ANALYST
·
2024
·
IF 3.6
Juan Huang,Huaxu Zhou,Yanqi Zou,Huiqing Liu,Qianjin Chen
An electrochemical method was developed for ultrasensitive and selective detection of dopamine in human serum using mesoporous silica thin film modified gold microelectrodes. Vertically aligned mesoporous silica thin films were deposited onto Au microelectrodes by electrochemically assisted self-assembly (EASA). The mesochannels have uniform pore sizes of 2.1 nm in diameter and a negatively charged wall surface. Cyclic voltammetry reveals effective charge permselectivity through the negatively charged mesoporous channels. By using differential pulse voltammetry, the mesoporous silica thin film modified Au microelectrode can be employed for the ultrasensitive detection of dopamine with a detection limit as low as 0.084 μM. In addition, thanks to the electrostatic and steric effects of the silica mesochannels, excellent anti-interference and anti-fouling properties of the electrochemical sensors are demonstrated.
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高影响因子
Materia-Rio de Janeiro
·
2025
·
IF 1.2
Wang Lina,Li Lili,Pang Zhenxing,Hui Xuesong
This study reports a facile synthesis of Au-modified Nano-SnS2 composites through a combined water-thermal and in situ chemical reduction method, aimed at advancing low-temperature gas sensing technology. Comprehensive structural analyses using X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and X-ray photoelectron spectroscopy confirmed that incorporation of Au nanoparticles significantly alters the nanostructure. The results reveal that optimal Au loading at 0.5 wt% refines the crystallite size from approximately 25 nm to 20–23 nm, while uniformly distributed Au particles with diameters of 3–5 nm effectively form Schottky junctions that enhance interfacial charge transfer. Gas sensing measurements demonstrate that the sensor response increases from 4.7 at 1 ppm to 22.6 at 10 ppm NO2, and a linear correlation (R2 = 0.998) was observed in the lower concentration range of 1–4 ppm. Furthermore, the optimal operating temperature decreased from 140°C for the unmodified sensor to 120°C, contributing to reduced power consumption. The transient response characteristics also improved markedly, with a response time of 42 s and a recovery time of 127 s, in contrast to 220 s and 520 s for the pristine material. Long-term stability tests over 40 days revealed less than 4% variation in sensor performance, and selectivity experiments confirmed a strong preference for NO2 over other interfering gases. Overall, the synergistic effects of Au-induced electronic sensitization and catalytic activity result in enhanced sensitivity, faster kinetics, and excellent durability. These significant findings offer valuable insights for designing highly efficient sensors for environmental monitoring, paving the way for future sensor technology.
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ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Xiaoxuan Ren,Yue Sun,Shengjie Li,Junyuan Bai,Xuwen Gao,Guizheng Zou
The commercialized immunoassay of glow-type chemiluminescence (CL) is always performed in an enzyme-assisted and indirect CL way, with molecular luminophores as tags. Herein, dual-stabilizer-capped Au nanoclusters (NCs) are proposed as nanoparticulate glow-CL luminophores and perform automatic immunoassays on commercialized in vitro diagnosis (IVD) instruments in a direct and enzyme-free CL way. The thiosalicylic acid (TSA) and bovine serum albumin (BSA) stabilized AuNCs (TSA/BSA-AuNCs) are water-soluble, biocompatible, and n-type CL luminophores, which can give off dark-red and glow-type CL with the coexistence of both hydrazine hydrate (N2H4·H2O) and hydrogen peroxide (H2O2). The glow-CL of TSA/BSA-AuNCs is generated in a combined route of bandgap-engineered CL (∼711 nm) and surface-defect-engineered CL (∼860 nm), and its total emission is strong enough to linearly determine procalcitonin (PCT) from 0.1 to 5000 pg/mL with a limit of detection of 0.05 pg/mL (S/N = 3), which is superior to the limit of detection for all of the commercialized CL immunoassays. Promisingly, TSA/BSA-AuNCs can be safely stored over 5 months and safely labeled to proteins without permanent precipitation and damage, which are strongly anticipated for the design of CL reagent kits with nanoparticles as tags and might initiate the commercialized application of NCs CL.
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高影响因子
Nano-Micro Letters
·
2024
·Vol. 16
·期 1
·1-21
·
IF 31.6
Zhou Xi,Zhou Quan,He Zhaozhi,Xiao Yi,Liu Yan,Huang Zhuohang,Sun Yaoji,Wang Jiawei,Zhao Zhengdong,Liu Xiaozhou,Zhou Bin,Ren Lei,Sun Yu,Chen Zhiwei,Zhang Xingcai
The innovation of this work mainly lies in the auto-regulation of reactive oxygen species (ROS) balance effective by combination of ROS antibacterial and ROS scavenging anti-inflammatory functions with a core–shell nanoplatform (CeO 2 @ZIF-8/Au), which can not only achieve high antibacterial efficiency, but also promote wound healing, and provide a new idea for the nano-catalytic system in the field of wound healing of bacterial infection.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Boyang Shao,Yanlin Zhu,Yaqian Du,Dan Yang,Shili Gai,Fei He,Piaoping Yang
As an emerging technology, nanocatalytic medicine attracts much attention, especially the ones according to the enzymatic reaction by using excess H 2 O 2 in the tumor. Among various candidates, single-atom catalyst (SAC) revealed unique and outstanding redox reaction performance, since the active sites consisting of single metal atoms may achieve the maximum utilization of metal atoms and emerge obviously amplified reaction rate. Here we developed an M−N x (M = Mn, Zn) center-based SAC with a hollow structure by calcination of Mn 2+ -doped zeolitic imidazolate frameworks (ZIF-8), and PEGylation was applied to improve the hydrophilicity. According to the enzymatic reaction, the M−N x (M = Mn, Zn) centers have an inherent peroxidase-like activity to catalyze over-expressed H 2 O 2 in the weak acidic tumor microenvironment and generate a large amount of toxic reactive oxygen species (ROS) like hydroxyl radicals for therapy. To keep efficient therapeutic output, we integrated the hollow SAC with Au which could expend the glucose in tumor and supply H 2 O 2 as the substrate of peroxidase-like activity. Better yet, Au may boost the photothermal effect of SAC and offer another non-invasive photothermal therapy (PTT) to promote the effect of tumor removal. This platform provided a new idea for the construction of more efficient peroxidase-like activity in tumor therapy.
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高影响因子
MICROCHEMICAL JOURNAL
·
2019
·
IF 3.206
Wenwen Wang,Hui Ouyang
Luminol-reduced Au nanoparticles (AuNPs) were prepared by using a facile one-step method. Luminol-reduced AuNPs were utilized as a novel dual-readout probe to develop a qualitative/quantitative immunochromatographic test strip (ITS) for detecting pesticide residues , by adopting fenvalerate as a model analyte . Fenvalerate in sample solution could compete with its corresponding immobilized coating antigen in test line of ITS to bind the AuNPs-tagged fenvalerate monoclonal antibody. After the complete immunoreaction, the AuNPs-tagged antibody in test line was the dual-readout probe. Superior to signal readout-based ITSs, especially traditional Au nanoparticles-based ITSs, luminol-reduced AuNPs-based dual-readout ITSs could simultaneously meet the demand of qualitative analysis and quantitative detection. Colorimetric signal from luminol-reduced AuNPs could be adopted as a qualitative readout, which could increase analysis efficiency in field analysis and rapid testing. In the proposed analytical platform, fenvalerate could be semi-quantitated within 15 min. Furthermore, as for affirmed contaminated sample through colorimetric analysis , chemiluminescent (CL) signal originating from luminophor-modified AuNPs as a quantitative readout aided to improve analytical sensitivity after triggering luminol-H 2 O 2 CL reaction. Under the optimal conditions, the detection limit for fenvalerate were 0.067 ng/mL (S/N = 3). The reliability of dual-readout ITSs was demonstrated through the successful practical application on traditional Chinese medicines. Owing to high analysis efficiency, low cost, high facility and improved accuracy, the dual-readout ITSs by using only one probe showed great potential in field analysis and rapid testing for drug safety, environmental sanitation and clinical diagnosis.
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Analytical Methods
·
2016
·Vol. 8
·期 17
·3564-3569
·
IF 1.915
Chunzhi Xuan,Qiao Xia,Juanjuan Xu,Qinghong Wang,Xia Lin,Yingzi Fu
The nanocomposite (Au@BSA) which was synthesized using gold nanoparticles (AuNPs) and bovine serum albumin (BSA) was used as an electrochemical sensing layer for chiral recognition of propranolol (PRO). Scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy, transmission electron microscopy (TEM), ultraviolet-visible (UV-vis) spectroscopy and amperometric testing technique were employed to characterize the Au@BSA nanocomposite. Differential pulse voltammetry (DPV) and atomic force microscopy (AFM) were used to assess the enantioselective performance of the fabricated interface, and the optimal experimental conditions, such as acidity and incubation time were also discussed. The results showed that after the modified interface interacted with PRO enantiomers larger discrepancy was obtained from S-PRO, and linear electrochemical responses to PRO enantiomers were obtained from 1.0 × 10−5 to 5.0 × 10−3 mol L−1 with a detection limit of 3.3 × 10−6 mol L−1 (S/N = 3). To gain more information on the role of gold nanoparticles (AuNPs) and bovine serum albumin (BSA) in the chiral recognition of PRO enantiomers, the interface fabricated using AuNPs or BSA was also allowed to interact with PRO enantiomers, and no obvious signal discrepancy was obtained. The results suggested that only Au@BSA could be employed for the enantioselective recognition of PRO enantiomers.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2018
·Vol. 410
·期 25
·6489-6495
·
IF 3.307
Wen Aoli,Peng Xiaoxiao,Zhang Pingping,Long Yunfei,Gong Huiming,Xie Qingru,Yue Ming,Chen Shu
Berberine hydrochloride (BHC), a natural isoquinoline alkaloid, is widely applied as a an agent in traditional Chinese medicine. Almost all the traditional methods for BHC detection require complicated preprocessing steps or expensive instruments. In this article, we report a simple, rapid, sensitive, and selective method for BHC detection using fluorescent gold nanoclusters (F-AuNCs) as the fluorescent probe with a large Stokes shift of 237 nm. The F-AuNCs prepared with citrate-stabilized stannous chloride and hydrogen tetrachloroaurate(III) as raw materials in an aqueous medium display strong and stable fluorescence at 566 nm. When F-AuNCs are mixed with BHC, the fluorescence of F-AuNCs is effectively quenched. Under optimized conditions, this method allows sensitive and selective measurements of BHC in a concentration ranging from 1.0 × 10 -6 to 1.0 × 10 -4 mol L -1 with a detection limit of 7.5 × 10 -8 mol L -1 , which is relatively low among reported spectral methods. This method provides excellent selectivity for the detection of BHC against inorganic anions and natural amino acids. In addition, the BHC content in two different types of berberine tablets was successfully determined by this method and the results showed high accuracy.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2015
·
IF 4.097
Wenfeng Zhao,Wei Jia,Mimi Sun,Xiaojun Liu,Qingquan Zhang,Chenghua Zong,Jie Qu,Hongwei Gai
A new simple colorimetric chemosensor for sensitive and selective detection of Cu 2+ using polyethyleneimine (PEI)-capped Au nanoparticles (PEI/Au NPs) has been developed. PEI/Au NPs are synthesized by using PEI as reducer without adding nanoparticles seeds and stabilizing agent. Copper ions are captured by the amino groups of the PEI/Au NPs to form an absorbent complex at the surface of PEI/Au NPs, resulting in the color of PEI/Au NPs changing from wine red to purple. Under the optimal conditions, the proposed colorimetric sensor is capable of sensitively and specifically detecting Cu 2+ with a detection limit of 0.29 μM and a linear range of 25–300 μM. This method is simple, fast and highly selective for Cu 2+ in the presence of high concentrations of other environmentally relevant metal ions because of the great specific coordination between Cu 2+ and PEI, which potentially meets the requirement of the detection in real samples. Moreover, addition of EDTA to PEI/Au NPs-Cu 2+ recovers the color offering PEI/Au NPs as a promising reversible sensor for practical application.
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高影响因子
Russian Journal of Physical Chemistry A
·
2022
·Vol. 96
·期 11
·2490-2496
·
IF 0.791
Khan Misbah Ullah,Ullah Hayat,Honey Shehla,Gul Zarif,Ullah Shaheed,Ullah Bakhtar,Manan Abdul,Ullah Munzer,Ali Shad
Abstract Noble metal bimetallic nanostructures, such as Ag and Au, are used in a variety of fields including nanoscience, catalysis, electronics and nanotechnology because of high stability and adsorption rate etc. However controlled synthesis of bimetallic nanostructures is challenging. Therefore, the current study emphasizes on two step controlled synthesis of Au/Ag nanostructures with tunable sizes for catalytic purposes. Using electrochemical deposition (EC) technique, the fabrication of Au/Ag nanostructures were achieved in two stages, through galvanic reaction. The catalytic capabilities of an Au/Ag nanostructure and Ag flower-like structure were examined through reduction of p -nitrophenol in the presence of sodium borohydride (NaBH 4 ). The catalytic investigation was measured in temperatures rage of 25 to 45°C at constant time. The study shows that catalytic activity of Au/Ag nanostructure is higher than that of Ag flower-like structure in the reduction of p -nitrophenol.
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Nanoscale
·
2018
·Vol. 11
·期 3
·1169-1176
·
IF 7.233
Ge Gao,Qiaoyue Xi,Yanqun Zhang,Manyu Jin,Yongxia Zhao,Cunqi Wu,Hua Zhou,Pengran Guo,Jingwei Xu
A surface-engineered heterogeneous catalyst with a controllable catalytic interface is the most straightforward approach for boosting catalytic activity. However, changing the surface structure of nanocrystals and ensuring the exposure of active sites still face challenges. In this work, a three-dimensional self-supported catalyst with ultrathin Au nanoclusters encapsulated in Cu-doped ZIF-8 nanorod arrays on Ni foam (AuNC@ZIF-8(Cu) NRAs) is synthesized by a bottom-up strategy. This catalyst exhibits high catalytic activity with a 98% conversion of 4-nitrophenol to 4-aminophenol within 6 min. Meanwhile, it also has superior catalytic activity for other nitrobenzene compounds, such as 3-nitrophenol, 2-nitrophenol and p-nitroaniline. Furthermore, after 10 cycles, the catalytic performance and morphology of the catalyst have no obvious change. The excellent catalytic performance and stability of AuNC@ZIF-8(Cu) NRAs are attributed to the synergistic effect of ZIF-8(Cu) and AuNC. The doping of Cu in the ZIF-8 framework effectively alters the superficial electronic structure of encapsulated Au nanoclusters, which can dramatically promote the formation of gold hydride intermediates. The confinement effect of the porous ZIF-8 framework makes the AuNC active sites more stable and accessible to substrates. This method can be used to alter the activity of the catalyst by regulating the metal ion coordination of MOFs to influence the surface properties of encapsulated AuNC and opens the door to the rational design of new catalysts.
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高影响因子
RSC Advances
·
2016
·Vol. 6
·期 34
·28263-28269
·
IF 3.289
Xiumin Ma,Quantong Jiang,Weimin Guo,Meng Zheng,Weichen Xu,Fubin Ma,Baorong Hou
In this study, a sandwich-structured C3N4/Au/CdZnS photocatalyst with Au nanoparticles sandwiched between C3N4 and CdZnS was fabricated. The results showed that there was a 6.3 mmol g−1 increase of hydrogen production for C3N4/Au/CdZnS photocatalyst compared to C3N4/CdZnS in 4 h. The photoinduced I–t curve, electrochemical impedance spectrum (EIS), photogenerated electron lifetime and photoluminescence spectra showed that the photocatalytic ability of the composite was enhanced by anchoring Au as the electron transfer mediator between C3N4 and CdZnS through the Z-scheme charge-carrier transfer mechanism. Au functioned as an electron transition mediator, which could induce a combination between photogenerated electrons and holes in the CdZnS and C3N4, respectively. These photogenerated holes of CdZnS can be involved in the S2−/SO32− oxidation process and the electrons from the C3N4 surface might be involved in the water to hydrogen reduction reaction, thus enhancing the photocatalysis performance of C3N4/Au/CdZnS photocatalyst.
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