FITOTERAPIA
·
2025
·
IF 2.6
Mingxuan Guo,Huanxin Zhao,Nannan Song,Ping Huang,Man Li,Liwen Han,Ke-wu Zeng,Zhiyuan Lu
Sepsis-associated acute lung injury (SA-ALI), a critical complication of sepsis, is characterized by immune dysregulation-induced pulmonary dysfunction. Shenmai Injection (SMI) is a standardized herbal preparation consisting of Panax ginseng C.A.Mey (Hongshen) and Ophiopogon japonicus (Thunb.) Ker Gawl (Maidong), traditionally used for qi-replenishing, collapse-stabilizing, and lung-moistening therapy. Although clinically utilized in the management of SA-ALI, the specific mechanisms by which it acts against SA-ALI necessitate further investigation. The present study endeavors to comprehensively determine the therapeutic efficacy of SMI against SA-ALI through an integrated approach combining network pharmacology, metabolomics, metagenomic sequencing, and experimental validation. In this study, murine SA-ALI was established using lipopolysaccharide (LPS) and Poly(I:C). Results indicated that SMI administration significantly attenuated pulmonary inflammation, restored blood-gas barrier integrity, reduced serum pro-inflammatory cytokines and suppressed NF-κB pathway activation in SA-ALI mice. Network pharmacology elucidated the multi-targeted mechanism of SMI in modulating steroid hormone biosynthesis. Integrated metabolomics and target analysis revealed that ophiopogonin A/B and luteolin in SMI alleviates metabolic dysregulation by targeting key enzymes, including AKR1C3, HSD17B1/2, and SULT1E1. Metagenomic profiling demonstrated SMI-mediated gut microbiota remodeling, marked by suppression of pathogenic Chlamydiaceae (particularly Chlamydia abortus ) and enrichment of commensal Lactobacillaceae . Correlation analysis showed that intestinal androstenedione and androsterone levels during SMI treatment recovery were negatively correlated with Chlamydia abortus abundance. In conclusion, SMI enhances the recovery from sepsis-associated SA-ALI by dual modulation of gut microbial ecology and host metabolic homeostasis, thereby establishing its potential as a multi-mechanistic therapeutic candidate for sepsis-related organ injury.
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WATER AIR AND SOIL POLLUTION
·
2025
·Vol. 236
·期 15
·1-15
·
IF 3
Lv Tingting,Wang Hong,Li Ding,Li Ruihai,Yang Chengliang,Zhao Wei,Cui Zhenyu,Li Jianxin
Organophosphorus pesticide contaminated sites have been categorized as a global priority contaminated site type for remediation due to the excessive accumulation of persistent organic pollutants. This study investigated the removal effect of phorate (PHR) in polluted soil through co-solvent-assisted alkaline activation of persulfate (PS) system, and evaluated the contribution of the co-solvent to the desorption behavior and solubilizing effect of PHR. Results showed that a high PHR degradation rate of 56.1% was obtained on the second day under the following conditions: 40% (v/v) acetonitrile (ACN) as co-solvent, C PS = 382 mmol L –1 , pH 12, and a W L /W s ratio of 1:2. It was a significant improvement over the system without co-solvent (19.9%). Moreover, a degradation rate of PHR was up to 93.9% on the 21st day under the optimized operating conditions, which was significantly higher than that observed in the persulfate oxidation system (13.1%) and the alkaline hydrolysis system (33.6%). The critical active species, including sulfate radicals \(S{O}_{4}^{\bullet -}\) and hydroxyl radicals (•OH) for the oxidation of PHR in contaminated soil during the alkaline-activated persulfate system were identified using electron spin resonance (ESR) and radical quenching experiments. The degradation pathways involved both hydrolytic pre-activation and radical mineralization. Furthermore, the luminescent bacteria tests demonstrated that the luminescence inhibition rate of the PHR-contaminated soil decreased from an initial value of 100% (highly toxic) to 16.2% (low toxicity) after remediation. In summary, this study offers a promising approach for the remediation of organophosphorus pesticide-contaminated soils.
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2025
·
IF 4.7
Xin Yao,Gongnv Xu,Bingchen Tan,Xuankai Deng,Yanhua Yu
Photoswitches with multiple fluorescent states known as photofluorochromism under light irradiation show practical applications in optical information storage, anticounterfeiting, and sensors. Despite considerable progress, current photoresponsive systems mainly operate in solution phase, with solid-state implementations remaining challenging. Herein, in this article, we reported three green fluorescent protein (GFP) chromophore like analogues (denoted as p -CBIE, m -CBIE and m -DCBIE) demonstrating photofluorochromic behavior in solid-state. Intriguingly, these compounds exhibited opposite photo responses between solution and solid states. In solution phase, UV irradiation induced fluorescence quenching through photoisomerization. Remarkably, the solid-state displayed light-activated fluorescence enhancement with chromatic shifts: p -CBIE and m -DCBIE exhibited green-to-blue emission switching with fluorescence quantum yield (Φ F ) enhancements from 8.2 % to 18.2 % and 11.3 % to 25.8 %, respectively. m -CBIE demonstrated blue emission increase with Φ F improvement from 4.8 % to 16.6 %. Mechanism studies revealed that light-induced molecular reorganization facilitated tighter packing and enhanced structural rigidity in the solid state, thereby suppressing non-radiative decay pathways. Moreover, p -CBIE, m -CBIE and m -DCBIE were successfully used for selective photoactivation imaging of SK-OV-3 cancer cells and photo-patterning.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Zehao Wang,Huayu Chen,Yesheng Fu,Hang Yin,Dandan Yu,Junhui Liang,Yuexiang Huang,Liuqi Wang,Wei Gao,Da Chen,Yang Hou
Hydrogen production technology by water electrolysis highly relies on active and durable electrocatalysts for oxygen evolution reaction (OER). For Fe-containing electrocatalysts, the surface evolution during OER generally induces the dissolution of Fe into electrolyte. The excessive changed and dynamic surface quite puzzles the initial catalyst design, and moreover the excessive Fe loss could result in instability of the reconstructed surface, which might affect the formation of active species and the durability on the reaction interface. Here, we introduced a functional component of ethylenediamine-intercalated black phosphorus (eda-BP) to the Ni 1.5 Fe 0.5 B. Through electronic interaction between eda-BP and Ni 1.5 Fe 0.5 B, the excessive Fe loss during surface reconstruction process is effectively suppressed and the formation of Ni oxyhydroxide active species is facilitated, thereby enhancing the stability of the catalytic reaction interface. At the meantime, the ⁎ OH adsorption capacity on the reaction surface is regulated and the heterostructure catalyst exhibits significantly improved OER reaction kinetics. The Ni 1.5 Fe 0.5 B/eda-BP demonstrates a low OER overpotential ( η = 221 mV) at the current density of 10 mA cm −2 and sustainable activity. This work offers a facile strategy for improving the reactive interface for efficient and durable OER process.
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WATER RESEARCH
·
2025
·
IF 12.4
Haokun Bai,Peike Cao,Lanlan Liang,Shuo Chen,Xie Quan
Metal atomic cluster (AC) catalysts exhibit remarkable catalytic activity in environmental catalysis owing to their tunable structural and electronic properties regulated by electronic metal-support interactions (EMSI). Nevertheless, the precise size control of metal AC remains challenging owing to their inherent aggregation tendency under harsh synthetic conditions. Herein, we propose a confined synthesis strategy for fabricating cobalt AC within the interlayer channels of a two-dimensional molybdenum disulfide membrane (CoAC@MoS 2 membrane) for peroxymonosulfate (PMS) activation. The interlayer confinement of MoS 2 nanosheets enforces the in-plane assembly of metal precursors, yielding ultrafine CoAC (2.1 nm) with excellent Fenton-like activity (0.733 min -1 ), outperforming unconfined Co nanoparticles (29.3 nm, 0.291 min -1 ). Experiments and density functional theory calculations reveal that electrons transfer from sulfur vacancy and Mo sites in MoS 2 to Co 3d orbitals, generating electron-rich Co sites with an upshifted d -band center, which optimizes PMS adsorption and electron transfer to generate SO 4 ⚫- and ⚫OH radicals. The as-prepared CoAC@MoS 2 membrane achieved a sulfamethoxazole degradation rate of 5.33 × 10 6 μmol g metal -1 s -1 , which was 1-2 orders of magnitude higher than state-of-the-art nanoconfined catalytic membranes, and also proved effective in treating secondary pharmaceutical wastewater. This work establishes a universal paradigm for size and electronic structure engineering of metal catalysts through spatial confinement, advancing the development of high-performance Fenton-like catalytic systems for sustainable water remediation.
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ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Shuyi Lu,Qian Wu,Shanshan Wang,Dongru Sun,Yan Liu,Shaohua Huang,Biling Huang
19F-labeled molecular probes offer significant advantages in chiral analysis, with their stereostructures playing a critical role in enantiodiscrimination. Rapid and accurate assignment of absolute configurations is particularly important for the pharmaceutical field and asymmetric synthesis. This work presents a comparative evaluation of two 19F-labeled probes as CDAs: aromatic P1 ((S)-1-(2-fluorophenyl)ethylamine) and aliphatic P2 (trans-2-fluorocyclohexanamine), focusing on their enantiomeric recognition of chiral carboxylic acids. The results demonstrate that P1 outperformed P2, particularly in analyzing carboxylic acids with chiral centers positioned several carbons away from the carboxyl group or possessing multiple chiral centers. Density functional theory calculations elucidated the underlying mechanisms, revealing that P1’s great recognition efficiency arises from a larger energy difference between diastereomers and the formation of hydrogen bonds between its fluorine atom and the analytes’ protons. These findings emphasize the importance of probe–analyte interactions in CDA-based enantiorecognition systems for achieving high-resolution discrimination. Moreover, P1 exhibited practical applications in determining ee values and analyzing various brands of ibuprofen capsules and tablets, highlighting its potential for pharmaceutical quality control. Furthermore, we introduced a novel online platform combining a P1-guided 19F NMR approach with machine learning for automated prediction of absolute configurations. This work sheds light on the differences between aromatic and aliphatic probes in enantiorecognition, while introducing an online predictive tool, in favor of the design of 19F molecular probes and the rapid assignment of absolute configurations.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Qiang Tan,Zhonglin Chen,Jimin Shen,Pengwei Yan,Jing Kang,Binyuan Wang,Shengxin Zhao,Yang Shen,Yabin Li
A ZnFe-LDH-derived ZnFe-LDO with high surface hydrophilicity was synthesized for catalytic ozonation to achieve durable water purification. It showed high catalytic performance towards ozone (O 3 ) decomposition to generate hydroxyl radicals (·OH), as well as enhancing the decontamination efficiency compared to ozonation alone. The ZnFe-LDO catalytic ozonation system promoted the degradation ratio of diatrizoic acid (DTA) from 20.6 % (ozonation alone) to 100 % within 10 mins, and the observed degradation rate constant (k obs ) of DTA under O 3 /ZnFe-LDO system was 14.8 times that of O 3 alone system and 3.1 times that of O 3 /ZnFe-LDH system. The constructed ZnFe-LDO and ZnFe-LDH catalyzed ozonation systems for water purification were comprehensively evaluated. ZnFe-LDO showed excellent structure and catalytic stability during the long-lasting catalytic ozonation process. The hydrophilic surface of ZnFe-LDO benefited the adsorption of H 2 O, and O 3 was more readily adsorbed on the hydrated surface ( E ads = −1.89 eV) to react with -OH sites. The continuous flow technique based on the O 3 /ZnFe-LDO process was well adopted for the purification of raw water. In short, regulating the surface hydrophilicity of ZnFe-LDO was an effective strategy to achieve durable catalytic ozonation.
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Reaction Kinetics Mechanisms and Catalysis
·
2025
·
IF 1.7
Guo Lirong,Yang Xiaodie,Shao Huijuan,Zhang Xuzhi,Wang Yating,Jiang Tao
We have investigated the effect of different impurities (CO, CO 2 , CS 2 , CH 3 OH, H 2 O, C 4 H 4 S) on the silicon-bridged diphosphine(PNSiP)/CrCl 3 (C 4 H 8 O) 3 /modified methylaluminoxane ethylene tri-/tetramerization system. The results showed that the addition of trace impurities has a certain inhibitory effect on catalytic activity. The influence of impurities on the catalytic activity of the catalyst system was as follows: CO > CO 2 > CS 2 > CH 3 OH > H 2 O > C 4 H 4 S. CO showed the most significant inhibitory effect in reducing activity from 1.75 × 10 6 g/(mol Cr h) to 0.74 × 10 6 g/(mol Cr h) at an addition of 0.2 ppm. Through the analysis of nuclear magnetic resonance (NMR) and ultraviolet–visible spectrophotometry (UV–vis), we found that carbon monoxide mainly inactivates the catalytic system by coordinating with chromium active sites, while methanol and water reduce the catalytic activity by destroying the structure of modified methylaluminoxane. Furthermore, we also proposed a possible reaction path between carbon monoxide and the chromium active center. Graphical abstract
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Liling Wang,Yanbin Wang
Hg 2+ ions, as one of the prevalent toxic heavy metals, are ubiquitously distributed in food and environmental systems. Consequently, there is an urgent demand to develop a convenient and reliable detection platform. In this study, heteroatom-doped PdCo@NC nanozymes were synthesized by pyrolyzing bimetallic metal-organic frameworks (MOFs) in argon, combining MOF-derived porous carbon with C/N co-doping. The resultant PdCo@NC-500 material exhibits a flower-like morphology with defects and uniform elemental distribution, demonstrating unique intrinsic peroxidase-like activity. This enables the oxidation of TMB in the absence of H₂O₂, with catalytic performance surpassing that of single-metal systems. Key reaction intermediates (•OH, 1 O₂) were verified through quenching experiments. Kinetic analysis revealed that this material possesses high catalytic efficiency ( K m = 0.101 mM, V max = 238.9 × 10 −3 M/s). Notably, following the distinctive REDOX reaction between H₂O₂ and Hg 2+ , the peroxidase-like activity of PdCo@NC-500 is significantly inhibited, enabling selective alteration of the reaction pathway and changing the product color from blue to yellow. This unique response characteristic provides a foundation for designing colorimetric sensors, achieving dual-wavelength colorimetric detection of Hg 2+ . Experimental results indicate that the linear range of this method is 50–1000 μM (λ = 450 nm) and 0.5–100 μM (λ = 652 nm), with a detection limit of 0.02 μM. This method has been successfully applied to highly sensitive detection of Hg 2+ in real water samples and rice, with recovery rates ranging from 94.87 % to 109.1 %.
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Yuan Li,Xuejiang Wang,Yuan Wang,Siqing Xia,Hongbin Xu,Jianfu Zhao
The co-occurrence of biodegradable microplastics (BMPs) and antibiotics in wastewater poses environmental concern. However, the effects of different environmental ageing processes on antibiotic-BMPs interfacial interactions remain inadequately characterized. This study systematically compared the adsorption-desorption behaviour of sulfamethazine (SM2) onto biodegradable poly(butylene succinate) microplastics (PBS-MPs) subjected to sewage microbial exposure (B-PBS-MPs) and sunlight exposure (P-PBS-MPs). Kinetics of SM2 adsorbed on all MPs conformed to the Elovich model, indicating that the adsorption rates synergistic controlled by liquid-film and intra-particle diffusion. The maximum adsorption capacities predicted by Langmuir model increased from 76.52 μg/g for PBS-MPs to 316.58 μg/g for B-PBS-MPs and 351.49 μg/g for P-PBS-MPs, indicating that sunlight exposure exerted more pronounced adsorption enhancement than microbial exposure. Mechanistic divergences were observed: pristine PBS-MPs exhibited Langmuir-type monolayer adsorption dominated by non-bonding interactions, whereas sunlight-exposed P-PBS-MPs followed Freundlich-type multilayer adsorption driven by hydrogen bonding and van der Waals forces. For microbial-exposed B-PBS-MPs, adsorption obeyed the Langmuir-Freundlich model—micropore filling may dominated at low SM2 concentrations, while complexation of SM2 and biofilm-associated extracellular polymeric substances (EPS) prevailed at higher concentrations. The results of desorption hysteresis indicated the most stable SM2 retention in microbial-exposed MPs via SM2-EPS chemical bonds and the least stable SM2 adsorption in sunlight-exposed MPs due to the weak binding force. These findings demonstrate that ageing differentiates biodegradable MPs into distinct antibiotic vectors: microbial exposure enhanced adsorption capacity and stability, whereas sunlight exposure elevated remobilization risks. This work contributes to the assessment of the compounded environmental risks of BMPs and antibiotics.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Xuedong Jia,Hongyuan Guo,Runying Chai,Jingbin Shi,Hao Wu,Yujue Feng,Wei Ji,Suozhu Wu
A dual-functional membrane modified electrode - based molecularly imprinted electrochemical sensor was developed for the ultrasensitive and selective detection of quercetin (Que). The dual-functional membrane consisted of chitosan-modified carboxylated multi-walled carbon nanotubes (cMWCNT-CS) nanocomposites and β-cyclodextrin/dopamine molecularly imprinted polymer (β-CD-DA-MIP). The synergistic interactions between the conductive layer of cMWCNT-CS and the recognition element of β-CD-DA-MIP enabled high-performance detection of Que. This sensor exhibited an ultra-wide linear response range of 1.0 × 10 −14 to 1.0 × 10 −4 M with a limit of detection of 2.9 × 10 −16 M (S/N = 3). The sensor also had the advantages of simple fabrication, rapid response (6 min), excellent reproducibility, and high selectivity. The sensor was successfully used to detect Que. concentration in grape, grape juice, and wine samples with satisfactory results. This study provided a simple, efficient, and ultrasensitive method for monitoring the natural bioactive compounds, which offered potential applications for food quality control and pharmaceutical analysis.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Yanni Lang,Dongfeng Hong,Rongze Ma,Haoqiang Zhang,Liang Xu,Xinye Zhao,Dan Wu,Yongjin Li,Dacheng Zhou,Zhiguo Song,Yugeng Wen,Yong Yang,Jin Han,Jianbei Qiu
The construction of chiral materials has always been a research hotspot in the field of non-chiral nanomaterials. By introducing chiral destructive agents, materials are endowed with chiral nanostructures, which can be used in the field of photocatalysis. Au nanoparticles (Au NPs) are a typical photosensitizer capable of producing surface plasmon resonance (SPR) effects, producing CO and CH 4 in photocatalytic CO 2 reduction. We suggest that the SPR effect of the photocatalyst (D-BiOBr/Au) for Au NPS deposition of nonchiral bismuth bromide oxide nanomaterials can enhance the photocatalytic CO 2 reduction by enhancing spin-polarized electrons. It is worth noting that D-BiOBr/Au chiral materials enhance spin-polarized electrons due to SPR effect, and their photocatalytic CO 2 reduction performance is significantly better than D-BiOBr and original BiOBr without SPR effect. The CO yield of D-BiOBr/Au is 24.39 μmol/g h −1 , which is 2.02 times of D-BiOBr and 2.43 times of BiOBr, respectively. The mechanism of photocatalytic CO 2 reduction was further studied by FDTD simulation. The reason for the improved photocatalytic CO 2 reduction efficiency of D-BiOBr/Au is the increase of spin-polarized electrons due to the SPR effect, thus prolonging the carrier lifetime and promoting spin-polarized electron-hole separation. The results show that enhancing spin-polarized electrons through SPR effect is an effective strategy to improve photocatalyzed CO 2 reduction in photocatalyzed semiconductors.
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