ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Kuibao Yu,Hailong Hu,Yuan Qie,Chao Zhong,Zhihan Lin,Tian Liu,Fushan Li
Near infrared (NIR)-to-visible up-conversion devices (UCDs) offer significant advantages in pixelless bio-imaging and monitoring. Herein, a flexible NIR-to-blue quantum dot (QD) UCD is developed by directly stacking an organic bulk-heterojunction (BHJ) photodetector unit with an environmentally-friendly ZnSe/ZnS QD light-emitting unit in tandem. Aiming at the interconnection layer (ICL) that couples these two units, an Mg-doped ZnO ICL is rationally designed to achieve high conductivity and a low work function, facilitating the rapid transport of photo-generated electrons and their efficient injection into the QD emitting layer. Importantly, Mg-passivated ICL with fewer surface defects alleviates the exciton quenching at the QD/ICL interface and suppresses the undesired charge recombination at the ICL/BHJ interface. The resultant QD-UCDs enable a high photon-to-photon conversion efficiency (? P-P ) of 8.68%, which is ≈3 times higher than that with un-doped ICLs (2.91%). The flexible QD-UCDs can readily measure human heart rate and provide high-contrast microscopic imaging of various biological tissues.
研究领域:
生物医学工程
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纳米医学
·
光学成像
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柔性电子学
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转化医学
·
生物传感器
✓ 已验证
DOI
高影响因子
Analytical Methods
·
2025
·
IF 2.6
Changqiu Ma,Daheng Jiang,Linghui Zeng,Lixin Zhu,Xiaoliang Xu
Conventional photoelectrochemical (PEC) biosensors based on ZnO and TiO2 face challenges in applications in vivo due to the poor penetration of excitation light through the skin. To address this limitation, we designed a novel near-infrared (NIR)-driven FTO@UC@Cu2O@TiO2 heterojunction biosensor for subcutaneous L-cysteine detection. NIR light penetrates the skin and excites the upconversion material (called UC for short, NaYF4:Er, Yb), which emits visible light at 540 nm. This emission activates the Cu2O semiconductor to generate photocurrent. The Cu2O@TiO2 heterojunction facilitates charge carrier separation and suppresses electron-hole recombination. The biosensor demonstrates stable, sensitive, and reproducible detection of L-cysteine over a range of 10 μM to 10 pM, with a detection limit of 5.2 pM. Notably, it also enables subcutaneous detection covering a range from 10 μM to 100 pM, with a detection limit of 74 pM. These results provide a promising strategy for real-time in situ monitoring of L-cysteine in clinical applications.
研究领域:
生物传感器
·
纳米技术
·
分析化学
·
生物医学工程
·
光化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Jie Meng,Shuang Xie,Zhanlin Zhang,Pan Ran,Xia Lei,Long He,Xiaohong Li
Pyroelectrodynamic therapy (PEDT) of tumors faces challenges due to its low electrocatalytic efficiency at mild temperature and the potential for off-target toxicity to healthy tissue. To overcome these issues, we have engineered pyroelectric nanoparticles (NPs) that feature a pH-triggered heterojunction structure and tumor-selective reactive oxidative species (ROS) production, faclitating synergistic PEDT and mild photothermal therapy (PTT). Herein, molybdenum trioxide (MoO 3 ) was deposited in-situ on the surface of tetragonal BaTiO 3 (tBT) to create tBT@MO. Subsequently, a metal-acid treatment was utrilized to hydrogenate MoO 3 , and the yielded HMO was grafted with poly(ethylene glycol) (PEG) to produce tBT@HMO-PEG. In contrast to vulnerability in normal tissues, hydrogen-doped NPs exhibit stability against H + attacks in the slightly acidic microenvironment of tumors, faclitating efficient near-infrared II (NIR-II) absorption, and the enhanced photothermal conversion enables tumor-selective mild PTT and PEDT. The formation of heterojunctions between tBT and HMO markedly improves electron-hole separations and ROS productions, and the generated pyroelectric field selectively disrupts the membrane potentials of tumor cells, theraby promoting NP internalization. In a tumor-bearing model, NPs exhibit deep tumor penetration and widesperead ROS distribution, overcoming the limitations of the short lifespan and diffusion distance of ROS to achieve potent antitumor efficacy. Moreover, the tumor-selective PEDT and mild hyperthermia ensure treatment safety. Therefore, the innovative design of pH-triggered Schottky heterojunctions effectively mitigate off-target toxicity to normal tissue while improving the precision and efficacy of tumor therapy.
研究领域:
纳米医学
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癌症治疗
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材料科学
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生物医学工程
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光电治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Bio
·
2025
·
IF 10.2
Hui Liu,Xiaochuan Yang,Xianwen Liang,Ying Xia
The hindrance posed by the blood-brain barrier (BBB) and the unique characteristics of the tumor microenvironment (TME) remain major challenges in glioblastoma (GBM) therapy. Here, we developed a dual-magnetically driven ultrasmall Mo 0.2 Fe 2.8 O 4 @CeO x /FA (MFCF) nanozyme exhibiting multienzyme catalytic activities for targeted synergistic therapy of GBM. This nanozyme demonstrated dual responsiveness to alternating magnetic fields (AMF) and static magnetic fields, synergized with folic acid (FA)–mediated molecular targeting to enhance BBB penetration and achieve high-precision GBM localization. Upon simultaneous exposure to AMF and near-infrared (NIR) laser irradiation, MFCF amplified reactive oxygen species (ROS) generation, depleted glutathione, and alleviated hypoxia through synergistic magnetothermal effects, type-II photodynamic therapy, and its intrinsic multienzyme catalytic activities, ultimately inducing both ferroptosis and apoptosis. Notably, this hybrid cell-death pathway triggered immunogenic cell death, promoting the proliferation and differentiation of T cells and thereby achieving systemic immune activation. Concurrently, it reprogrammed M2-polarized macrophages into pro-inflammatory M1 phenotypes, remodeling the immunosuppressive TME and enhancing antitumor immunotherapy. Furthermore, the excellent superparamagnetism of MFCF enabled T 2 -weighted magnetic resonance imaging (MRI)-guided treatment monitoring. Overall, this work presents a multifunctional nanoplatform that overcomes BBB and TME barriers to enable precise, immunomodulatory therapy for GBM.
研究领域:
肿瘤学
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神经肿瘤学
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免疫学
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纳米医学
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分子影像学
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转化医学
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药剂学
·
生物材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Powder Materials
·
2025
·
IF 24.9
Rujun Yang,Kunjie Song,Yuantian Zheng,Chenhan Zhan,Yajing Wang,Cunjian Lin,Tianliang Zhou,Yixi Zhuang,Rong-Jun Xie
Persistent Luminescence (PersL) materials, which use traps to store energy and emit photons over a long period, have found important applications in the fields of optical information storage, security labeling, and biological imaging. The trap depth is a crucial factor determining the performance of these materials; however, achieving the desired trap depth with high precision remains a great challenge. Here, we provide double perovskite phosphors (Cs 2 SnCl 6 -Cs 2 ZrCl 6 -Cs 2 HfCl 6 series) with highly compatible crystal structures, enabling continuous and precise tuning of trap depth over an ultra-wide range of 0.11 to 1.25 eV. By incorporating W 4+ as the luminescent centers, these phosphors exhibit outstanding near-infrared (NIR) PersL performance at approximately 900 nm and a lasting emission duration exceeding 10 h. The underlying mechanism of PersL is elucidated, and the wide-range tunability of trap depth is attributed to the universal applicability of band-gap engineering in the entire material system. Furthermore, we demonstrate the practical application of these materials by designing a flexible detector plate for X-ray imaging. The detector plate exhibits a storage time of more than 1 week, a detection limit of 0.83 μGy air ·s -1 in the near-infrared region, and real-time and delay-time imaging resolutions of 14.2 lp·mm -1 and 2.5 lp·mm -1 , respectively. These attributes demonstrate strong potential for X-ray luminescence extension imaging.
研究领域:
材料科学
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光学材料
·
固体物理
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纳米技术
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生物医学成像
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X射线探测
✓ 已验证
产品关联
DOI
高影响因子
Advanced Science
·
2022
·Vol. 9
·期 12
·2102220
·
IF 17.521
Chenle Dong,Chen Yang,Muhammad Rizwan Younis,Jing Zhang,Gang He,Xingdi Qiu,Lian-Hua Fu,Dong-Yang Zhang,Hao Wang,Wenli Hong,Jing Lin,Xueqing Wu,Peng Huang
Intrauterine adhesions (IUAs) caused by mechanical damage or infection increase the risk of infertility in women. Although numerous physical barriers such as balloon or hydrogel are developed for the prevention of IUAs, the therapeutic efficacy is barely satisfactory due to limited endometrial healing, which may lead to recurrence. Herein, a second near-infrared (NIR-II) light-responsive shape memory composite based on the combination of cuprorivaite (CaCuSi 4 O 10 ) nanosheets (CUP NSs) as photothermal conversion agents and polymer poly( d , l -lactide- co -trimethylene carbonate) (PT) as shape memory building blocks is developed. The as-prepared CUP/PT composite possesses excellent shape memory performance under NIR-II light, and the improved operational feasibility as an antiadhesion barrier for the treatment of IUAs. Moreover, the released ions (Cu, Si) can stimulate the endometrial regeneration due to the angiogenic bioactivity. This study provides a new strategy to prevent IUA and restore the injured endometrium relied on shape memory composite with enhanced tissues reconstruction ability.
研究领域:
生物医学工程
·
材料科学
·
生殖医学
✓ 已验证
DOI
PubMed
高影响因子
Nature Communications
·
2022
·Vol. 13
·期 1
·1-10
·
IF 17.694
Yin Xiumei,Xu Wen,Zhu Ge,Ji Yanan,Xiao Qi,Dong Xinyao,He Ming,Cao Baosheng,Zhou Na,Luo Xixian,Guo Lin,Dong Bin
The second near-infrared (NIR II) response photon up-conversion (UC) materials show great application prospects in the fields of biology and optical communication. However, it is still an enormous challenge to obtain efficient NIR II response materials. Herein, we develop a series of Er 3+ doped ternary sulfides phosphors with highly efficient UC emissions under 1532 nm irradiation. β-NaYS 2 :Er 3+ achieves a visible UC efficiency as high as 2.6%, along with high brightness, spectral stability of lights illumination and temperature. Such efficient UC is dominated by excited state absorption, accompanied by the advantage of long lifetimes ( 4 I 9/2 , 9.24 ms; 4 I 13/2 , 30.27 ms) of excited state levels of Er 3+ , instead of the well-recognized energy transfer UC between sensitizer and activator. NaYS 2 :Er 3+ phosphors are further developed for high-performance underwater communication and narrowband NIR photodetectors. Our findings suggest a novel approach for developing NIR II response UC materials, and simulate new applications, eg., simultaneous NIR and visible optical communication.
研究领域:
材料科学
·
光学
·
生物医学工程
✓ 已验证
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Zhenfeng Yu,Jialing Zhou,Zi-Han Chen,Zhihua Wang,Aliyah Almomen,Ahmed Mohamed El-Toni,Aibin Liang,Yong Fan,Fan Zhang
Cancer remains a leading cause of mortality worldwide. Although chemotherapeutic agents can effectively induce tumor regression, they often cause severe vascular damage that adversely affects patient prognosis. To address this issue, using the representative chemotherapeutic agent doxorubicin (DOX) as the model, a biocompatible rare-earth nanoagent capable of dual-wavelength emission in the UV and NIR-IIb (1500–1700 nm) regions upon excitation at 980 and 808 nm is reported. This unique property endows the spatiotemporally controlled release of Angiopoietin-1 (Ang-1), guided by NIR-IIb imaging, to promote vascular repair following DOX chemotherapy. Furthermore, the system allows for real-time monitoring of angiogenesis to assess therapeutic efficacy. In a 4T1 tumor-bearing mouse, this combined strategy reduced the number of abnormal vascular branches by ≈50% at each time point and significantly prolonged the survival time of mice. This study introduces a novel therapeutic paradigm that integrates tumor eradication with concurrent nanomedicine-driven vascular repair, paving the way for more effective and durable treatment strategies for tumors.
研究领域:
纳米医学
·
癌症治疗学
·
分子成像
·
生物医学工程
·
药物递送
✓ 已验证
产品关联
DOI
高影响因子
DYES AND PIGMENTS
·
2018
·
IF 3.767
Weifen Niu,Zhiwen Wei,Juan Jia,Shaomin Shuang,Chuan Dong,Keming Yun
A novel ratiometric emission NIR-fluorescence probe N , N -dimethyl-4-((1E, 3E)-4-(3,3-dimethyl-3H-indol-2-yl)buta-1,3-dienyl)benzenamine, namely, DIDBA, is facilely synthesized on the basis of ethylene bridging of indole derivatives and 4-(dimethylamino) cinnamaldehyde. The probe exhibits a remarkable NIR ratiometric fluorescence emission ( F 618nm / F 697nm ) characteristic with p K a 4.5, and the linear response over the pH range of 3.5–5.2. DIDBA also displays favorable features include large Stokes shift of 200 nm under acidic conditions, high sensitivity, good selectivity, fine photostability and reversibility . The probe has low cytotoxicity and excellent cell membrane permeability, and is applied successfully to visualize intracellular pH fluctuations in live cells without influence of autofluorescence and native cellular species in biological systems.
研究领域:
生物化学
·
细胞生物学
·
医学影像学
✓ 已验证
DOI
高影响因子
Laser & Photonics Reviews
·
2023
·Vol. 18
·期 1
·2300732
·
IF 11
Zhuowei Li,Ge Zhu,Shanshan Li,Wen Xu,Qingfeng Bian,Yan Cong,Ming He,Xixian Luo,Shuangyu Xin,Bin Dong
The burgeoning phosphor-converted near-infrared light-emitting diodes (pc-NIR LEDs) have important applications in special illumination and spectroscopy analysis. However, the development of efficient NIR-emitting phosphors with high performance is still a challenge. In this work, a chemical unit co-substitution strategy is proposed to realize the excitation transition regulation and successfully achieve high-performance NIR luminescence in Ca 3- y Na y Mg 1- y Sb 2- x Al 2+ y O 12 : x Cr 3+ (0 ≤ x ≤ 0.05, 0 ≤ y ≤ 1) garnet-type solid solution phosphors. Through the excitation transition modulation from the 4 A 2 ground state to the 4 T 1 ( 4 P) and 4 T 1 ( 4 F) excitation state, the excitation intensity at the blue light region is largely enhanced by 25.6 times. Moreover, the NIR-emitting efficiency and thermal stability are improved, with the optimal luminescence internal quantum efficiency of 90.6% and thermal stability of 97%@423 K, without any flux-assisted sintering or reduction atmosphere protection. The structure regulation induced small Stokes shift, weak electron-phonon coupling effect, and decreased non-radiative transition are responsible for the excellent NIR-emitting performance. Finally, the NIR pc-LED is fabricated with photoelectric efficiencies of 18.7%@100 mA and NIR output powers of 63 mW@100 mA, presenting potential applications in nondestructive internal defect detection, veins imaging, and night vision surveillance.
研究领域:
材料科学
·
光学工程
·
固体化学
·
发光材料
·
半导体器件
✓ 已验证
DOI
高影响因子
JOURNAL OF RARE EARTHS
·
2026
·
IF 7.2
Yu Zha,Fangxue Chen,Fanju Meng,Xiancheng Ning,Tianyu Guo,Danxia Liu,Jin Han,Yugeng Wen,Jianbei Qiu
Transition metal ion-activated phosphors are promising candidates for broadband near-infrared (NIR) spectroscopy applications. However, achieving high external quantum efficiency (EQE) and good thermal stability in low-dimensional halide perovskites has presented challenge. Herein, a design strategy based on cerium doping has been developed for realizing high-efficiency broadband NIR tetravalent molybdenum (Mo 4+ ) luminescence to overcome multivalent Mo-related lattice defects and self-absorption. Particularly, Ce 4+ , Mo 4+ -codoped Cs 2 TeCl 6 shows broadband NIR emissions ranging from 800–1300 nm with a full width at half-maximum of 186 nm, high EQE > 50% and good thermal stability (85%@150 °C). Experimental and theoretical studies verify the synergistic effects of breakdown of site symmetry, reduction of lattice defects and relaxation of the spin-selection rule of Mo 4+ . Moreover, gas sensing of toxic toluene with low detection limit and high sensitivity is presented due to strong molecular interaction-induced luminescence quenching. These findings provide new opportunities for broadband NIR spectroscopy applications.
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2026
·
IF 11.8
Xinyue Kou,Juan Yue,Yingge Cong,Ruoqian Gao,Wenfei Dong,Li Li
Boron-doped aggregation-induced emission (AIE) nanomaterials (B@AIE NPs) were successfully synthesized via a facile one-pot solvothermal method for dual-modality fluorescence (FL) and magnetic resonance (MR) imaging. The as-prepared B@AIE NPs exhibited a uniform core–shell structure, excellent dispersibility, and strong NIR-II fluorescence emission at 984 nm upon aggregation, attributed to restricted intramolecular motion. Moreover, the boron doping conferred remarkable T 1 -weighted MR contrast capability, with a high longitudinal relaxivity (r 1 ) of 6.12 m m − 1 s − 1 . In vitro studies demonstrated excellent biocompatibility and efficient cellular uptake, with preferential localization in lysosomes. In vivo experiments in HeLa tumor-bearing mice revealed effective tumor accumulation via the enhanced permeability and retention (EPR) effect, enabling high-contrast NIR-II fluorescence and MR imaging. These results highlight the great potential of B@AIE NPs as a promising metal-free nanoprobe for precise tumor diagnosis through FL/MR dual-modal imaging.
✓ 已验证
DOI
PubMed
高影响因子
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