ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
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IF 4.1
Wu Youyi,Wu Jingyi,Lu Xingyu,Wang Yuanjie,Gao Shiqian,Zhao Yang,Zhu Qionghui,Wang Xuedong
This study presented a new method of dispersive liquid–liquid microextraction based on Fe 3 O 4 nanoparticles-enhanced hydrophobic magnetic deep eutectic solvent (NPE-MDES-DLLME) for the simultaneous enrichment of six estrogens and bisphenols in water samples. The enriched analytes were then detected by ultra-performance liquid chromatography-fluorescence detection (UPLC-FLD). The innovations of the proposed method lie in two aspects: synthesis of a new hydrophobic MDES extractant composed of bis(2-ethylhexyl) phosphate, 1-hexanol, and nickel chloride, and addition of Fe 3 O 4 nanoparticles to enhance the extraction efficiency as well as speed up phase separation. Key parameters affecting extraction efficiency, including MDES composition, sample volume, extraction time, and elution conditions, were systematically optimized. Consequently, the method exhibited excellent analytical performance, characterized by good linearity (0.070–500 µg·L −1 , R 2 > 0.99), high enrichment factors (543–640), and low limits of detection (0.021–0.096 µg·L −1 ). When applied to real water samples, the proposed method yielded spiked recoveries ranging from 90.1% to 112.0% with relative standard deviations (RSDs) below 8.0%. Furthermore, greenness assessments using the ComplexAPI and AGREE metrics confirmed the method’s eco-friendliness. The developed NPE-MDES-DLLME/UPLC-FLD method provided a reliable, sensitive, and cost-effective approach for determining ultra-trace levels of estrogenic and bisphenol pollutants in the aquatic environment. Graphical
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COLLOID AND POLYMER SCIENCE
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2026
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IF 2.9
Xing Youmei,Hu Tao,Ying Ting,Zhang Zhijun,Wang Chen,Liu Jiani,Liu Zining,Hu Bin,Deng Chengwen,Xu Wen,Fang Weihua,Yin Yunjian,Jiang Huier,Wu Zhen,Wang Guojie
High-soluble nonionic Gemini surfactants are critically important in applications such as industrial cleaning. Herein, four nonionic Gemini surfactants with varying polyoxyethylene (EO) chain lengths, denoted as S1 ( n = 2), S2 ( n = 4), S3 ( n = 5), and S4 ( n = 7), are synthesized using 2,5-dimethyl-3-hexyne-2,5-diol and ethylene oxide as the raw materials. The structures of S1-S4 are confirmed by infrared spectroscopy and nuclear magnetic resonance spectroscopy. The S1-S4 surfactants exhibit a high solubility in both acidic and alkaline solutions and a high cloud point above 65 ℃, demonstrating good high-temperature stability. The surfactant with the shortest EO chain (S1) achieves the highest surface activity, reducing the surface tension to 47.21 mN/m (at 0.1 mol/L), while the surfactant with the longest EO chain (S4) exhibits the optimal cleaning performance with an impressive oil removal efficiency of 80.2%. Meanwhile, we systematically investigate the influence of EO chain length on surface tension, wettability, water solubility, and foaming performance. The results indicate that shorter EO chains contribute to higher surface activity, enhanced wetting performance, and reduced foam stability. In addition, the S1-S4 surfactants possess strong cleaning capabilities. This study provides a theoretical basis for the molecular design and screening of surfactants tailored for different application scenarios such as high-temperature stability, wettability optimization, and oil stain removal. Graphical
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Nature Communications
·
2026
·Vol. 17
·期 1
·5836
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IF 18.1
Tursumamat Nafisa,Liu Qiannan,Lu Jihong,Guo Shuhong,Du Shuangshuang,Liu Shengyang,Wu Shuye,Li Heming,Wu Peng,Li Bin,Wei Juan
High-sensitivity glycomic analysis is essential for advancing both basic and translational biomedical research, yet remains methodologically challenging for limited-quantity samples, primarily due to complex workflows and reliance on specialized instrumentation. Here, we introduce solution-enhanced glycan reduction and permethylation (seGRAP), a streamlined, accessible, and high-sensitive method that enables glycan profiling from sub-nanogram protein inputs and picoliter-scale human plasma using widely available mass spectrometry (MS) platforms. seGRAP-MS demonstrates consistently robust and reproducible glycomic performance and enables comprehensive N -glycome characterization of human oocytes at single-cell resolution. Our single-oocyte analysis uncovers a highly conserved N -glycome across both individuals and developmental stages, revealing a previously uncharacterized layer of molecular stability in human reproduction. By significantly lowering technical and logistical barriers, seGRAP-MS redefines the benchmark for high-sensitive glycomics, expanding accessibility and empowering broader applications in fundamental biology, clinical research, and precision medicine.
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Nano-Micro Letters
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2026
·Vol. 18
·期 1
·421
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IF 38.5
Jiang Yujia,Chu Depeng,Pi Jiacheng,Liu Naiming,Sun Xueni,Zhang Yunxia,Feng Ziyang,Wang Yuquan,Chen Wenjie,Wang Xinxin,Tian Jingyun,Zhao Lei,Jia Binxia,Shi Ruixin,He Yihui,Liu Yucheng,Liu Shengzhong Frank
An amine-salt-assisted solution crystallization strategy is developed to grow high-quality CsPbCl 3 single crystals (SCs) with a size as large as 15 mm, the SCs exhibit a high carrier mobility-lifetime product, low trap density, and large resistivity.
The CsPbCl 3 SC X-ray detector achieved a high detection sensitivity of 76,624 μC Gy -1 cm -2 and a low detection limit of 47.9 nGy s -1 , a short response time of 700 μs, therefore realized high contrast X-ray imaging.
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JOURNAL OF MATERIALS SCIENCE
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2026
·Vol. 61
·期 31
·22909-22923
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IF 4.4
Kang Chenchen,Wang Xinyi,Zhang Fan,Deng Jiahao,Xiang Ziqi,Pang Lingyan,Liu Hui
Lithium–sulfur (Li–S) batteries are regarded as one of the most promising next-generation energy storage technologies owing to their ultrahigh theoretical specific capacity and energy density. Nevertheless, their practical application is still hampered by severe polysulfide shuttling, poor electrode conductivity, and large volume variation during cycling. Herein, medical-grade cotton wool was employed as a sustainable carbon precursor to construct a porous carbon framework, followed by solvothermal and thermal treatment to obtain orthorhombic Nb 2 O 5 /PC (T-Nb 2 O 5 /PC). Furthermore, thiourea was introduced as a dopant source to achieve nitrogen and sulfur co-doping, generating nitrogen/sulfur co-doped T-Nb 2 O 5 -modified biomass-derived porous carbon (NS-T-Nb 2 O 5 /PC) with synergistic catalytic activity and enlarged surface area. Comprehensive structural analyses reveal that N/S co-doping not only induces abundant lattice defects and active sites but also optimizes the electronic configuration and ion-transport channels while preserving the crystal integrity. Benefiting from these features, the NS-T-Nb 2 O 5 -1/PC/S electrode delivers a high initial discharge capacity of 1263.5 mAh g −1 at 0.1 C and maintains 685.5 mAh g −1 after 200 cycles, together with outstanding reversibility and rapid kinetics in the 0.1–1 C range. This work offers an effective strategy to regulate the electronic structure and interfacial chemistry of Nb 2 O 5 -PC host via in situ heteroatom doping, thereby enabling suppressed shuttle effect and enhanced Li–S battery performance.
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PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
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2026
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IF 3.5
Wu Xingjie,Zhu Guihua,Guo Qianqian,Chen Ying,Wang Yu-E,Yang Naijia,Mei Ju,Shen Xiangchun,Tao Ling
Lipopolysaccharide (LPS) contamination in biopharmaceuticals poses severe clinical risks, yet its detection and removal remain enduring challenges. Conventional detection methods are frequently hindered by low endotoxin recovery. Established clearance techniques often compromise the integrity of sensitive biologics or introduce secondary contaminants. To overcome these constraints, we developed an integrated platform for simultaneous LPS detection and removal. This system employs aptamer-conjugated micelles that encapsulate an aggregation-induced emission photosensitizer with high reactive oxygen species quantum yield. The surface aptamers facilitate specific LPS capture, followed by efficient light-triggered oxidative degradation. The capture-first design concentrates LPS near the photosensitizer-loaded core to maximize degradation efficiency. When validated in endotoxin-contaminated insulin solutions, the platform markedly reduced the ELISA-detectable LPS signal under the tested conditions, without measurably impairing insulin-induced glucose uptake in 3T3-L1 adipocytes in this preliminary assay. This biocompatible strategy bridges the gap between LPS monitoring and safe decontamination.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Zhang Bing Ying,Liu A. Fang,Zhou Cong,Kang Tian Tai,Xu Yu Fang,Guo Yao Hao,Wang Li,Wan Fu
An environmentally friendly ultrasound-assisted liquid-liquid microextraction method based on the in situ formation of a hydrophobic deep eutectic solvent (DES) was developed for monitoring seven polychlorinated biphenyl (PCB) congeners as residues in and migrants from food contact paper. The extraction phase was generated in situ from tetrapropylammonium chloride and 1-octanol (molar ratio 1:3), followed by analyte quantification using high-performance liquid chromatography with diode-array detection (HPLC-DAD). Optimization of the parameters affecting extraction efficiency was performed. Under optimal conditions, the method exhibited good linearity and sensitivity. For residual PCB analysis, the limit of quantification (LOQ) was 0.093–0.11 mg/kg; relative recoveries ranged between 89 and 108%; and relative standard deviations were 4–8%. For migration studies, the LOQ was in the range of 0.47–0.53 μg/L, relative recoveries ranged between 90 and 110%, and relative standard deviations were under 9%. The developed method’s intra-day and inter-day relative standard deviations were 1.9–2.7% and 2.4–3.6%, respectively. The developed approach offers high extraction efficiency, operational simplicity, and environmental compatibility, demonstrating considerable promise for routine monitoring of PCBs in food contact paper materials. Graphical abstract
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Nature Communications
·
2026
·
IF 18.1
Ma Yiyuan,Yin Zhuoyu,Chang Yide,Meng Qi,Qi Qi,Hua Yingkai,Yu Jingya,Zhan Zhen,Deng Canbin,Zhang Zeyu,Wu Mengcheng,Cheung Chi Fai,Huang Jiaqiang,Wang Yanming,Kim Yoonseob,Aurbach Doron,Xu Zheng-Long
Rechargeable calcium batteries are promising for next-generation energy storage devices due to the high crustal abundance of calcium (Ca) and the high-capacity and dendrite-free nature of Ca metal. However, their implementation is hindered by the lack of high-power and high-capacity positive electrodes, largely due to sluggish Ca 2+ diffusion in inorganic hosts and limited active-site utilization in organic electrodes. Here we design a series of covalent organic frameworks incorporating different quinone units to construct carbonyl-staggered channels that accelerate Ca 2+ hopping, enhance accessibility of deep-layer active sites even at high rates, and facilitate electronic charge transport through in situ conjugation reconstruction at ortho-carbonyl sites during repeated Ca 2+ insertion. These combined effects contribute to fast charge-transfer kinetics, endowing the optimized heterogeneous framework with high-rate capability (56.4% capacity retention from 0.05 A g −1 to 2 A g −1 ) and long cyclability (71.7% capacity retention after 5,000 cycles at 2 A g −1 ), with further validation in Ca-metal pouch cells. This work highlights carbonyl staggering as a molecular design strategy for regulating Ca-ion transport and improving active-site utilization in calcium-organic batteries.
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MOLECULAR DIVERSITY
·
2026
·
IF 4.3
Yang Yangyang,Sun Dezhong,Jia Qingyun,Zhu Bing,Lv Huaiqing,Che Fengyuan
Excitotoxicity is a core pathological mechanism underlying various neurological disorders, including depression. It is primarily driven by the overactivation of NMDA receptors and disruption of calcium homeostasis. However, effective therapeutic interventions targeting this process remain limited. In this study, aloe-emodin was shown to reverse NMDA-induced reduction in cell viability, apoptosis, and calcium overload in a dose-dependent manner, while also attenuating NMDA-induced autophosphorylation of CaMKII. In a chronic unpredictable mild stress (CUMS) model, aloe-emodin significantly ameliorated depression-like behaviors, suppressed inflammatory responses and oxidative stress, and downregulated the expression of cleaved-PARP. By conducting biotin pull-down coupled with liquid chromatography-tandem mass spectrometry (LC–MS/MS) analysis, cellular thermal shift assay (CETSA), drug affinity responsive target stability (DARTS) analysis, and surface plasmon resonance (SPR) analysis, RANBP9 was identified as a direct molecular target of aloe-emodin, with a binding affinity (KD) of 716 nM. Molecular docking and molecular dynamics simulations revealed that aloe-emodin selectively binds to the His332 residue of RANBP9. Aloe-emodin promoted the degradation of RANBP9 via the ubiquitin–proteasome pathway by facilitating the interaction between RANBP9 and the E3 ligase CHIP. After RANBP9 was knocked down, the protective effects of aloe-emodin on cell viability and apoptosis were significantly weakened, confirming that the anti-excitotoxic activity of aloe-emodin is RANBP9-dependent. These findings collectively demonstrate that aloe-emodin is a novel and potent RANBP9-targeting compound with antidepressant activity and suggest that RANBP9 may serve as a promising target for developing antidepressant drugs. Graphical abstract
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npj Science of Food
·
2026
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IF 9.7
Shi Xuening,Zhang Huiqian,Zheng Jingying,Wang Juan,Zhao Chao
Sterilization technologies for microorganisms in food are limited by safety and antibiotic residue concerns and resistance, creating an urgent need for novel sterilization methods. Photothermal conversion nanomaterials can rapidly convert near-infrared light into thermal energy, offering fast, efficient, and environmentally friendly sterilization, leading to their increasing application. Herein, we designed and prepared a composite multilayer photothermal nanomaterial (MCOF@Au@PEI NPs), integrating “capture-photothermal sterilization-separation and recycling” functions and achieving rapid and efficient sterilization. The material maintains high photothermal conversion efficiency even after multiple cycles and exhibits excellent biocompatibility. Using Escherichia coli and Staphylococcus aureus as model bacteria in milk and drinking water, the material achieves a 100% bacterial sterilization rate within 435 seconds under irradiation, equivalent to pasteurization. Moreover, the material exhibits potent destructive effects on bacterial biofilms, showing broad application prospects in developing novel nano-photothermal sterilization methods and antibiotic alternative therapies.
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Cell Death & Disease
·
2026
·Vol. 17
·期 1
·750
·
IF 12.2
Luomeng Qian,Ping Chen,Bo Wang,Qing Zhang,Yuan Guo,Jie Cui,Ran Ding,Hongkai Zhang,Sihe Zhang
Sorafenib is a widely used targeting drug for hepatocellular carcinoma (HCC) patients; however, sorafenib resistance poses a significant clinical challenge. Hypoxia and extracellular vesicles (EVs) induce vasculogenic mimicry (VM) which is linked to sorafenib resistance in HCC. Migrasomes (Migs), the newly discovered large EVs, foster HCC malignant phenotypes by facilitating the intercellular transfer of functional molecules. Despite these advancements, the precise mechanism by which Migs cause sorafenib resistance is still unknown. In this study, we found that hypoxia upregulates the Migs release and CD147 expression on Migs surface, which is related to sorafenib resistance in HCC. Further investigations revealed that hypoxia-induced migrasomes (hypo-Migs) induce VM formation, thereby promoting sorafenib resistance in HCC. Notably, hypo-Migs are internalized into HCC cells through macropinocytosis, which depends on the expression of lysophosphatidic acid receptor 6 (LPAR6). Mechanistically, CD147-positive (CD147 + ) hypo-Migs activate the PI3K/AKT/TWIST1 signaling pathway, subsequently inducing VM formation and promoting sorafenib resistance. Importantly, dual blockade of CD147 + -hypo-Migs macropinocytosis and VM formation enhances the sorafenib-killing efficacy to HCC. Conclusively, our findings uncover a novel sorafenib resistance mechanism induced by CD147 + -hypo-Migs, and highlight dual-targeting of macropinocytosis and VM as a promising strategy to overcome the sorafenib resistance in HCC.
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PubMed
高影响因子
International Journal of Peptide Research and Therapeutics
·
2026
·Vol. 32
·期 5
·80
·
IF 2.5
Jiang Xinyi,Li Junxiang,Lu Yi,Ni Fangyuan,Li Sen
Purpose Advanced glycation end products (AGEs) and their downstream inflammatory consequences contribute to skin dysfunction and aging-related deterioration. EQ-9 has been identified as a novel functional peptide with anti-aging and skin repair potential. In this study, we investigated the effects of EQ-9 and its two derivatives (EL-6 and ac EL-6) on Methylglyoxal (MGO)-induced glycation and inflammatory damage. Methods We exposed HaCaT cells to MGO to simulate hyperglycemic conditions. The protective effects of these peptides were assessed through measurements of cell viability, migration, CML levels, inflammatory cytokine secretion, RAGE expression, and NF-κB pathway activation. Additionally, TNF-α/IFN-γ were used to induce inflammatory injury and evaluate the anti-inflammatory effectiveness of the peptides. A murine excision wound model was also established to examine the effects of ac EL-6 on skin inflammation, collagen deposition, angiogenesis, and wound healing. Results All three peptides significantly reduced MGO-induced CML generation, downregulated RAGE, inhibited NF-κB activation, attenuated proinflammatory cytokine secretion, alleviated cell damage, and promoted migration. They also mitigated TNF-α/IFN-γ-evoked inflammatory responses via NF-κB suppression. Topical application of ac EL-6 decreased cytokine levels, increased VEGF expression and collagen deposition, and consequently accelerated wound healing in mice. Conclusion Together, these findings identify ac EL-6 as a stabilized lead candidate derived from EQ-9, which exhibits anti-glycation activity and modulates NF-κB-mediated inflammatory signaling in keratinocytes, and demonstrates initial skin-repair potential in vivo. The data support further development of ac EL-6 for skin-directed applications. Graphical
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