ANALYST
·
2025
·
IF 3.3
Jingwen Li,Yifei Li,Kai Zhang,Xiaomei Liu,Yuguo Tang,Kun Han
We developed a novel fluorescence detection method utilizing graphene quantum dots (GQDs) and manganese dioxide (MnO2) nanocomposites to enhance the sensitivity and specificity of in vitro monitoring of Bcl-2 gene expression, a key factor in tumor survival and treatment resistance. This method leverages the interplay between reduced glutathione (GSH) and hairpin DNA structures (H1 and H2) to simulate a cellular environment, enabling the redox-mediated disintegration of MnO2 nanosheets and the release of GQDs, restoring fluorescence. The presence of the Bcl-2 gene triggers a catalytic hairpin assembly (CHA) reaction, amplifying the Cy3 fluorescence signal and achieving a detection limit of 20.7 pM. The system demonstrated high specificity and stability, validated through control experiments with various DNA sequences. Optimization of key parameters, including MnO2 nanosheet concentration, GSH levels, and the ratio of hairpins H1 and H2, was critical for maximizing assay performance. The MnO2 nanosheets quench GQDs fluorescence and act as carriers for DNA probes, which are released upon reduction by GSH, mimicking intracellular redox conditions. The CHA reaction further amplifies the signal, allowing sensitive detection of low target gene levels. This biosensing platform integrates the unique properties of GQDs and MnO2 nanosheets, offering a real-time, sensitive, and selective method for monitoring Bcl-2 gene expression. This approach holds significant promise for early cancer diagnosis and personalized treatment strategies.
研究领域:
纳米技术
·
生物化学
·
分子生物学
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生物医学工程
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癌症研究
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale Horizons
·
2024
·
IF 8
Yingnan Qin,Tongzhu Han,Ligang Chen,Kexin Yan,Jing Wang,Ning Wang,Baorong Hou
Marine biofouling severely limits the development of the marine economy, and reactive oxygen species (ROS) produced by electrocatalytic antifouling techniques could inactivate marine microorganisms and inhibit the formation of marine biofouling. Compared with an electro-Fenton reaction, a three-electron oxygen reduction reaction (3e− ORR) could generate a hydroxyl radical (˙OH) in situ without the limitation of pH and iron mud pollutants. Herein, Ov-rich γ-MnO2 is designed to enhance the 3e− ORR performance in neutral media and exhibits excellent sterilization performance for typical marine bacteria. DFT calculation reveals that Ov is beneficial to the “end-on” adsorption and activation of O2, and the Mn site could accept the electrons from *OOH and promote its further reduction to form ˙OH; Ov and Mn sites together guarantee the high 3e− ORR efficiency. In addition, liquid chromatography–tandem mass spectrometry (LC–MS/MS) proves the vast formation of ˙OH in the primary reaction stage, which is the key to sterilization. This work explores the reaction mechanism of the 3e− ORR in neutral media and provides the possibility for the application of electrocatalysis technology in the treatment of marine biofouling pollution.
研究领域:
电化学
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材料科学
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环境科学
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海洋生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Energy Materials
·
2022
·
IF 6.959
Shumin Zheng,Dianming Li,Wenbiao Li,Jun Chen,Xianfa Rao,Nü Wang,Jian Qi,Bao Wang,Shuangjiang Luo,Yong Zhao
Freestanding electrodes are critical for lithium-ion batteries (LIBs) and sodium-ion batteries (SIBs) with high energy density and long cycling stability. We fabricated freestanding MnO2 nanosheet-coated carbon nanofibers by synchronous in situ spraying of MnO2 nanosheets onto electrospinning polymer nanofibers, which might be a high-voltage electric field-induced assembly process. The designed film is used as anode material for LIBs and SIBs. It demonstrates good cycling stability without capacity loss after long cycling for LIBs, delivers a capacity of 256.4 mAh g–1 at 1.00 A g–1, and has an extremely stable cycle life for over 200 cycles at 0.05 A g–1. For SIBs, it delivers a capacity of 135.0 mAh g–1 at 1.00 A g–1 and has a stable cycle life for over 500 cycles at 0.50 A g–1. The capacitive contribution ratio increases from 44.4 to 76.2% (0.2–1.0 mV s–1), and the capacitive process plays a major role in the total capacity. The enhancement of the electrochemical performance is attributed to the good conductivity of the carbon nanofiber network and the one-dimensional (1D)/two-dimensional (2D) composite structure of the electrode, in which the high performance of carbon nanofibers and MnO2 nanosheets is fully exploited. Importantly, the combination of in situ spraying and electrospinning can be extended to two or more materials with different polarities, ζ-potential values, or solubilities, broadening the applications of composites.
研究领域:
材料科学
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电化学
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能源存储
✓ 已验证
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2022
·
IF 6.371
Jiahao Zu,Weitao Jing,Xin Dai,Zheng Feng,Junjie Sun,Qiang Tan,Yuanzhen Chen,Yongning Liu
Lithium-sulfur (Li-S) batteries have attracted enormous attentions as new-generation energy storage devices due to their high theoretical energy density , high theoretical specific capacity, low cost and environmental friendliness. However, polysulfide shuttle and the growth of lithium dendrites significantly restrain the practical application of the Li-S batteries. In this work, a modified PP separator with nanoscale rod-like α-MnO 2 supported on carbon nanotubes was prepared. The α-MnO 2 @CNT modified separator can effectively inhibit the shuttle of polysulfide , enhance the electrochemical activity and accelerate the transfer of ions and electrons. The density functional theory (DFT) calculations demonstrate that α-MnO 2 @CNT can efficiently adsorb and catalyze the conversion of polysulfides. Due to these advantages, the α-MnO 2 @CNT-based Li-S battery delivers a initial discharge capacity of 1469 mAh g −1 at 0.05 C, 1039 mAh g −1 at 0.5 C and the capacity can still maintain 648 mAh g −1 over 500 cycles at 0.5 C (capacity decay rate of 0.075%). Expressly, the capacity decay rate is only 0.022% after 600 cycles at a high current density of 2 C. The excellent performance could be attributed to the α-MnO 2 @CNT modified separator not only accelerating the transmission of electrons but also effectively inhibiting the shuttle of polysulfides. Moreover, this work provides a better idea for practical applications of lithium-sulfur batteries in the future.
研究领域:
材料科学
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电化学
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能源存储
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电池技术
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Ping Shen,Yuanyuan Hu,Shanguo Ji,Hao Luo,Cuiping Zhai,Kai Yang
Hydrogel electrolytes are an attractive class of conductive materials for flexible energy storage devices given their reassuring flexibility and stable electrochemical performance . However, it still remains a challenge to assemble the smart battery with mechanical stability and self-healing property when suffering from inevitable physical damages. Here, a novel Zn 2+ -based polyacrylamide/halloysite nanotubes (PAAm/HNTs) nanocomposite hydrogel electrolyte is designed and prepared through rigid HNTs doped into the chemical cross-linked PAAm network. The PAAm/HNTs hydrogel with tensile performance, self-healing property and extended Zn 2+ transport channels was used as hydrogel electrolyte in Zn/MnO 2 batteries which possess an initial capacity of 347 mA h g 1 at a current density of 0.2 A g –1 with good cycle stability. This work offers an effective design method to improve strength , self-healing and fatigue resistance of nanocomposite hydrogel electrolytes which would provide alterative view for the construct of hydrogel electrolytes with desirable properties.
研究领域:
材料科学
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电化学
·
能量存储
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yifan Zhang,Sylvestre Ndayiragije,Ming Chen,Xiaobo Wang,Lihua Zhu,Nan Wang
Fe- and nitrogen-doped carbonaceous (Fe-N-C) sites supported on MnO 2 (Fe-N-C@MnO 2 ) were prepared by a solvent-free mechanochemical method for peroxymonosulfate (PMS) activation to degrade norfloxacin (NFX). After a 50-min ball milling of iron(II) phthalocyanine (Fe( II )Pc) and MnO 2 at a weight ratio of 7.5 %, the obtained Fe-N-C@MnO 2 exhibited exceptional activity in PMS activation, achieving nearly complete degradation of NFX in 5 min with a rate constant of 0.62 min −1 . This rate constant was 11.5 and 28.2 times higher than that for milled MnO 2 (bm-MnO 2 ) and the mixture of Fe( II )Pc and MnO 2 , respectively. Alternative iron sources (FeSO 4 , FeCl 2 , Fe(III)-EDTA) and phthalocyanine showed no enhancement. Characterization revealed Fe-N-C@MnO 2 possessed abundant Mn 3+ , oxygen vacancies and Fe-N-C sites. Combined experimental and computational studies demonstrated Fe-N-C@MnO 2 simultaneously enhanced the 1 O 2 generation and facilitated the formation of SO 4 •− , •OH and O 2 •− , with contributions to NFX degradation following: 1 O 2 > •OH ≈ O 2 •− > SO 4 •− . This work establishes mechanochemical coordination engineering as a facile strategy for constructing high-performance metal-N-C hybrid catalysts.
研究领域:
环境科学
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催化
·
材料化学
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机械化学
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水处理
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Fei Tong,Zan Yang,Zheng Wang,Wenya Liu,Wanqi Jiang,Lu Zhu,Lei Wang,Mingming Zheng,Ruyan Hou,Yibin Zhou,Yingnan Liu
In view of the potential hazards of organophosphorus pesticides (OPs), this paper constructed a ratiometric fluorescent probe utilizing a functionalized metal–organic framework to detect OPs. Ru(bpy) 3 Cl 2 was encapsulated inside UiO-66 as a reference signal, and MnO 2 nanosheets (MnO 2 NSs) were grown on the surface to obtain [email protected] @MnO 2 NSs. Acetylcholinesterase catalyzed the decomposition of acetylcholine into reductive thiocholine, which consumed MnO 2 NSs, thus restoring the [email protected] fluorescence. Due to the enzymatic inhibition of OPs and the redox reaction between MnO 2 NSs and thiamine, this probe emitted blue fluorescence in the presence of OPs. The probe achieved linear responses to dichlorvos and chlorpyrifos with LODs of 9.99 × 10 -6 μg mL −1 and 9.99 × 10 -5 μg mL −1 . The probe exhibited a satisfactory recovery rate for OPs in green tea. Furthermore, a hydrogel detection platform was developed by embedding the probe into sodium alginate. Overall, this work provides a visual approach to detect OPs in agricultural products.
研究领域:
分析化学
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环境科学
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材料科学
·
农业科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SOLAR ENERGY MATERIALS AND SOLAR CELLS
·
2023
·
IF 6.9
Menghan Tian,Xueqing Liu,Xungang Diao,Xiaolan Zhong
The conductive polymer polyaniline (PANI) has attracted much attention in the field of electrochromic energy storage device (EESD) due to its rich color changes and good pseudocapacitive properties, however, the operating voltage window and cycling stability of PANI material, as an essential part in the full electrochromic devices , has failed to be fully explored and employed. Herein, we synthesized the PANI and MnO 2 nanocomposite structure via robust one-step electrodeposition approach, forming an intriguing architecture similar to the coral-like nano-porous. The rougher coral-like structure provides a great quantity nano porous ion transport channel, which greatly improves the working voltage range and cycling stability of the electrode, and shows great potential as an anode electrode for EESDs. In addition, we built a complementary full EESD prepared with tungsten oxide (WO 3 ) as the counter electrode, which has both electrochromic and energy storage dual function integration, allowing real-time observation of the EESD operating state based on color change. It can work stably under a large voltage window of -2V–1.5V, with good bistable performance, fast response speed and more than 1000 times electrochemical cycle life. This work provides a new opportunity to design next-generation high-performance and intelligent hybrid energy storage system for consumer electronics.
研究领域:
材料科学
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电化学
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纳米技术
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能量存储
·
电致变色器件
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 17
·3677-3688
·
IF 6.331
Lei Zhang,Ruihao Yang,Honglian Yu,Zhigang Xu,Yuejun Kang,Hongjuan Cui,Peng Xue
Silk fibroin (SF), derived from Bombyx mori, is a category of fibrous protein with outstanding potential for applications in the biomedical and biotechnological fields. In spite of its many advantageous properties, the exploration of SF as a versatile nanodrug precursor for tumor therapy has still been restricted in recent years. Herein, a multifunctional SF-derived nanoplatform was facilely developed via encapsulating the photosensitizer chlorin e6 (Ce6) into MnO2-capped SF nanoparticles (NPs). SF@MnO2 nanocarriers were synthesized through a surface crystallization technique, using SF as a reductant and sacrificial template. Afterwards, Ce6 was covalently incorporated into the loose structure of the SF@MnO2 nanocarrier on the basis of adsorption to abundant peptide-binding sites. To modulate the tumor microenvironment (TME), SF@MnO2/Ce6 (SMC) NPs were capable of catalyzing the decomposition of H2O2 into O2, which can be converted into cytotoxic reactive oxygen species (ROS) during photodynamic therapy (PDT). Moreover, the MnO2 component was able to oxidize intracellular glutathione (GSH) into non-reducing glutathione disulfide (GSSG), and the consumption of GSH could significantly protect the local ROS from being reduced, which further augmented the therapeutic outcome of PDT. Via another angle, SMC NPs can produce strong hyperthermia under near-infrared (NIR) light activation, which was highly desirable for efficient photothermal therapy (PTT). Both in vitro and in vivo studies demonstrated the intense tumor inhibitory effects as a result of augmented PTT/PDT mediated by SMC NPs. We believe that this study may provide useful insights for employing SF-based nanocomposites for more medical applications in the near future.
研究领域:
生物医学工程
·
纳米医学
·
癌症治疗
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2023
·
IF 10
Yi Lu,Xinni Pan,Cheng Cao,Shanshan Fan,Haisong Tan,Shengsheng Cui,Yanlei Liu,Daxiang Cui
As one of the most widely used drugs, acetaminophen, is the leading cause of acute liver injury. In addition, acetaminophen-induced liver injury (AILI) has a strong relationship with the overproduced reactive oxygen species, which can be effectively eliminated by nanozymes. To address these challenges, mesoporous PdPt@MnO 2 nanoprobes (PPM NPs) mimicking peroxide, catalase, and superoxide dismutase-like properties are synthesized. They demonstrate nontoxicity, high colloidal stability, and exceptional reactive oxygen species (ROS)-scavenging ability. By scavenging excessive ROS, decreasing inflammatory cytokines, and inhibiting the recruitment and activation of monocyte/macrophage cells and neutrophils, the pathology mechanism of PPM NPs in AILI is confirmed. Moreover, PPM NPs’ therapeutic effect and good biocompatibility may facilitate the clinical treatment of AILI.
研究领域:
纳米技术
·
药理学
·
肝病学
·
生物化学
·
治疗学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2020
·Vol. 12
·期 23
·12508-12521
·
IF 6.895
Qian Li,Junjie Ren,Qiubing Chen,Weiwei Liu,Zhigang Xu,Yang Cao,Yuejun Kang,Peng Xue
Hollow mesoporous copper sulfide nanoparticles (HMCuS NPs) are advantageous for loading small-molecule therapeutic drugs coupled with photothermal ablation for synergistic tumor therapy. However, treatment efficacy mediated by HMCuS NPs is not always satisfactory owing to their insensitivity toward the tumor microenvironment (TME), and unpredictable drug leakage may also result in deleterious systemic toxicity. Here, a novel HMCuS@MnO2-based core–shell nanoplatform was developed as a highly efficient TME modulator, which could alleviate tumor hypoxia, deplete the level of intracellular glutathione (GSH) and trigger the dissolution of Mn2+. Moreover, MnO2, in situ grown on the surface of HMCuS, may act as a gatekeeper by forming a stimulus-responsive plug within the mesoporous structure, which effectively prevented the premature release of encapsulated photosensitizer chlorin e6 (Ce6) and was responsive to the acidic TME for demand-based drug release. Under the condition of 660/808 nm dual-wavelength laser irradiation, hyperthermia-mediated photothermal therapy (PTT) and reactive oxygen species (ROS)-mediated photodynamic therapy (PDT) can be triggered for tumor eradication, which were further enhanced upon the modification of the TME. In the meantime, splendid photoacoustic (PA)/fluorescence (FL)/magnetic resonance (MR) imaging properties of HMCuS@MnO2/Ce6 (CMC) NPs could enable the realization of more precise, reliable and on-demand combination therapy. In a word, this study illustrated a promising approach to strengthen the efficacy of HMCuS-based nanotherapeutics, which would definitely promote the further exploitation of smarter nanoplatforms for synergistic disease management.
研究领域:
纳米医学
·
癌症治疗
·
生物医学工程
·
材料科学
·
成像技术
✓ 已验证
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Tong Zhou,Jisheng Ran,Peifang Xu,Liyin Shen,Yuzhe He,Juan Ye,Lidong Wu,Changyou Gao
The osteoarthritis (OA) symptoms cannot be fully remedied by using only a single functional component because of its complex pathogenesis. Herein, a MnO 2 nanozyme-encapsulated hydrogel was fabricated via dispersing bovine serum albumin (BSA)-MnO 2 (BM) nanoparticles (NPs) into a hyaluronic acid (HA)/platelet-rich plasma (PRP) gel network crosslinked by Schiff base reaction. Due to the self-healing and pH-responsive properties of Schiff base bonds, the hydrogel not only functioned as viscosupplementation but also exhibited pH-responsive release of BM NPs and growth factors in PRP. The BM NPs could attenuate the severe oxidative stress , and the PRP could promote chondrocyte proliferation. In a rat OA model, the HA/PRP/BM hydrogel markedly suppressed cartilage matrix degradation. Both the in vitro and in vivo studies showed that this novel hydrogel platform could inhibit the development of osteoarthritis through a synergetic effect of mechanical dissipation, depressing inflammation, facilitating cartilage repair, and thus has essential application prospects in OA treatment.
研究领域:
生物医学工程
·
组织工程
·
骨科
·
纳米技术
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）