Molecular Catalysis
·
2022
·
IF 5.089
Yaning Xu,Nan Zhao,Fengxi Li,Hanqing Xie,Junhao Wu,Chunyu Wang,Zhengqiang Li,Lei Wang
We reported the synthesis of 2-aryl benzothiazoles catalyzed by Vitreoscilla hemoglobin (VHb). With TBHP (tert-Butyl hydroperoxide) as oxidant, DMSO (Dimethyl sulfoxide) as solvent, 0.05 mol% VHb loading, the oxidation reaction was catalyzed to produce corresponding 2-aryl benzothiazoles in excellent yield (85%-97%) within 5 min at room temperature. Notably, this strategy had the advantages of high efficiency, mild reaction conditions, and wide substrate scope, indicating its valuable application in the biocatalysis of non-natural oxidative reactions.
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DOI
高影响因子
FOOD CHEMISTRY
·
2020
·
IF 6.306
Xiao-Yuan Wang,Yun-Jiao Ma,Yu Guo,Xiao-Lin Luo,Ming Du,Liang Dong,Pei Yu,Xian-Bing Xu
2-Acetylthiazole possesses a nutty, cereal-like and popcorn-like aroma and a low odor threshold, and this compound has been identified in some processed foods, while the formation pathway of 2-acetylthiazole has not been clearly elucidated. Here, a model reaction of d -glucose and l -cysteine was constructed to investigate the formation pathway of 2-acetylthiazole. l -Cysteine, d -glucose and the corresponding intermediates, namely, dicarbonyl compounds (DCs), were involved in the formation of 2-acetylthiazole and detected by high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS), high-performance ion chromatography (HPIC) and HPLC, respectively. The carbon module labeling (CAMOLA) technique revealed that the C-4 and C-5 of 2-acetylthiazole were derived from the carbons of glucose. The potential of glyoxal, which is degraded by glucose, to form 2-acetylthiazole was revealed for the first time. A novel route to form 2-acetylthiazole by the reaction of glyoxal and methylglyoxal produced by d -glucose with H 2 S and NH 3 produced by l -cysteine was proposed.
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DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2016
·
IF 5.557
Lina Xu,Jia Xu,Baotian Shan,Xiulin Wang,Congjie Gao
Pure organic nature and nanoporous structure make covalent organic frameworks (COFs) a promisingly potential candidate in mixed matrix membranes (MMMs). However, COFs-based MMMs have hardly ever been applied in water purification due to their hydrolytic nature. In this study, we elaborately selected TpPa-2 with extensive stability in complicated water-environments as nanofiller to prepare MMMs for water treatment for the first time. Microwave synthetic technique was employed and optimized to construct the TpPa-2(MW) with a much higher BET surface area, smaller particle size, less agglomeration tendency and excellent stability. TpPa-2 was also synthesized mechanochemically (MC) for comparison to indicate how the synthetic technique influences the TpPa-2 and TpPa-2-incorporated MMMs. Membrane structure and property, water transport capacity and separation performance of both TpPa-2(MW)- and TpPa-2(MC)-incorporated MMMs were comprehensively investigated. It proved that our MMMs with an ultralow amount (0.2 wt%) of TpPa-2(MW) featured both improved water flux and rejection, breaking the trade-off between permeability and selectivity for polymer membrane. A membrane forming mechanism was further proposed to understand the effectiveness of TpPa-2(MW) in MMMs. This new generation COFs-based MMMs would be highly efficient, resource saving and cost-effective, which promise a great potential application in practical water purification .
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DOI
高影响因子
Chinese Physics B
·
2022
·Vol. 31
·期 3
·037406
·
IF 1.652
Dong Yan,Lingyong Zeng,Yijie Zeng,Yishi Lin,Junjie Yin,Meng Wang,Yihua Wang,Daoxin Yao,Huixia Luo
The relationship between charge-density-wave (CDW) and superconductivity (SC), two vital physical phases in condensed matter physics, has always been the focus of scientists' research over the past decades. Motivated by this research hotspot, we systematically studied the physical properties of the layered telluride chalcogenide superconductors CuIr2−xAlxTe4 (0 ⩽ x ⩽ 0.2). Through the resistance and magnetization measurements, we found that the CDW order was destroyed by a small amount of Al doping. Meanwhile, the superconducting transition temperature (Tc) kept changing with the change of doping amount and rose towards the maximum value of 2.75 K when x = 0.075. The value of normalized specific heat jump (Δ C/γ Tc) for the highest Tc sample CuIr1.925Al0.075Te4 was 1.53, which was larger than the BCS value of 1.43 and showed the bulk superconducting nature. In order to clearly show the relationship between SC and CDW states, we propose a phase diagram of Tc vs. doping content.
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Chun Yu,Weinan Dong,Weng Fu,Weiran Zuo,Bao Guo
The flotation of copper bearing minerals is always a hot topic in the field of minerals processing. In this paper, the adsorption of a flotation collector, 2-mercaptobenzothiazole(MBT), onto a typical secondary copper sulfide mineral, chalcocite, depending on electrochemical potential was investigated with the help of shell-isolated nanoparticle enhanced Raman spectroscopy (SHINERS). The MBT adsorbs through its exocyclic sulfur, in addition to its endocyclic nitrogen at negative potentials. This is because negative potentials are thermodynamically unfavorable for the adsorption to occur. Especially, chalcocite electrode that has been exposed to deep negative potential (−600 mV versus SCE) can be totally inhibited from MBT adsorption. A “cathodic passivating” process is proposed possibly accompanied by the formation of a passivation layer, kinetically preventing adsorption, even after potentials switch back to positive. Cyclic voltammetry (CV) and X-ray photoelectron spectroscopy (XPS) were also used to explain this phenomenon. The present work implicates enhanced separation efficiency of chalcocite by using electrochemical controlled flotation.
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DOI
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 22
·5384
·
IF 4.2
He Huang,Yating Zhang,Qiu Du,Changji Zheng,Chenghua Jin,Siqi Li
The escalating threat of antibiotic-resistant bacteria and fungi underscores an urgent need for new antimicrobial agents. This study aimed to synthesize and evaluate the antimicrobial activities of two series of 3-alkylidene-2-indolone derivatives. We synthesized 32 target compounds, among which 25 exhibited moderate to high antibacterial or antifungal activities. Notably, compounds10f,10g, and10hdemonstrated the highest antibacterial activity with a minimum inhibitory concentration (MIC) of 0.5 μg/mL, matching the activity of the positive control gatifloxacin against three Gram-positive bacterial strains:Staphylococcus aureusATCC 6538, 4220, and Methicillin-resistantStaphylococcus aureusATCC 43300. Moreover, the three most active compounds10f,10g, and10hwere evaluated for their in vitro cytotoxicity in the HepG2 cancer cell line and L-02; only compound10hwas found to exert some level of cytotoxicity. These findings suggest that the synthesized 3-alkylidene-2-indolone derivatives hold potential for further development as antibacterial agents.
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DOI
PubMed
高影响因子
Translational Research
·
2024
·
IF 6.4
Hao Chen,Qianchao Hu,Zhongshan Lu,Jie Zhao,Anxiong Liu,Zhongzhong Liu,Jun Luo,Qifa Ye,Zibiao Zhong
Renal ischemia-reperfusion injury (IRI) is a prevalent clinical syndrome, yet its underlying pathogenesis remains largely unknown. Aldehyde dehydrogenase 2 (ALDH2), an enzyme responsible for detoxifying lipid aldehydes, has been suggested to play a protective role against IRI. In our study, we observed that Aldh2 knock-out C57BL/6 mice experienced more severe renal functional impairment following IRI. This was characterized by elevated levels of creatinine and blood urea nitrogen, as well as increased apoptosis. Proteomic analysis further revealed that ALDH2 deficiency significantly disrupted lipid metabolism, resulting in higher levels of the proinflammatory protein CYP4A and its metabolic byproduct, 20-HETE. This metabolic disruption exacerbated renal inflammation and triggered endoplasmic reticulum stress. However, we found that administration of the CYP4A inhibitor, HET0016, could ameliorate these effects. Mechanistically, we discovered that after IRI, ALDH2 translocates to the nucleus and interacts with nuclear receptor corepressor 1 (NCOR1) to repress Cyp4a transcription. ALDH2 specifically interacts with the N-terminal domain of NCOR1, which is responsible for its interaction with its E3 ligase SIAH2. This interaction inhibits the proteasome degradation of NCOR1, ultimately stabilizing the NCOR1 transcriptional repression complex. In summary, our research uncovers the role of ALDH2 in mitigating renal IRI by inhibiting 20-HETE synthesis through the transcriptional repression of Cyp4a .
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DOI
PubMed
高影响因子
JOURNAL OF POLYMER SCIENCE
·
2024
·
IF 3.9
Jingwen Yao,Jiaying Tong,Dan Zhao,Dong Chen,Yuhong Ma,Wantai Yang
The reversible addition-fragment chain transfer (RAFT) alternating copolymerization of 2-hydroxyethyl vinyl ether (HEVE) and dimethyl maleate (DMM) is achieved with S -(cyanomethyl) O -ethyl carbonodithioate (CMX) as medaitor and 2,2′-azobis(2-methylpropionitrile) (AIBN) as radical initiator. The effects of monomer concentrations, comonomer feeding ratios, molar ratio of monomer to CMX and solvent on the copolymerization and copolymer structure are systematically investigated. The living feature of the HEVE and DMM copolymerization is demonstrated by the linear increasement of the molecular weights with the monomer conversions, and relatively narrow molecular weight distributions of the copolymers. With dimethyl carbonate as solvent, poly(HEVE- alt -DMM) with M n = 5200 and M w / M n = 1.34 are synthesized at [HEVE]/[DMM]/[CMX]/[AIBN] = 100/100/3/1. The alternating structure of the copolymer is demonstrated by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and proton nuclear magnetic resonance spectroscopy ( 1 H NMR). The both α, ω-end groups are mainly originated from the moiety of CMX. To further demonstrate the living feature of the alternating copolymerization, chain extension and block copolymerization are also carried out. With poly(HEVE- alt -DMM) as macro-CTA ( M n = 5200, M w / M n = 1.34), the chain-extension reaction has been successfully realized ( M n = 9600, M w / M n = 1.70), and the block copolymer with vinyl neonanoate as monomer also successfully synthesized ( M n = 9800, M w / M n = 1.42). Graphical
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高影响因子
Soft Matter
·
2017
·Vol. 13
·期 19
·3514-3520
·
IF 3.889
Huifang Xu,Na Du,Yawen Song,Shue Song,Wanguo Hou
In the current work, the microviscosity, encapsulation, and permeability of 2-ketooctanoic acid (KOCOOH) vesicle membranes were investigated by steady-state and time-resolved fluorescence techniques, using 1,6-diphenyl-1,3,5-hexatriene (DPH), riboflavin, and calcein as fluorescence probes. Our results show that the microviscosity of KOCOOH membranes is similar to that of common bilayer aggregates, the KOCOOH vesicles have the ability to encapsulate hydrophilic guests, and the KOCOOH membranes are permeable to ions. The permeation of OH− across KOCOOH membranes can be well described using a first-order kinetic model. The KOCOOH vesicles may be a good alternative protocell model that possesses some functional properties necessary for early cell membranes. To the best of our knowledge, this is the first report on the characteristics of vesicle membranes of single-tailed keto-acid amphiphiles.
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DOI
高影响因子
CATALYSIS TODAY
·
2024
·
IF 5.2
Guojia Li,Yan Xu,Lanxin Ye,Panpan Wang,Siyuan Peng,Yuan Zhou,Hongxia Liu,Qixun Shi,Chuan Wang
The uniformity of nanoparticles on supported catalysts is crucial for the understanding of their active sites. Compared to traditional synthesis methods, continuous flow method can effectively control the size of nanoparticles. Herein, we successfully synthesized a series of Pt/C catalysts with uniform Pt nanoparticles by continuous flow method and discriminated the active sites for 2-methylfuran (2-MF) hydrogenation. The activation energy and XPS characterization results indicate that the 2-MF hydrogenation is mainly governed by Pt geometric properties for Pt nanoparticles ≥ 3.05 nm. Based on the truncated cuboctahedron model, the dominant active sites for 2-MF hydrogenation are further discriminated as follows: the (111) facet for 2-MF conversion, the (100) facet for 2-pentanone (2-PN) formation, the edge site for 2-methyltetrahydrofuran (2-MTHF) formation and the corner site for 2-pentanol (2-POL) formation. For Pt nanoparticles < 3.05 nm, the reaction is mainly influenced by the electronic properties of Pt.
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产品关联
DOI
高影响因子
ACS Catalysis
·
2025
·
IF 13.1
Shihao Li,Jiafu Shi,Yu Chen,Xinyu Mao,Shusong Liu,Yang Yang,Hong Wu,Zhongyi Jiang
Amino alcohols are widely used in chemical and pharmaceutical industries, while conventional synthesis methods face drawbacks such as low selectivity and high energy consumption. Multienzyme catalysis combined with light-driven cofactor regeneration affords a platform of light-driven synthesis of chemicals, where the transfer of electrons and protons as well as the route of enzymatic reactions dominates the energy conversion efficiency and atomic economy of carbon utilization. Herein, we construct a light-driven synthesis system comprising an energy-supplying module and a multienzyme catalytic module for 2-aminoethanol synthesis from formaldehyde and ammonia. First, a S-scheme heterojunction photocatalysts with a metal–organic framework core and a bipyridine-based conjugated polymer shell are prepared as an energy-supplying module. Through synergistic intensification of proton transfer and electron transfer, the photocatalysts render cofactor (NADH) regeneration efficiency with a turnover frequency of 30.49 h–1. Second, a multienzyme catalytic module is constructed for 2-aminoethanol synthesis in the presence of NADH. Under optimal conditions, this module produces 2-aminoethanol with an average reaction rate of 76.34 μmol L–1 h–1 within 24 h. Finally, the energy-supplying module is coupled with the multienzyme catalytic module for continuous synthesis of 2-aminoethanol from formaldehyde and ammonia, generating 0.55 mmol L–1 2-aminoethanol after 4 light–dark cycles. In addition, triethanolamine (TEOA) and glucose, a biomass-derived carbon source, are both confirmed as effective electron donors for NADH regeneration and light-driven synthesis system. This work opens a pathway for the synthesis of amino alcohols and demonstrates a paradigm for the intensification of reaction processes.
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2016
·
IF 3.902
Fei Ge,Mengfei Yu,Cuixia Yu,Jun Lin,Wenjian Weng,Kui Cheng,Huiming Wang
In the process of biomaterials mediated bone regeneration, rhBMP-2 delivery at efficient dose in sustained kinetics is crucial for promoting cell osteogenic differentiation. Meanwhile, surface morphology of the biomaterials could regulate cellular responses as well as strengthen the rhBMP-2 interaction with cells for better bone induction. Herein, TiO 2 nanorod films with varied mesoporous bioactive glass (MBG) incorporation amount were designed to strengthen the efficacy of rhBMP-2, basing on optimized loading/release behaviors and surface nanostructure cooperatively. The MBG incorporation improved rhBMP-2 loading amount and regulated its release behavior. Consequently, the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) on the incorporated films was extremely enhanced, and the incorporated nanorod film with 200 nm MBG thickness exhibited the best osteoinduction effect. However, MBG film and the incorporated nanorod film had the same loading amount of rhBMP-2, the latter showed a much higher expression of 7-day osteogenic differentiation index than the former, which could be attributed to the synergistic effect of optimized rhBMP-2 release behavior and surface morphology. The MBG incorporated TiO 2 nanorod films here presents a promising strategy for enhancing osteoinduction through optimized rhBMP-2 release behavior.
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PubMed
高影响因子
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