COMPOSITES PART B-ENGINEERING
·
2020
·
IF 7.635
Jueying Yang,Yu Chen,Lin Zhao,Zhipan Feng,Kelin Peng,Ailing Wei,Yalun Wang,Zongrui Tong,Bin Cheng
The preparation of hydrogel wound dressing materials with high antibacterial activities and good biosafety simultaneously can be relatively challenging. Aiming at solving this crucial problem, a multi-functional chitosan/carboxymethyl chitosan/silver nanoparticles (CTS/CMCTS/AgNPs) polyelectrolyte composite physical hydrogel is constructed by in situ photoreduction of silver ions with α-hydroxy of CMCTS and semi-dissolution acidification sol-gel transition (SD-A-SGT) methods using natural polymers with no chemical reductant involved. The XRD , TEM and IR characterizations reveal a highly uniform structure of the composite hydrogel with good mechanical strength . The composite hydrogel also exhibits good self-healing ability, and the self-healing mechanism of the composite hydrogel prepared by natural polymers with high similarity is put forward on the basis of molecular dynamics simulation. The AgNPs gives the hydrogel excellent antibacterial activities against both S. aureus and P. aeruginosa ., while the preparation method with no chemical reductant and crosslinking agent required endows the hydrogel high biocompatibility. The great application potentials of CTS/CMCTS/AgNPs polyelectrolyte composite hydrogel are demonstrated with its promoting effects on the healing of P. aeruginosa infected wounds as the wound dressing. It is a breakthrough in achieving hydrogels with desired biosafety and antibacterial activities simultaneously. The composite hydrogel is found with great application potentials as wound dressing.
研究领域:
材料科学
·
生物材料
·
纳米技术
·
生物医学工程
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DOI
高影响因子
International Journal of Nanomedicine
·
2025
·
IF 6.5
Mengya Jin,Jinming Liu,Mengliu Shao,Shaoqin He,Yue He,Qingliang Yang,Gensheng Yang
Background/Objective Pulmonary fibrosis is a chronic, progressive lung disease with a high mortality rate. Currently, the treatment options for IPF involve the oral administration of nintedanib (NDNB); however, these therapies are hampered by low oral bioavailability. This study aimed to develop chitosan-based nanoparticles for pulmonary delivery to enhance the therapeutic effects of curcumin (Cur) and NDNB.Methods We successfully prepared and optimized Cur-loaded chitosan nanoparticles (Cur/CS-VES NPs) and NDNB-loaded chitosan nanoparticles (NDNB/CS-PGA NPs) through a standardized process. In vitro, Calu-3 and HFL1 cells were treated to evaluate the biocompatibility of chitosan nanocarrier materials and the antifibrotic activity of drug-loaded nanoparticles, respectively. In vivo, the bleomycin-induced rat models of pulmonary fibrosis were established to study the efficacy of chitosan nanoparticles.Results In vitro experiments indicated that the drug-loaded chitosan nanoparticles exhibited good stability and low cytotoxicity. In vivo pharmacodynamic studies revealed that, compared with oral administration of Cur or NDNB alone, the pulmonary delivery of Cur/CS-VES NPs and NDNB/CS-PGA NPs effectively inhibited the progression of pulmonary fibrosis, improved lung function, reduced levels of inflammatory factors, and mitigated pathological lesions in the lungs. These findings suggest that chitosan-based nano-particles have promising potential as pulmonary inhalation agents for the treatment of pulmonary fibrosis.Conclusion These findings highlight the great potential of chitosan-based nanoparticles as a therapeutic strategy for treating IPF and related pulmonary fibrosis with pulmonary delivery pathways.
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产品关联
DOI
PubMed
高影响因子
NANO
·
2025
·
IF 1.1
Guangyu Wu,Fangzhou Wen,Lini Huo,Peiyuan Li
In this study, a novel chitosan carbon dot/quercetin (CS-CDs/Que) composite nanosystem was constructed. Utilizing the abundant carbon, nitrogen, hydroxyl, and amino functional groups in the molecular structure of chitosan, carbonization, molecular polycondensation, and surface passivation were achieved through a hydrothermal method, ultimately forming chitosan carbon quantum dot carriers (CS-CDs) with an average size of 6.27 nm. Quercetin (Que) was then loaded onto these carriers to construct the composite nanosystem. Structural characterization of the composite nanosystem was conducted using techniques such as transmission electron microscopy and infrared spectroscopy, confirming the successful hybridization of the nanocomposites. Notably, compared with Que alone, the CS-CDs/Que composite nanosystem exhibit significantly enhanced antioxidant capacity under the same mass concentration. The scavenging rates of CS-CDs/Que for DPPH and ABTS can reach 92% and 62%, respectively; their chelating ability for ferrous ions is also much stronger than that of Que. Furthermore, CS-CDs/Que can effectively scavenge superoxide anion free radicals and hydroxyl free radicals. When the concentration of CS-CDs/Que is 15 µg mL −1 , it achieved a 100% scavenging rate for hydroxyl radicals. Overall, the prepared CS-CDs/Que composite nanosystem show excellent antioxidant activity, providing new insights for the development of novel antioxidants.
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Jiangjie Tang,Ruimin Tang,Liangjian Chen,Chunsheng Shao,Li Yi
Recent advances in osteoimmunology have underscored the crucial role of the host immune response in bone regeneration. In this study, we developed a double-crosslinked carboxymethyl chitosan-alginate-hydroxyapatite composite hydrogel bone scaffold (CAHA) by directional freeze-casting. The content of HA (15 wt%, 25 wt%, 35 wt%, and 45 wt%) has significantly influenced the physical properties of the scaffold, including pore size, porosity, swelling behaviour, Ca 2+ ion release, surface stiffness, and compressive modulus. In vitro experiments indicated that the CAHA scaffold upregulated the expression of anti-inflammatory genes ( p < 0.0001) and downregulated the expression of proinflammatory genes ( p < 0.0001) in RAW 264.7 macrophages, promoting a shift from the M1 phenotype to the M2 phenotype. The M2 phenotype effectively enhanced osteogenic differentiation of MC3T3-E1 cells and angiogenesis in HUVECs. In vivo studies using an air pouch model revealed a greater number of M2 macrophages surrounding the CAHA scaffolds. Tibial defect experiments showed that 8 weeks after implantation, the group treated with the CAHA scaffold containing 45 wt% HA exhibited significant bone healing compared with the control group ( p < 0.05). Thus, the novel CAHA composite hydrogel scaffold shows promise as an immunomodulatory biomaterial for bone tissue engineering.
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产品关联
DOI
PubMed
高影响因子
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
·
2018
·
IF 1.241
Mingcong Shao,Lili Xiu,Haijiang Zhang,Jianying Huang,Xingwen Gong
Chitosan/cellulose-based beads (CCBs) for the affinity purification of histidine-tagged proteins were prepared from chitosan/cellulose dissolved in ionic liquid as a solvent, and their structures were characterized by Fourier transform infrared spectroscopy, transmission electron microscopy, and thermogravimetric analysis. The affinity purification was used to separate hexahistidine-tagged (his-tagged) enhanced green fluorescent protein (EGFP) from Escherichia coli. The results showed that Zn2+–CCB exhibited more specific adsorption capacity toward the target protein compared with Ni2+–CCB and Cu2+–CCB. The maximum adsorption of EGFP was 1.84 mg/g of Zn2+–CCB, with 90% purity under the optimized conditions (ionic strength (1.0 M NaCl), pH (7.2) and imidazole concentration (500 mM)). In addition, a regeneration method for the sorbent was further developed by washing with ethylenediaminetetraacetic acid disodium and then reimmobilizing with metal ions. This technique is an alternative method for the purification of his-tagged proteins, making the process more economical, fast, stable, and large batch.
研究领域:
生物化学
·
蛋白质工程
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DOI
PubMed
高影响因子
POLYMER SCIENCE SERIES A
·
2021
·Vol. 63
·期 5
·576-584
·
IF 1.206
Cong Ding,Xu Bohao,Zhang Juzhong,Sun Qingqing,Chen Zhihao,Liu Shuiren,Liu Xuying,Chen Jinzhou
Abstract The development of flexible capacitive pressure sensors with high sensitivity and fast response demands the need for thin dielectric films with excellent mechanical flexibility and remarkable dielectric properties. Herein, a graphene/polyurethane (TPU) dielectric was designed by dispersing graphene fillers into TPU elastomer through chitosan (CS) modification. The dispersion of graphene fillers in the TPU matrix can be effectively improved by using CS as mediating agents, thus further elevating the dielectric properties of the composites. The as prepared dielectric films exhibit high permittivity (90), low dielectric loss (0.02) and remarkable flexibility. Afterwards, the flexible dielectric films were employed to construct capacitive sensors by integrating the top electrode, dielectric layer, and bottom electrode into a sandwich structure. Taking advantage of the high permittivity of the dielectrics and the microcapacitors generated between graphene fillers, the corresponding sensors exhibit high sensitivity to loaded pressure ( S = 0.53 kPa –1 for the range 1.6–4.8 kPa) and out-of-plane bending ( S = 0.08 deg –1 for the range 0 ~ 150°). In addition, a 3 × 3 sensor array was successfully fabricated and applied in the real-time monitoring of water drop, sensing subtle touch, and mapping the spatial distribution of pressure. The fabricated sensors demonstrate promising potential in the application of human-machine interfaces and wearable devices.
研究领域:
材料科学
·
电子工程
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DOI
高影响因子
Journal of Chemistry
·
2022
·
IF 3.241
Anxiang Huang,Wenlian Bai,Shoulu Yang,Zhongwei Wang,Nengying Wu,Yanxiong Zhang,Ning Ji,Dan Li
The purpose of this study was to fabricate a low-cost and eco-friendly adsorbent using bamboo biochar (BB), a kind of charcoal composed of high Brunauer–Emmett–Teller surface area and variety of functional groups, and chitosan as substrates for remediation of Cd(II) in Cd(II) contaminated water and characterized the functional group characteristics, surface morphology, and Cd(II) adsorption effect using the Fourier transform infrared (FT-IR), scanning electron microscope (SEM), and energy-dispersive X-ray spectrometer (EDS). Results showed that chitosan-modified bamboo biochar (CBB) provided more active adsorption sites (such as –NH2, –COOH, –OH, and C=O) on the surface to enhance the Cd(II) removal efficiency in Cd(II) contaminated wastewater. Meanwhile, the optimal pH, contact time, and dose of CBB on the Cd(II) removal efficiency are 7, 120 min, and 600 mg, respectively. In addition, the adsorption isotherm results revealed that the possible adsorption mechanisms might include surface adsorption, electrostatic adsorption, and ion exchanges. Furthermore, the maximum adsorption capacity (Qm) values predicted from the Langmuir model were 37.74 and 93.46 mg/g for BB and CBB, respectively, also indicating a potential application of CBB in practical wastewater. Desorption and regeneration of CBB were attained simultaneously and the results showed that even after five cycles of adsorption-elution, the adsorption and desorption of CBB exhibited a slight decline and still reached at 71.70% and 65.92%. Results from this study would provide a reference to functionalized CBB for Cd(II) adsorption in contaminated water.
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
POLYMER SCIENCE SERIES B
·
2021
·Vol. 63
·期 3
·272-279
·
IF 1.049
Liangliang Yang,Liu Fang,Zhao Qun
Abstract The antibacterial properties of chitosan and self-repairing properties of collagen-I play important roles in the medical field. New types of collagen-I/chitosan/methyl vinyl silicone rubber materials have been synthesized by blending and grafting copolymerization. The effects of chitosan contents on mechanical and antibacterial properties of collagen-I/chitosan/methyl vinyl silicone rubber were investigated, while the morphology and molecular structure were observed and analyzed. It was determined that the antibacterial and self-repairing properties of collagen-I/chitosan/methyl vinyl silicone rubber were better than those of methyl vinyl silicone rubber. Additionally, the optimal contents of chitosan and collagen-I were determined to be 5 wt % and 5 mg/mL, respectively.
研究领域:
生物医学材料
·
高分子化学
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DOI
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
·
2016
·
IF 1.988
Fang Wang,Siqian Yang,Jian Yuan,Qinwei Gao,Chaobo Huang
In the present study, alginate nanoparticles were firstly prepared for paclitaxel (PTX) delivery with an average size of 200 ± 21 nm. To improve the stability and targeting effect, the chitosan (CS) and folate-chitosan (FA-CS) were introduced to form PTX-loaded CS/ALG NPs and FA-CS/ALG NPs by a new double emulsion cross-linking electrostatic attraction method. The optimization chitosan concentration was 0.5% obtained from the experiment results. The CS/ALG-PTX NPs and FA-CS/ALG-PTX NPs had the average particle size of 306.9 ± 12.9 nm and 283.6 ± 19.2 nm with the zeta potential of 31.1 ± 1.3 mV and −2.98 ± 0.7 mV, and had higher drug loading and entrapment efficiencies than ALG-PTX NPs. The in vitro drug release profile along with release kinetics and mechanism from PTX-loaded NPs were studied under two simulated physiological conditions. Further, the in vitro anti-cancer activity of nanoparticles and the cellular uptake of nanoparticles on HepG2 cells were investigated. The results demonstrated that alginate, CS/ALG and FA-CS/ALG can be used as nanoformulation drug carriers by our new method, and FA-CS/ALG was a promising vehicle for anticancer drug targeted delivery system.
研究领域:
药学
·
纳米技术
·
癌症研究
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DOI
PubMed
高影响因子
Advanced Materials Technologies
·
2025
·
IF 6.2
Mingyu Cui,Suiyuan Huang,Jianwei Xin,Panpan Ma,Liping Heng,Yuqi Zhang,Ji-Jiang Wang
Dexamethasone sodium phosphate (DSP) and betamethasone sodium phosphate (BSP) are synthetic corticosteroids used for anti-inflammatory and immunosuppressive purposes. However, prolonged use may cause severe side effects, necessitating sensitive detection methods. Conventional techniques often suffer from complexity, signal interference, and a lack of real-time capability. This study develops molecularly imprinted 2D photonic hydrogels (DSP/BSP-MIPH) for selective, sensitive, and regenerable detection of DSP and BSP. The DSP-MIPH sensor exhibits swelling in DSP solution, enabling linear detection in three ranges (0.1–9, 10–100, and 100–1000 µ M ) with a limit of detection (LoD) of 41 nM. BSP-MIPH shows shrinkage upon binding, with linear responses in 0.05–1 and 5–1000 µ M ranges and a LoD of 28 n M . The limits of quantitation are 1.2 µ M and 146 n M for DSP and BSP, respectively. The opposite volume changes stem from distinct hydrogen bonding interactions between drug functional groups and the hydrogel network. The sensors successfully quantify DSP and BSP in commercial injections, achieving recovery rates of 96.7%–109.5% for DSP and 97.9%–104.8% for BSP, with RSDs 3.91%–6.21% for DSP and 3.57%–5.76% for BSP. These results demonstrate that the MIPH sensors provide accurate, reliable, and straightforward detection for DSP and BSP in real samples, giving a promising strategy for precise hormone drug monitoring.
研究领域:
分析化学
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生物传感与生物工程
·
药物分析
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高分子科学
·
环境与生物医学监测
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产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2018
·
IF 6.578
Zhi Xu,Guozhen Liu,Hua Ye,Wanqin Jin,Zhanfeng Cui
Pervaporation dehydration is an energy efficient process for purifying organic solvents , whose application depends on the development of highly permeable and selective membranes. In this work, synthesized two-dimensional Ti 3 C 2 T x MXene nanosheets were incorporated into chitosan (CS) to fabricate a new MXene/CS mixed-matrix membrane used for solvent dehydration via pervaporation process. The morphology, chemical structure and surface hydrophilicity of the membranes were studied by SEM, AFM, IR, XPS and water contact angle measurement. Three kinds of organic solvents , ethanol, ethyl acetate and dimethyl carbonate were used for evaluating the membrane dehydration performance. The results indicated that incorporation of MXene nanosheets did not increase the surface sorption , whereas the assembled MXene laminates with interlayer channels greatly enhanced the permeation of water molecular through the membrane. Thus, flux and separation factor of CS membrane were simultaneously improved by introducing the MXene nanosheets . Specifically, the optimized 3 wt% MXene/CS MMM exhibited total flux of ~ 1.4–1.5 kg/(m 2 h) and separation factor of 1421, 4898 and 906 for dehydration of ethanol, ethyl acetate and dimethyl carbonate at 50 °C, respectively.
研究领域:
材料科学
·
化学工程
·
环境科学
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DOI
高影响因子
MOLECULES
·
2018
·Vol. 23
·期 10
·2604
·
IF 3.098
Lijie Wei,Yuan Chen,Wenqiang Tan,Qing Li,Guodong Gu,Fang Dong,Zhanyong Guo
In this study, a series of triple quaternized chitosan derivatives, including 6-O-[(2-hydroxy-3-trimethylammonium)propyl]-2-N-(1-pyridylmethyl-2-ylmethyl)-N,N-dimethyl chitosan chloride (7), 6-O-[(2-hydroxy-3-trimethylammonium)propyl]-2-N-(1-pyridylmethyl-3-yl- methyl)-N,N-dimethyl chitosan chloride (8), and 6-O-[(2-hydroxy-3-trimethylammonium)propyl]- 2-N-(1-pyridylmethyl-4-ylmethyl)-N,N-dimethyl chitosan chloride (9) were successfully designed and synthesized via reacting epoxypropyl trimethylammonium chloride with theN-pyridinium double quaternized chitosan derivatives. Detailed structural characterization was carried out using FT-IR and1H-NMR spectroscopy, and elemental analysis. Besides, the activity of the triple quaternized chitosan derivatives against three common plant pathogenic fungi,Watermelon fusarium,Fusarium oxysporum, andPhomopsis asparagi, was investigated in vitro. The results indicated that the triple quaternized chitosan derivatives had enhanced antifungal activity when compared to double quaternized chitosan derivatives and chitosan, especially at 1.0 mg/mL, which confirmed the theory that the higher density of positive charge contributed to the antifungal activity. Moreover,8with an almost 99% inhibitory index showed the better antifungal activity againstWatermelon fusarium. Moreover, the cytotoxicity of the products was also evaluated in vitro on 3T3-L1 cells and all the triple quaternized chitosan derivatives exhibited low cytotoxicity. These results suggested that triple quaternized chitosan derivatives may be used as good antifungal biomaterials.
研究领域:
生物化学
·
药学
·
植物保护学
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DOI
高影响因子
危险品化学品经营许可证（带存储）