COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2019
·
IF 3.131
Hui Zhao,Ying Li
Tremella polysaccharide , a novel polysaccharide , not only has good ability of film forming, but also has excellent physiological functions, which was suitable to be used to prepare eco-friendly hydrogels. In this study, a novel pH/temperature responsive micelle-laden hydrogel based on tremella polysaccharide (WSK), carboxymethyl cellulose (CMC) and nonionic surfactant-decyl polyglucoside (C 10 APG) was fabricated through radical polymerization by crosslinking N-isopropylacrylamide (NIPAM), for the purpose to achieve controlled release of hydrophobic drugs indomethacin (IND). Firstly, WSK/CMC/PNIPAM hydrogels were prepared and their characteristics were investigated by FTIR, TGA , SEM, rheological and compressive tests as well as swelling experiments. Then the hydrophobic drug IND molecules were solubilized in C 10 APG micelles which were uniformly dispersed in the WSK/CMC/PNIPAM/C 10 APG networks. Lastly, the IND release behavior of WSK/CMC/PNIPAM/C 10 APG hydrogels was studied, which exhibited both pH and temperature sensitivity. The obtained WSK/C 10 APG-based pH/temperature sensitive hydrogel may have potential in biomedical applications such as drug vehicles and tissue engineering.
研究领域:
材料科学
·
药学
·
生物医学工程
·
高分子化学
✓ 已验证
DOI
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2022
·
IF 6.064
Wu Shichao,Hu Shuo,Yang Xiangrui
The strategy for dual drug-loaded nanomedicine with targeting properties was always complex. Herein, a novel strategy for the preparation of metal-organic particle-based nanomedicine has been developed, and combretastatin A4 (CA4) and mitoxantrone (MIT) loaded MOPs (CMMOPs) have been obtained. In this system, using merely Cu(II) as a bridge to connect and coordinate with the dual drugs has resulted in the CMMOPs possessing a fairly high drug load of almost 90%. Moreover, the coordination between Cu(II) and the drugs was stable at physiological pH but easily cleavable in the tumor acidic microenvironment, which would provide a good targeting property for CMMOPs. The in vivo experiments indicated that CMMOPs possessed a significantly enhanced antitumor efficiency with negligible side effects. The results suggest that CMMOPs could be a potential anticancer formulation for tumor-targeted drug delivery.
研究领域:
药学
·
纳米技术
·
肿瘤学
✓ 已验证
DOI
高影响因子
FUEL
·
2025
·
IF 7.5
Zilong Liu,Wenqi Zhao,Yanxiao Hei,Yaru Xin,Fengzhi Guo,Yufei Xiao,Wenxiu Leng,Weichao Sun
Owing to its ability to be reversibly switched on-demand, pH-responsive surfactants show promising applications in agriculture, detergents, and oil recovery. However, maintaining the stability of pH-responsive emulsions under harsh shear and salinity conditions remains challenging. To address this issue, we developed novel Pickering emulsions with both pH-responsiveness and high environmental robustness stabilized by a series of synthesized pH-responsive surfactants, (CH 3 ) x NCOONa (x = 2, 4, 6), and investigated their interfacial behavior and emulsion stability using experiments and dissipative particle dynamics (DPD) simulations. Among them, (CH 3 ) 4 NCOONa showed a better surface activity and pH responsiveness. Pickering emulsion composed of (CH 3 ) 4 NCOONa and SiO 2 nanoparticles was found to exhibit excellent viscosity response with 26 times decrease from 204.1 to 7.8 mPa·s when pH increased from 7.3 ± 0.5 to 9.2 ± 0.5. To further enhance the shear and salinity resistance of Pickering emulsions, three green polymers were introduced into the system. Among the tested polymers, chitosan most effectively enhanced the static viscosity from 204.1 to 550.2 mPa·s and kept stable at a high shear rate of 60 s −1 at pH = 7.3 ± 0.5, whereas its viscosity slightly changed at pH = 9.2 ± 0.5, indicating that the chitosan synergistic-stabilized Pickering emulsion showed a good pH response. Notably, the chitosan stabilized Pickering emulsion also remained stable in 4 wt% simulated seawater. Additionally, the stability mechanism of Pickering emulsions with pH-responsive surfactants was demonstrated by DPD, revealing denser interfacial packing of zwitterionic DEU z over anionic DEU a , consistent with experimental stability trends. These findings demonstrate a novel strategy for constructing environmentally responsive and mechanically robust emulsions, providing both mechanistic understanding and practical pathways for demanding applications in harsh field conditions.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2023
·Vol. 21
·期 1
·1-19
·
IF 10.2
Chen Bing,Zheng Kaifan,Fang Shubin,Huang Kangping,Chu Chengchao,Zhuang Junyang,Lin Jin,Li Shaoguang,Yao Hong,Liu Ailin,Liu Gang,Lin Jizhen,Lin Xinhua
Background The combination of drug delivery with immune checkpoint targeting has been extensively studied in cancer therapy. However, the clinical benefit for patients from this strategy is still limited. B7 homolog 3 protein (B7-H3), also known as CD276 (B7-H3/CD276), is a promising therapeutic target for anti-cancer treatment. It is widely overexpressed on the surface of malignant cells and tumor vasculature, and its overexpression is associated with poor prognosis. Herein, we report B7H3 targeting doxorubicin (Dox)-conjugated gold nanocages (B7H3/Dox@GNCs) with pH-responsive drug release as a selective, precise, and synergistic chemotherapy-photothermal therapy agent against non-small-cell lung cancer (NSCLC). Results In vitro, B7H3/Dox@GNCs exhibited a responsive release of Dox in the tumor acidic microenvironment. We also demonstrated enhanced intracellular uptake, induced cell cycle arrest, and increased apoptosis in B7H3 overexpressing NSCLC cells. In xenograft tumor models, B7H3/Dox@GNCs exhibited tumor tissue targeting and sustained drug release in response to the acidic environment. Wherein they synchronously destroyed B7H3 positive tumor cells, tumor-associated vasculature, and stromal fibroblasts. Conclusion This study presents a dual-compartment targeted B7H3 multifunctional gold conjugate system that can precisely control Dox exposure in a spatio-temporal manner without evident toxicity and suggests a general strategy for synergistic therapy against NSCLC.
研究领域:
癌症治疗
·
纳米医学
·
药物递送系统
·
免疫学
·
生物偶联化学
✓ 已验证
DOI
高影响因子
BIOMEDICINE & PHARMACOTHERAPY
·
2019
·
IF 3.743
Gang Zheng,Meizhu Zheng,Ben Yang,Hui Fu,Yongqing Li
Breast cancer is the leading cause of cancer mortality in women worldwide. To overcome the toxic side effects and multidrug resistance (MDR) during doxorubicin (DOX) chemotherapy, an arginine-glycine-aspartic (RGD) tripeptide modified, pH-sensitive solid lipid nanoparticles (SLNs) is employed in this study. In this study, a RGD conjugated, pH sensitive lipid was synthesized using glycerin monostearate (GMS) and adipic acid dihydrazide (HZ) as lipid materials and named RGD-HZ-GMS. RGD-HZ-GMS was applied to encapsulate DOX to construct a RGD modified, DOX loaded SLNs (RGD-DOX-SLNs). To evaluate the anticancer effect of RGD-DOX-SLNs, breast cancer cell line (MCF-7 cells) and DOX resistant cell line (MCF-7/ADR cells) were used. in vivo tumor suspension and toxicity effects were evaluated on mice bearing MCF-7/ADR cells breast cancer model. RGD-DOX-SLNs had a uniformly spherical shape. The mean particle size and zeta potential of the RGD-DOX-SLNs was 96.3 nm and 35.6 mV, respectively. RGD-DOX-SLNs showed 5.58 fold higher area under the plasma concentration – time curve (AUC) compared with DOX solution. Terminal half life (T 1/2 ) and peak concentration (C max ) of RGD-DOX-SLNs was 10.85 h and 39.12 ± 2.71 L/kg/h. in vitro and in vivo antitumor results indicate that RGD-DOX-SLNs might be a promising novel lipid carrier which could improve breast cancer therapy.
研究领域:
肿瘤学
·
药剂学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
LANGMUIR
·
2022
·
IF 4.331
Saijie Song,Minghui Wan,Wenli Feng,Yu Tian,Xuefeng Jiang,Yi Luo,Jian Shen
The stimuli responsive pesticide delivery system (PDS) has drawn increasing attention in recent years, a system which can effectively improve the utilization of pesticides. In the current research, we report a pH responsive PDS by using carboxymethyl cellulose (CMC) modified Zr-based metal organic frameworks (UiO-66-NH2) as the nanocarrier for acetamiprid (ATP). UiO-66-NH2-CMC possesses a large surface area and abundant pores, which can effectively load ATP, and the loading rate is as high as 90.79%. Compared with free ATP, the ATP@UiO-66-NH2-CMC nanopesticide exhibits pH responsive controlled release behavior, and the pesticide can sustained release to the medium. In addition, it also shows improved leaf affinity, which makes it easier to wet the leaf surface and improve the utilization of pesticide. Therefore, ATP@UiO-66-NH2-CMC displays better antipest activity against aphids than free ATP does. Meanwhile, ATP@UiO-66-NH2-CMC shows no negative effects on the germination and growth of maize, showing good biosafety. Moreover, the ATP@UiO-66-NH2-CMC nanopesticide does not contain any toxic organic solvents or additives. Therefore, we hope that it can be a suitable candidate for plant protection and sustainable agriculture.
研究领域:
农业科学
·
材料科学
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Huiwen Hou,Didi Gao,Na Lu,Wen Tang,Wenjie Liu,Feiyan Zhao,Xinqing Gao,Hanlin Wang,Yuhan Di,Hui Zhang,Hailong Wang,Feng Sun,Haining Tan
Hepatocellular carcinoma (HCC) is among the most prevalent and deadly cancers worldwide, with high recurrence and metastasis rates that significantly impact patient survival. Targeted therapy has emerged as a promising alternative to conventional treatments. This offers tumor-specific drug delivery while minimizing adverse systemic effects. In this study, we present folate acid (FA)-carboxymethylated mannan (CM)- monomethyl auristatin E (MMAE) conjugate (FA-CM-MMAE, FCMMM), an innovative glycosylated dual-target nanoparticle designed for the precise delivery of MMAE to HCC cells. These nanoparticles utilize FA and CM as their targeting ligands and exhibit pH-responsive drug release in acidic tumor microenvironments. This allows enhanced specificity and reduces off-target toxicity. In vitro studies have demonstrated that FCMMM nanoparticles selectively deliver MMAE to HepG2 cells via receptor-mediated pathways, alleviating MMAE-associated toxicity in normal cells. Furthermore, in vivo experiments in HCC-bearing mouse models have shown efficient tumor-specific accumulation of the drug, significant inhibition of tumor growth, and markedly lower levels of systemic toxicity than MMAE. This dual-targeting strategy integrates precise tissue targeting with controlled drug release. It addresses critical limitations of traditional HCC therapies such as nonspecific drug distribution, systemic toxicity, and drug resistance mechanisms. FCMMM shows potential as a next-generation nanoparticle platform for safer, more effective chemotherapeutic intervention in hepatic cancer.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Huabiao Ye,Ting Dong,Ruoxuan Li,Lihua Fang,Kaifang Xie,Guangting Han,Que Chen,Shan Chi,Jia-Horng Lin,Ching-Wen Lou
A dynamic drug-payload release dressing (H@GmJ-P) was logically engineered for promoting diabetic wound healing using two purpose-specific units: a pH/glucose dual-responsive hydrogel and a Janus membrane with centrally graded-thickness. The underlying hydrogels were created by a sequential functionalization strategy with recipes of dopamine-grafted oxidized sodium alginate, methacrylate-phenylboronic acid functionalized carboxymethyl chitosan, tannic acid and borax, which functionalized the H@GmJ-P with excellent bio-adhesive (∼74.5 kPa), antibacterial (>98 %), antioxidant, hemostatic, and self-healing properties. The upper Janus membranes composed of polycaprolactone (PCL) hydrophobic layer and PCL/F127 hydrophilic layer were engineered by thickness-varied design, functionalizing the H@GmJ-P with gradient decreasing modulus from ∼1.5 MPa (middle) to ∼0.6 MPa (periphery) for superior wound tear-resistance (∼197 kPa). Functional collaboration between the two units established unidirectional drug delivery platform following drug-sustained release behavior by pathophysiological wound pH/glucose stimuli. In vivo chronic diabetes skin wound model confirmed that H@GmJ-P promoted wound closure with only 8.2 ± 2.2 % unhealed area by day 21. This work proposes rational design of soft hydrogel dressing with stiff membrane can create matched modulus/tissue adhesion against wound tear. In addition, an innovative regenerative strategy emphasizing precise drug-sustained release offers a novel paradigm for managing challenging wounds.
研究领域:
生物材料学
·
创伤修复与再生医学
·
糖尿病并发症
·
药物递送系统
·
功能高分子材料
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Bio Materials
·
2023
·
IF 4.7
Hui Zhi,Fengya Wang,Xiaobo Zhang,Qinxin Cai,Meng Chen,Yushu Shi,Liang Feng
Traditional hydrogel dressings generally have poor mechanical properties and stability when subjected to external stress due to the undesirable chain entanglement structure of their single valence bond compositions. Therefore, it is particularly important to develop a type of gel dressing with good mechanical strength, stability, and environment-friendly monitoring. In this work, a transparent, pH-sensitive, highly stretchable, and biocompatible anthocyanidin ionogel dressing was prepared, realizing green and accurate detection. Attributed to the antibacterial activity of the ionic liquid, the biocompatibility of the pectin, and the ability to scavenge free radicals of the anthocyanidin, the ionogel dressing exhibited excellent re-epithelialization in the 14 day wound healing process. Besides, changes in pH values monitoring of the ionogel over 3 days coincided with normal wound exudate. The obtained ionogel also showed good water retention, swelling properties, mechanical stretchability, and 5 week stability, illustrating great potential in wound dressings.
研究领域:
材料科学
·
生物医学工程
·
伤口护理
✓ 已验证
DOI
高影响因子
ACS Applied Bio Materials
·
2020
·
IF 0
Min Mu,Yuelong Wang,Shasha Zhao,Xiaoling Li,Rangrang Fan,Lan Mei,Min Wu,Bingwen Zou,Na Zhao,Bo Han,Gang Guo
Chemotherapy works against tumors by inducing cell apoptosis; however, evasion of apoptosis is recognized to result in resistance to anticancer therapy. Ferroptosis is an iron-dependent cell death pathway that differs from apoptosis in morphological, biochemical, and genetic levels. Combined ferroptosis and apoptosis may shed light on strategies for cancer treatment. Therefore, we have designed a nanoparticle (NP) that can simultaneously cause tumor cell apoptosis and ferroptosis. This NP is composed of epigallocatechin gallate (EGCG) and Fe3+ through a simple and green process and can be used to deliver doxorubicin hydrochloride (DOX) and iron ions to the tumor site at the same time. DOX/Fe3+/EGCG (DF) NPs display a great resolubility and long-term storage stability, and efficient DOX and Fe3+ release is realized after cellular internalization under the high level of glutathione and acidic nature in tumor. EGCG is likely to chemically reduce the released Fe3+ to Fe2+. The generated Fe3+/Fe2+ converts intracellular H2O2 to hydroxyl radicals (•OH) via the Fenton reaction. In addition, the generated •OH subsequently induces lethal ferroptosis to improve DOX-induced apoptosis. In vitro and in vivo investigations indicate that a great therapeutic effect was achieved, suggesting that the formation of the DF NP delivery system is a promising strategy to fight against tumors by an apoptosis and ferroptosis combination modality.
研究领域:
纳米技术
·
癌症生物学
·
药学科学
·
材料科学
✓ 已验证
DOI
PubMed
BIOCONJUGATE CHEMISTRY
·
2017
·
IF 4.818
Ludan Yue,Jinlong Wang,Zhichao Dai,Zunfu Hu,Xue Chen,Yafei Qi,Xiuwen Zheng,Dexin Yu
Multifunctional nanotheranostic agents have been highly commended due to the application to image-guided cancer therapy. Herein, based on the chemically disordered face centered cubic (fcc) FePt nanoparticles (NPs) and graphene oxide (GO), we develop a pH-responsive FePt-based multifunctional theranostic agent for potential in vivo and in vitro dual modal MRI/CT imaging and in situ cancer inhibition. The fcc-FePt will release highly active Fe ions due to the low pH in tumor cells, which would catalyze H2O2 decomposition into reactive oxygen species (ROS) within the cells and further induce cancer cell apoptosis. Conjugated with folic acid (FA), the iron platinum-dimercaptosuccinnic acid/PEGylated graphene oxide-folic acid (FePt-DMSA/GO-PEG-FA) composite nanoassemblies (FePt/GO CNs) could effectively target and show significant toxicity to FA receptor-positive tumor cells, but no obvious toxicity to FA receptor-negative normal cells, which was evaluated by WST-1 assay. The FePt-based multifunctional nanoparticles allow real-time monitoring of Fe release by T2-weighted MRI, and the selective contrast enhancement in CT could be estimated in vivo after injection. The results showed that FePt-based NPs displayed excellent biocompatibility and favorable MRI/CT imaging ability in vivo and in vitro. Meanwhile, the decomposition of FePt will dramatically decrease the T2-weighted MRI signal and increase the ROS signal, which enables real-time and in situ visualized monitoring of Fe release in tumor cells. In addition, the self-sacrificial decomposition of fcc-FePt will be propitious to the self-clearance of the as-prepared FePt-based nanocomposite in vivo. Therefore, the FePt/GO CNs could serve as a potential multifunctional theranostic nanoplatform of MRI/CT imaging guided cancer diagnosis and therapy in the clinic.
研究领域:
生物医学工程
·
肿瘤学
·
医学影像学
✓ 已验证
DOI
PubMed
高影响因子
RSC Advances
·
2020
·Vol. 10
·期 8
·4232-4242
·
IF 3.119
Wenbo Liu,Rui Hu,Yanke Li,Yangze Huang,Yixi Wang,Zhong Wei,Erlei Yu,Xuhong Guo
A new high-efficiency adsorbent for cationic and anionic dyes named PAGD was synthesized via polymerization of dimethylaminoethyl methacrylate by employing glycidyl-methacrylate-modified phytic acid as a cross-linker. The experiment demonstrated that PAGD is pH-sensitive, and the maximum adsorption capacities of anionic dye Reactive Red 24 (RR24) and cationic dye Fuchsin Basic (FB) were 1871.23 and 482.54 mg g−1, respectively. To the best of our knowledge, there has been no previous report on a dye adsorbent possessing an adsorption capacity of over 465 mg g−1 for RR24. The excellent adsorption abilities toward RR24 are due to the introduced phytic acid groups, which could promote protonation of tertiary amine groups under acid pH conditions. Moreover, PAGD is able to selectively remove RR24 in a mixed solution of cationic dye and RR24. The adsorption isotherms and kinetics of PAGD fit well with the Langmuir isotherm and pseudo-second-order kinetic model, respectively. These results imply that PAGD is a promising adsorbent for removal of both cationic and anionic dyes.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）