JOURNAL OF CATALYSIS
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2026
·
IF 6
Zhengxi Zou,Zhenke Xu,Weiming Hua,Yinghong Yue,Zi Gao
Catalytic ethane dehydrogenation to ethylene is an attractive route for ethylene production following the shale gas revolution. However, its industrial implementation remains challenging due to high costs and environmental concerns. Iron-based catalysts have been identified as promising alternatives, while their catalytic performance is significantly dependent on the coordination environment and oxidation state of the iron species. Herein, a series of Fe/ZSM-5 catalysts were synthesized via urea precipitation (FeZ-P) and incipient wetness impregnation (FeZ-I) methods to investigate the relationship between Fe species evolution and catalytic behavior during ethane dehydrogenation. The FeZ-P catalysts exhibited significantly enhanced activity compared with FeZ-I, which was attributed to the improved dispersion of iron species and their favorable transformation behavior under reaction conditions. Detailed characterizations of fresh and spent catalysts revealed that the initial Fe 2 O 3 species on FeZ-P surface possessed limited dehydrogenation activity but underwent reaction-induced reduction and carbonization, generating Fe 3 C with enhanced ethane dehydrogenation performance. In contrast, the Fe 2 O 3 bulks on FeZ-I exhibited slower transformation rates, resulting in inferior catalytic activity. Air oxidation treatment enabled partial regeneration of the catalyst by removing carbon deposits and modifying Fe species evolution. This study highlights the importance of regulating Fe species dispersion and dynamic reduction-carbonization behavior, through which catalytically active Fe 3 C can be generated for enhanced ethane dehydrogenation performance. These findings provide valuable insights into the rational design of efficient Fe-based catalysts for non-oxidative alkane dehydrogenation.
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ENVIRONMENTAL TECHNOLOGY
·
2023
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IF 2.8
Yuyang Long,Liqun Xiao,Dan Zhou,Yanjun Meng,Lulu Wang,Dongsheng Shen
Chitin biomass is the second largest biomass resource on Earth but under-utilized. In this study, pretreated shrimp shells were converted into value-added platform chemical 5-hydroxymethylfurfural (HMF) using microwave hydrothermal treatment. Under the combined pretreatment of acid decalcification at room temperature and microwave-assisted alkali deacetylation, the HMF yield could reach 1.8 wt%. The key process parameters, including the holding temperature, holding time, and pH value, were evaluated and optimised. The highest HMF yield of 6.5 wt% was obtained at 202.6°C at a holding time of 5.8 min and a pH value of 1.5. This result demonstrates the potential of synchronously treating waste and recycling it, thereby offering a highly promising valorisation strategy for chitin-biomass utilisation.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2019
·
IF 4.833
Wen-Lin Tang,Yu Zhang,De-Xuan Hu,Hui Yang,Qian Yu,Jian-Wen Chen,Keli Agama,Yves Pommier,Lin-Kun An
DNA topoisomerase IB (TOP1) regulates DNA topological structure in many cellular metabolic processes and is a validated target for development of antitumor agents. Our previous study revealed that the benzophenanthridone scaffold is a novel chemotype for the discovery of TOP1 inhibitors. In this work, a series of novel 5-aminoethyl substituted benzophenanthridone derivatives have been synthesized and evaluated for TOP1 inhibition and cytotoxicity. Compound 12 exhibits the most potent TOP1 inhibition (+++) and cytotoxicity in human cancer cell lines with GI 50 values at nanomolar concentration range. 12 induces the cellular TOP1cc formation and DNA damage, resulting in HCT116 cell apoptosis . The pharmacokinetics , acute toxicity and antitumor efficiency in vivo of 12 were also studied.
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PubMed
高影响因子
LANGMUIR
·
2023
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IF 3.9
Changhao Bing,Xubin Zhang,Fumin Wang,Yi Zhai,Yongwang Li,Kaiwei Wang,Xiaolu Fan,Jinjin Zhang,Qi Shen,Xinyuan He
Zeolite is considered an ideal catalyst for olefin hydration due to its high specific surface area and abundant acid sites. However, the immiscibility of the water–oil two phases in olefin hydration limits mass transfer, and the side reaction of etherification occurs acutely, resulting in a low yield of alcohol. Thus, water–oil amphiphilic HZSM-5 was prepared by sulfonating silanized zeolite. The successful introduction of organic and sulfonic acid groups is demonstrated by FT-IR, TG, and water contact angles. Amphiphilic HZSM-5 can stabilize the Pickering emulsion and catalyze cyclopentene hydration at the phase interface. In addition, NH3-TPD and Py-IR show that the amount of strong Bro̷nsted acid sites of zeolites increases significantly after sulfonation. This facilitates the rate-determining step of cyclopentene activation by H+ to form carbocation. Moreover, the nucleophilic side reactions are inhibited by a high concentration of H+. Finally, under the optimized reaction condition, the conversion of cyclopentene can achieve 5.066% with a selectivity of 85.37% to cyclopentanol, which almost reaches the reaction equilibrium.
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Zhenfei Yang,Xinnian Xia,Ming Fang,Longlu Wang,Yutang Liu
The selective oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-dicarbofuran (DFF), and 2,5-furanedicarboxylic acid (FDCA) is essential to its practical application. Herein, a novel Pt/ZIS/MnO 2 (PMZIS) photocatalysts with photothermal effect were well designed for selective and controlled oxidation of HMF toward DFF or FDCA. The product distribution of HMF photo-oxidation on PMZIS can be regulated by the photothermal effect. At a low temperature (10 °C) with PMZIS, DFF is the primary oxidation product with the yield of 54.6% and selectivity of 85.4%. At a high temperature (60–70 °C) induced by photothermal effect, the FDCA can be obtained with the yield of 61.5 % and selectivity of 82.9%. Moreover, the Z-scheme transfer pathway and Pt cocatalysts realize the spatial charge separation structure of PMZIS heterojunctions. This unique structure greatly inhibits charge recombination and maximizes the activation ability of molecular oxygen to efficiently generate of the reactive oxygen species (e.g., 1O 2 and O 2– ), thus significantly improving the photocatalytic performance. This work would provide valuable insight in the product regulation through photothermal effect for the photocatalytic specific selective oxidation of organic molecules.
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RENEWABLE ENERGY
·
2021
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IF 8.001
Feng Lin,Yulong Ma,Yonggang Sun,Kanghe Zhao,Tingting Gao,Yingbo Zhu
Due to the inertness and structural complexity of lignin, upgrading lignin to biofuels and fine chemicals still faces great challenges. In this paper, a one-pot method was used to catalyze straw lignin with H-ZSM-5 supported by Ni and Ru bimetals, and the lignin conversion rate reached 88.1%. The yield of monophenol was 19.5%, of which the yield of 4-ethylphenol and 4-ethylguaiacol was 4.9% and 3.8%, respectively. The 2D HSQC NMR analysis confirmed that the Ni–Ru/H-ZSM-5 catalyst had an obvious activity of breaking C β -O bonds before and after the reaction. The result showed that after loading metal Ni and Ru, the Lewis acid of the catalytic system was greatly increased, which caused electron transfer between Ni and Ru. 3Ni-1.5Ru/H-ZSM-5 had the strongest activity due to the largest synergy among Ni, Ru and H-ZSM-5. The synergy was the key factor leading to the cleavage of C–C and C–O bonds in straw lignin and the high-performance catalytic degradation of lignin. Besides, the effect of reaction solvent and hydrogen resource on upgrading lignin to fine chemicals over 3Ni-1.5Ru/HZSM-5 catalyst was also intensively investigated. This research developed a method for the direct conversion of lignin into valuable monophenols.
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NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 45
·期 18
·8306-8313
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IF 3.591
Hui Xu,Yue Xiao,Jinlu Tang,Dongfang Liu,Xinxin Shi,Aaron Albert Aryee,Hongmin Meng,Lingbo Qu,Zhaohui Li
Chemotherapy for cancer treatment is widely used but remains restricted by several limitations, including inefficient drug delivery and concomitant adverse side effects. Herein, we report a new prodrug-based self-assembled nanoparticle for the efficient treatment of cancer. Amphiphilic prodrug molecules (3′,5′-dioleoyl floxuridine, DOF) were constructed to form prodrug nanoparticles (DOF NPs) through a self-assembly process in water via hydrophobic interactions. The DOF NPs with high stability can be quickly enriched in tumor cells and release the floxuridine drug via hydrolysis of ester bonds by esterase. In vitro experiments reveal that the DOF NPs possess satisfactory tumor killing effects and weak toxicity and side effects. These unique features could further promote the research progress of prodrug-based self-assembled strategies for the application of chemotherapy in cancer.
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JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
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2021
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IF 2.262
Xueshuai Chen,Rongli Jiang,Zihan Zhou,Xingwen Wang
In this work, ZSM-5 crystals with sheet-like morphology and well-dispersion were successfully synthesized from addition of green and cheap natural polymer (gelatin). The morphology and dispersion of crystals were related to the gelatin amount added to the synthesis gel, the three-dimensional pores of polymer hydrogels can serve as microreactors for controlling zeolite growth and dispersion in a confined space. Catalytic activity for the methanol to hydrocarbons (MTH) reaction of sample synthesized by adding gelatin at a gelatin/H2O mass ratio of 2% was better than that obtained from the synthesis gel free of gelatin. Its excellent catalytic performance can be attributed to the proper acidity, well-dispersion, and sheet-like morphology.
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ANALYTICAL CHEMISTRY
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2021
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IF 6.986
Jinmin Wang,Xianglong Qu,Limin Zhao,Bing Yan
Covalent organic framework (COF) nanosheets (NSs) are a new member in the family of two-dimensional (2D) nanomaterials that received increasing attention. The ability to prepare COF NSs with rapid acquisition is of great importance to explore their distinctive properties and potential applications. Herein, we elaborate design a new COF hybrid material EB-TFP:Eu(BTA)4 as a sensing platform. In the process of ratiometric fluorescence detection of 5-fluorouracil (5FU), an anticancer drug, we realize the preparation of COF NSs. Interaction occurs between 5FU and COF hybrid material, where the interlayer π–π stacking of COF was weakened, benefiting the exfoliation of bulk COF to acquire 2D COF NSs. This strategy provides not only a sensitive and selective 5FU sensor but also a significant inspiration for engineering 2D COF NSs.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Qian Wang,Huanshun Yin,Yunlei Zhou,Jun Wang,Shiyun Ai
As an important epigenetic modification, 5-formylcytosine (5fC) plays a vital role in cell differentiation, genomic DNA structure and function regulation. Its low abundance in all suckler tissues and cells and high structural similarity with cytosine (C) and its derivatives, the sensitive and selective detection method for 5fC is required. In this work, a photoelectrochemical biosensor was constructed using BiIO 4 -WS 2 composite as photosensitive material, the synergy of ternary heterojunction of BiIO 4 -WS 2 /CuO as signal amplification technology and 5-formylcytosine deoxyribonucleoside (5fdC) as target. Firstly, the ITO electrode modified by BiIO 4 -WS 2 was aminated by (3- aminopropyl) triethoxysilane. 5fC was captured on the electrode surface with amidogen as recognition reagent, based on the amide bond formed between amidogen and aldehyde group. Then, 4-carboxyphenylboronic acid (4-CPBA) was linked by covalent reaction between boronic acid and O -diol of 5fdC. Finally, the signal amplification material of amino-functionalized CuO was deposited on the electrode surface through the formation of amide bond based on −COOH of 4-CPBA and –NH 2 on CuO. In view of the constitution of a ternary heterojunction between CuO and BiIO 4 -WS 2 , the photoactivity of BiIO 4 -WS 2 was greatly enhanced, which also increased the detection sensitivity with the wide examination area from 0.005 to 200 nM and low limit of detection was 0.38pM (3σ). Based on the specific covalent identification pattern, this method showed high selectivity for 5fC, even discriminating 5fC with C and 5hmC. The impacts of antibiotics and heavy metals on 5fdC content change in genomic DNA of wheat tissues were investigated, and thus the feasibility of this work was evaluated.
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CONSTRUCTION AND BUILDING MATERIALS
·
2020
·
IF 4.419
Feng Zhang,Yin Bai,Yuebo Cai
Under low temperature environment, the concrete strength develops slowly, which will seriously hinder the construction progress. Traditional early-strength components can not meet the requirements of green and high-performance concrete, combined with the research and application of early-strength accelerators under low temperature is relatively few, and its low-temperature early-strength performance is limited, the early strength development rate of specimens is far lower than that of blank samples at 20 °C, so it is urgent to develop new early-strength component to promote the strength development rate of concrete at low temperature. In this paper, calcium bromide (CaBr 2 ) was used as an early strength component to test the 1-, 3-, 7-, and 28-d compressive strengths of the mortars and cement pastes mixed with 0–1.0% CaBr 2 under 5 °C curing. CaBr 2 had a significant effect of early strength at low temperature (5 °C), and the strength of the specimens mixed with 1.0% CaBr 2 at each age was close to or even exceeded that of the contrast samples cured at 20 °C. The equilibrium method (gravimetric method) was used to study the effect of 1 mol/L of CaBr 2 in water on the dissolution of the single ores C 3 S at different ages. CaBr 2 could promote the dissolution of C 3 S at a low temperature of 5 °C, and the solubility of C 3 S had an obvious tendency to increase. Further, X-ray diffraction (XRD) analysis, scanning electron microscope (SEM) and energy-dispersive spectrometry (EDS) analysis and mercury infusion porosimetry (MIP) analysis were used to perform microscopic characterization (e.g., product composition, morphology, pore structure, etc.) of the hydration products of the cement single ores or mortars mixed with CaBr 2 . On this basis, the early-strength mechanism of CaBr 2 was discussed. CaBr 2 could promote the initial hydration of cement at low temperature (5 °C) and significantly increase the degree and rate of hydration of C 3 S and C 3 A single ores, and also generated new type of products, bromine-containing C–S–H gels and bromoaluminate calcium hydrate (Ca 4 Al 2 O 6 Br 2 ·10H 2 O), and the Ettringite and Ca(OH) 2 crystals were mostly formed on the surface of gel products or inside the pores. Large amounts of hydration products were generated, which refined the pore diameter of samples by reducing the most probable pore size and total porosity, thus making the microstructure of samples denser and enhancing the strength of specimens.
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CATALYSIS TODAY
·
2020
·
IF 5.825
Linhao Yu,Hong Chen,Zhe Wen,Mengmeng Jin,Zewei Ma,Xueli Ma,Yushuai Sang,Mengmeng Chen,Yongdan Li
Selective oxidation of 5-hydroxymethylfurfural (HMF) to 2, 5-diformylfuran (DFF) with molecular oxygen is realized with an α-MnO 2 catalyst under mild conditions. In this work, α-MnO 2 exhibited the best performance among the samples examined. Meanwhile, solvent shows a significant effect on the product selectivity and isopropanol is found good for improving the selectivity of DFF. 93.2 % conversion of HMF was achieved at 140 °C for 4 h with 84.3 % selectivity of DFF. Moreover, α-MnO 2 catalyst keeps good reusability in recycling for five times. The reaction pathway indicated that the lattice oxygen species on α-MnO 2 is involved in the selective oxidation of hydroxyl group in HMF molecule.
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