity parameters were optimised. The findings demonstrated that the solvent and ambient humidity had a substantial influence on the microspheres' surface morphology . Through smooth surface morphology, chloroform (CF) single solvent formed an ideal microsphere and DMF/CF mixed solvent produced a ‘pit’ surface morphology. Furthermore, the surface roughness of microspheres increases with an increase in humidity. The static contact angles of electrostatic spraying polyester fabric were 147.1° ± 1.8°, 150.9° ± 1.5°, 156.3° ± 2.6° and 155.9° ± 3.3°, under 20 %, 40 %, 60 % and 80 % humidity, respectively. The findings demonstrated that during the electrostatic spraying, the PFPE chain's introduction into PCL helped construct the secondary rough morphology on the microsphere surface and substantially enhanced the hydrophobicity of coatings, providing the finished polyester fabric super-hydrophobicity. The PCL-b-PFPE microspheres were directly sprayed and coated with the developed spray solution via electrostatic spraying. The water contact angle of the finished polyester fabric was found to be ≥140°, which provided hydrophobicity after 5 cycles of laundry. Following the sandpaper abrasion and adhesion tests, the contact angle of the fabrics coated with the microspheres remained ≥145°, indicating a good mechanical stability.
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高影响因子
Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Xudong Yin,Xiaojie Sun,Yufeng Mao,Ruzhen Wang,Dehao Li,Wenyu Xie,Zhenghui Liu,Zhisen Liu
The elimination of tetracycline hydrochloride (TC-HCl) from water has attracted extensive research attention. This study hydrothermally synthesized composite photocatalysts composed of BiVO 4 microspheres containing coexisting phases of monoclinic scheelite (M-BiVO 4 ) and tetragonal zircon (T-BiVO 4 ), i.e., MT-BiVO 4 , loaded onto P-doped g-C 3 N 4 nanosheets (PCNS). Furthermore, their morphology, structure, and photoelectrochemical properties were comprehensively characterized, and the performance and stability of photocatalytic degradation of TC-HCl were examined. Additionally, the effects of humic acid (HA), coexisting anions/cations, and actual water samples on the degradation efficiency of TC-HCl were investigated, and the degradation mechanism and pathways were examined. The findings indicated that the percentage of M-BiVO 4 in MT-BiVO 4 considerably influences the photocatalytic activity of the composite catalyst. Furthermore, the excellent photocatalytic performance of 5% BVO/PCNS was attributed to the synergistic effects of P-doping the modified g-C 3 N 4 , MT-BiVO 4 isotype heterojunction effects, and the Z-scheme heterojunction constructed from MT-BiVO 4 and PCNS, which can enhance the absorption range of the visible light and accelerate the transfer and separation of charge carriers between catalysts. The free radical capture experiments and electron spin resonance tests indicated that holes and O 2 - were the dominant active species in the photocatalytic degradation process. With high reusability and stability, the 5% BVO/PCNS composite has great potential for practical wastewater treatment applications. This study offers a new approach for preparing photocatalysts synergized by isotype and Z-scheme heterojunctions.
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Foods
·
2023
·Vol. 12
·期 15
·2818
·
IF 5.2
Yan Su,Gelin Liu,Haozhe Hou,Yaojia Peng,Jianping Wang
The residues of progestins in milk are significant risk factors for teenage acne and may cause hormone-dependent cancers in consumers, so the determination of these residues in milk is very important. However, an immunoassay or immunoassay-like method capable of determining multiple progestins in milk has not been reported so far. The present study, for the first time, synthesized a type of magnetic molecularly imprinted microsphere that was capable of simultaneously recognizing five progestins. At the same time, an enzyme labeled conjugate was synthesized by coupling progesterone 3-(o-carboxymethyl)oxime with streptavidinated horseradish peroxidase. The above two reagents were used to develop a semi-homogeneous method for the simultaneous detection of the residues of the five progestins in milk. During the experiments, biotinylated horseradish peroxidase was used to amplify the signal, so the sensitivity to the five drugs (limits of detection 0.04–0.1 pg/mL) was increased 44–75-fold. In addition, the magnetic molecularly imprinted microsphere could be regenerated four times by using simple elution. Through general comparison of its detection spectrum, sensitivity, simplicity, and reusability, the present method exhibited better performance than the previous immunoassays for the detection of progestins, and so it could be used as a routine tool for the screening of progestins residues in milk.Keywords:progesterone;magnetic molecularly imprinted microsphere;signal amplification system;semi-homogeneous method;progestins;milk
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高影响因子
FUEL
·
2022
·
IF 8.035
Qiangqiang Xue,Huilin Yi,Zhengwen Li,Zhao Jiang,Meng Chen,Yujun Wang,Binhang Yan,Guangsheng Luo
Surface modification of 600-µm-sized monodisperse gamma-alumina microspheres into magnesium–aluminum spinel, and co-impregnation-based loading of Rh–Ni (0.46 wt% Rh, 9.03 wt% Ni) were performed to synthesize catalysts for diesel-steam-reforming to hydrogen. The intimate interactions between Rh and Ni, the formation of the Rh–Ni alloy, and the Rh-doping-induced decrease in the particle size of Ni were determined. The DFT calculations results revealed that Rh-doped Ni(1 1 1) established remarkably weak bonds with oxygen-containing intermediates, and the reaction barrier of the rate-limiting step (CH 2 * + O* → CH 2 O*) on Rh–Ni(1 1 1) (0.76 eV) was lower than those of Ni(1 1 1) (1.14 eV) and Rh(1 1 1) (1.56 eV). The bimetallic catalyst shows the enhanced activity and resistance of sintering and carbon deposition compared with those of Ni-based (9.33 wt% Ni) and Rh-based (0.47 wt% Rh) catalysts. The catalytic performance of Rh–Ni-based catalyst was superior to that of physically mixed Ni-based and Rh-based catalysts at similar active metal loadings, which further confirmed the synergistic effect of Rh–Ni.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Yuling Shi,Qing Liu,Qianqian Pan,Danlong Yang,Tao Wang
Polymer@metal core-shell microspheres are widely used in anisotropic conductive adhesives (ACAs). Styrene-divinylbenzene copolymer (PS-DVB) copper core-shell microspheres (PS-DVB@Cu) with high conductivity and anti-oxidation performance were successfully prepared by combining copper nanoparticles (Cu NPs) and electroless plating copper. The Cu NPs served as catalytic seeds, substituting noble metals to promote electroless deposition . Using environmentally benign ammonia borane as the reductant to replace toxic formaldehyde, the dense copper film was deposited on the surface of PS-DVB microspheres. The thickness of the Cu layer and bulk electrical resistivity of PS-DVB@Cu were tuned by controlling the concentration of the reducing agent. The minimum resistivity of PS-DVB@Cu was 3.27 × 10 −6 Ω·m and merely slightly changed in the air for two months. The prepared PS-DVB@Cu-based ACAs could be effectively applied to anisotropic conductive connections in small-scale circuits with satisfactory anisotropic conductivity.
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