APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Yiting Liao,Lanzhen Peng,Xiaosong Zhou,Jin Luo,Limei Xu,Xiaomei Ning,Xiaoqin Zhou,Xunfu Zhou,Yueping Fang
Two major challenges in photocatalysis are the separation and utilization of photogenerated charge carriers that have limited their wider applications. To address these issues, significant studies have been devoted to the surface modification of photocatalysts. Herein, CdS nanorods were surface-modified by an ion-conducting LiTi 2 (PO 4 ) 3 (LTP) shell. This modification could accelerate the rapid separation and efficient utilization of photoinduced charge carriers. Therefore, CdS@LTP composite photocatalyst displayed a photocatalytic H 2 evolution rate of 26.01 mmol g −1 h −1 without any addition of cocatalysts in a Na 2 S/Na 2 SO 3 solution, which was over 6-fold compared to CdS, and showed improved stability. Furthermore, this shell can prevent the reverse reactions between H 2 and O 2 during photocatalytic water splitting. With the photo-deposition of Pt cocatalysts, CdS@LTP-Pt can achieve efficient overall water splitting with the highest H 2 generation rate (351 μmol g −1 h −1 ), which is 3.25 times higher than that of CdS-Pt. This study broadens the application of ionic conductor materials and provides a new way for the design of advanced photocatalysts for solar energy conversion.
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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2022
·
IF 6.364
Ling Pan,Ling He,Zibo Niu,Peng Xiao,Wei Zhou,Yang Li
In this work, Yb 4 Hf 3 O 12 ceramic, a typical rare-earth hafnate, was exposed to water vapor with Al(OH) 3 impurities at 1400 ℃, and microstructural evolution and corrosion mechanisms were investigated. The long-term corrosion can be divided into initial hydration and gasification of Hf 4+ and steady-state corrosion after the formation of Al 5 Yb 3 O 12 . In the initial stage, Hf 4+ and the surrounding O 2- tend to be hydrated and then volatilized in the form of Hf(OH) 4 , causing a metastable state of Yb 4 Hf 3 O 12 on the surface. Besides, the preferential corrosion of small grains, grain boundary, and specific crystal plane on the surface and sintered and densified grains result in varied corrosion behavior from the early linear law to the later parabolic law. In the steady-state corrosion stage, due to the consumption of Hf 4+ , more vacancies promote bonding and diffusion of Al 3+ to form corrosion product (Al 5 Yb 3 O 12 ), and during this stage, regrowth and shedding of the corrosion layer reach a dynamic balance.
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CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Liping Tan,Weihua Zhang,Xiaoguang Zhu,Yue Ru,Wenbo Yi,Bo Pang,Tongjun Liu
Lanthanum (La)-based nanoparticles (NPs) are promising candidates for phosphate removal owing to their inherently high affinity towards phosphate. However, significant challenges remain to be addressed before their practical deployment, especially the problems associated with their aggregation. Herein, we fabricated a high-efficient sorbent for phosphate removal through in-situ synthesizing La(OH) 3 NPs on a natural support, bacterial cellulose (BC), which is pre-modified with polyethyleneimine. The resultant La(OH) 3 NPs-immobilized BC with different La contents (BPLa-X) exhibited a highly fibrous porous structure, in which BPLa-3 was selected for further phosphate adsorption studies. BPLa-3 demonstrated a high adsorption capacity of 125.5 mg P g −1 , and high adsorption selectivity due to the large surface area and abundant exposed active adsorption sites for phosphate. Additionally, BPLa-3 also displayed high reusability and still possessed high adsorption capacity after four consecutive cycles of adsorption-desorption. Therefore, the present adsorbent is believed to be a promising candidate for practical phosphate removal.
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EUROPEAN JOURNAL OF PHARMACOLOGY
·
2022
·
IF 5.195
Xin Zhao,Lingyu Li,Shuang Li,Jinyu Liu,Hongya Wang,Yulin Lin,Dayong Cai
Portal hypertension (PHT) is a complication of liver diseases. Increased intrahepatic vascular resistance is attributed to reduced bioavailability of vasodilator substances . The macrophage activation and superoxide dismutase 3 (SOD3) involve in the pathogenesis of PHT. Diammonium glycyrrhizinate (DG) is the salt form of glycyrrhizin derived from Radix glycyrrhizae , exerting anti-oxidant activities and be beneficial for liver injury. Here, we aimed to investigate effects of DG on PHT and explore its underlying mechanisms on regulation of macrophages and SOD3. The carbon tetrachloride induced PHT rats received administration of liposome-encapsulated clodronate for hepatic macrophage depletion, or PBS liposomes for matched control. DG (25 mg/kg) or vehicle was gavaged. Portal pressure in vivo, and serum biomarkers of macrophage activation were measured. The nitric oxide (NO) and prostacyclin (PGI 2 ) bioavailability was evaluated in the isolated portal perfused rat livers. Liver tissues were collected to evaluate cirrhosis , macrophage oxidation, and SOD3 activity. Depletion of hepatic macrophages decreased portal pressure, increased bioavailability of NO and PGI 2 , and restored SOD3 activity. DG effectively decreased portal pressure, relieved cirrhosis, inhibited macrophage activation. DG increased bioavailability of NO and PGI 2 to relax portal veins. DG relieved portal macrophage oxidation through decreasing nicotinamide adenine dinucleotide phosphate oxidase 2 and inducible NO synthase expressions, elevated SOD3 activities and increased SOD3 expressions at portal triads. These findings indicated that DG restored SOD3 activity, against portal macrophage oxidation, protected bioavailability of NO and PGI 2 , thereby reduced portal pressure. It suggested a potential use of DG for PHT treatment.
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Processes
·
2022
·Vol. 10
·期 7
·1302
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IF 3.352
Hailun Ren,Weihong Li
3-hydroxybutyraldehyde (3-HBA) is mainly employed to synthesize 1,3-BDO (1,3-butanediol), which is one of the most important components in cosmetics moisturizers. In this study, a series of composite oxide catalysts were prepared by bringing alkaline earth metal Ca and rare earth metal La to the composite oxide MgO/Al2O3, which were made through the co-precipitation method. These catalysts were applied in the synthesis of 3-HBA through acetaldehyde (AcH) condensation. The structure, texture, and acidic properties of these catalysts were characterized using various characterization methods, and the effects of catalyst composition, reaction temperature, reaction pressure, and residence time on the conversion of AcH were investigated as well. The results showed that the introduction of Ca and La weakened the acidic property and enhanced the basic property, which favored the AcH condensation to synthesize 3-HBA. At a temperature of 20 °C, pressure of 200 kPa, and residence time of 70 min, 0.5%La-2.3%Ca-2MgO/Al2O3exhibited a better catalytic activity, and the conversion of AcH reached 95.89%. The selectivity and yield of 3-HBA were 92.08% and 88.30%, respectively. The stability test indicated that the high AcH conversion could be maintained for 5 h.Keywords:composite oxides;acetaldehyde;condensation catalyst;3-hydroxybutyraldehyde
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INORGANIC CHEMISTRY
·
2022
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IF 5.436
Dan Zhao,Wen Liu,Ya-Nan Li,Rui-Juan Zhang,Li-Na Zhang
A modulated structure with symmetrical characteristic higher than three-dimensional is a fascinating crystallographic type, and it is randomly encountered by researchers. Herein, we prepared 0.1 mm level single crystals of Na3La(VO4)2 and determined its structure to be a (3 + 1)-dimensional modulated structure using the X-ray diffraction analysis method for single crystals. Its super space group was determined to be Pca21(0β0)000. On the other hand, we introduced Tb3+ into the Na3La(VO4)2 host lattice to fabricate phosphors Na3La1-x(VO4)2:xTb3+ and studied their photoluminescence properties. Interestingly, for the strong absorption of the Na3La(VO4)2 host lattice in the range of 200–400 nm, the traditional 330–385 nm light is unable to efficiently excite Tb3+ ions in the Na3La(VO4)2 host to generate luminescence of Tb3+. Instead, Na3La1–x(VO4)2:xTb3+ is suitable to be excited by 487 nm to generate emitting light at 543, 584, and 622 nm, due to Tb3+ characteristic 4f → 4f transitions of 5D4 → 7FJ (J = 5, 4, 3). Hence, the Tb3+-doped Na3La(VO4)2 phosphors have potential applications for white-light-emitting diodes.
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CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
·
2022
·Vol. 100
·期 7
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IF 2.245
Yanzhen Han,Yan Zhou,Liyuan Zhou,Xiaoyan Jia,Xiangjun Yu,Xiaohong An,Zhe Shi
Chemotherapy is one of the most important strategies in the treatment of cancer; however, chemoresistance restricts the effect of chemotherapy. Growing reports suggest that chloride channel-3 (ClC-3) is involved in regulating the sensitivity of multiple chemotherapeutic agents in the chemotherapy of various tumours, while its role in the chemotherapy of cholangiocarcinoma (CCA) is still poorly understood. Herein, we observed that ClC-3 was highly expressed in CCA chemoresistant tissues and CCA cisplatin-resistant cells QBC939/DDP, and the sensitivities of QBC939 and QBC939/DDP cells to cisplatin were all increased after inhibition of ClC-3. Further mechanism exploration revealed that ClC-3 knockdown reduced the level of autophagy. Furthermore, in both QBC939 and QBC939/DDP cells, the autophagy agonist rapamycin eliminated the increased cisplatin sensitivity of ClC-3 knockdown without affecting ClC-3 expression. Collectively, all the findings demonstrate that ClC-3 knockdown increases cisplatin-induced cell death in CCA cells though inhibiting autophagy, regardless of the occurrence of cisplatin resistance. In addition, our results also suggest that targeted inhibition of ClC-3 may be a potential strategy for chemosensitization in CCA chemotherapy.
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CRYSTENGCOMM
·
2022
·Vol. 24
·期 16
·2966-2975
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IF 3.756
Shuang-Yin Zhu,Dan Zhao,Shao-Jie Dai,Rui-Juan Zhang,Lin-Ying Shi
For Mn-activated phosphors, the luminescent performance is strongly dependent on the oxidation state of Mn. In this paper, a series of red phosphors NaMg(PO3)3:xMn2+ (NMP:xMn2+) were synthesized by high temperature solid-state reaction in the open atmosphere. The single oxidation state of Mn2+ was confirmed by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and photoluminescence spectroscopy (PL). We suspected that a self-reduction process occurred to prevent the oxidation of Mn2+. The doped Mn2+ ions occupy the strong crystal field environment of the Mg site (octahedral point), forming a red luminescence center with a peak position centered at 630 nm and a full width at half maximum (FWHM) of 80 nm. The thermal stability and quenching luminescence are explained by the temperature dependence of the PL spectrum. The results show that the NaMg(PO3)3:Mn2+ red phosphor has potential applications in LED backlight display areas.
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Frontiers in Chemistry
·
2023
·
IF 5.5
Zhang Chen,Wang Minqiang,Shi Jindou,Wang Junnan,Da Zheyuan,Zhou Yun,Xu Youlong,Gaponenko Nikolai V.,Bhatti Arshad Saleem
The inherent single narrow emission peak and fast anion exchange process of cesium lead halide perovskite CsPbX3 (X = Cl, Br, I) nanocrystals severely limited its application in white light-emitting diodes. Previous studies have shown that composite structures can passivate surface defects of NCs and improve the stability of perovskite materials, but complex post-treatment processes commonly lead to dissolution of NCs. In this study, CsPb(Cl/Br)3 NCs was in-situ grown in TiO2 hollow shells doped with Eu3+ ions by a modified thermal injection method to prepare CsPb(Cl/Br)3/TiO2:Eu3+ composites with direct excitation of white light without additional treatment. Among them, the well-crystalline TiO2 shells acted as both a substrate for the dopant, avoiding the direct doping of Eu3+ into the interior of NCs to affect the crystal structure of the perovskite materials, and also as a protection layer to isolate the contact between PL quenching molecules and NCs, which significantly improves the stability. Further, the WLED prepared using the composites had bright white light emission, luminous efficiency of 87.39 lm/W, and long-time operating stability, which provided new options for the development of perovskite devices.
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MOLECULES
·
2023
·Vol. 28
·期 23
·7703
·
IF 4.6
Hongda Cheng
Metal–organic frameworks (MOFs) are considered to be promising materials for drug delivery. In this work, a Zinc-based MOF nanocomposite IRMOF-3 was introduced as a drug carrier for 10-hydroxycamptothecine (HCPT). Without an extra drug-loading process, a nanoscale drug delivery material HCPT@IRMOF-3 was prepared via one-pot synthesis. The composition and structure of the material were investigated, and the drug release character was measured. Compared with preparing IRMOF-3 first and loading the drug, the one-pot-prepared HCPT@IRMOF-3 exhibited a higher drug-loading capacity. The material presented pH-responsive release. The HCPT release rate at pH 5.0 was significantly higher than that at pH 7.4. The cytotoxicity experiments showed that IRMOF-3 was non-toxic, and HCPT@IRMOF-3 exhibited notable cytotoxicity to Hela and SH-SY5Y cells. One-pot synthesis is a simple and rapid method for the preparation of an MOF drug delivery system, and IRMOF-3 can be potentially used in pH-responsive drug delivery systems.Keywords:IRMOF-3;drug delivery;one pot;pH response;HCPT
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Nanoscale Advances
·
2023
·
IF 4.7
Chunying Cui,Shuang Zhang,Dandan Li,Danni Liu,Yaoqi Wang,Qi Sun,Ran Sun,Jie Zhang,Xiaoxuan Hong,Ran Huo
Atherosclerosis is a chronic inflammatory disease, characterized by a lipid accumulated plaque. Anti-oxidative and anti-inflammation as well as lipid metabolism promoting therapeutic strategies have been applied for atherosclerosis treatment. However, the therapeutic effect by a single therapeutic method is limited. Combination of the two strategies could for one thing prevent lipid accumulation cause by inflammation and oxidative stress, for another thing promote lipid efflux from atherosclerotic plaque, to normalize arteries maximumly. Hence, a multifunctional liposome co-encapsulating an antioxidant and anti-inflammatory drug epigallocatechin-3-gallate(EGCG) as well as a lipid-efflux promoting gene miR-223 was established. The system (lip@EGCG/miR-223) could encapsulate miR-223 in core areas of the liposomes to provide an effective protective effect for gene drugs. Moreover, lip@EGCG/miR-223 was smaller in size (91.28±2.28 nm characterized by DLS), making it easier to target to AS lesions which had a smaller vascular endothelial spaces. After internalized into cellular efficiently, lip@EGCG/miR-223 exhibited excellent antioxidant and anti-inflammatory effects in vitro by eliminating overproduced ROS and decreasing the level of inflammatory cytokines (TNF-α, IL-1β and MCP-1), which is due to the effect of EGCG. Besides, the lipid-efflux promoting protein ABCA1 was up-regulated when treated with lip@EGCG/miR-223. By the two therapies mentioned, lip@EGCG/miR-223 could effectively inhibit the formation of foam cells, which is a main component of atherosclerotic plaques. In AS model mice, after intravenous (i.v.) administration, lip@EGCG/miR-223 was effectively accumulated in atherosclerotic plaques, and the distribution of drugs in heart and aorta to that in kidney was significantly increased when compared with free drugs (the ratio was 6.27% for free miR-223 treated group, and was increased to 66.10% for lip@EGCG/miR-223 treated group.). By decreasing inflammation level and lipid accumulation, the arterial vessels in AS were normalized with less macrophages and micro-angiogenesis when treated with lip@EGCG/miR-223. Overall, this study demonstrates lip@EGCG/miR-223 can be developed as a potential system for atherosclerosis treatment by a combined treatment of antioxidant, anti-inflammatory and lipid-efflux promoting effects, which provides a novel strategy for safe and efficient management of atherosclerosis.
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BIORESOURCE TECHNOLOGY
·
2023
·
IF 11.4
Yufei Zhang,Junhua Yun,Guoyan Zhang,Amreesh Parvez,Lei Zhou,Hossain M. Zabed,Jia Li,Xianghui Qi
3-Hydroxypropionic acid (3-HP) is a top value-added chemical with multifaceted application in chemical, material, and food field. However, limited availability of robust strains and elevated fermentation costs currently impose constraints on sustainable biosynthesis of 3-HP. Herein, transporter engineering, metabolic dynamic modulation, and enzyme engineering were combined to address above limitations. First, a glucose-utilizing 3-HP biosynthetic pathway was constructed in Escherichia coli , followed by recruiting alternative glucose transport system to overcome center metabolism overflow. Next, the Cra (a transcription factor)-dependent switch was applied to autonomously fine-tune carbon flux, which alleviated growth retardation and improved the 3-HP production. Subsequently, inactivation of glycerol facilitator (GlpF) increased intracellular glycerol levels and boosted 3-HP biosynthesis, but caused toxic intermediate 3-hydroxypropionaldehyde (3-HPA) accumulation. Furthermore, semi-rational design of aldehyde dehydrogenase (YdcW) increased its activity and eliminated 3-HPA accumulation. Finally, fed-batch fermentation of the final strain resulted in 52.73 g/L 3-HP, with a yield of 0.59 mol/mol glucose.
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