Acta Biomaterialia
·
2023
·
IF 9.7
Yuan-Fu Ding,Xun Xu,Junyan Li,Ziyi Wang,Jingwei Luo,Greta S.P. Mok,Shengke Li,Ruibing Wang
Dual- or multi-modality combination therapy has become one of the most effective strategies to overcome drug resistance in cancer therapy, and the optimized ratio of the therapeutic agents working on the tumor greatly affects the therapeutic outcomes. However, the absence of a facile method to optimize the ratio of therapeutic agents in nanomedicine has, at least in part, impaired the clinical potential of combination therapy. Herein, a new cucurbit[7]uril (CB[7])-conjugated hyaluronic acid (HA) based nanomedicine was developed, in which both chlorin e6 (Ce6) and oxaliplatin (OX) were co-loaded non-covalently at an optimized ratio via facile host-guest complexation, for optimal, combined photodynamic therapy (PDT)/chemotherapy. To maximize the therapeutic efficacy, a mitochondrial respiration inhibitor, atovaquone (Ato), was also loaded into the nanomedicine to limit consumption of oxygen by the solid tumor, sparing oxygen for more efficient PDT. Additionally, HA on the surface of nanomedicine allowed targeted delivery to cancer cells with over-expressed CD44 receptors (such as CT26 cell lines). Thus, this supramolecular nanomedicine platform with an optimal ratio of photosensitizer and chemotherapeutic agent not only provides an important new tool for enhanced PDT/chemotherapy of solid tumors, but also offers a CB[7]-based host-guest complexation strategy to facilely optimize the ratio of therapeutic agents for multi-modality nanomedicine. Statement of significance Chemotherapy remains the most common modality for cancer treatment in clinical practice. Combination therapy by co-delivery of two or more therapeutic agents has been recognized as one of the most effective strategies to improve therapeutic outcome of cancer treatment. However, the ratio of loaded drugs could not be facilely optimized, which may greatly affect the combination efficiency and overall therapeutic outcome. Herein, we developed a hyaluronic acid based supramolecular nanomedicine with facile method to optimize the ratio of two therapeutic agents for improved therapeutic outcome. This supramolecular nanomedicine not only provides an important new tool for enhanced photodynamic therapy/chemotherapy of solid tumors, but also offers insights in using macrocyclic molecule-based host-guest complexation to facilely optimize the ratio of therapeutic agents in multi-modality nanomedicine.
研究领域:
纳米技术
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药学
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肿瘤学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2015
·Vol. 4
·期 4
·1399-1407
·
IF 7.443
Guangyu Zhao,Li Zhang,Jixian Lv,Changle Li,Kening Sun
Hydrothermal self-assembly is a highly efficient and low cost method to prepare graphitic foam from graphene oxides; however, the self-assembly frameworks usually do not have controllable pore structures because of the spontaneous process. In this paper, a hydrothermal synthesis assisted by ammonium peroxo-polymolybdate [(NH4)2Mo2O11] tailoring to fabricate graphitic foam is presented. The foam possesses pore structures which can be controlled by adjusting the rate of charge in the hydrothermal experiments. Furthermore, the foam obtained from a definite rate of charge [(NH4)2Mo2O11 : graphene oxide is 1 : 2 in weight] has a hierarchical pore structure and a through-hole net. In electrochemical energy storage, such unique features are beneficial for providing efficient mass transport as well as abundant, accessible active sites. The graphitic foam was tested for use as self-supported electrodes of Li–O2 batteries (LOBs) and Li ion batteries (LIBs) without any metallic current collectors or organic binders, and the foam frameworks exhibited remarkable lithium ion storage properties in both of the two batteries (e.g., 5500 mA h g−1 at 0.2 A g−1 as LOB cathodes and 250 mA h g−1 at 50 A g−1 as LIB anodes).
研究领域:
材料科学
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能源技术
✓ 已验证
DOI
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2021
·Vol. 38
·期 1
·200-208
·
IF 1.307
Wang Yue,Wang Xiaoxue,She Ping,Guan Dehui,Song Lina,Xu Jijing
D esign and fabrication of functional porous air cathode materials with superior catalytic activity is still the key point for non-aqueous lithium-oxygen(Li-O 2 ) batteries. Herein, inspired by the self-standing three-dimensional(3D) structure of the natural spinach leaves, a unique binder-free and self-standing porous Au/spinach cathode for high-performance Li-O 2 batteries has been developed. The carbonized spinach leaves serve as a superconductive current collector and an ideal porous host for accommodating catalysts. The Au/spinach cathode could offer enough spaces for accommodating the discharge products, shorten the distance of the oxygen and electrolyte diffusion, and promote the oxygen reduction reaction(ORR) and oxygen evolution reaction (OER) processes. This optimized Au/spinach cathode achieved a high specific area capacity of 7.23 mA·h/cm 2 at a current density of 0.05 mA/cm 2 and exhibited excellent stability(280 cycles at 0.05 mA/cm 2 with a fixed capacity of 0.2 mA·h/cm 2 ). The superior performance encourages the construction of more advanced cathode architectures by the use of bio-composites for Li-O 2 batteries.
研究领域:
材料科学
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能源存储
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电化学
✓ 已验证
产品关联
DOI
高影响因子
COMPOSITES PART B-ENGINEERING
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2022
·
IF 11.322
Xinbin Wu,Wei Yu,Wei Xu,Yujun Zhang,Shundong Guan,Zheng Zhang,Shuwei Li,Huanchun Wang,Xuanjun Wang,Liang Zhang,Ce-Wen Nan,Liangliang Li
Lithium-oxygen (Li–O 2 ) batteries are promising next-generation energy storage devices due to their ultrahigh theoretical specific energy. Oxide electrocatalysts such as RuO 2 are often used to improve the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) processes in Li–O 2 batteries, but the relation between the structural parameters and their catalytic properties is unclear so far. In this work, we synthesize RuO 2 nanoparticles at different annealing temperatures and investigate the influence of the Ru–O bond distances of RuO 2 on the OER and ORR processes in Li–O 2 batteries. The results of X-ray absorption fine structure show that the bond distances decrease with the increase of the annealing temperature. The RuO 2 with longer Ru–O bond distances renders a lower charge plateau to Li–O 2 batteries, showing a better OER performance, while that with shorter bond distances gives a larger discharge capacity and is more friendly to the ORR process. The cycle life of Li–O 2 batteries with a carbon nanotube-RuO 2 composite cathode is improved to 287 cycles (1148 h) under an extreme testing condition (the voltage range is 2.3–4.2 V), when the Ru–O bond distances are optimized. In addition, the influence of the Ru–O bond distances on the catalytic properties of RuO 2 is analyzed by density functional theory calculations. The findings in this work provide a guidance to enhance the ORR and OER efficiency of RuO 2 and other oxide catalysts.
研究领域:
材料科学
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电化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2020
·Vol. 8
·期 19
·9813-9824
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IF 11.301
Yue Li,Jian Song,Mengting Jiang,Mbage Bawa,Xiaohong Wang,Yuyang Tian,Guangshan Zhu
Na5[IMo6O24]·3H2O and a porous aromatic framework (iPAF-1) were used to build an off-the-shelf building material (IMo6@iPAF-1) to realize the highly efficient oxidation of organic sulfurs like oxygenase. The synergy between IMo6 and iPAF-1 resulted in a higher BET surface area, hydrophobic microenvironment, and redox sites to show higher activity in aerobic oxidative desulfurization with almost 100% removal of model organic sulfurs under atmospheric pressure with almost 246 times higher TOFs compared to IMo6. It also showed efficiency in the desulfurization of gasoline and diesel to give very low S contents of 7.1 and 7.6 ppm with 99.3% and 99.4% removal, respectively, at 100 °C for 6 h. More importantly, IMo6@iPAF-1 could also catalyze desulfurization using concentrated O2 mixed with N2 or air instead of pure O2 with better safety and economics, while as low as 4.9 and 6.9 ppm S contents were achieved for gasoline and diesel, respectively. The special surroundings of IMo6@iPAF-1 repelled the sulfone product and allowed it to perform with the same efficiency when recycled without any treatment of the used catalyst.
研究领域:
化学
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环境科学
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材料科学
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产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2020
·
IF 9.038
Yong Liu,Ni Tan,Jinrui Guo,Jianlong Wang
In this study, a novel Al°-CNTs-Cu 2 O composite, capable of activating O 2 to generate H 2 O 2 and further to reactive oxygen species (ROSs) at a wide pH range, was synthetized, characterized and applied for the degradation of sulfamerazine. In the activation of O 2 by Al°-CNTs-Cu 2 O composite, H 2 O 2 was generated from the reaction of O 2 with Al°-CNTs, which could be catalytically decomposed into O 2 − and OH by Cu 2 O, the formed Cu(II) could be rapidly reduced to Cu 2 O by Al°-CNTs in composite, which made Al°-CNTs-Cu 2 O composite reusable and decreased the leaching of copper ions into solution. The removal efficiency of SMR and TOC was 73.91 % and 56.80 %, respectively at initial pH = 5.8, T = 20 °C, O 2 flow rate = 100 mL/min, Al°-CNTs-Cu 2 O dosage = 2 g/L, SMR = 50 mg/L, and reaction time = 60 min. The removal efficiency of SMR kept almost unchanged and the concentration of copper ions in solution was below 0.5 mg/L. The Al°-CNTs-Cu 2 O/O 2 process could be used as a novel catalyst for the degradation of refractory organic contaminants in water and wastewater by Fenton-like process at a wide pH range through the in situ generation of H 2 O 2 .
研究领域:
环境科学
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化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Advanced Ceramics
·
2022
·Vol. 11
·期 11
·1801-1814
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IF 11.534
Cheng Fuhao,Zhang Fengnian,Liu Yufeng,Guo Meng,Cheng Chufei,Hou Jiadong,Miao Yang,Gao Feng,Wang Xiaomin
Environmental barrier coatings (EBCs) with excellent chemical resistance and good high-temperature stability are of great significance for their applications in next-generation turbine engines. In this work, a new type of high-entropy fluorite-structured oxide (Ce 0.2 Hf 0.2 Y 0.2 Pr 0.2 Gd 0.2 )O 2− δ (HEFO-1) with different Ti 4+ contents were successfully synthesized. Minor addition of Ti 4+ could be dissolved into a high-entropy lattice to maintain the structure stable, effectively reducing the phase formation temperature and promoting the shrinkage of bulk samples. Heat treatment experiments showed that all the samples remained a single phase after annealing at 1200–1600 °C for 6 h. In addition, high-entropy (Ce 0.2 Hf 0.2 Y 0.2 Pr 0.2 Gd 0.2 Ti 0.2 x )O 2− δ demonstrated great resistance to calcium—magnesium—alumina—silicate (CMAS) thermochemical corrosion. When the content of Ti was increased to x = 0.5, the average thickness of the reaction layer was about 10.5 after being corroded at 1300 °C for 10 h. This study reveals that high-entropy (Ce 0.2 Hf 0.2 Y 0.2 Pr 0.2 Gd 0.2 Ti 0.2 x )O 2− δ is expected to be a candidate for the next-generation EBC materials with graceful resistance to CMAS corrosion.
研究领域:
材料科学
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涂层
·
高温材料
·
腐蚀抗性
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
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2022
·
IF 24.319
Shaomian Liu,Wenjuan Xue,Yongjun Ji,Wenqing Xu,Wenxing Chen,Lihua Jia,Tingyu Zhu,Ziyi Zhong,Guangwen Xu,Donghai Mei,Fabing Su
Simultaneously improving both NO x conversion and N 2 selectivity in the selective catalytic reduction of NO by CO (CO-SCR) under O 2 -containing conditions is highly challenging because of the competitive reactions of NO x and CO with O 2 . Here, we demonstrate that the interfacial oxygen vacancies (IOVs) generated at the Co 3 O 4 -CeO 2 heterointerfaces by ball-milling-induced strain can remarkably boost both NO x conversion and N 2 selectivity in the temperature range of 100–400 °C. The Co 3 O 4 -CeO 2 -IOV catalyst achieved approximately 100% NO x conversion and 100% N 2 selectivity (200–350 °C, 1–5 vol% O 2 , and 20,000 h −1 ); even under 10 vol% O 2 , it still showed good catalytic performance. The spectroscopy analysis and theoretical calculations reveal that compared with O 2 activation, IOVs are more favorable for the rate-limiting step of NO adsorption and dissociation. This work provides an effective strategy to create IOVs within metal oxide composite catalysts using ball-milling-induced interfacial strain for improving CO-SCR performance.
研究领域:
材料科学
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环境催化
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Chufei Cheng,Fengnian Zhang,Fuhao Cheng,Jiadong Hou,Bei Ren,Yang Miao,Libiao Xin,Xiaomin Wang
The sintering process of high entropy fluorite oxide ceramics prepared by the conventional solid-phase reaction method suffers from high single-phase synthesis temperature, low densities, and abnormal grain growth . To improve the sintering characteristics of high entropy fluorite oxide ceramics, the oxide mixture was dealt with dielectric barrier discharge plasma-assisted ball milling. The samples were analyzed using XRD , SEM, TEM, TG/DTG, visual high-temperature deformation analyzer, and nanoindentation meter. The results show that the plasma field activates the raw material powder and promotes powder finer. The rapid heating effect of the plasma during the ball milling process causes micro-area sintering and micro-area melting on the powder surface, which increases the active sites of the solid phase reaction of the material, accelerates the mass transfer process, and improves the sintering activity. Compared with conventional ball milling, plasma-assisted ball milling reduces the single-phase synthesis temperature of high entropy ceramics from 1500 °C to 1300 °C. The sintered ceramic pellets have intact grain growth, no noticeable abnormal grain growth, and improved density and mechanical properties .
研究领域:
材料科学
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陶瓷工程
✓ 已验证
产品关联
DOI
高影响因子
MOLECULES
·
2022
·Vol. 27
·期 17
·5576
·
IF 4.927
Songtao Liu,Rui Yan,Muhammad Humayun,Huanli Zhang,Yang Qu,Yingxue Jin
It is highly desired to enhance charge separation and O2adsorption of the pyropheophorbide-a (Ppa) to promote visible-light activity and stability. Herein, Ppa modified 001-facet-exposed TiO2nanosheets (Ppa/001T) nanocomposites with different weight ratios were fabricated via the self-assembly approach by OH induced. Compared with the bare Ppa, the 8% amount optimized 8Ppa/001T sample displayed 41-fold enhanced activity for degradation of Ametryn (AME) under visible-light irradiation. The promoted photoactivities could be attributed to the accelerated charge carrier’s separation by coupling TiO2as thermodynamic platform for accepting the photoelectrons with high energy from Ppa and the promoted O2adsorption because of the residual fluoride on TiO2. As for this, a distinctive two radicals (•O2−and •OH) involved pathway of AME degradation is carried out, which is different from the radical pathway dominated by •O2−for the bare Ppa. This work is of utmost importance since it gives us detailed information regarding the charge carrier’s separation and the impact of the radical pathway that will pave a new approach toward the design of high activity visible-light driven photocatalysts.Keywords:Ppa;001-facet-exposed TiO2;charge separation;visible-light photocatalysis;Ametryn
研究领域:
材料科学
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环境科学
·
光催化
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Energy Chemistry
·
2022
·
IF 13.599
Dongdong Li,Jinbiao Chen,Yingtong Chen,Yian Wang,Yanpeng Fu,Minhua Shao,Zhicong Shi
Rechargeable aprotic Li-O 2 batteries have attracted increasing attention due to their extremely high capacity, and it is very important to design appropriate strategies to synthesize efficient catalysts used as oxygen cathode. In present work, we present an expedient “instantaneous nucleation and epitaxial growth” (INEG) synthesis strategy for convenient and large-scale synthesis of ultrafine MOCPs nanoparticles (size 50–100 nm) with obvious advantages such as fast synthesis, high yields, low costs and reduced synthetic steps. The bimetallic Ru/Co-MOCPs are further pyrolyzed to obtain bimetallic Co– and low content of Ru-based nanoparticles embedded within nitrogen-doped carbon (Ru/Co@N C) as an efficient catalyst used in Li-O 2 battery. The Ru/Co@N C provides porous carbon framework for the ion transportation and O 2 diffusion, and has large amounts of metal/nonmetal sites as active site to promote the oxygen reduction reaction (ORR)/oxygen evolution reaction (OER) in Li-O 2 batteries. As a consequence, a high discharge specific capacity of 15246 mA h g −1 at 250 mA g −1 , excellent rate capability at different current densities, and stable overpotential during cycling, are achieved. This work opened up a new understanding for the industrialized synthesis of ultrafine catalysts for Li-O 2 batteries with excellent structural characteristics and electrochemical performance.
研究领域:
材料科学
·
电化学
·
能源存储与转换
✓ 已验证
产品关联
DOI
高影响因子
RARE METALS
·
2023
·Vol. 42
·期 6
·1969-1982
·
IF 8.8
Liao Jia-Lin,Zhang Shuai,Bai Tian-Sheng,Ji Feng-Jun,Li De-Ping,Cheng Jun,Zhang Hong-Qiang,Lu Jing-Yu,Gao Quan,Ci Li-Jie
Lithium metal batteries (LMBs) with a high theoretical capacity are seen as a type of the most potential energy storage system. Unfortunately, the growth of lithium dendrite, the irreversible side reactions, and the infinite volume alteration still curb the practical utilization of lithium metal anodes, resulting in low Coulombic efficiency (CE) and safety problems, etc. Herein, we synthesize a lithiophilic 3D copper foam host with uniformly distributed nano-flower-like ZnO particles (CuF/ZnO) and obtain the composite lithium metal anode containing the Li 2 O, LiZn alloy, and pure Li by the infusion of molten Li (CuF/Li 2 O-LiZn@Li). Benefitting from the advantages of the 3D structure of copper foam and the lithiophilicity of ZnO sites, the composite lithium metal anode can restrain the volume alternation and regulate the uniform deposition of lithium. The symmetrical cells of the composite lithium metal anode have a 1600 h long cycle life with a low polarization voltage of 15 mV, and the Coulombic efficiency can maintain about 97.8% at 1.0 mA·cm −2 , 1.0 mAh·cm −2 . Graphical abstract
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）