INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Atef S. Kobisy,Fang Guan,Jizhou Duan,Salah M. Tawfik,Ding Guo,Yali Wang,Silvia J. Salgar-Chaparro
A major cause of marine corrosion is sulfate-reducing bacteria (SRB). Traditional chemicals may pose an environmental threat to this sector. Therefore, this research aims to develop eco-friendly alternatives to biocides and corrosion inhibitors. This work successfully modified chitosan, a natural and biodegradable biopolymer, into cationic and non-ionic surfactants. H 1 NMR, FTIR, and elemental analysis characterized the modified compounds. Mixed SRB culture was isolated from rust samples collected from steel immersed in a coastal area in Qingdao, China. Various techniques were used to evaluate the biological activity and corrosion protection provided by the newly modified chitosan surfactants in both abiotic and biotic environments, and their surface parameters in an aqueous solution were studied. SEM was used to display the surface morphology of the carbon steel; corrosion products were analyzed by EDS; surface topography and pitting were visualized by AFM; moreover, TEM was used to investigate the biocidal effect on the bacterial cell wall. Based on surface and thermodynamic calculations, the two surfactants exhibited adsorption behavior at the interface first, followed by aggregation in the bulk of the solution. The findings indicate that the newly modified chitosan-based surfactant displays significant corrosion protection over carbon steel and high antimicrobial activity against the isolated bacteria.
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WATER AIR AND SOIL POLLUTION
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2025
·Vol. 236
·期 9
·1-18
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IF 3
Huang Xiong,Pan Yuanfeng,Cai Pingxiong
To address the prevailing issue of arsenic contamination in water bodies, a novel composite microsphere (Fe-CB) was developed for the effective removal of As(V) ions from aqueous solutions. This microsphere was prepared using a sol–gel-titration-freeze-drying method, with chitosan and ferric chloride as raw materials, polyethyleneimine as a modifier and glutaraldehyde as a cross-linking agent. The effects of pH, adsorbent dosage, initial heavy metal concentration, and contact time on the performance of the adsorbent were investigated by a series of adsorption experiments. It was showed that pH played a significant role in determining the adsorption efficiency, while temperature had a relatively minor influence. The adsorption isothermal of As(V) on Fe-CB was best described by Langmuir isotherm model, whereas the dynamic adsorption process fitted the pseudo-second-order or secondary kinetic model well. Notably, the theoretical maximum adsorption capacity was 80.97 mg/g. Furthermore, regeneration experiments demonstrated that Fe-CB maintained a regeneration rate of over 85% even after five cycles, highlighting its excellent recyclability. This study underscores the potential of Fe-CB as an efficient and reusable adsorbent for the removal of As(V) ions from contaminated waters.
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DESALINATION
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2026
·
IF 9.8
Xiaohuan Tang,Jinying Zhang,Huiyuan Chu,Jiwei Shen,Chaozhan Wang,Yinmao Wei
Adsorption is effective for removing radioactive iodine in nuclear wastewater treatment, while composite adsorbents can optimize the adsorption performance of adsorbents. In this work, Chitosan and polyphosphazene were used to prepare an aerogel monolith (CS/PCD) with facile recyclability, high hydrophilicity, ultra-lightweight properties, and hierarchical porous structure via hydrothermal synthesis and freeze-drying. Under static conditions, the effects of adsorbent dosage, pH, coexisting ions, and contact time on iodine adsorption were studied. The results demonstrate that CS/PCD reaches a saturated iodine adsorption capacity of 1.20 g·g −1 in aqueous solution, exhibiting good regeneration performance and anti-ion interference capability in accordance with the Freundlich isotherm and pseudo-second-order kinetic models. Under dynamic adsorption conditions, the breakthrough behavior further confirms the material’ effective iodine capture performance. Notably, CS/PCD exhibited a broad applicable pH range (3–8) and good acid-base stability. Furthermore, CS/PCD also demonstrates exceptional performance in gaseous iodine adsorption, achieving a saturation capacity of 3.49 g·g −1 at 348 K. FT-IR and XPS analysis revealed the driving force of adsorption arises from charge transfer through N and O atoms, π-π stacking, hydrogen bonding (N-H···I and O-H···I), and hierarchical porous (microporous-mesoporous-macroporous). In conclusion, this work develops a high-efficiency monolithic adsorbent for radioactive iodine capture, offering a promising continuous-flow method for nuclear wastewater treatment.
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Pharmaceutics
·
2026
·Vol. 18
·期 1
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IF 5.5
Lizhen Yu,Fengge Wang,Shuyun Bao,Yue Zhang,Xuebin Shen,Desheng Wang,Zhisheng Liu,Xinyi Liu,Lihua Li,Renmin Gong
Background: Oral insulin improves compliance and convenience in patients with diabetes who require regular needle injections. However, the clinical application of oral insulin preparations has been limited due to instability and inefficient permeation through the gastrointestinal tract. In this study, a novel cationic polysaccharide nanodrug delivery platform was designed for efficient oral insulin delivery.Methods: The innovative thiolated trimethyl chitosan-grafted β-cyclodextrin (NCT) was synthesized by utilizing N-trimethyl chitosan (TMC) as the polymer backbone. This involved modifying TMC with thiol group-containing N-acetylcysteine and carboxymethyl-β-cyclodextrin that possesses hydrophobic cavities via an amide condensation reaction. Subsequently, this polymer was employed to construct the NCT nanoparticle system using an ionic cross-linking method. The physicochemical properties of the NCT nanoparticles were systematically analyzed, and their therapeutic efficacy was comprehensively evaluated in streptozotocin (STZ)-induced animal models.Results: The NCT nanoparticles demonstrated mucus adhesion, permeability, and pH sensitivity, which facilitated a slow and controlled release within the gastrointestinal microenvironment due to both ionic electrostatic interactions and disulfide bonding interactions. The experiments revealed in vivo that insulin/NCT nanoparticles extended the retention time of insulin in the small intestine. Blood glucose levels decreased to approximately 39% of the initial level at 5 h post-administration while exhibiting smooth hypoglycemic efficacy. Simultaneously, insulin bioavailability increased to 12.58%.Conclusions: The NCT nanoparticles effectively protect insulin from degradation in the gastrointestinal microenvironment while overcoming intestinal barriers, thereby providing a promising approach to oral biomolecule delivery.
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WATER SCIENCE AND TECHNOLOGY
·
2014
·Vol. 70
·期 4
·649-655
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IF 1.212
Zhang Conglu,Hou Xiaohong,Liang Ning,Ding Yueyue,Hu Xiaomin
Magnetic quaternary chitosan salt CS/EPTAC/Fe 3 O 4 was used for the removal of acid red 1 (AR1), xylenol orange (XO) and alizarin red (AR) in single, binary and ternary systems. In the single system, the maximal adsorption capacity was 781.55 for AR1, 537.40 for XO and 992.61 mg g −1 for AR at pH 3.0 and 25 °C. The adsorption kinetics of the three dyes followed the pseudo-second-order model. In the multicomponent system, preferential adsorption was observed for AR at low adsorbent quantities due to the small size of the molecule. When the adsorbent amount was greater, AR1 was adsorbed first because of the greater number of sulfonic acid roots. In the entire adsorption process, XO always adsorbed most slowly.
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Foods
·
2026
·Vol. 15
·期 2
·192
·
IF 5.1
Yujie Hou,Sitong Zhou,Shiqi Liu,Peng Jin,Yonghua Zheng,Zhengguo Wu
Mechanical damage and microbial contamination are major challenges in the postharvest logistics of perishable fruit. In this study, two types of functionally modified chitosan-based aerogel pads were developed to enhance cushioning and preservation of wax apples. A chitosan/polyvinyl alcohol (CP) aerogel was first optimized by adjusting solid content, CS:PVA ratio, and crosslinker concentration. The optimal formulation (2% solids, 1:1 CS: PVA, 3% glutaraldehyde) exhibited a uniform porous structure and improved compressive strength. A chitosan/montmorillonite (CM) aerogel with 5% montmorillonite (MMT) showed high porosity, low density, and excellent cyclic stability. Incorporating 10% copper nanoparticle-loaded antibacterial fibers (CuNPs-TNF) into CM aerogels yielded CM-Cu aerogels with enhanced cushioning and antimicrobial properties. Under simulated transport and cold storage conditions, all aerogel-packaged groups reduced mechanical damage and decay of wax apples. Compared to the control, the CM-Cu group showed 66% lower decay, 5% less weight loss, 6 N greater firmness, 7% less juice yield, and a 13% reduction in relative electrical conductivity. Additionally, it better preserved fruit color and total soluble solids, extending shelf life by 4 d at 20 °C. These results demonstrate the potential of chitosan-based aerogels as multifunctional packaging materials that combine mechanical protection with antimicrobial activity for perishable fruit preservation.
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Journal of Biological Engineering
·
2026
·
IF 6.3
Mingdong Yan,Yanjing Ou,Ruimin Liu,Changfu Xie,Jiang Chen
The repair of jawbone defects faces critical challenges, such as the mechanical-bioactivity imbalance and limited bioactivity of traditional scaffold materials. This study proposes a “mechanical reinforcement–bio-mineralization” synergistic strategy to construct a chitin nanowhiskers (CHWs)/octacalcium phosphate (OCP) co-modified chitosan (CS) composite hydrogel (CS/CHWs-OCP) and systematically investigates its bone regeneration efficacy. Results demonstrate the successful fabrication of CS/CHWs-OCP hydrogels with gradient OCP loading (3%–12% wt). The hydrogels exhibit three-dimensional interconnected porous structures, favorable swelling properties, and effective protein loading/sustained-release capabilities. In vitro experiments reveal that CS/CHWs-OCPs significantly promote osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and angiogenic differentiation of EA.hy926 cells, with the 12 wt% OCP group showing the highest alkaline phosphatase (ALP) activity. Micro-CT 3D reconstruction and histological analysis demonstrate that the 12 wt% OCP group exhibits optimal calvarial defect repair capacity, with its new bone volume fraction (BV/TV: 57.2 ± 10.2%) at 8 weeks being significantly superior to both the blank control and OCP-free hydrogel groups. In conclusion, the developed CS/CHWs-OCP hydrogel provides an effective solution for bone defect regeneration.
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BIOMEDICINE & PHARMACOTHERAPY
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2026
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IF 7.5
Jian-tao Zheng,Hui Ma,Qing He,Chan-juan Zhou,Xian Xu,Li Ye,Dongcui Li,Yan Huang
Liposomes, as effective drug delivery systems, face limitations in their low efficiency of traditional preparation methods and inherent physical instability. In this study, we systematically compared two strategies based on Flash Nanoprecipitation (FNP) technology for the rapid and controllable preparation of chitosan hybrid liposomes. We hypothesize that the “one-step” FNP method, which mixed chitosan and lipid solutions simultaneously, potentially enabled direct co-assembly between chitosan and lipid molecules, so that chitosan molecules likely embedded within the phospholipid bilayer, resulting in liposomes with more uniform structure and smaller particle size (∼70 nm). Meanwhile, the “two-step” FNP method, which mixed chitosan with preformed liposomes, likely yielded a core-shell structure through chitosan adsorption onto the liposome surface. The one-step FNP prepared particles exhibit excellent long-term storage stability and resistance to pH and ionic strength variations, likely due to the steric effect provided by the embedded polymer chains. To investigate the drug loading capability of FNP prepared chitosan-liposomes, we encapsulated an antifungal drug, fluconazole, into these hybrid nanoparticles. Compared to the free drug, the drug-loaded liposomes not only achieved sustained release, but also reduced the minimum inhibitory concentration against Candida albicans by an order of magnitude. This study demonstrates that FNP technology, particularly the one-step strategy, provides a robust platform for constructing polymer hybrid liposomes, showing potential for enhancing the delivery and functionality of poorly soluble drugs.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Yu Song,Zhiqi Lou,Chang Luo,Danyang Song,Jiekun Sun,Qiu Zhao,Miao Xu,Ziyu Liu,Zhonghua Liu,Tingsheng Yan
Angiogenesis is a fundamental prerequisite for functional tissue regeneration, and biomaterials that drive endogenous vascularization hold immense translational potential for treating tissue defects, organ damage, and ischemic diseases. Herein, gelatin methacryloyl (GelMA) and chitosan methacryloyl (CSMA) were synthesized via a copolymerization-based modification method. Hydrogel microspheres were prepared by emulsification, followed by cross-linking through photoinitiator-induced radical polymerization under UV light. Combined with freeze-drying, size-tunable porous GelMA/CSMA composite microspheres (G/CMS) were fabricated. The as-prepared G/CMS establish a favorable pro-regenerative microenvironment by integrating size-dependent mechanical feedback and charge-mediated cellular interactions. Specifically, CSMA incorporation imparted a positive surface charge, enhancing cellular affinity, while smaller diameters amplified mechanical stimuli promoting adhesion via mechanotransduction. In vitro, the optimized formulation (G/CMS-B) significantly promoted the proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs), and upregulated key angiogenic genes (VEGF, ANG, KDR) without exogenous growth factors. In vivo, subcutaneous implantation and hindlimb ischemia models confirmed accelerated neovascularization and blood flow recovery. The developed G/CMS exhibited excellent biocompatibility, controllable degradability, injectability, and excellent elastic recovery. This synergistic platform effectively modulates physicochemical cues to promote vascularization, offering a promising, cost-effective strategy for regenerative medicine.
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International Journal of Nanomedicine
·
2025
·
IF 6.5
Mengya Jin,Jinming Liu,Mengliu Shao,Shaoqin He,Yue He,Qingliang Yang,Gensheng Yang
Background/Objective Pulmonary fibrosis is a chronic, progressive lung disease with a high mortality rate. Currently, the treatment options for IPF involve the oral administration of nintedanib (NDNB); however, these therapies are hampered by low oral bioavailability. This study aimed to develop chitosan-based nanoparticles for pulmonary delivery to enhance the therapeutic effects of curcumin (Cur) and NDNB.Methods We successfully prepared and optimized Cur-loaded chitosan nanoparticles (Cur/CS-VES NPs) and NDNB-loaded chitosan nanoparticles (NDNB/CS-PGA NPs) through a standardized process. In vitro, Calu-3 and HFL1 cells were treated to evaluate the biocompatibility of chitosan nanocarrier materials and the antifibrotic activity of drug-loaded nanoparticles, respectively. In vivo, the bleomycin-induced rat models of pulmonary fibrosis were established to study the efficacy of chitosan nanoparticles.Results In vitro experiments indicated that the drug-loaded chitosan nanoparticles exhibited good stability and low cytotoxicity. In vivo pharmacodynamic studies revealed that, compared with oral administration of Cur or NDNB alone, the pulmonary delivery of Cur/CS-VES NPs and NDNB/CS-PGA NPs effectively inhibited the progression of pulmonary fibrosis, improved lung function, reduced levels of inflammatory factors, and mitigated pathological lesions in the lungs. These findings suggest that chitosan-based nano-particles have promising potential as pulmonary inhalation agents for the treatment of pulmonary fibrosis.Conclusion These findings highlight the great potential of chitosan-based nanoparticles as a therapeutic strategy for treating IPF and related pulmonary fibrosis with pulmonary delivery pathways.
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NANO
·
2025
·
IF 1.1
Guangyu Wu,Fangzhou Wen,Lini Huo,Peiyuan Li
In this study, a novel chitosan carbon dot/quercetin (CS-CDs/Que) composite nanosystem was constructed. Utilizing the abundant carbon, nitrogen, hydroxyl, and amino functional groups in the molecular structure of chitosan, carbonization, molecular polycondensation, and surface passivation were achieved through a hydrothermal method, ultimately forming chitosan carbon quantum dot carriers (CS-CDs) with an average size of 6.27 nm. Quercetin (Que) was then loaded onto these carriers to construct the composite nanosystem. Structural characterization of the composite nanosystem was conducted using techniques such as transmission electron microscopy and infrared spectroscopy, confirming the successful hybridization of the nanocomposites. Notably, compared with Que alone, the CS-CDs/Que composite nanosystem exhibit significantly enhanced antioxidant capacity under the same mass concentration. The scavenging rates of CS-CDs/Que for DPPH and ABTS can reach 92% and 62%, respectively; their chelating ability for ferrous ions is also much stronger than that of Que. Furthermore, CS-CDs/Que can effectively scavenge superoxide anion free radicals and hydroxyl free radicals. When the concentration of CS-CDs/Que is 15 µg mL −1 , it achieved a 100% scavenging rate for hydroxyl radicals. Overall, the prepared CS-CDs/Que composite nanosystem show excellent antioxidant activity, providing new insights for the development of novel antioxidants.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2017
·
IF 3.671
Xiang Li,Hu Tu,Mengtian Huang,Jiajia Chen,Xiaowen Shi,Hongbing Deng,Shuangfei Wang,Yumin Du
The demand for designing antibacterial materials was quite substantial in packing and biomedical materials fields. Chitosan had a wide utilization to satisfy this demand. In this study, by incorporating lysozyme (LY) – rectorite (REC) into chitosan films, the ultimately obtained hybrid films can own the enhanced antibacterial properties and still remains good mechanical properties . Scanning electron microscopy (SEM) images revealed that LY and REC could be homogeneously distributed in the CS films. X-ray photoelectron spectroscopy (XPS) and Energy-dispersive X-ray analysis (EDX) results verified that the LY-REC incorporation process was successful. Small angle X-ray diffraction (SAXRD) and Fourier transform infrared (FT-IR) spectra revealed that some intercalation reactions occurred between CS chains and REC. The hydrophobic properties of the CS films were increased by the addition of LY and REC, determined by water contact angle measurement. In comparison with CS films, the mechanical properties of the composite films after adding LY-REC were reduced by 27.58%, but still maintained high tensile strength . Besides, the antibacterial properties of the films could be enhanced by introducing LY-REC. This method exhibited great application value in the food packaging fields.
研究领域:
材料科学
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食品包装
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生物医学工程
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高分子科学
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抗菌材料
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