Biomaterials Science
·
2023
·
IF 6.6
Gao-Feng Qi,Xin Cui,Xue-Feng Gong,Xu Cui,Huan-Ge Xu,Qi-Lin Liang,Kuo Zhang,Xiao-Ling Sha,Litao Li,Gui-Yuan Wang,Hong-Wen Liang,Lei Wang
Fungal infections contribute substantially to human morbidity and mortality. Particular concern is the high rate of mortality associated with invasive fungal infections, which often exceeds 50.0% despite the availability of several antifungal drugs. Herein, we show a self-assembling antifungal peptide (AFP), which is able to bind to chitin on the fungal cell wall and in situ form AFP nanofibers, wrapping fungi. As a result, AFP limits the proliferation of fungi, slows the morphological transformation of biphasic fungi, inhibits the adhesion of fungi to host cells and the formation of biofilms. Compared to the broadspectrum antifungal fluconazole, AFP achieved the comparable inhibitory effect (MIC50 = 3.5 µM) on fungal proliferation. In addition, AFP significantly inhibits the formation of fungal biofilms with the inhibition rate of 69.6% at 1 µM, better than fluconazole (17.2% at 1 µM). In skin infection model of mice, it was demonstrated that AFP showed significantly superior efficacy than fluconazole. In systemic candidiasis mice model, AFP showed similar efficacy with first-line antifungal amphotericin B (AmpB) and anidulafungin (AFG). This study provides a promising wrapping strategy for the anti-fungal infection.
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ACS Sustainable Chemistry & Engineering
·
2023
·
IF 8.4
Haohan Wu,Yingchun Liu,Liheng Chen,Zhengwen Li,Zhaosong Hu,Xuliang Lin,Xueqing Qiu
Enhancing the interface compatibility between the polymer matrix and filler is still a hotspot issue for the fabrication of thermal management materials. In this work, biomass lignin was used innovatively as coupling reagents to optimize the interface microstructure of the matrix/filler. The as-prepared lignin-graphite (AL@GP) and epoxy resin with a Schiff base structure (PBD-EP) were employed as functionalized filler and polymer matrix, respectively. And a degradable and thermally conductive epoxy composite was prepared through the hot-press technique. Experimental and theoretical calculations results based on the first principles demonstrated enhanced interface bonding between GP and PBD-EP. Besides, the developed polymeric composites exhibited excellent thermal conductivity (2.852 W m–1 K–1) when loaded with 50 wt % AL@GP, increasing by 26.1% compared with the PBD-EP/GP system. Moreover, it presented a reduced interface thermal resistance (0.10745 m2 K W–1) and superior solvent-free green degradability. LED heat dissipation experiments indicated the potential of as-prepared composites for thermal management applications. This work not only provides a novel and facile filler functionalization strategy for improving the interfacial interaction of the matrix/filler but also promotes the high-value applications of biomass lignin.
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Journal of Water Process Engineering
·
2023
·
IF 7
Longxiang Xia,Jing Shen,Dengfeng Wu
Herein, Al 2 O 3 supported ultra-small Mn-CeOx nanoparticles (Mn-CeOx/Al 2 O 3 ) are prepared by a facile impregnation method for removal of phenolic compounds via catalytic ozonation . Mn and Ce species are in the form of polyvalent oxide nanoparticles with an average size of 0.9 nm. The removal efficiency of total organic carbon for phenol-containing model wastewater by Mn-CeOx/Al 2 O 3 shows a volcano relationship by changing the mass ratio of Mn and Ce, and reaches up to the peak value when the mass ratio is 5:5. The cycle stability tests suggest the removal efficiency of Mn-CeOx/Al 2 O 3 could maintain at 90.16 % after 5 circles. The enhanced performance should be attributed to the optimized magnetism and accelerated charge transfer by composition regulation. The magnetic strength changing affects the adsorption mode of O 3 , while the redox cycle of Mn(IV)/Mn(III) and Ce(IV)/Ce(III) could enhance the activation of O 3 to produce more ·OH and 1 O 2 for the organic molecules mineralization.
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Qian Liu,Tao Wang,Caige Wang,Dongling Wu
Developing a novel preparation strategy for the fabrication of high-performance porous carbon electrode materials is still the focus of current research. Herein, O/N doped coal tar pitch (CTP)-based porous carbon with a fishnet-like structure is prepared via the electrospinning technology. CTP is used as a carbon source and ChCl/phenol deep eutectic solvent (DES) is used as a spinning solution directly, and not any polymer is added. The complexes obtained by electrospinning are then activated by a small amount of K 3 C 6 H 5 O 7 and get the porous carbon. Specifically, the DES has a specific viscosity and can be used not only as a solvent to improve the spinnability of CTP, but also as N source and act as a multifunctional solution. The electrospinning technology constructs the macropores and mesopores, while K 3 C 6 H 5 O 7 can make micropores and even ultra-micropores in the prepared carbon material. Benefiting from the constructive hierarchical pore channels and abundant heteroatoms doping, the prepared porous carbon electrode possesses a high specific capacitance of 202 F g −1 even when reaching commercial loading. Simultaneously, a novel K 3 C 6 H 5 O 7 /glycol/acetonitrile DES gel electrolyte is synthesized, and an extended working voltage (2.2 V) can be achieved. The fabricated capacitor has large energy density of 23.9 Wh kg −1 , and can still operate normally in a wide temperature range (-25 ∼ 100 °C). The multifunctionality of DES uncovers the feasibility of preparation of porous carbon using DES as the spinning solution directly, and may expect to prepare other carbon materials using the proposed strategy with different carbon precursors.
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NEW JOURNAL OF CHEMISTRY
·
2023
·
IF 3.3
Ming Gao,Chang Bian,Hongjie Zhao,Huili Wang,Xuedong Wang
p-aminophenol nitrophenol (p-AP) is widespread in various aquatic environments with teratogenic effects, nephrotoxicity, and genotoxicity. Hence, developing a quick, sensitive, and focused approach for p-AP detection is crucial. In this study, monodisperse, evenly dispersed fluorescent sulfur quantum dots (SQDs) with a 5 - 10 nm size were produced via the "assembly-fission" technique. Tyrosinase (Tyr) catalyzes the oxidation of p-AP to 4-amino-1, 2-benzoquinone, which efficiently quenches the fluorescence of SQDs through the internal filtering effect (IFE) between the oxidative product and SQDs. The quenching mechanism of the SQDs/Tyr/p-AP system is demonstrated by analyzing fluorescence, Zeta potential, and UV-Vis absorption spectrum overlap. When the concentration of p-AP is between 0.5 and 120 μM in the presence of Tyr, the fluorescence quenching efficiency of SQDs exhibits a strong linear relationship. The limit of detection is 0.15 μM, which is comparable to most other methods, and also shows a wider linear range with less matrix interference. With outstanding recoveries of 93.2 ~ 105.8% and relative standard deviations (RSDs) of 1.8 ~ 3.7% and 3.6 ~ 6.6%, respectively, the newly proposed approach has been effectively used to detect p-AP in a variety of waters. Overall, this proposed method is having high recoveries and low detection limits for the great potential application of actual determination of p-AP in different waters.
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Nanomaterials
·
2023
·Vol. 14
·期 1
·74
·
IF 5.3
Xin Zhong,Meihuan Ji,Wenxin Wu,Caicai Lu,Wenping Liu,Fubin Jiang
In this work, the heterojunctions of CuInS2embedded in the g-C3N4materials (xCuInS2/g-C3N4, abbreviated as xCIS/GCN) was successfully prepared for peroxymonosulfate (PMS) activation under visible light. The catalysts are characterized by different techniques, such as XRD, FTIR, SEM, TEM, and UV-vis. The unique heterojunction composites can suppress the recombination of photogenerated pairs. The catalytic results showed that the 3CIS/GCN exhibited excellent catalytic levofloxacin (LVF) degradation efficiency, while more than 98.9% of LVF was removed in 60 min over a wide pH range. SO4•−, O2•−, OH•, and1O2were verified as the main reactive species for LVF degradation via the quenching experiments and electron paramagnetic resonance technology (EPR). The synergetic effect of xCIS/GCN, PMS, and visible light irradiation was discussed. The possible LVF degradation pathway was proposed through byproducts analysis (LC-MS). Moreover, the 3CIS/GCN/vis-PMS system has very low metal leaching. Owing to xCIS/GCN having good properties for PMS activation, it has potential applications for LVF or other hazardous pollutants degradation.Keywords:peroxymonosulfate;visible-light-assisted PMS activation;antibiotics
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2023
·Vol. 141
·期 10
·e55051
·
IF 3
Xiaoling Da,Zhaoyi Deng,Tong Wu,Ya Cao,Ming Xiang,Feng Yang
To study the effect of molecular structure on ethylene-vinyl alcohol copolymer (EVOH) thermal stability during processing, EVOH samples with different molecular weights and comonomer distributions were prepared by solubility fractionation from two different commercial materials, and then, the structure features of samples were characterized by 1 H-NMR, viscometry, differential scanning calorimetry, and, especially, successive self-nucleation and annealing. Their thermal stabilities were further analyzed by isothermal oxygen treatment and thermogravimetry. Attenuated total internal reflectance Fourier transform infrared spectroscopy and UV were used to obverse the structural changes in samples (the formation of chromogenic groups: CO and CC ). According to the results of isothermal oxygen treatment at 200°C, at the same ethylene content, low-molecular-weight samples have worse thermal stability, which were extremely easy to yellowing and form insoluble gel. To investigate the structure differences between the low-molecular-weight samples, it was found that long vinyl alcohol segments may not worsen the thermal stability in the conditions of the same ethylene content. But samples with a uniform distribution of ethylene segments and a certain length of ethylene segments will have better thermal stability, which makes it more difficult to form carbonyl even diketene conjugation structure.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2023
·
IF 11.4
Mengxi Tan,Xiaoshan Zheng,Wanchao Yu,Baoliang Chen,Chiheng Chu
Reactive oxygen species (ROS) are widespread in nature and play central roles in numerous biogeochemical processes and pollutant dynamics. Recent studies have revealed ROS productions triggered by electron transfer from naturally abundant reduced iron minerals to oxygen. Here, we report that ROS productions from pyrite oxidation exhibit a high facet dependence. Pyrites with various facet compositions displayed distinct efficiencies in producing superoxide (O2• –), hydrogen peroxide (H2O2), and hydroxyl radical (•OH). The 48 h •OH production rates varied by 3.1-fold from 11.7 ± 0.4 to 36.2 ± 0.6 nM h–1, showing a strong correlation with the ratio of the {210} facet. Such facet dependence in ROS productions primarily stems from the different surface electron-donating capacities (2.2–8.6 mmol e– g–1) and kinetics (from 1.2 × 10–4 to 5.8 × 10–4 s–1) of various faceted pyrites. Further, the Fenton-like activity also displayed 10.1-fold variations among faceted pyrites, contributing to the facet depedence of •OH productions. The facet dependence of ROS production can greatly affect ROS-driven pollutant transformations. As a paradigm, the degradation rates of carbamazepine, phenol, and bisphenol A varied by 3.5–5.3-fold from oxidation of pyrites with different facet compositions, where the kinetics were in good agreement with the pyrite {210} facet ratio. These findings highlight the crucial role of facet composition in determining ROS production and subsequent ROS-driven reactions during iron mineral oxidation.
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Yuxiang Yang,Xiaocui Huang,Mengyang Dong,Ziling Chang,Hongming Yuan,Yan Huang,Xiangnong Liu,Jianbo Zhang,Anbang Dai
As a common pollutant in the environment, trichloroacetic acid (TCA) is difficult to be completely degraded by common advanced oxidation processes (AOPs) due to its high C-Cl bond content. Advanced oxidation–reduction processes (AORPs) may improve the degradation performance of TCA. In this work, we use Fe 0 Ni 0 bimetal as reducing catalyst, hollow mesoporous silicone nanoparticles (HMONs) modified by ZIF-8 as immobilized carrier, horseradish peroxidase (HRP) and Fe 0 Ni 0 were fixed in the carrier to form a AORP system for degradation of TCA. The effects of temperature, pH, H 2 O 2 concentration, doping ratio on the degradation performance of the catalyst and the degradation mechanism of the composite catalyst were investigated. Degradation experiments showed that H· and OH· were present in the dual system, dechlorination and decarboxylation exist at the same time. Under the condition of 55 °C and pH = 4, 30 mg Fe 0 Ni 0 and 20 mg immobilized enzyme shows the best degradation on TCA, and 81.48 % of 20 mg·L −1 TCA could be degraded by 2 h.
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Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
JunHui Hu,Ying Yan,Huiping Zhang
A new structured catalyst consisting of boron-doped carbon nanotubes growing directly on paper-like stainless steel fibers support (B-CNTs/PSSF) was developed for continuous catalytic wet peroxide oxidation (CWPO) of phenol in a structured fixed bed. Firstly, B-CNTs/PSSF was synthesized by chemical vapor deposition (CVD) with phenyboronic acid as a single precursor and CNTs/PSSF was prepared with camphor for comparison. Secondly, the effects of different deposition temperatures, deposition times, and phenylboronic acid dosages on the morphology and properties of B-CNTs were investigated, respectively. The results verified that under the conditions of deposition temperature of 750 °C, deposition time of 20 min, and phenylboronic acid dosage of 2 g, the B-CNTs/PSSF composite catalyst with uniform growth density, wavy and kinked morphology, abundant oxygen-containing functional groups and defect sites, and boron-doped content of 2.96% was successfully prepared. Then, the performance of B-CNTs/PSSF for continuous CWPO of phenol was evaluated. Catalytic results revealed that the B-CNTs/PSSF showed excellent catalytic activity in phenol degradation within 7 h (phenol conversion reached about 100% and total organic carbon (TOC) conversion was up to 68%). In contrast, the average phenol and TOC conversion of CNTs/PSSF were about 75% and 35%, respectively. It indicated that boron doping endowed CNTs with higher catalytic activity.
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APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Peng Ye,Deming Wu,Manye Wang,Yi Wei,Aihua Xu,Xiaoxia Li
A heterogeneous magnetic CuFe 2 O 4 @OMS-2 catalyst was fabricated through a facile solvent-free process using Mn(CH 3 COO) 2 and KMnO 4 in the presence of CuFe 2 O 4 . It was found that the BET surface area of OMS-2 as well as the ratio of low-valent manganese species significantly increased in the hybrid catalyst, due to interactions between CuFe 2 O 4 and the precursor of amorphous manganese oxide . Acid Orange 7 (AO7) and other organic pollutants could be completely degraded by the CuFe 2 O 4 @OMS-2 catalyst within 30 min in the presence of peroxymonosulfate (PMS), while CuFe 2 O 4 and OMS-2 showed no significant activity for the reaction. The hybrid catalyst also exhibited excellent long-term stability and could be easily recovered with the assistance of an external magnetic field. A possible degradation mechanism for the synergistic effects of different valent metal species and reactive radicals was proposed, which involved the electron transfer from Mn(III) or Mn(II) species to PMS with the generation of sulfate and hydroxyl radicals, and from AO7 and Cu(I) in CuFe 2 O 4 to Mn(IV) and Mn(III) to reduce these Mn species.
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AMINO ACIDS
·
2019
·Vol. 52
·期 3
·361-369
·
IF 2.52
Li Jinlei,Lu Kui,Lv Mingxiu,Liu Guangbin,Ma Li,Qi Jianzhao
Breast cancer susceptibility gene 2 ( BRCA2 ) is an important tumor suppressor, which is participated in repair of damaged DNA by its highly conserved BRC repeat motifs regulating RAD51 protein homologous recombination and thereby preventing cell carcinogenesis. In this study, the BRCA2(1524–1548)–RAD51(241–260) complex structure was obtained based on PDB bank data 1N0W, which provided the basis for site-specific mutation of BRCA2(1524–1548). The BRC4 and BRC4 analogous peptides were synthesized, and the interaction between BRC peptide and RAD51(241–260) was studied by fluorescence spectroscopy, circular dichroism spectroscopy and microscale thermophoresis (MST). The results of circular dichroism showed that the changes in secondary structures of RAD51(241–260) occurred after adding BRC4 analogous peptides, and the α-helix content increased significantly. Fluorescence spectral data demonstrated that the model of BRC peptide binding to RAD51(241–260) was static quenching, and the binding constants of BRC4, P1, P2, P4 with RAD51(241–260) were 1.647 × 10 −4 L mol −1 , 2.532 × 10 −4 L mol −1 , 3.161 × 10 −4 L mol −1 , 1.705 × 10 −4 L mol −1 , respectively. The results of MST indicated that P2 and RAD51(241–260) have better affinity for dissociation constant 44.286 μM. The strongest affinity between P2 and RAD51(241–260) indicated that the mutation of amino acid residue constituting BRC α-helix affects the structure and interaction of BRC peptide and RAD51(241–260).
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