MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING
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2025
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IF 4.6
Ting Zhang,Ruipeng Hou,Rong Wu,Chen Zhang,Yindi Yu,Wenlong Yang,Shunhang Wei
Limited by rapid carrier recombination, the photocatalytic hydrogen peroxide (H 2 O 2 ) generation performance of Zn 2 In 2 S 5 is far from practical application. Herein, Zn 2 In 2 S 5 /In 2 S 3 S-scheme heterostructures were constructed by employing a one-step hydrothermal strategy that precisely adjusted the Zn:In precursor ratio. Thanks to the band structures with sufficiently redox ability of In 2 S 3 and Zn 2 In 2 S 5 , as well as enhanced carrier separation and transfer efficiency, the optimal Zn 2 In 2 S 5 /In 2 S 3 heterostructures (ZIS/In 2 S 3 -1:4) achieved a sacrificial-agent-free H 2 O 2 production rate of 339.5 μM h −1 under AM 1.5 irradiation, which approximately 1.7 times higher than that of pristine Zn 2 In 2 S 5 . Meanwhile, it also exhibited good H 2 O 2 evolution rate under visible-light irradiation and reusability. Its apparent quantum yield (AQY) at 380 nm, 420 nm, and 450 nm reached to 1.32 %, 1.11 %, and 0.63 %, respectively. In addition, the introduction of In 2 S 3 inhibited H 2 O 2 decomposition and enhanced the selectivity of H 2 O 2 production. In the photocatalytic process, superoxide radicals and holes were the key reactive substances, thereby H 2 O 2 was generated via a two-step single-electron O 2 reduction reaction process and one-step two-electron water oxidation reaction process. The construction strategy of the Zn 2 In 2 S 5 /In 2 S 3 S-scheme heterostructures is expected to provide a new perspective for the design of photocatalysts for efficient H 2 O 2 synthesis.
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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2025
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IF 6.1
Ke Zhang,Xing Zhang,Yaopeng Zheng,Binquan Wang,Xiaoyan Zhang,Yuanyuan Song,Xiaoxiao Luo,Mingkuan Sun
Bisphenol S (BPS), a widely used substitute for Bisphenol A (BPA), has been implicated in neurodevelopmental disorders by numerous studies. While BPS has been known for neurodevelopmental disturbance, the analysis and molecular mechanisms underlying the neurotoxicity are not completely understood. This study utilizes a Drosophila model to investigate the developmental neurotoxicity of BPS and its underlying molecular mechanisms. The results demonstrate that BPS exposure significantly induces abnormal behaviors in Drosophila , including social interaction deficits, increased self-grooming, and impaired locomotor activity. Moreover, BPS disrupts axonal development, leading to abnormal α and β lobes in the mushroom body (MB) and structural damage in the neuromuscular junction (NMJ). NMJ defects are marked by reductions in area, length, perimeter, bouton number, branching, and overall morphological integrity. A genome-wide association study (GWAS) identified Lar as a key mediator of BPS-induced neurotoxicity. Molecular docking simulations and Western blot analyses further confirmed that BPS interferes with the cytoplasmic functions of Lar . Notably, neuronal overexpression of Lar ’s cytoplasmic domain rescued MB and NMJ defects and mitigated BPS-induced behavioral abnormalities. These findings suggest that BPS impairs Lar function, thereby disrupting MB and NMJ morphology and ultimately inducing abnormal behaviors in Drosophila .
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
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2025
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IF 3
Feng Tianxu,Shan Wei,Zhang Yongzhou,Huang Haibo,Tang Hua
Solar photocatalytic degradation and adsorption using metalorganic frameworks (MOFs) offer safe and energy-efficient remediation for water contaminated with small organic pollutants, leveraging their semiconductor-like tunable band structures and inherent porosity. This study reports the de novo synthesis of a visible-light-responsive Ti@Ce MOF heterojunction composite for synergistic photocatalytic degradation and adsorption of recalcitrant organic contaminants. An in-situ growth strategy deposited NO.-functionalized UiO-66(Ce) onto NH 2 -modified MIL-125, forming an S-scheme heterojunction engineered for efficient visible-light-driven hydrogen peroxide (H 2 O 2 ) generation. This in-situ photogenerated H 2 O 2 acts as a potent oxidant, effectively degrading tetracycline. A significantly enhanced photocatalytic degradation rate constant ( k ) for tetracycline was observed, indicating boosted catalytic activity. Mechanistic analysis underscores the critical role of the S-scheme heterojunction in promoting charge carrier separation and enhancing H 2 O 2 production, thereby efficiently driving organic pollutant oxidative degradation. This work provides a novel strategic framework for designing multifunctional MOF composites, advancing high-performance, sustainable water purification technologies.
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Cell Death Discovery
·
2026
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IF 10.4
Wei Ziyi,Wu Ren,Ruan Jiawen,Yang Jiahe,Fu Xinxin,Li Yashi,Jiao Lijie,Xiang Lifei,Yu Dan,Yan Guoliang,Zhang Lili,Li Hongzhu
Diabetic vasculopathy represents one of the most serious complications of type 2 diabetes mellitus (T2DM). Growing evidence suggests that its pathogenesis is closely linked to chronic inflammation-driven phenotypic switching of vascular smooth muscle cells (VSMCs), which under hyperglycemic conditions exhibit heightened proliferative and migratory activity. While hydrogen sulfide (H₂S) is known for its antioxidant and anti-inflammatory roles in diabetic vasculopathy, the specific mechanisms by which H₂S alleviates these abnormal VSMCs phenotypes in T2DM remain unclear. Using T2DM mice and mouse aortic vascular smooth muscle cells (MOVAS) cultured under high-glucose-high-fat (HGHF) conditions, we observed a marked decrease in both the expression of the H₂S-synthesizing enzyme cystathionine γ-lyase (CSE) and endogenous H₂S production. These changes were accompanied by elevated oxidative stress, activation of the NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome, and enhanced MOVAS proliferation and migration. Notably, the H₂S donor NaHS reversed these changes. Further investigation into protein S-sulfhydration revealed that H₂S promotes the S-sulfhydration of thioredoxin reductase 1 (TrxR1). Through pharmacological inhibition and rescue experiments, we demonstrated that H₂S mediates S-sulfhydration at the Cys611 residue of TrxR1, thereby regulating its enzymatic activity and influencing the thioredoxin 1 (Trx1)–thioredoxin-interacting protein (TXNIP)–NLRP3 signaling axis. This process leads to suppression of inflammasome activation and contributes to the antioxidant, anti-inflammatory, anti-migratory, and anti-proliferative effects observed in MOVAS. Our study reveals a novel pathway whereby H₂S alleviates diabetic vascular complications via TrxR1 S-sulfhydration at Cys611 and subsequent inhibition of the Trx1–TXNIP–NLRP3 axis, highlighting a promising therapeutic target.
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JOURNAL OF HAZARDOUS MATERIALS
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2025
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IF 11.3
Jiaqi Hu,Mingyue Wang,Min Wang,Dandan Wang,Yuqiang Xiao,Yue Lan,Lingling Li,Meiling Yang,Minmin Wang,Leijiao Peng,Famin Ke,Xiurong Guo,Die Gao
Considering the efficient utilization of resources and the simultaneous detection of multiple analytes, achieving selective detection of diverse analytes on one fluorescent covalent organic framework (COF) is of great significance. Herein, a carboxyl-carbazole-rich fluorescent COF (COF-DABT) was strategically synthesized using 3,6-diamino carbazole, capable of forming halogen bonds with analytes, and 2,5-bis(4′-formylphenyl) terephthalic acid, rich in carboxyl groups, which interacts with various analytes and adjusts fluorescence performance via its electron-withdrawing properties. The introduction of carbazole imparts fluorescence to COF-DABT through the intramolecular charge transfer (ICT) effect, while enabling selective fluorescence quenching. Specifically, the ICT of carbazole can be disrupted via linear halogen bond interactions with TBBPS, resulting in selectively detection of TBBPS in a fluorescence-off mode. Furthermore, efficient enrichment of TBBPS is facilitated by halogen bonds with carbazole and hydrogen bonds with carboxyl groups on COF-DABT. Selective fluorescence quenching of COF-DABT by Fe 3 + is achieved through chelating effect around carboxyl group, as well as cation-π interaction with carbazole benzene ring. This enables high selectivity detection of Fe 3+ via a fluorescence-off mode. Additionally, Fe 3+ can be reduced by ascorbic acid through REDOX reaction, mitigating interference with TBBPS detection and facilitating fluorescence-off-on mode detection of AA. Besides, rich carboxyl groups on COF-DABT exert a negative regulatory effect on the carbazole ICT mechanism. To counter this, D/L-Arg, with a size complementary to the adjacent carboxyl groups on COF-DABT, is introduced. Hydrogen bond interactions between D/L-Arg and carboxyl groups reduce the negative regulatory effect, allowing fluorescence enhancement for highly selective detection of D/L-Arg. Through rational design and functional optimization of fluorescent COF structures, multi-mode detection methods enable simultaneous detection of different analytes, achieving the goal of "one stone, several birds."
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2025
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IF 21.1
Xiao Chen,Yating Hou,Jinghan Xu,Ningyuan Song,Xinru Wei,Yanru Liu,Kang Liu,Yunmei Du,Lei Wang
Nowadays, the electrocatalytic regulation mechanism of quantum dots (QDs)-supported materials is limited to strong metal-support interaction (SMSI) and electron-metal-support interaction (EMSI). However, the lattice strain of the carrier induced by QDs is neglected, which is not conducive to the directional design of the QDs-supported electrode and the establishment of its structure-performance correlation. Given these, the size and distribution of Pt QDs controlled by electrodeposition effectively regulate the strain degree on S-NiFeP nanosheets. DFT results reveal that Pt@S-NiFeP/NF complies with a Fe-Pt dual active sites mechanism for alkaline HER, and a Fe active site mechanism for OER. Interestingly, the compressive strain in the S-NiFeP substrate effectively promotes the d‐band center shift and the energy barrier reduction, thereby optimizing the alkaline HER and OER kinetics. As expected, Pt@S-NiFeP/NF with appropriate strain owns alkaline HER and OER performance at 1 A cm −2 that exceeds the commercial Pt/C and RuO 2 . Overall, this work has guided the structural design of the 'noble metal QDs@carrier' model and laid a foundation for its application at ampere-level current densities.
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Nature Chemical Biology
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2024
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IF 12.9
Wang Shiwen,Liu Min,Hu Dongping,Dong Zhicheng,Zhao Zhong
Superoxide anion is thought to be a natural by-product with strong oxidizing ability in all living organisms and was recently found to accumulate in plant meristems to maintain stem cells in the shoot and undifferentiated meristematic cells in the root. Here we show that the DNA demethylase repressor of silencing 1 (ROS1) is one of the direct targets of superoxide in stem cells. The Fe–S clusters in ROS1 are oxidized by superoxide to activate its DNA glycosylase/lyase activity. We demonstrate that superoxide extensively participates in the establishment of active DNA demethylation in the Arabidopsis genome and that ARABIDOPSIS RESPONSE REGULATOR 12 acts downstream of ROS1-mediated superoxide signaling to maintain stem cell fate. Our results provide a mechanistic framework for superoxide control of the stem cell niche and demonstrate how redox and DNA demethylation interact to define stem cell fate in plants.
研究领域:
植物生物学
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表观遗传学
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干细胞生物学
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高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
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2021
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IF 9.028
Yang Yang,Rui Huang,Wenqing Xu,Jixiang Zhang,Chaoqun Li,Jianfei Song,Tingyu Zhu
ZnS is a promising sorbent in recovering Hg0 from industrial flue gas due to its excellent Hg0 adsorption capacity. However, the internal structure–activity relationship still needs to be further clarified. In this work, ZnS sorbents with different structures were synthesized with the hydrothermal method by tuning the temperature. The samples had significant differences in the crystallinity, morphology, particle size, and sulfur (S) active sites. The results indicated that Hg0 removal performance was determined by the specific surface area and S active sites. ZnS synthesized at low temperatures (80-ZnS and 120-ZnS) had a larger surface area, while the S sites on the high-temperature-synthesized sample (160-ZnS) were more active for Hg0 adsorption. The 160-ZnS sample exhibited a much higher Hg0 adsorption amount per unit surface area. Further characterization revealed that S22– and Sx were the main active sites for Hg0 adsorption. Sx existed in the form of long-chain polysulfur (L-Sx) on 80-ZnS and 120-ZnS, while it exhibited in the form of short-chain polysulfur (S-Sx) on 160-ZnS. L-Sx had negligible adsorption ability, while S-Sx had a high affinity for Hg0. Hg0 can react with S22– and S-Sx, forming α-HgS and β-HgS, respectively. The new insight in this work can provide theoretical guidance for the design and structure optimization of ZnS, facilitating its practical industrial application.
研究领域:
环境科学
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材料科学
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化学工程
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CANADIAN JOURNAL OF PLANT SCIENCE
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2015
·Vol. 95
·期 5
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IF 0.919
ZhaoLi-Xia,QuHai-Tao,FuYing,GaoShuang,YeFei
Zhao, L.-X., Qu, H.-T., Fu, Y., Gao, S. and Ye, F. 2015. Alleviation of injury from chlorimuron-ethyl in maize treated with safener 3-dichloroacetyl oxazolidine. Can. J. Plant Sci. 95: 897–903. The protective effects of herbicide safeners, including 3-dichloroacetyl-2,2-dimethyl-1,3-oxazolidine (R-28725), 3-dichloroacetyl-2,2-dimethyl-4-ethyl-1,3-oxazolidine (Racemate), and its two enantiomers (R)-3-dichloroacetyl-2,2-dimethyl-4-ethyl-1,3-oxazolidine (R-enantiomer) and (S)-3-dichloroacetyl-2,2-dimethyl-4-ethyl-1,3-oxazolidine (S-enantiomer), on reducing the phytotoxicity of chlorimuron-ethyl to maize were investigated. Soaking the seeds in safeners increased the endogenous glutathione (GSH) content and glutathione-S-transferase (GST) activity of maize. When induced by R-enantiomer, the GST activity in vivo and in vitro increased 180 and 192% compared with control, respectively. R-28725 and R-enantiomer also increased the acetolactate synthase (ALS) activity inhibited by chlorimuron-ethyl from 45 to 100 and 97% compared with the control, respectively. The kinetic parameter Vmax of GST in the maize treated with R-28725 and R-enantiomer increased by 103 and 92%, respectively, compared with the control. Our results suggest that R-28725 and R-enantiomer could significantly improve the GSH content, GST activity, and ALS activity of maize. Overall, maize could be protected from the injury caused by chlorimuron-ethyl.
研究领域:
植物科学
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农业化学
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2022
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IF 5.999
Xiaomei Dai,Xiaojun Liu,Lele Yang,Siyuan Yuan,Qingqing Xu,Yu Li,Feng Gao
Intracellular bacterial infections pose enormous challenges to food safety and public health. Antibiotic-based polymer prodrugs have been used to treat intracellular bacterial infection. However, the overuse of antibiotics may lead to the emergence of antibiotic resistance . In this work, we aimed to develop antibiotic-free pH-responsive polymeric prodrugs to combat intracellular S. aureus infection. Amphiphilic poly(ethylene glycol)- b -poly[(3-phenylprop-2-ene-1,1-diyl)bis(oxy)bis(enthane-2,1- diyl)diacrylate] (PEG- b -PCAE) was obtained by radical polymerization and they could self-assemble to form micelles . PEG- b -PCAE micelles could uptake by macrophage. Upon exposure to the acidic phagolysosome, PEG- b -PCAE micelles could release cinnamaldehyde (CA) through hydrolysis of the acetal linkage. PEG- b -PCAE could kill intracellular bacteria by damaging the bacterial membrane. Furthermore, PEG- b -PCAE micelles could generate reactive oxygen species (ROS) in macrophages and subsequently activate immune system to clear bacteria by inducing macrophages differentiation to M1 phenotype. PEG- b -PCAE micelles could accelerate the wound healing process of the S. aureus -infected model in vivo . It is anticipated that multifunctional antibiotic-free PEG- b -PCAE micelles with intrinsic antibacterial activities hold promise for improved outcomes in intracellular S. aureus infections.
研究领域:
微生物学
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免疫学
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药物化学
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Journal of Water Process Engineering
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2025
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IF 6.7
Leikai Ye,Fangyan Chen,Yubin Tang,Wenqian Sun,Yanhua Song
At present, the rapid, sensitive, and highly selective detection of trace organic contaminants is a research spot in the field of environment. Herein, a novel fluorescent nanoprobe N, S-CDs@MIP based on N/S co-doped carbon quantum dots (CDs) coupled with amoxicillin molecularly imprinted polymer was synthesized. The fluorescent property of N, S-CDs@MIP and fluorescence quenching level of amoxicillin to N, S-CDs@MIP was explored. Furthermore, the fluorescence analysis method based on N, S-CDs@MIP probe for quantitatively detecting amoxicillin was established. The synthesized N, S-CDs@MIP has a maximum fluorescence emission wavelength of 440 nm and a significantly selective fluorescence response toward amoxicillin with a large imprinting factor of 4.07. For the developed fluorescence analysis method, the detection limit, the linear range of the standard curve, and relative standard deviation (RSD) were obtained as 1.17 ng/mL, 5.8–200 ng/mL, and <3 %, respectively. The real environmental water samples were measured with a high accuracy with the recovery of 83.6 % ~ 104.7 % and RSD of 2.3 % ~ 5.1 %. Compared to the HPLC-UV, HPLC-MS, and the fluorescence detection method based on CDs or doped CDs, the established fluorescence detection method exhibits high selectivity, wide linear range, and low detection limit. It is greatly promising in the quick detection of trace amoxicillin.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2025
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IF 6.3
Feng Zhu,Haibin Niu,Xiaoming Li,Shaoqing Zhang,Xiutao Yang,Hongwen Yu,Guopeng Zhu
Hydrogen production via photocatalytic water splitting holds great promise for efficient solar energy conversion. While ZnIn₂S₄ (ZIS) exhibits a suitable band structure for visible-light-driven hydrogen production, its practical application is significantly limited by low charge separation efficiency and poor stability. This work pioneers an acousto-hydrothermal strategy utilizing high-frequency ultrasonic atomization to synthesis structurally optimized ZIS. Systematic characterization reveals that ultrasonic cavitation compresses crystal lattices to enhance Zn 3d-S 3p orbital hybridization, assembles nanosheets with a 20 % increased surface area, leading to enhanced charge separation efficiency. The optimized ZIS demonstrates significantly enhanced photocatalytic activity and stability. It achieves a remarkable hydrogen evolution rate of 51.8 mmol g⁻¹ h⁻¹ under 455 nm visible light irradiation, representing an 86 % improvement over pristine ZIS. After a 15 h reaction, the catalytic system produces 8.3 mmol of H₂ (185.9 mL at standard conditions). This work presents an innovative strategy for designing nanosheet-based materials to achieve high-efficiency photocatalytic hydrogen evolution.
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